PLPPR4 (phospholipid phosphatase related 4) - Rat Genome Database

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Gene: PLPPR4 (phospholipid phosphatase related 4) Homo sapiens
Analyze
Symbol: PLPPR4
Name: phospholipid phosphatase related 4
RGD ID: 1605099
HGNC Page HGNC:23496
Description: Predicted to enable lysophosphatidic acid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in several processes, including axonogenesis; lipid import into cell; and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within inner ear development. Located in postsynaptic density membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2-lysophosphatidate phosphatase PLPPR4; brain-specific phosphatidic acid phosphatase-like protein 1; inactive 2-lysophosphatidate phosphatase PLPPR4; KIAA0455; lipid phosphate phosphatase-related protein type 4; LPPR4; LPR4; phospholipid phosphatase-related protein type 4; PHP1; plasticity related gene 1; plasticity related gene-1; plasticity-related gene 1 protein; PRG-1; PRG1; RP4-788L13.1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,262,924 - 99,309,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,264,292 - 99,309,590 (+)EnsemblGRCh38hg38GRCh38
GRCh37199,730,048 - 99,775,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,502,488 - 99,547,728 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,983,902 - 98,029,193 (+)NCBICelera
Cytogenetic Map1p21.3-p21.2NCBI
HuRef197,852,810 - 97,898,096 (+)NCBIHuRef
CHM1_1199,846,184 - 99,891,476 (+)NCBICHM1_1
T2T-CHM13v2.0199,111,296 - 99,157,921 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9455484   PMID:12069809   PMID:12477932   PMID:12730698   PMID:15280885   PMID:16169070   PMID:19766573   PMID:20379614   PMID:21873635   PMID:23213074   PMID:26671989   PMID:33378226  
PMID:33961781   PMID:37550884  


Genomics

Comparative Map Data
PLPPR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,262,924 - 99,309,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,264,292 - 99,309,590 (+)EnsemblGRCh38hg38GRCh38
GRCh37199,730,048 - 99,775,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,502,488 - 99,547,728 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,983,902 - 98,029,193 (+)NCBICelera
Cytogenetic Map1p21.3-p21.2NCBI
HuRef197,852,810 - 97,898,096 (+)NCBIHuRef
CHM1_1199,846,184 - 99,891,476 (+)NCBICHM1_1
T2T-CHM13v2.0199,111,296 - 99,157,921 (+)NCBIT2T-CHM13v2.0
Plppr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393117,112,794 - 117,154,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3117,112,788 - 117,154,525 (-)EnsemblGRCm39 Ensembl
GRCm383117,319,145 - 117,360,876 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3117,319,139 - 117,360,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv373117,022,063 - 117,063,794 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363117,311,149 - 117,352,880 (-)NCBIMGSCv36mm8
Celera3123,722,032 - 123,763,668 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.57NCBI
Plppr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82208,056,206 - 208,097,191 (-)NCBIGRCr8
mRatBN7.22205,371,317 - 205,412,302 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2205,371,322 - 205,412,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2213,018,609 - 213,059,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02210,933,198 - 210,974,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02205,751,648 - 205,792,638 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02220,298,239 - 220,341,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2220,298,245 - 220,341,866 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02238,365,252 - 238,405,892 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42213,686,578 - 213,727,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12213,649,335 - 213,690,585 (-)NCBI
