DRAM1 (DNA damage regulated autophagy modulator 1) - Rat Genome Database

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Gene: DRAM1 (DNA damage regulated autophagy modulator 1) Homo sapiens
Analyze
Symbol: DRAM1
Name: DNA damage regulated autophagy modulator 1
RGD ID: 1605066
HGNC Page HGNC:25645
Description: Involved in regulation of autophagy. Located in lysosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: damage-regulated autophagy modulator; DNA damage-regulated autophagy modulator protein 1; DNA-damage regulated autophagy modulator 1; DRAM; FLJ11259
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC727709  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812101,877,580 - 101,923,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12101,877,580 - 102,012,130 (+)EnsemblGRCh38hg38GRCh38
GRCh3712102,271,358 - 102,317,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612100,795,236 - 100,841,532 (+)NCBINCBI36Build 36hg18NCBI36
Celera12101,935,130 - 101,981,421 (+)NCBICelera
Cytogenetic Map12q23.2NCBI
HuRef1299,330,839 - 99,376,998 (+)NCBIHuRef
CHM1_112102,237,780 - 102,284,071 (+)NCBICHM1_1
T2T-CHM13v2.012101,838,785 - 101,884,733 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
antirheumatic drug  (EXP)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
dioxygen  (ISO)
disodium selenite  (EXP)
disulfiram  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
ethyl methanesulfonate  (EXP)
formaldehyde  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nickel sulfate  (EXP)
nitrofen  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (EXP)
potassium chromate  (EXP)
quercetin  (EXP)
quinolin-8-ol  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)
lysosomal membrane  (IEA)
lysosome  (IBA,IDA,IEA)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:16344560   PMID:16839873   PMID:16839881   PMID:17102582   PMID:17207965   PMID:17397945   PMID:19556885   PMID:19706754   PMID:19895784   PMID:21386980  
PMID:21516116   PMID:21832049   PMID:21873635   PMID:22082963   PMID:22525272   PMID:22981223   PMID:23273568   PMID:23337876   PMID:23658518   PMID:23696801   PMID:23832602   PMID:24133622  
PMID:24556693   PMID:24922577   PMID:25416956   PMID:25633293   PMID:28893313   PMID:29501488   PMID:30144448   PMID:30362153   PMID:30902093   PMID:31356858   PMID:31492633   PMID:32296183  
PMID:32513696   PMID:32943616   PMID:33184797   PMID:35044719   PMID:35299128   PMID:37443303  


Genomics

Comparative Map Data
DRAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812101,877,580 - 101,923,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12101,877,580 - 102,012,130 (+)EnsemblGRCh38hg38GRCh38
GRCh3712102,271,358 - 102,317,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612100,795,236 - 100,841,532 (+)NCBINCBI36Build 36hg18NCBI36
Celera12101,935,130 - 101,981,421 (+)NCBICelera
Cytogenetic Map12q23.2NCBI
HuRef1299,330,839 - 99,376,998 (+)NCBIHuRef
CHM1_112102,237,780 - 102,284,071 (+)NCBICHM1_1
T2T-CHM13v2.012101,838,785 - 101,884,733 (+)NCBIT2T-CHM13v2.0
Dram1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391088,158,663 - 88,200,218 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1088,158,666 - 88,214,942 (-)EnsemblGRCm39 Ensembl
GRCm381088,322,801 - 88,364,359 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1088,322,804 - 88,379,080 (-)EnsemblGRCm38mm10GRCm38
MGSCv371087,785,549 - 87,819,820 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361087,752,603 - 87,786,874 (-)NCBIMGSCv36mm8
Celera1090,300,347 - 90,334,626 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.81NCBI
Dram1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,630,233 - 24,665,270 (-)NCBIGRCr8
mRatBN7.2722,742,794 - 22,776,888 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,742,849 - 22,776,765 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,737,427 - 24,771,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,900,112 - 26,934,103 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,677,146 - 26,711,152 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,898,647 - 28,932,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,898,649 - 28,932,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0729,007,043 - 29,040,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4725,024,991 - 25,060,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera719,903,485 - 19,937,259 (-)NCBICelera
