CCDC85B (coiled-coil domain containing 85B) - Rat Genome Database

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Gene: CCDC85B (coiled-coil domain containing 85B) Homo sapiens
Analyze
Symbol: CCDC85B
Name: coiled-coil domain containing 85B
RGD ID: 1605406
HGNC Page HGNC
Description: Enables delta-catenin binding activity. Involved in negative regulation of cell growth and negative regulation of transcription, DNA-templated. Located in adherens junction; centrosome; and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coiled-coil domain-containing protein 85B; delta-interacting protein A; DIPA; hepatitis delta antigen interacting protein A; hepatitis delta antigen-interacting protein A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,890,673 - 65,891,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1165,890,673 - 65,891,635 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,658,144 - 65,659,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,414,451 - 65,415,682 (+)NCBINCBI36hg18NCBI36
Celera1162,981,782 - 62,983,013 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,984,466 - 61,985,697 (+)NCBIHuRef
CHM1_11165,542,289 - 65,543,520 (+)NCBICHM1_1
T2T-CHM13v2.01165,883,735 - 65,884,697 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8810253   PMID:8848724   PMID:9115212   PMID:12477932   PMID:15489334   PMID:15605074   PMID:15644333   PMID:16189514   PMID:16713569   PMID:17014843   PMID:17207965   PMID:17873903  
PMID:21873635   PMID:22666460   PMID:23128233   PMID:24366813   PMID:24927181   PMID:25009281   PMID:25416956   PMID:26186194   PMID:27107014   PMID:28330616   PMID:28514442   PMID:30242906  
PMID:30833792   PMID:32296183   PMID:32513696   PMID:33961781  


Genomics

Comparative Map Data
CCDC85B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,890,673 - 65,891,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1165,890,673 - 65,891,635 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,658,144 - 65,659,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,414,451 - 65,415,682 (+)NCBINCBI36hg18NCBI36
Celera1162,981,782 - 62,983,013 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,984,466 - 61,985,697 (+)NCBIHuRef
CHM1_11165,542,289 - 65,543,520 (+)NCBICHM1_1
T2T-CHM13v2.01165,883,735 - 65,884,697 (+)NCBI
Ccdc85b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,503,191 - 5,507,591 (-)NCBIGRCm39mm39
GRCm39 Ensembl195,503,208 - 5,507,922 (-)Ensembl
GRCm38195,453,163 - 5,457,563 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,453,180 - 5,457,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,453,163 - 5,457,549 (-)NCBIGRCm37mm9NCBIm37
MGSCv36195,456,539 - 5,457,549 (-)NCBImm8
Celera195,325,136 - 5,329,522 (-)NCBICelera
Cytogenetic Map19ANCBI
Ccdc85b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,763,645 - 202,764,631 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1202,763,631 - 202,764,703 (-)Ensembl
Rnor_6.01220,835,647 - 220,837,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,764,980 - 227,766,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,099,703 - 208,100,997 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1200,299,725 - 200,301,298 (-)NCBICelera
Cytogenetic Map1q43NCBI
Ccdc85b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,432,602 - 19,433,210 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,432,368 - 19,433,386 (-)NCBIChiLan1.0ChiLan1.0
CCDC85B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11164,578,202 - 64,581,942 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01161,250,913 - 61,251,926 (+)NCBIMhudiblu_PPA_v0panPan3
CCDC85B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,375,015 - 51,376,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,375,261 - 51,375,866 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,983,525 - 49,984,536 (-)NCBI
ROS_Cfam_1.01852,413,106 - 52,414,117 (-)NCBI
ROS_Cfam_1.0 Ensembl1852,413,212 - 52,414,066 (-)Ensembl
UMICH_Zoey_3.11851,513,175 - 51,514,186 (-)NCBI
UNSW_CanFamBas_1.01851,087,534 - 51,088,545 (-)NCBI
UU_Cfam_GSD_1.01851,876,848 - 51,877,859 (-)NCBI
Ccdc85b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,207,023 - 7,208,062 (-)NCBI
SpeTri2.0NW_0049365993,649,372 - 3,650,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC85B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,436,794 - 6,437,808 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,436,787 - 6,437,828 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,540,816 - 5,542,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC85B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,366,166 - 8,367,670 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl18,366,409 - 8,367,017 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038105,655,347 - 105,656,856 (-)NCBIVero_WHO_p1.0
Ccdc85b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,525,942 - 20,526,550 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476720,525,728 - 20,527,337 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
STS-U63825  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,658,860 - 65,659,101UniSTSGRCh37
Build 361165,415,436 - 65,415,677RGDNCBI36
Celera1162,982,767 - 62,983,008RGD
Cytogenetic Map11q12.1UniSTS
HuRef1161,985,451 - 61,985,692UniSTS
GeneMap99-GB4 RH Map11248.39UniSTS
NCBI RH Map11573.2UniSTS
RH47013  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,658,819 - 65,658,987UniSTSGRCh37
Build 361165,415,395 - 65,415,563RGDNCBI36
Celera1162,982,726 - 62,982,894RGD
Cytogenetic Map11q12.1UniSTS
HuRef1161,985,410 - 61,985,578UniSTS
GeneMap99-GB4 RH Map11247.43UniSTS
NCBI RH Map11573.2UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:300
Count of miRNA genes:266
Interacting mature miRNAs:290
Transcripts:ENST00000312579
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 5
Medium 2388 2890 1603 498 1719 350 4319 2144 3727 320 1444 1597 164 1 1202 2755 5 2
Low 51 100 123 126 230 115 38 53 7 99 10 15 11 2 33 1
Below cutoff 1 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000312579   ⟹   ENSP00000311695
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,890,673 - 65,891,635 (+)Ensembl
RefSeq Acc Id: NM_006848   ⟹   NP_006839
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,890,673 - 65,891,635 (+)NCBI
GRCh371165,657,875 - 65,659,106 (+)RGD
Build 361165,414,451 - 65,415,682 (+)NCBI Archive
Celera1162,981,782 - 62,983,013 (+)RGD
HuRef1161,984,466 - 61,985,697 (+)ENTREZGENE
CHM1_11165,542,289 - 65,543,520 (+)NCBI
T2T-CHM13v2.01165,883,735 - 65,884,697 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_006839 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB05928 (Get FASTA)   NCBI Sequence Viewer  
  AAH08796 (Get FASTA)   NCBI Sequence Viewer  
  BAG35045 (Get FASTA)   NCBI Sequence Viewer  
  EAW74468 (Get FASTA)   NCBI Sequence Viewer  
  Q15834 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_006839   ⟸   NM_006848
- UniProtKB: Q15834 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000311695   ⟸   ENST00000312579