Celera2197,848,561 - 197,889,304 (-)NCBICelera
Cytogenetic Map2q42NCBI
Plppr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554354,091,165 - 4,114,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554354,085,918 - 4,112,207 (+)NCBIChiLan1.0ChiLan1.0
PLPPR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,720,740 - 127,766,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11126,875,286 - 126,920,897 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01101,919,714 - 101,965,146 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11100,640,187 - 100,685,483 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1100,640,187 - 100,685,483 (+)Ensemblpanpan1.1panPan2
PLPPR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1650,553,769 - 50,594,298 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl650,554,949 - 50,594,383 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha653,237,104 - 53,277,408 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0650,906,076 - 50,946,382 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl650,906,113 - 50,946,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1650,599,385 - 50,639,586 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0650,578,764 - 50,619,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0651,011,414 - 51,051,742 (-)NCBIUU_Cfam_GSD_1.0
Plppr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058108,444,124 - 108,485,378 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936537462,583 - 503,874 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936537462,595 - 503,770 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLPPR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4118,713,994 - 118,752,224 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14118,713,987 - 118,752,499 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24130,278,777 - 130,316,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLPPR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12033,996,027 - 34,042,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2033,996,021 - 34,042,004 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603824,010,104 - 24,055,697 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plppr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248571,907,932 - 1,956,093 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248571,761,972 - 1,955,112 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLPPR4
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p31.1-13.3(chr1:72661709-107456880)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|See cases [RCV000051825] Chr1:72661709..107456880 [GRCh38]
Chr1:73127392..107999502 [GRCh37]
Chr1:72899980..107801025 [NCBI36]
Chr1:1p31.1-13.3		 pathogenic
GRCh38/hg38 1p21.3-13.3(chr1:98557000-107949047)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053878]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053878]|See cases [RCV000053878] Chr1:98557000..107949047 [GRCh38]
Chr1:99022556..108491669 [GRCh37]
Chr1:98795144..108293192 [NCBI36]
Chr1:1p21.3-13.3		 pathogenic
GRCh38/hg38 1p21.3-13.3(chr1:97410602-110670510)x1 copy number loss See cases [RCV000053877] Chr1:97410602..110670510 [GRCh38]
Chr1:97876158..111213132 [GRCh37]
Chr1:97648746..111014655 [NCBI36]
Chr1:1p21.3-13.3		 pathogenic
NM_001166252.1(LPPR4):c.740C>T (p.Ser247Phe) single nucleotide variant Malignant melanoma [RCV000064973] Chr1:99300914 [GRCh38]
Chr1:99766470 [GRCh37]
Chr1:99539058 [NCBI36]
Chr1:1p21.2		 not provided
GRCh38/hg38 1p21.3-13.3(chr1:97272349-108893138)x1 copy number loss See cases [RCV000135333] Chr1:97272349..108893138 [GRCh38]
Chr1:97737905..109435760 [GRCh37]
Chr1:97510493..109237283 [NCBI36]
Chr1:1p21.3-13.3		 pathogenic
