CLEC18B (C-type lectin domain family 18 member B) - Rat Genome Database

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Gene: CLEC18B (C-type lectin domain family 18 member B) Homo sapiens
Analyze
Symbol: CLEC18B
Name: C-type lectin domain family 18 member B
RGD ID: 1605475
HGNC Page HGNC:33849
Description: Predicted to enable polysaccharide binding activity. Predicted to be located in Golgi apparatus; endosome; and sarcoplasmic reticulum. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-type lectin domain family 18 member A-like; C-type lectin domain family 18 member B-like; C-type lectin domain family 18 member C-like; C-type lectin domain family 18, member B; LOC124907805; mannose receptor-like 2; mannose receptor-like protein 1; MRCL2; secretory protein LOC497190
RGD Orthologs
Bonobo
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381674,408,631 - 74,424,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1674,408,631 - 74,421,478 (-)EnsemblGRCh38hg38GRCh38
GRCh371674,442,529 - 74,456,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,000,030 - 73,012,791 (-)NCBINCBI36Build 36hg18NCBI36
Celera1654,500,393 - 54,513,191 (+)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1660,201,481 - 60,204,917 (-)NCBIHuRef
CHM1_11675,854,636 - 75,867,465 (-)NCBICHM1_1
T2T-CHM13v2.01680,223,868 - 80,242,200 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12975309   PMID:16336259   PMID:16344560   PMID:21873635   PMID:26170455   PMID:29914265  


Genomics

Comparative Map Data
CLEC18B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381674,408,631 - 74,424,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1674,408,631 - 74,421,478 (-)EnsemblGRCh38hg38GRCh38
GRCh371674,442,529 - 74,456,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,000,030 - 73,012,791 (-)NCBINCBI36Build 36hg18NCBI36
Celera1654,500,393 - 54,513,191 (+)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1660,201,481 - 60,204,917 (-)NCBIHuRef
CHM1_11675,854,636 - 75,867,465 (-)NCBICHM1_1
T2T-CHM13v2.01680,223,868 - 80,242,200 (-)NCBIT2T-CHM13v2.0
CLEC18B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21884,125,162 - 84,139,480 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11689,929,284 - 89,941,730 (-)NCBINHGRI_mPanPan1
CLEC18C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,256,660 - 76,270,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha576,218,563 - 76,232,374 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0576,693,265 - 76,707,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,693,435 - 76,836,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,515,443 - 76,529,247 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,338,563 - 76,352,369 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,830,650 - 76,844,465 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in CLEC18B
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q22.1-24.3(chr16:70514631-90081985)x3 copy number gain See cases [RCV000052422] Chr16:70514631..90081985 [GRCh38]
Chr16:70548534..90148393 [GRCh37]
Chr16:69106035..88675894 [NCBI36]
Chr16:16q22.1-24.3		 pathogenic
GRCh38/hg38 16q22.1-23.1(chr16:69918076-76723348)x1 copy number loss See cases [RCV000053356] Chr16:69918076..76723348 [GRCh38]
Chr16:69951979..76757245 [GRCh37]
Chr16:68509480..75314746 [NCBI36]
Chr16:16q22.1-23.1		 pathogenic
GRCh38/hg38 16q22.3-23.3(chr16:73049467-82576326)x1 copy number loss See cases [RCV000053357] Chr16:73049467..82576326 [GRCh38]
Chr16:73083366..82609931 [GRCh37]
Chr16:71640867..81167432 [NCBI36]
Chr16:16q22.3-23.3		 pathogenic
GRCh38/hg38 16q22.3-23.1(chr16:73917167-75319927)x3 copy number gain See cases [RCV000053868] Chr16:73917167..75319927 [GRCh38]
Chr16:73951066..75353825 [GRCh37]
Chr16:72508567..73911326 [NCBI36]
Chr16:16q22.3-23.1		 uncertain significance
GRCh38/hg38 16q22.1-24.1(chr16:70414573-84908120)x1 copy number loss See cases [RCV000133814] Chr16:70414573..84908120 [GRCh38]
Chr16:70448476..84941726 [GRCh37]
Chr16:69005977..83499227 [NCBI36]
Chr16:16q22.1-24.1		 pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1		 pathogenic
