DCANP1 (dendritic cell associated nuclear protein 1) - Rat Genome Database

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Gene: DCANP1 (dendritic cell associated nuclear protein 1) Homo sapiens
Analyze
Symbol: DCANP1
Name: dendritic cell associated nuclear protein 1
RGD ID: 1605576
HGNC Page HGNC:24459
Description: Predicted to enable DNA binding activity. Involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. Located in nuclear body.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C5orf20; DCNP1; dendritic cell associated nuclear protein; dendritic cell nuclear protein 1; dendritic cell nuclear protein-1
RGD Orthologs
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,444,214 - 135,447,348 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,444,214 - 135,447,348 (-)EnsemblGRCh38hg38GRCh38
GRCh375134,779,904 - 134,783,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,807,803 - 134,810,937 (-)NCBINCBI36Build 36hg18NCBI36
Celera5130,903,693 - 130,906,827 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5129,967,608 - 129,970,742 (-)NCBIHuRef
CHM1_15134,212,547 - 134,215,681 (-)NCBICHM1_1
T2T-CHM13v2.05135,971,385 - 135,974,519 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear body  (IDA)
nucleoplasm  (IDA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10737800   PMID:11181995   PMID:11798177   PMID:12477932   PMID:15489334   PMID:16189510   PMID:17207965   PMID:17460725   PMID:20351714   PMID:20693543   PMID:23419067   PMID:23619526  
PMID:25416956   PMID:29219947   PMID:31515488   PMID:32296183   PMID:32814053   PMID:33961781   PMID:36724073  