GRCh38/hg38 1p31.1-21.1(chr1:83457325-104273917)x3 copy number gain See cases [RCV000135654] Chr1:83457325..104273917 [GRCh38]
Chr1:83923008..104816539 [GRCh37]
Chr1:83695596..104618062 [NCBI36]
Chr1:1p31.1-21.1		 pathogenic
GRCh38/hg38 1p21.3-21.2(chr1:99110744-99679244)x3 copy number gain See cases [RCV000136682] Chr1:99110744..99679244 [GRCh38]
Chr1:99576300..100144800 [GRCh37]
Chr1:99348888..99917388 [NCBI36]
Chr1:1p21.3-21.2		 uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p22.1-11.2(chr1:93837992-121343783)x3 copy number gain See cases [RCV000512354] Chr1:93837992..121343783 [GRCh37]
Chr1:1p22.1-11.2		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p22.1-13.3(chr1:94054724-111671707)x3 copy number gain not provided [RCV000749068] Chr1:94054724..111671707 [GRCh37]
Chr1:1p22.1-13.3		 pathogenic
NM_014839.5(PLPPR4):c.216T>A (p.Ile72=) single nucleotide variant not provided [RCV000974852] Chr1:99288102 [GRCh38]
Chr1:99753658 [GRCh37]
Chr1:1p21.3		 benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p21.2(chr1:99767886-99799729)x1 copy number loss not provided [RCV000845791] Chr1:99767886..99799729 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.5(PLPPR4):c.702G>C (p.Leu234Phe) single nucleotide variant not provided [RCV000994052] Chr1:99301777 [GRCh38]
Chr1:99767333 [GRCh37]
Chr1:1p21.2		 uncertain significance
GRCh37/hg19 1p21.2(chr1:99747868-99956188)x3 copy number gain not provided [RCV001259057] Chr1:99747868..99956188 [GRCh37]
Chr1:1p21.2		 uncertain significance
GRCh37/hg19 1p21.3-13.2(chr1:95046805-114714931) copy number loss not specified [RCV002053503] Chr1:95046805..114714931 [GRCh37]
Chr1:1p21.3-13.2		 pathogenic
NM_014839.5(PLPPR4):c.1154C>T (p.Ala385Val) single nucleotide variant Inborn genetic diseases [RCV002969968] Chr1:99306016 [GRCh38]
Chr1:99771572 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.5(PLPPR4):c.-9G>A single nucleotide variant Inborn genetic diseases [RCV002989925] Chr1:99264585 [GRCh38]
Chr1:99730141 [GRCh37]
Chr1:1p21.3		 uncertain significance
NM_014839.5(PLPPR4):c.1757T>C (p.Ile586Thr) single nucleotide variant Inborn genetic diseases [RCV002736981] Chr1:99306619 [GRCh38]
Chr1:99772175 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.5(PLPPR4):c.2074A>G (p.Arg692Gly) single nucleotide variant Inborn genetic diseases [RCV002926332] Chr1:99306936 [GRCh38]
Chr1:99772492 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.4(PLPPR4):c.40G>T (p.Asp14Tyr) single nucleotide variant Inborn genetic diseases [RCV002854567] Chr1:99264489 [GRCh38]
Chr1:99730045 [GRCh37]
Chr1:1p21.3		 uncertain significance
NM_014839.5(PLPPR4):c.637G>A (p.Val213Met) single nucleotide variant Inborn genetic diseases [RCV002916031] Chr1:99300955 [GRCh38]
Chr1:99766511 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.5(PLPPR4):c.1906G>A (p.Asp636Asn) single nucleotide variant Inborn genetic diseases [RCV002787538] Chr1:99306768 [GRCh38]
Chr1:99772324 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.5(PLPPR4):c.263C>T (p.Thr88Met) single nucleotide variant Inborn genetic diseases [RCV002699723] Chr1:99288149 [GRCh38]
Chr1:99753705 [GRCh37]
Chr1:1p21.3		 uncertain significance
NM_014839.5(PLPPR4):c.1378G>T (p.Ala460Ser) single nucleotide variant Inborn genetic diseases [RCV002788022] Chr1:99306240 [GRCh38]
Chr1:99771796 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.5(PLPPR4):c.-63C>A single nucleotide variant Inborn genetic diseases [RCV002788023] Chr1:99264531 [GRCh38]
Chr1:99730087 [GRCh37]
Chr1:1p21.3		 uncertain significance
NM_014839.5(PLPPR4):c.1502A>G (p.Lys501Arg) single nucleotide variant Inborn genetic diseases [RCV002814227] Chr1:99306364 [GRCh38]
Chr1:99771920 [GRCh37]
Chr1:1p21.2		 uncertain significance
NM_014839.5(PLPPR4):c.410G>A (p.Gly137Glu) single nucleotide variant Inborn genetic diseases [RCV003356757] Chr1:99299050 [GRCh38]