GRCh38/hg38 16q22.1-24.3(chr16:70749398-90096995)x3 copy number gain See cases [RCV000137495] Chr16:70749398..90096995 [GRCh38]
Chr16:70783301..90163403 [GRCh37]
Chr16:69340802..88690904 [NCBI36]
Chr16:16q22.1-24.3		 pathogenic
GRCh38/hg38 16q23.1(chr16:74207339-74862823)x1 copy number loss See cases [RCV000139276] Chr16:74207339..74862823 [GRCh38]
Chr16:74241238..74896721 [GRCh37]
Chr16:72798739..73454222 [NCBI36]
Chr16:16q23.1		 uncertain significance
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q22.1-23.3(chr16:69053457-83274681)x3 copy number gain See cases [RCV000142038] Chr16:69053457..83274681 [GRCh38]
Chr16:69087360..83308286 [GRCh37]
Chr16:67644861..81865787 [NCBI36]
Chr16:16q22.1-23.3		 pathogenic
GRCh38/hg38 16q23.1(chr16:74340127-74421435)x3 copy number gain See cases [RCV000142848] Chr16:74340127..74421435 [GRCh38]
Chr16:74374025..74455333 [GRCh37]
Chr16:72931526..73012834 [NCBI36]
Chr16:16q23.1		 likely benign
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3		 pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3		 uncertain significance
GRCh37/hg19 16q22.2-24.3(chr16:72107834-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207182] Chr16:72107834..90142285 [GRCh37]
Chr16:16q22.2-24.3		 uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3		 uncertain significance
GRCh37/hg19 16q22.3-23.1(chr16:74052465-74562784)x3 copy number gain See cases [RCV000599240] Chr16:74052465..74562784 [GRCh37]
Chr16:16q22.3-23.1		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q23.1(chr16:74150909-77077326)x1 copy number loss See cases [RCV000512133] Chr16:74150909..77077326 [GRCh37]
Chr16:16q23.1		 uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
NM_001385193.1(CLEC18B):c.1328G>A (p.Gly443Asp) single nucleotide variant Inborn genetic diseases [RCV003270785] Chr16:74409019 [GRCh38]
Chr16:74442917 [GRCh37]
Chr16:16q23.1		 likely benign
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q22.2-24.3(chr16:72515938-90155062)x3 copy number gain not provided [RCV000683831] Chr16:72515938..90155062 [GRCh37]
Chr16:16q22.2-24.3		 pathogenic
GRCh37/hg19 16q22.3-23.1(chr16:74063678-74577132)x3 copy number gain not provided [RCV000683832] Chr16:74063678..74577132 [GRCh37]
Chr16:16q22.3-23.1		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q23.1(chr16:74386934-74467693)x1 copy number loss not provided [RCV000739209] Chr16:74386934..74467693 [GRCh37]
Chr16:16q23.1		 benign
GRCh37/hg19 16q22.2-23.1(chr16:72677179-77439111)x1 copy number loss not provided [RCV000847084] Chr16:72677179..77439111 [GRCh37]
Chr16:16q22.2-23.1		 uncertain significance
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3		 not provided
GRCh37/hg19 16q23.1(chr16:74356233-75432089)x1 copy number loss not provided [RCV001006805] Chr16:74356233..75432089 [GRCh37]
Chr16:16q23.1		 uncertain significance
GRCh37/hg19 16q22.1-23.1(chr16:68971067-74823560)x1 copy number loss See cases [RCV002285074] Chr16:68971067..74823560 [GRCh37]
Chr16:16q22.1-23.1		 pathogenic
GRCh37/hg19 16q22.3-23.1(chr16:73867846-74577132)x3 copy number gain not provided [RCV001259866] Chr16:73867846..74577132 [GRCh37]
Chr16:16q22.3-23.1		 uncertain significance
GRCh37/hg19 16q23.1(chr16:74150909-74848930)x3 copy number gain not provided [RCV001829192] Chr16:74150909..74848930 [GRCh37]
Chr16:16q23.1		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
GRCh37/hg19 16q22.2-24.3(chr16:71641395-90161959)x3 copy number gain Syndromic anorectal malformation [RCV002286607] Chr16:71641395..90161959 [GRCh37]
Chr16:16q22.2-24.3		 likely pathogenic
GRCh37/hg19 16q22.3-23.1(chr16:73673334-76105189)x4 copy number gain not provided [RCV002475008] Chr16:73673334..76105189 [GRCh37]
Chr16:16q22.3-23.1		 uncertain significance
GRCh37/hg19 16q22.3-23.1(chr16:73858079-75855162)x1 copy number loss not provided [RCV002475848] Chr16:73858079..75855162 [GRCh37]
Chr16:16q22.3-23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.19T>C (p.Ser7Pro) single nucleotide variant Inborn genetic diseases [RCV002864653] Chr16:74421252 [GRCh38]
