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Gene: TMEM123 (transmembrane protein 123) Homo sapiens
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Symbol: TMEM123
Name: transmembrane protein 123
Description: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: KCT-3; KCT3; keratinocytes associated transmembrane protein 3; keratinocytes-associated transmembrane protein 3; porimin; PORMIN; pro oncosis receptor inducing membrane injury; pro-oncosis receptor inducing membrane injury; serine/threonine-rich receptor
Orthologs:
Mus musculus (house mouse) : Tmem123 (transmembrane protein 123)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tmem123 (transmembrane protein 123)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmem123 (transmembrane protein 123)
Pan paniscus (bonobo/pygmy chimpanzee) : TMEM123 (transmembrane protein 123)
Canis lupus familiaris (dog) : LOC100856041 (uncharacterized LOC100856041)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmem123 (transmembrane protein 123)
Sus scrofa (pig) : TMEM123 (transmembrane protein 123)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,396,332 - 102,452,765 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,267,056 - 102,323,775 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,772,266 - 101,828,985 (-)NCBINCBI36hg18NCBI36
Celera1199,428,614 - 99,485,334 (-)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,193,581 - 98,250,555 (-)NCBIHuRef
CHM1_111102,150,071 - 102,206,782 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TMEM123
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605596
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.