Chr1:99764606 [GRCh37]
Chr1:1p21.3		 uncertain significance
GRCh37/hg19 1p21.3-21.2(chr1:99164335-99746304)x3 copy number gain not provided [RCV003484024] Chr1:99164335..99746304 [GRCh37]
Chr1:1p21.3-21.2		 uncertain significance
NM_014839.5(PLPPR4):c.1959C>A (p.Thr653=) single nucleotide variant not provided [RCV003406614] Chr1:99306821 [GRCh38]
Chr1:99772377 [GRCh37]
Chr1:1p21.2		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3477
Count of miRNA genes:581
Interacting mature miRNAs:684
Transcripts:ENST00000370184, ENST00000370185, ENST00000457765
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S2428  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,774,858 - 99,775,036UniSTSGRCh37
Build 36199,547,446 - 99,547,624RGDNCBI36
Celera198,028,911 - 98,029,089RGD
Cytogenetic Map1p21.2UniSTS
HuRef197,897,814 - 97,897,992UniSTS
Whitehead-YAC Contig Map1 UniSTS
SHGC-75185  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,773,567 - 99,773,646UniSTSGRCh37
Build 36199,546,155 - 99,546,234RGDNCBI36
Celera198,027,620 - 98,027,699RGD
Cytogenetic Map1p21.2UniSTS
HuRef197,896,523 - 97,896,602UniSTS
TNG Radiation Hybrid Map154596.0UniSTS
GeneMap99-GB4 RH Map1286.96UniSTS
NCBI RH Map1676.7UniSTS
SHGC-75202  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,773,922 - 99,774,138UniSTSGRCh37
Build 36199,546,510 - 99,546,726RGDNCBI36
Celera198,027,975 - 98,028,191RGD
Cytogenetic Map1p21.2UniSTS
HuRef197,896,878 - 97,897,094UniSTS
TNG Radiation Hybrid Map154596.0UniSTS
GeneMap99-GB4 RH Map1287.06UniSTS
NCBI RH Map1672.6UniSTS
SHGC-75201  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,773,589 - 99,773,689UniSTSGRCh37
Build 36199,546,177 - 99,546,277RGDNCBI36
Celera198,027,642 - 98,027,742RGD
Cytogenetic Map1p21.2UniSTS
HuRef197,896,545 - 97,896,645UniSTS
TNG Radiation Hybrid Map154596.0UniSTS
GeneMap99-GB4 RH Map1287.06UniSTS
SHGC-75184  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,773,345 - 99,773,489UniSTSGRCh37
Build 36199,545,933 - 99,546,077RGDNCBI36
Celera198,027,398 - 98,027,542RGD
Cytogenetic Map1p21.2UniSTS
HuRef197,896,301 - 97,896,445UniSTS
TNG Radiation Hybrid Map154596.0UniSTS
GeneMap99-GB4 RH Map1270.59UniSTS
NCBI RH Map1652.0UniSTS
A009B28  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,774,150 - 99,774,262UniSTSGRCh37
Build 36199,546,738 - 99,546,850RGDNCBI36
Celera198,028,203 - 98,028,315RGD
Cytogenetic Map1p21.2UniSTS
HuRef197,897,106 - 97,897,218UniSTS
GeneMap99-GB4 RH Map1289.79UniSTS
A006O32  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,773,844 - 99,774,065UniSTSGRCh37
Build 36199,546,432 - 99,546,653RGDNCBI36
Celera198,027,897 - 98,028,118RGD
Cytogenetic Map1p21.2UniSTS
GeneMap99-GB4 RH Map1287.36UniSTS
NCBI RH Map1652.0UniSTS
D1S3698  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map10p12.31UniSTS
G34958  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37199,774,150 - 99,774,262UniSTSGRCh37
Celera198,028,203 - 98,028,315UniSTS
Cytogenetic Map1p21.2UniSTS
HuRef197,897,106 - 97,897,218UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2 11 282 1 2 144 4 1652 11 27 37 98 38
Low 1582 1160 736 184 239 33 3309 985 2040 117 897 1294 154 1 1087 1921 1 1
Below cutoff 747 1436 535 299 727 286 872 1177 37 223 445 157 16 19 827 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001166252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054339887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB007924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF357013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF541281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL834390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY304518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000370184   ⟹   ENSP00000359203