Chr16:74455150 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.259G>A (p.Ala87Thr) single nucleotide variant Inborn genetic diseases [RCV002728351] Chr16:74418256 [GRCh38]
Chr16:74452154 [GRCh37]
Chr16:16q23.1		 uncertain significance
GRCh37/hg19 16q22.3-23.1(chr16:73673334-78137887)x1 copy number loss not provided [RCV002475774] Chr16:73673334..78137887 [GRCh37]
Chr16:16q22.3-23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.421T>C (p.Cys141Arg) single nucleotide variant Inborn genetic diseases [RCV002869352] Chr16:74418094 [GRCh38]
Chr16:74451992 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.821G>A (p.Arg274Gln) single nucleotide variant Inborn genetic diseases [RCV002951757] Chr16:74412210 [GRCh38]
Chr16:74446108 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.169C>T (p.Arg57Cys) single nucleotide variant Inborn genetic diseases [RCV002758022] Chr16:74420548 [GRCh38]
Chr16:74454446 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.82G>A (p.Val28Met) single nucleotide variant Inborn genetic diseases [RCV002659930] Chr16:74421189 [GRCh38]
Chr16:74455087 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.475A>G (p.Ser159Gly) single nucleotide variant Inborn genetic diseases [RCV002757529] Chr16:74413658 [GRCh38]
Chr16:74447556 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.620G>A (p.Cys207Tyr) single nucleotide variant Inborn genetic diseases [RCV003004728] Chr16:74413093 [GRCh38]
Chr16:74446991 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.206T>C (p.Met69Thr) single nucleotide variant Inborn genetic diseases [RCV002697299] Chr16:74420511 [GRCh38]
Chr16:74454409 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.853G>A (p.Gly285Ser) single nucleotide variant Inborn genetic diseases [RCV002804290] Chr16:74412178 [GRCh38]
Chr16:74446076 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.439T>C (p.Cys147Arg) single nucleotide variant Inborn genetic diseases [RCV002832481] Chr16:74418076 [GRCh38]
Chr16:74451974 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.1321C>T (p.Arg441Trp) single nucleotide variant Inborn genetic diseases [RCV002960739] Chr16:74409026 [GRCh38]
Chr16:74442924 [GRCh37]
Chr16:16q23.1		 likely benign
NM_001385193.1(CLEC18B):c.290C>T (p.Ala97Val) single nucleotide variant Inborn genetic diseases [RCV002672717] Chr16:74418225 [GRCh38]
Chr16:74452123 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.398G>A (p.Arg133Gln) single nucleotide variant Inborn genetic diseases [RCV002963897] Chr16:74418117 [GRCh38]
Chr16:74452015 [GRCh37]
Chr16:16q23.1		 likely benign
NM_001385193.1(CLEC18B):c.997G>T (p.Val333Leu) single nucleotide variant Inborn genetic diseases [RCV003196454] Chr16:74411022 [GRCh38]
Chr16:74444920 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.409G>A (p.Ala137Thr) single nucleotide variant Inborn genetic diseases [RCV003207135] Chr16:74418106 [GRCh38]
Chr16:74452004 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.1307A>G (p.Gln436Arg) single nucleotide variant Inborn genetic diseases [RCV003179290] Chr16:74409040 [GRCh38]
Chr16:74442938 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.1262A>C (p.Asp421Ala) single nucleotide variant Inborn genetic diseases [RCV003357516] Chr16:74409591 [GRCh38]
Chr16:74443489 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.430A>C (p.Asn144His) single nucleotide variant Inborn genetic diseases [RCV003378851] Chr16:74418085 [GRCh38]
Chr16:74451983 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.250G>A (p.Ala84Thr) single nucleotide variant Inborn genetic diseases [RCV003376572] Chr16:74418265 [GRCh38]
Chr16:74452163 [GRCh37]
Chr16:16q23.1		 uncertain significance
NM_001385193.1(CLEC18B):c.60C>G (p.Leu20=) single nucleotide variant not provided [RCV003456945] Chr16:74421211 [GRCh38]
Chr16:74455109 [GRCh37]
Chr16:16q23.1		 likely benign
GRCh37/hg19 16q22.1-23.2(chr16:70607067-81561138)x3 copy number gain not provided [RCV003485121] Chr16:70607067..81561138 [GRCh37]
Chr16:16q22.1-23.2		 pathogenic
