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Gene: SPPL3 (signal peptide peptidase like 3) Homo sapiens
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Symbol: SPPL3
Name: signal peptide peptidase like 3
Description: Exhibits aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Localizes to several cellular components, including the Golgi-associated vesicle membrane; integral component of endoplasmic reticulum membrane; and rough endoplasmic reticulum; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; benzo[a]pyrene diol epoxide I; benzo[e]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp586C1324; IMP-2; IMP2; intramembrane protease 2; MDHV1887; MGC126674; MGC126676; MGC90402; presenilin homologous protein 1; presenilin-like protein 4; PRO4332; PSH1; PSL4; signal peptide peptidase-like 3; SPP-like 3
Orthologs:
Mus musculus (house mouse) : Sppl3 (signal peptide peptidase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sppl3 (signal peptide peptidase like 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl3 (signal peptide peptidase like 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL3 (signal peptide peptidase like 3)
Canis lupus familiaris (dog) : SPPL3 (signal peptide peptidase like 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl3 (signal peptide peptidase like 3)
Sus scrofa (pig) : SPPL3 (signal peptide peptidase like 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,762,510 - 120,904,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712121,200,313 - 121,342,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,685,418 - 119,826,534 (-)NCBINCBI36hg18NCBI36
Celera12120,835,168 - 120,976,050 (-)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12118,209,451 - 118,351,576 (-)NCBIHuRef
CHM1_112121,169,084 - 121,310,844 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SPPL3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605007
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.