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Gene: NUAK1 (NUAK family kinase 1) Homo sapiens
Symbol: NUAK1
Name: NUAK family kinase 1
Description: Exhibits p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Localizes to the cytoplasm; microtubule cytoskeleton; and nuclear lumen; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; ARK5; KIAA0537; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; omphalocele kinase 1
Mus musculus (house mouse) : Nuak1 (NUAK family, SNF1-like kinase, 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nuak1 (NUAK family kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nuak1 (NUAK family kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NUAK1 (NUAK family kinase 1)
Canis lupus familiaris (dog) : NUAK1 (NUAK family kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nuak1 (NUAK family kinase 1)
Sus scrofa (pig) : NUAK1 (NUAK family kinase 1)
Chlorocebus sabaeus (green monkey) : NUAK1 (NUAK family kinase 1)
Heterocephalus glaber (naked mole-rat) : Nuak1 (NUAK family kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12106,063,340 - 106,140,033 (-)Ensembl
GRCh3812106,063,347 - 106,140,033 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712106,457,125 - 106,533,811 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,981,255 - 105,057,941 (-)NCBINCBI36hg18NCBI36
Celera12106,122,505 - 106,199,131 (-)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12103,517,880 - 103,594,537 (-)NCBIHuRef
CHM1_112106,422,717 - 106,499,407 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NUAK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605098
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.