GRCh37/hg19 16q22.3-23.1(chr16:73808625-74466419)x3 copy number gain not provided [RCV003485123] Chr16:73808625..74466419 [GRCh37]
Chr16:16q22.3-23.1		 uncertain significance
GRCh37/hg19 16q22.3-23.1(chr16:74079694-75352818)x1 copy number loss not specified [RCV003987133] Chr16:74079694..75352818 [GRCh37]
Chr16:16q22.3-23.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:945
Count of miRNA genes:592
Interacting mature miRNAs:682
Transcripts:ENST00000339953, ENST00000425714, ENST00000564842
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH102328  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map16q22.3UniSTS
GeneMap99-GB4 RH Map16442.72UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 9 2 22 143 75 6 9
Low 99 563 587 104 363 57 744 50 2642 160 625 362 48 24 662
Below cutoff 2149 2229 1067 473 1121 361 3234 1829 1027 87 688 1135 121 1095 1914 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001011880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047446639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007086622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM695392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA374548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA375446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC309733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000339953   ⟹   ENSP00000341051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1674,408,631 - 74,421,392 (-)Ensembl
RefSeq Acc Id: ENST00000425714
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1674,411,887 - 74,421,470 (-)Ensembl
RefSeq Acc Id: ENST00000564842
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1674,411,353 - 74,412,799 (-)Ensembl
RefSeq Acc Id: ENST00000617101   ⟹   ENSP00000482974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1674,408,270 - 74,421,756 (-)Ensembl
RefSeq Acc Id: ENST00000619275   ⟹   ENSP00000483587
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1674,408,270 - 74,421,953 (-)Ensembl
RefSeq Acc Id: ENST00000620745   ⟹   ENSP00000477577
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1674,408,633 - 74,421,404 (-)Ensembl
RefSeq Acc Id: ENST00000682950   ⟹   ENSP00000507367
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1674,408,631 - 74,421,478 (-)Ensembl
RefSeq Acc Id: NM_001011880   ⟹   NP_001011880
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,421,478 (-)NCBI
GRCh371674,442,529 - 74,455,368 (-)RGD
Build 361673,000,030 - 73,012,791 (-)NCBI Archive
HuRef1660,201,481 - 60,204,917 (-)ENTREZGENE
CHM1_11675,854,636 - 75,867,465 (-)NCBI
T2T-CHM13v2.01680,226,594 - 80,239,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385192   ⟹   NP_001372121
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,422,141 (-)NCBI
T2T-CHM13v2.01680,226,594 - 80,240,092 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385193   ⟹   NP_001372122
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,421,478 (-)NCBI
T2T-CHM13v2.01680,226,594 - 80,239,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385194   ⟹   NP_001372123
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,421,783 (-)NCBI
T2T-CHM13v2.01680,226,594 - 80,239,734 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001385195   ⟹   NP_001372124
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,421,478 (-)NCBI
T2T-CHM13v2.01680,226,594 - 80,239,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047434172   ⟹   XP_047290128
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,422,141 (-)NCBI
RefSeq Acc Id: XM_047434173   ⟹   XP_047290129
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,424,249 (-)NCBI
RefSeq Acc Id: XM_047434174   ⟹   XP_047290130
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,424,249 (-)NCBI
RefSeq Acc Id: XM_047434175   ⟹   XP_047290131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,421,756 (-)NCBI
RefSeq Acc Id: XM_047434176   ⟹   XP_047290132
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,408,631 - 74,421,766 (-)NCBI
RefSeq Acc Id: XM_047434177   ⟹   XP_047290133
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,409,551 - 74,421,478 (-)NCBI
