Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TMEM123 (transmembrane protein 123) Homo sapiens
Symbol: TMEM123
Name: transmembrane protein 123
Description: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: KCT-3; KCT3; keratinocytes associated transmembrane protein 3; keratinocytes-associated transmembrane protein 3; porimin; PORMIN; pro oncosis receptor inducing membrane injury; pro-oncosis receptor inducing membrane injury; serine/threonine-rich receptor
Mus musculus (house mouse) : Tmem123 (transmembrane protein 123)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tmem123 (transmembrane protein 123)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmem123 (transmembrane protein 123)
Pan paniscus (bonobo/pygmy chimpanzee) : TMEM123 (transmembrane protein 123)
Canis lupus familiaris (dog) : LOC100856041 (uncharacterized LOC100856041)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmem123 (transmembrane protein 123)
Sus scrofa (pig) : TMEM123 (transmembrane protein 123)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811102,396,332 - 102,452,765 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,267,056 - 102,323,775 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,772,266 - 101,828,985 (-)NCBINCBI36hg18NCBI36
Celera1199,428,614 - 99,485,334 (-)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,193,581 - 98,250,555 (-)NCBIHuRef
CHM1_111102,150,071 - 102,206,782 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TMEM123
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605596
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.