Cytogenetic Map7q13NCBI
Dram1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540537,153,561 - 37,171,309 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,153,847 - 37,170,007 (+)NCBIChiLan1.0ChiLan1.0
DRAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210109,946,880 - 109,996,882 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112109,947,242 - 109,991,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01299,464,540 - 99,509,793 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112102,862,707 - 102,907,385 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12102,862,707 - 102,907,385 (+)Ensemblpanpan1.1panPan2
DRAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11540,759,739 - 40,794,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1540,758,810 - 40,792,906 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1541,128,022 - 41,172,892 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01541,413,996 - 41,458,979 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1541,413,486 - 41,447,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11540,675,100 - 40,720,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01540,777,451 - 40,822,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01541,051,693 - 41,096,624 (+)NCBIUU_Cfam_GSD_1.0
Dram1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494519,138,514 - 19,196,509 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649212,169,815 - 12,206,845 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649212,171,642 - 12,206,845 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl582,290,385 - 82,325,562 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1582,292,578 - 82,325,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2586,272,198 - 86,307,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11197,136,158 - 97,180,669 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1197,136,578 - 97,180,693 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037147,823,538 - 147,867,881 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dram1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247506,288,721 - 6,305,112 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DRAM1
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.1-23.3(chr12:100670616-108583607)x1 copy number loss See cases [RCV000051320] Chr12:100670616..108583607 [GRCh38]
Chr12:101064394..108977383 [GRCh37]
Chr12:99588525..107501512 [NCBI36]
Chr12:12q23.1-23.3
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075)x3 copy number gain See cases [RCV000445929] Chr12:100580198..105804075 [GRCh37]
Chr12:12q23.1-23.3
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_018370.3(DRAM1):c.451T>G (p.Trp151Gly) single nucleotide variant Inborn genetic diseases [RCV003244349] Chr12:101908294 [GRCh38]
Chr12:102302072 [GRCh37]
Chr12:12q23.2
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q22-23.2(chr12:94881995-103635998)x3 copy number gain not provided [RCV000750524] Chr12:94881995..103635998 [GRCh37]
Chr12:12q22-23.2
pathogenic
GRCh37/hg19 12q23.2(chr12:102116591-102607083)x3 copy number gain not provided [RCV000848348] Chr12:102116591..102607083 [GRCh37]
Chr12:12q23.2
uncertain significance
GRCh37/hg19 12q23.2(chr12:101953283-102683945)x1 copy number loss not provided [RCV001006527] Chr12:101953283..102683945 [GRCh37]
Chr12:12q23.2
uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:101447925-102593349)x3 copy number gain not provided [RCV000847334] Chr12:101447925..102593349 [GRCh37]
Chr12:12q23.1-23.2
uncertain significance
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075) copy number gain not specified [RCV002053014] Chr12:100580198..105804075 [GRCh37]
Chr12:12q23.1-23.3
uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:100564593-103021075) copy number loss not specified [RCV002053013] Chr12:100564593..103021075 [GRCh37]
Chr12:12q23.1-23.2
uncertain significance
NM_018370.3(DRAM1):c.409A>G (p.Thr137Ala) single nucleotide variant Inborn genetic diseases [RCV003287270] Chr12:101908252 [GRCh38]
Chr12:102302030 [GRCh37]
Chr12:12q23.2
uncertain significance
NM_018370.3(DRAM1):c.505G>A (p.Ala169Thr) single nucleotide variant Inborn genetic diseases [RCV002901943] Chr12:101908348 [GRCh38]
Chr12:102302126 [GRCh37]
Chr12:12q23.2
uncertain significance
NM_018370.3(DRAM1):c.118C>T (p.Leu40Phe) single nucleotide variant Inborn genetic diseases [RCV002906351] Chr12:101877907 [GRCh38]