RefSeq Acc Id: XM_047434178   ⟹   XP_047290134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,410,540 - 74,421,478 (-)NCBI
RefSeq Acc Id: XM_047446629   ⟹   XP_047302585
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,223,868 - 80,240,052 (-)NCBI
RefSeq Acc Id: XM_047446630   ⟹   XP_047302586
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,223,868 - 80,240,052 (-)NCBI
RefSeq Acc Id: XM_047446631   ⟹   XP_047302587
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,223,868 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446632   ⟹   XP_047302588
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,223,868 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446633   ⟹   XP_047302589
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,223,868 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446634   ⟹   XP_047302590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,226,594 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446635   ⟹   XP_047302591
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,226,594 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446636   ⟹   XP_047302592
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,226,594 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446637   ⟹   XP_047302593
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,226,594 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446638   ⟹   XP_047302594
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,223,868 - 80,242,200 (-)NCBI
RefSeq Acc Id: XM_047446639   ⟹   XP_047302595
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,226,594 - 80,242,200 (-)NCBI
RefSeq Acc Id: XR_007086622
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01680,223,868 - 80,242,200 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001011880 (Get FASTA)   NCBI Sequence Viewer  
  NP_001372121 (Get FASTA)   NCBI Sequence Viewer  
  NP_001372122 (Get FASTA)   NCBI Sequence Viewer  
  NP_001372123 (Get FASTA)   NCBI Sequence Viewer  
  NP_001372124 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290128 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290129 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290130 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290131 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290132 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290133 (Get FASTA)   NCBI Sequence Viewer  
  XP_047290134 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302585 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302586 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302587 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302588 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302589 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302590 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302591 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302592 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302593 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302594 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302595 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ88739 (Get FASTA)   NCBI Sequence Viewer  
  BAG57351 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000341051
  ENSP00000341051.5
  ENSP00000507367
  ENSP00000507367.1
GenBank Protein Q6UXF7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001011880   ⟸   NM_001011880
- Peptide Label: isoform 2 precursor
- UniProtKB: B4DF90 (UniProtKB/Swiss-Prot),   Q6UXF7 (UniProtKB/Swiss-Prot),   F5H550 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000477577   ⟸   ENST00000620745
RefSeq Acc Id: ENSP00000341051   ⟸   ENST00000339953
RefSeq Acc Id: ENSP00000482974   ⟸   ENST00000617101
RefSeq Acc Id: ENSP00000483587   ⟸   ENST00000619275
RefSeq Acc Id: NP_001372121   ⟸   NM_001385192
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A804HJ60 (UniProtKB/TrEMBL),   F5H550 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001372123   ⟸   NM_001385194
- Peptide Label: isoform 3 precursor
