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Gene: RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase) Homo sapiens
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Symbol: RTCB
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Description: Exhibits RNA ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Localizes to several cellular components, including endoplasmic reticulum membrane; nucleus; and tRNA-splicing ligase complex; PARTICIPATES IN tRNA maturation pathway; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; bisphenol F; dexamethasone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3'-phosphate/5'-hydroxy nucleic acid ligase; ankyrin repeat domain 54; C22orf28; DJ149A16.6; FAAP; focal adhesion-associated protein; HSPC117; hypothetical protein LOC51493; novel protein HSPC117; RNA-splicing ligase RtcB homolog; RP1-149A16.6; tRNA-splicing ligase RtcB homolog
Orthologs:
Mus musculus (house mouse) : Rtcb (RNA 2',3'-cyclic phosphate and 5'-OH ligase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rtcb (RNA 2',3'-cyclic phosphate and 5'-OH ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rtcb (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Canis lupus familiaris (dog) : RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rtcb (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Sus scrofa (pig) : RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Chlorocebus sabaeus (African green monkey) : RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Heterocephalus glaber (naked mole-rat) : Rtcb (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2232,387,582 - 32,412,248 (-)EnsemblGRCh38hg38GRCh38
GRCh382232,387,582 - 32,412,247 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372232,783,562 - 32,808,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,113,569 - 31,138,235 (-)NCBINCBI36hg18NCBI36
Celera2216,585,734 - 16,610,445 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2215,740,893 - 15,765,605 (-)NCBIHuRef
CHM1_12232,742,920 - 32,767,632 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RTCB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605075
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.