Chr12:102271685 [GRCh37]
Chr12:12q23.2
uncertain significance
NM_018370.3(DRAM1):c.556C>A (p.Leu186Met) single nucleotide variant Inborn genetic diseases [RCV003175423] Chr12:101914209 [GRCh38]
Chr12:102307987 [GRCh37]
Chr12:12q23.2
uncertain significance
NM_018370.3(DRAM1):c.316G>A (p.Gly106Arg) single nucleotide variant Inborn genetic diseases [RCV003203078] Chr12:101901407 [GRCh38]
Chr12:102295185 [GRCh37]
Chr12:12q23.2
uncertain significance
NM_018370.3(DRAM1):c.187T>G (p.Ser63Ala) single nucleotide variant Inborn genetic diseases [RCV003208076] Chr12:101897918 [GRCh38]
Chr12:102291696 [GRCh37]
Chr12:12q23.2
uncertain significance
NM_018370.3(DRAM1):c.251C>A (p.Thr84Asn) single nucleotide variant Inborn genetic diseases [RCV003203228] Chr12:101901342 [GRCh38]
Chr12:102295120 [GRCh37]
Chr12:12q23.2
uncertain significance
NM_018370.3(DRAM1):c.560A>C (p.Glu187Ala) single nucleotide variant Inborn genetic diseases [RCV003369368] Chr12:101914213 [GRCh38]
Chr12:102307991 [GRCh37]
Chr12:12q23.2
uncertain significance
GRCh37/hg19 12q23.2(chr12:102012266-102738384)x3 copy number gain not specified [RCV003986977] Chr12:102012266..102738384 [GRCh37]
Chr12:12q23.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1607
Count of miRNA genes:819
Interacting mature miRNAs:945
Transcripts:ENST00000258534, ENST00000544152, ENST00000546729, ENST00000549066, ENST00000549365, ENST00000551403
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-57247  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712102,316,937 - 102,317,092UniSTSGRCh37
Build 3612100,841,068 - 100,841,223RGDNCBI36
Celera12101,980,957 - 101,981,112RGD
Cytogenetic Map12q23.2UniSTS
HuRef1299,376,534 - 99,376,689UniSTS
TNG Radiation Hybrid Map1250904.0UniSTS
G64541  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712102,306,031 - 102,306,246UniSTSGRCh37
Build 3612100,830,162 - 100,830,377RGDNCBI36
Celera12101,970,052 - 101,970,267RGD
Cytogenetic Map12q23.2UniSTS
HuRef1299,365,648 - 99,365,863UniSTS
RH47280  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712102,316,237 - 102,316,366UniSTSGRCh37
Build 3612100,840,368 - 100,840,497RGDNCBI36
Celera12101,980,257 - 101,980,386RGD
Cytogenetic Map12q23.2UniSTS
HuRef1299,375,834 - 99,375,963UniSTS
GeneMap99-GB4 RH Map12400.57UniSTS
NCBI RH Map12689.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1613 1382 767 186 1164 90 2031 704 722 348 842 1238 109 1135 1178 3
Low 822 1600 954 437 743 375 2324 1488 2958 71 616 354 62 1 69 1610 3 1
Below cutoff 4 8 5 1 43 1 4 46 2 21 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_018370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005269004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005269005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047429098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC063950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC084398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI079438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA721965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000258534   ⟹   ENSP00000258534
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12101,877,580 - 101,923,612 (+)Ensembl
RefSeq Acc Id: ENST00000544152   ⟹   ENSP00000445827
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12101,877,683 - 101,921,814 (+)Ensembl
RefSeq Acc Id: ENST00000546729
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12101,920,019 - 101,921,567 (+)Ensembl
RefSeq Acc Id: ENST00000549066   ⟹   ENSP00000447906
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12101,908,314 - 102,012,130 (+)Ensembl
RefSeq Acc Id: ENST00000549365   ⟹   ENSP00000447171
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12101,877,797 - 101,908,327 (+)Ensembl
RefSeq Acc Id: ENST00000551403   ⟹   ENSP00000448075
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12101,877,691 - 101,921,542 (+)Ensembl
RefSeq Acc Id: ENST00000614926
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12101,897,894 - 101,901,552 (+)Ensembl
RefSeq Acc Id: NM_018370   ⟹   NP_060840
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812101,877,580 - 101,923,612 (+)NCBI
GRCh3712102,271,105 - 102,317,401 (+)NCBI
Build 3612100,795,236 - 100,841,532 (+)NCBI Archive
Celera12101,935,130 - 101,981,421 (+)RGD
HuRef1299,330,839 - 99,376,998 (+)ENTREZGENE
CHM1_112102,237,780 - 102,284,071 (+)NCBI