Genomics

Comparative Map Data
DCANP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,444,214 - 135,447,348 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,444,214 - 135,447,348 (-)EnsemblGRCh38hg38GRCh38
GRCh375134,779,904 - 134,783,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,807,803 - 134,810,937 (-)NCBINCBI36Build 36hg18NCBI36
Celera5130,903,693 - 130,906,827 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5129,967,608 - 129,970,742 (-)NCBIHuRef
CHM1_15134,212,547 - 134,215,681 (-)NCBICHM1_1
T2T-CHM13v2.05135,971,385 - 135,974,519 (-)NCBIT2T-CHM13v2.0
DCANP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24130,734,268 - 130,735,012 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15128,873,828 - 128,874,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05130,838,844 - 130,839,588 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15136,979,950 - 136,980,694 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5136,979,950 - 136,980,694 (-)Ensemblpanpan1.1panPan2
DCANP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,224,287 - 38,227,481 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603439,688,872 - 39,689,774 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DCANP1
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:133401565-138437038)x1 copy number loss See cases [RCV000052114] Chr5:133401565..138437038 [GRCh38]
Chr5:132737257..137772727 [GRCh37]
Chr5:132765156..137800626 [NCBI36]
Chr5:5q31.1-31.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3		 pathogenic
GRCh38/hg38 5q31.1(chr5:131626503-135815054)x1 copy number loss See cases [RCV000135442] Chr5:131626503..135815054 [GRCh38]
Chr5:130962196..135150743 [GRCh37]
Chr5:130990095..135178642 [NCBI36]
Chr5:5q31.1		 pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_130848.3(DCANP1):c.713G>A (p.Arg238Lys) single nucleotide variant Inborn genetic diseases [RCV003295679] Chr5:135446396 [GRCh38]
Chr5:134782086 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2		 likely pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
NC_000005.9:g.(?_133533463)_(135398915_?)dup duplication not provided [RCV001966204] Chr5:133533463..135398915 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5q31.1-31.2(chr5:132031902-137623639) copy number loss not specified [RCV002053530] Chr5:132031902..137623639 [GRCh37]
Chr5:5q31.1-31.2		 pathogenic
GRCh37/hg19 5q31.1(chr5:132829317-134983855) copy number loss not specified [RCV002053531] Chr5:132829317..134983855 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.709C>T (p.Arg237Cys) single nucleotide variant Inborn genetic diseases [RCV003255168] Chr5:135446400 [GRCh38]
Chr5:134782090 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.46G>A (p.Gly16Ser) single nucleotide variant Inborn genetic diseases [RCV002730024] Chr5:135447063 [GRCh38]
Chr5:134782753 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.706C>T (p.His236Tyr) single nucleotide variant Inborn genetic diseases [RCV002682930] Chr5:135446403 [GRCh38]
Chr5:134782093 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.617A>G (p.His206Arg) single nucleotide variant Inborn genetic diseases [RCV002968404] Chr5:135446492 [GRCh38]
Chr5:134782182 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.353G>A (p.Arg118Lys) single nucleotide variant Inborn genetic diseases [RCV002772620] Chr5:135446756 [GRCh38]
Chr5:134782446 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5q31.1(chr5:134524754-135283222)x3 copy number gain not provided [RCV002475756] Chr5:134524754..135283222 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.125C>A (p.Ser42Tyr) single nucleotide variant Inborn genetic diseases [RCV002773943] Chr5:135446984 [GRCh38]
Chr5:134782674 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.502G>A (p.Glu168Lys) single nucleotide variant Inborn genetic diseases [RCV003001591] Chr5:135446607 [GRCh38]
Chr5:134782297 [GRCh37]
Chr5:5q31.1		 likely benign
NM_130848.3(DCANP1):c.604G>A (p.Ala202Thr) single nucleotide variant Inborn genetic diseases [RCV002757944] Chr5:135446505 [GRCh38]
Chr5:134782195 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.550T>C (p.Trp184Arg) single nucleotide variant Inborn genetic diseases [RCV002925030] Chr5:135446559 [GRCh38]
Chr5:134782249 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.247G>C (p.Glu83Gln) single nucleotide variant Inborn genetic diseases [RCV002707032] Chr5:135446862 [GRCh38]
Chr5:134782552 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.71A>T (p.Gln24Leu) single nucleotide variant Inborn genetic diseases [RCV002984343] Chr5:135447038 [GRCh38]
Chr5:134782728 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.436G>A (p.Val146Ile) single nucleotide variant Inborn genetic diseases [RCV002723585] Chr5:135446673 [GRCh38]
Chr5:134782363 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_130848.3(DCANP1):c.419C>T (p.Pro140Leu) single nucleotide variant Inborn genetic diseases [RCV003206994] Chr5:135446690 [GRCh38]
Chr5:134782380 [GRCh37]
Chr5:5q31.1		 likely benign
NM_130848.3(DCANP1):c.311C>T (p.Ala104Val) single nucleotide variant Inborn genetic diseases [RCV003185110] Chr5:135446798 [GRCh38]
Chr5:134782488 [GRCh37]
Chr5:5q31.1		 likely benign
NM_130848.3(DCANP1):c.665T>G (p.Val222Gly) single nucleotide variant Inborn genetic diseases [RCV003357117] Chr5:135446444 [GRCh38]
Chr5:134782134 [GRCh37]
Chr5:5q31.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1042
Count of miRNA genes:697
Interacting mature miRNAs:777
Transcripts:ENST00000503143
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH93048  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375134,779,963 - 134,780,064UniSTSGRCh37
Build 365134,807,862 - 134,807,963RGDNCBI36
Celera5130,903,752 - 130,903,853RGD
Cytogenetic Map5q31.1UniSTS
HuRef5129,967,667 - 129,967,768UniSTS
GeneMap99-GB4 RH Map5510.67UniSTS
UniSTS:482053  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375134,782,025 - 134,782,824UniSTSGRCh37
Celera5130,905,814 - 130,906,613UniSTS
HuRef5129,969,729 - 129,970,528UniSTS
UniSTS:485969  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375134,781,977 - 134,782,977UniSTSGRCh37
Celera5130,905,766 - 130,906,766UniSTS
HuRef5129,969,681 - 129,970,681UniSTS
UniSTS:480796  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375134,781,816 - 134,782,882UniSTSGRCh37
Celera5130,905,605 - 130,906,671UniSTS
HuRef5129,969,520 - 129,970,586UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system renal system reproductive system respiratory system
High
Medium
Low
Below cutoff 1 1 17 1 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000503143   ⟹   ENSP00000421871
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,444,214 - 135,447,348 (-)Ensembl
RefSeq Acc Id: NM_130848   ⟹   NP_570900
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385135,444,214 - 135,447,348 (-)NCBI
GRCh375134,779,904 - 134,783,038 (-)RGD
Build 365134,807,803 - 134,810,937 (-)NCBI Archive
Celera5130,903,693 - 130,906,827 (-)RGD
HuRef5129,967,608 - 129,970,742 (-)ENTREZGENE
CHM1_15134,212,547 - 134,215,681 (-)NCBI
T2T-CHM13v2.05135,971,385 - 135,974,519 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_570900   ⟸   NM_130848
- UniProtKB: Q8TF63 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000421871   ⟸   ENST00000503143

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8TF63-F1-model_v2 AlphaFold Q8TF63 1-244 view protein structure


Additional Information

Database Acc Id Source(s)
COSMIC DCANP1 COSMIC
Ensembl Genes ENSG00000251380 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000503143 ENTREZGENE
  ENST00000503143.3 UniProtKB/Swiss-Prot
GTEx ENSG00000251380 GTEx
HGNC ID HGNC:24459 ENTREZGENE
Human Proteome Map DCANP1 Human Proteome Map
KEGG Report hsa:140947 UniProtKB/Swiss-Prot
NCBI Gene 140947 ENTREZGENE
OMIM 609710 OMIM
PharmGKB PA142672373 PharmGKB
UniProt DCNP1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-25 DCANP1  dendritic cell associated nuclear protein 1  DCANP1  dendritic cell associated nuclear protein  Symbol and/or name change 19259463 PROVISIONAL
2016-06-21 DCANP1  dendritic cell associated nuclear protein  DCANP1  dendritic cell-associated nuclear protein  Symbol and/or name change 5135510 APPROVED
2014-08-26 DCANP1  dendritic cell-associated nuclear protein  C5orf20  chromosome 5 open reading frame 20  Symbol and/or name change 5135510 APPROVED