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q15834-F1-model_v2 AlphaFold Q15834 1-202 view protein structure


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.1(chr11:65881597-65893890)x3 copy number gain See cases [RCV000051909] Chr11:65881597..65893890 [GRCh38]
Chr11:65649068..65661361 [GRCh37]
Chr11:65405644..65417937 [NCBI36]
Chr11:11q13.1
uncertain significance
GRCh38/hg38 11q13.1-13.2(chr11:65741431-67705669)x1 copy number loss See cases [RCV000142881] Chr11:65741431..67705669 [GRCh38]
Chr11:65508902..67473140 [GRCh37]
Chr11:65265478..67229716 [NCBI36]
Chr11:11q13.1-13.2
pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:65138976-67574402) copy number gain not provided [RCV000767601] Chr11:65138976..67574402 [GRCh37]
Chr11:11q13.1-13.2
pathogenic
NC_000011.9:g.(?_65633902)_(66115026_?)dup duplication Cutis laxa, autosomal recessive, type 1B [RCV000798155] Chr11:65866431..66347555 [GRCh38]
Chr11:65633902..66115026 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
NC_000011.9:g.(?_65633902)_(66115026_?)dup duplication Autosomal recessive cutis laxa type 1B [RCV001305354] Chr11:65633902..66115026 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance
GRCh37/hg19 11q13.1-13.2(chr11:64935724-66405514) copy number loss not specified [RCV002052930] Chr11:64935724..66405514 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance
NC_000011.9:g.(?_64522783)_(66283694_?)del deletion Bardet-Biedl syndrome [RCV002014493]|Glycogen storage disease, type V [RCV002004587] Chr11:64522783..66283694 [GRCh37]
Chr11:11q13.1-13.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24926 AgrOrtholog
COSMIC CCDC85B COSMIC
Ensembl Genes ENSG00000175602 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000311695 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000312579 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000175602 GTEx
HGNC ID HGNC:24926 ENTREZGENE
Human Proteome Map CCDC85B Human Proteome Map
InterPro CCDC85 UniProtKB/Swiss-Prot
KEGG Report hsa:11007 UniProtKB/Swiss-Prot
NCBI Gene 11007 ENTREZGENE
OMIM 605360 OMIM
PANTHER PTHR13546 UniProtKB/Swiss-Prot
Pfam CCDC85 UniProtKB/Swiss-Prot
PharmGKB PA144596453 PharmGKB
UniProt CC85B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2R598 UniProtKB/Swiss-Prot
  Q96HA0 UniProtKB/Swiss-Prot