T2T-CHM13v2.012101,838,785 - 101,884,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005269004   ⟹   XP_005269061
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812101,877,580 - 101,923,612 (+)NCBI
GRCh3712102,271,105 - 102,317,401 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005269005   ⟹   XP_005269062
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812101,877,580 - 101,923,612 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047429098   ⟹   XP_047285054
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812101,890,189 - 101,923,612 (+)NCBI
RefSeq Acc Id: XM_054372449   ⟹   XP_054228424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012101,838,785 - 101,884,733 (+)NCBI
RefSeq Acc Id: XM_054372450   ⟹   XP_054228425
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012101,851,370 - 101,884,733 (+)NCBI
RefSeq Acc Id: XM_054372451   ⟹   XP_054228426
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012101,838,785 - 101,884,733 (+)NCBI
RefSeq Acc Id: NP_060840   ⟸   NM_018370
- UniProtKB: Q7L3E3 (UniProtKB/Swiss-Prot),   B7Z4T0 (UniProtKB/Swiss-Prot),   Q9NUN1 (UniProtKB/Swiss-Prot),   Q8N682 (UniProtKB/Swiss-Prot),   B3KT44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005269062   ⟸   XM_005269005
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005269061   ⟸   XM_005269004
- Peptide Label: isoform X1
- UniProtKB: B3KT44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000445827   ⟸   ENST00000544152
RefSeq Acc Id: ENSP00000258534   ⟸   ENST00000258534
RefSeq Acc Id: ENSP00000447171   ⟸   ENST00000549365
RefSeq Acc Id: ENSP00000447906   ⟸   ENST00000549066
RefSeq Acc Id: ENSP00000448075   ⟸   ENST00000551403
RefSeq Acc Id: XP_047285054   ⟸   XM_047429098
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054228424   ⟸   XM_054372449
- Peptide Label: isoform X1
- UniProtKB: B3KT44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054228426   ⟸   XM_054372451
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054228425   ⟸   XM_054372450
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N682-F1-model_v2 AlphaFold Q8N682 1-238 view protein structure

Promoters
RGD ID:6789875
Promoter ID:HG_KWN:16467
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_018370
Position:
Human AssemblyChrPosition (strand)Source
Build 3612100,794,276 - 100,795,442 (+)MPROMDB
RGD ID:7225183
Promoter ID:EPDNEW_H18337
Type:initiation region
Name:DRAM1_1
Description:DNA damage regulated autophagy modulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18338  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812101,877,315 - 101,877,375EPDNEW
RGD ID:7225185
Promoter ID:EPDNEW_H18338
Type:initiation region
Name:DRAM1_2
Description:DNA damage regulated autophagy modulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18337  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812101,877,691 - 101,877,751EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25645 AgrOrtholog
COSMIC DRAM1 COSMIC
Ensembl Genes ENSG00000136048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000258534 ENTREZGENE
  ENST00000258534.13 UniProtKB/Swiss-Prot
  ENST00000544152 ENTREZGENE
  ENST00000544152.5 UniProtKB/Swiss-Prot
  ENST00000549066.1 UniProtKB/TrEMBL
  ENST00000549365.1 UniProtKB/TrEMBL
  ENST00000551403.1 UniProtKB/TrEMBL
GTEx ENSG00000136048 GTEx
HGNC ID HGNC:25645 ENTREZGENE
Human Proteome Map DRAM1 Human Proteome Map
InterPro Frag1/DRAM/Sfk1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:55332 UniProtKB/Swiss-Prot
NCBI Gene 55332 ENTREZGENE
OMIM 610776 OMIM
PANTHER DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Frag1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA165512564 PharmGKB
UniProt A0A0B4J256_HUMAN UniProtKB/TrEMBL
  B3KT44 ENTREZGENE, UniProtKB/TrEMBL
  B7Z4T0 ENTREZGENE
  DRAM1_HUMAN UniProtKB/Swiss-Prot
  H0YHJ0_HUMAN UniProtKB/TrEMBL
  H0YHV0_HUMAN UniProtKB/TrEMBL
  Q7L3E3 ENTREZGENE
  Q8N682 ENTREZGENE
  Q9NUN1 ENTREZGENE
UniProt Secondary B7Z4T0 UniProtKB/Swiss-Prot
  Q7L3E3 UniProtKB/Swiss-Prot
  Q9NUN1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 DRAM1  DNA damage regulated autophagy modulator 1  DRAM1  DNA-damage regulated autophagy modulator 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 DRAM1  DNA-damage regulated autophagy modulator 1  DRAM  damage-regulated autophagy modulator  Symbol and/or name change 5135510 APPROVED