- UniProtKB: F8W692 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001372124   ⟸   NM_001385195
- Peptide Label: isoform 3 precursor
- UniProtKB: F8W692 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001372122   ⟸   NM_001385193
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A804HJ60 (UniProtKB/TrEMBL),   F5H550 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000507367   ⟸   ENST00000682950
RefSeq Acc Id: XP_047290130   ⟸   XM_047434174
- Peptide Label: isoform X1
- UniProtKB: A0A804HJ60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047290129   ⟸   XM_047434173
- Peptide Label: isoform X1
- UniProtKB: A0A804HJ60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047290128   ⟸   XM_047434172
- Peptide Label: isoform X1
- UniProtKB: A0A804HJ60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047290132   ⟸   XM_047434176
- Peptide Label: isoform X1
- UniProtKB: A0A804HJ60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047290131   ⟸   XM_047434175
- Peptide Label: isoform X1
- UniProtKB: A0A804HJ60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047290133   ⟸   XM_047434177
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047290134   ⟸   XM_047434178
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047302587   ⟸   XM_047446631
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047302594   ⟸   XM_047446638
- Peptide Label: isoform X10
RefSeq Acc Id: XP_047302588   ⟸   XM_047446632
- Peptide Label: isoform X5
RefSeq Acc Id: XP_047302589   ⟸   XM_047446633
- Peptide Label: isoform X6
RefSeq Acc Id: XP_047302586   ⟸   XM_047446630
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047302585   ⟸   XM_047446629
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047302595   ⟸   XM_047446639
- Peptide Label: isoform X11
RefSeq Acc Id: XP_047302593   ⟸   XM_047446637
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047302592   ⟸   XM_047446636
- Peptide Label: isoform X9
RefSeq Acc Id: XP_047302591   ⟸   XM_047446635
- Peptide Label: isoform X8
RefSeq Acc Id: XP_047302590   ⟸   XM_047446634
- Peptide Label: isoform X7
Protein Domains
C-type lectin   EGF-like   SCP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6UXF7-F1-model_v2 AlphaFold Q6UXF7 1-455 view protein structure

Promoters
RGD ID:7232821
Promoter ID:EPDNEW_H22156
Type:multiple initiation site
Name:CLEC18B_1
Description:C-type lectin domain family 18 member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381674,421,476 - 74,421,536EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33849 AgrOrtholog
COSMIC CLEC18B COSMIC
Ensembl Genes ENSG00000140839 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000339953 ENTREZGENE
  ENST00000339953.9 UniProtKB/Swiss-Prot
  ENST00000682950 ENTREZGENE
  ENST00000682950.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.33.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000140839 GTEx
HGNC ID HGNC:33849 ENTREZGENE
Human Proteome Map CLEC18B Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRISP-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:497190 UniProtKB/Swiss-Prot
NCBI Gene 497190 ENTREZGENE
OMIM 616572 OMIM
PANTHER C-TYPE LECTIN DOMAIN FAMILY 18 MEMBER A-RELATED UniProtKB/Swiss-Prot
  CYSTEINE-RICH SECRETORY PROTEIN-RELATED UniProtKB/Swiss-Prot
  LITHOSTATHINE UniProtKB/TrEMBL
  SI:DKEYP-75B4.10 UniProtKB/TrEMBL
Pfam CAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164718007 PharmGKB
PRINTS V5TPXLIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55797 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A804HJ60 ENTREZGENE, UniProtKB/TrEMBL
  B4DF90 ENTREZGENE
  CL18B_HUMAN UniProtKB/Swiss-Prot
  F5H550 ENTREZGENE
  F8W692 ENTREZGENE
  Q6UXF7 ENTREZGENE
UniProt Secondary B4DF90 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-23 CLEC18B  C-type lectin domain family 18 member B  LOC124907805  C-type lectin domain family 18 member C-like  Data merged from RGD:151671224 737654 PROVISIONAL
2015-12-22 CLEC18B  C-type lectin domain family 18 member B    C-type lectin domain family 18, member B  Symbol and/or name change 5135510 APPROVED