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,298,864 - 99,309,590 (+)Ensembl
RefSeq Acc Id: ENST00000370185   ⟹   ENSP00000359204
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,264,492 - 99,309,584 (+)Ensembl
RefSeq Acc Id: ENST00000457765   ⟹   ENSP00000394913
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl199,264,292 - 99,309,580 (+)Ensembl
RefSeq Acc Id: NM_001166252   ⟹   NP_001159724
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,264,492 - 99,309,584 (+)NCBI
GRCh37199,729,848 - 99,775,140 (+)RGD
Celera197,983,902 - 98,029,193 (+)RGD
HuRef197,852,810 - 97,898,096 (+)ENTREZGENE
CHM1_1199,846,184 - 99,891,476 (+)NCBI
T2T-CHM13v2.0199,112,833 - 99,157,921 (+)NCBI
Sequence:
RefSeq Acc Id: NM_014839   ⟹   NP_055654
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,264,492 - 99,309,584 (+)NCBI
GRCh37199,729,848 - 99,775,140 (+)RGD
Build 36199,502,488 - 99,547,728 (+)NCBI Archive
Celera197,983,902 - 98,029,193 (+)RGD
HuRef197,852,810 - 97,898,096 (+)ENTREZGENE
CHM1_1199,846,184 - 99,891,476 (+)NCBI
T2T-CHM13v2.0199,112,833 - 99,157,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011542498   ⟹   XP_011540800
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38199,262,924 - 99,309,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054339887   ⟹   XP_054195862
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0199,111,296 - 99,157,921 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_055654   ⟸   NM_014839
- Peptide Label: isoform 1
- UniProtKB: Q86XM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159724   ⟸   NM_001166252
- Peptide Label: isoform 2
- UniProtKB: B4DTT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011540800   ⟸   XM_011542498
- Peptide Label: isoform X1
- UniProtKB: Q86XM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000359203   ⟸   ENST00000370184
RefSeq Acc Id: ENSP00000359204   ⟸   ENST00000370185
RefSeq Acc Id: ENSP00000394913   ⟸   ENST00000457765
RefSeq Acc Id: XP_054195862   ⟸   XM_054339887
- Peptide Label: isoform X1
- UniProtKB: Q86XM6 (UniProtKB/TrEMBL)
Protein Domains
Phosphatidic acid phosphatase type 2/haloperoxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7Z2D5-F1-model_v2 AlphaFold Q7Z2D5 1-763 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23496 AgrOrtholog
COSMIC PLPPR4 COSMIC
Ensembl Genes ENSG00000117600 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000370185 ENTREZGENE
  ENST00000370185.9 UniProtKB/Swiss-Prot
  ENST00000457765 ENTREZGENE
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000117600 GTEx
HGNC ID HGNC:23496 ENTREZGENE
Human Proteome Map PLPPR4 Human Proteome Map
InterPro P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA_PP_rel UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report hsa:9890 UniProtKB/Swiss-Prot
NCBI Gene 9890 ENTREZGENE
OMIM 607813 OMIM
PANTHER 2-LYSOPHOSPHATIDATE PHOSPHATASE PLPPR4 UniProtKB/TrEMBL
  LIPID PHOSPHATE PHOSPHATASE UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PTHR10165:SF13 UniProtKB/Swiss-Prot
Pfam PAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA166181598 PharmGKB
SMART acidPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Acid phosphatase/Vanadium-dependent haloperoxidase UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt B4DTT9 ENTREZGENE, UniProtKB/TrEMBL
  PLPR4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q86XM6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E7EPS1 UniProtKB/Swiss-Prot
  O75043 UniProtKB/Swiss-Prot
  Q5T9R9 UniProtKB/Swiss-Prot
  Q86XQ5 UniProtKB/Swiss-Prot
  Q8N3F1 UniProtKB/Swiss-Prot
  Q96MP0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-20 PLPPR4  phospholipid phosphatase related 4  LPPR4  lipid phosphate phosphatase-related protein type 4  Symbol and/or name change 5135510 APPROVED