MAPK15 (mitogen-activated protein kinase 15) - Rat Genome Database

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Gene: MAPK15 (mitogen-activated protein kinase 15) Homo sapiens
Analyze
Symbol: MAPK15
Name: mitogen-activated protein kinase 15
RGD ID: 1604966
HGNC Page HGNC
Description: Exhibits MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Localizes to several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer; INTERACTS WITH acrylamide; atrazine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ERK-7; ERK-8; ERK7; ERK8; extracellular regulated kinase 8 delta; extracellular signal regulated kinase 8; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8143,716,340 - 143,722,458 (+)EnsemblGRCh38hg38GRCh38
GRCh388143,716,305 - 143,722,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,798,519 - 144,804,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,870,495 - 144,876,621 (+)NCBINCBI36hg18NCBI36
Celera8141,109,455 - 141,115,595 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,051,333 - 140,057,442 (+)NCBIHuRef
CHM1_18144,838,551 - 144,844,676 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Henrich LM, etal., Mol Cell Biol. 2003 Sep;23(17):5979-88.
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9880541   PMID:11875070   PMID:12239168   PMID:12477932   PMID:15342556   PMID:15489334   PMID:16336213   PMID:16484222   PMID:16624805   PMID:18029348   PMID:19166846   PMID:20395206  
PMID:20638370   PMID:20733054   PMID:21190936   PMID:21531765   PMID:21847093   PMID:21873635   PMID:22939624   PMID:22948227   PMID:23251661   PMID:23326322   PMID:23455922   PMID:23602568  
PMID:24618899   PMID:25852190   PMID:26035356   PMID:26186194   PMID:26291129   PMID:26595526   PMID:26988910   PMID:28065597   PMID:28514442   PMID:28842414   PMID:29021280   PMID:30070699  
PMID:30131341   PMID:30948266  


Genomics

Comparative Map Data
MAPK15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8143,716,340 - 143,722,458 (+)EnsemblGRCh38hg38GRCh38
GRCh388143,716,305 - 143,722,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,798,519 - 144,804,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,870,495 - 144,876,621 (+)NCBINCBI36hg18NCBI36
Celera8141,109,455 - 141,115,595 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,051,333 - 140,057,442 (+)NCBIHuRef
CHM1_18144,838,551 - 144,844,676 (+)NCBICHM1_1
Mapk15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,865,581 - 75,871,002 (+)NCBIGRCm39mm39
GRCm39 Ensembl1575,865,618 - 75,871,003 (+)Ensembl
GRCm381575,993,732 - 75,999,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,993,769 - 75,999,154 (+)EnsemblGRCm38mm10GRCm38
MGSCv371575,824,199 - 75,829,583 (+)NCBIGRCm37mm9NCBIm37
MGSCv361575,821,024 - 75,826,408 (+)NCBImm8
Celera1577,494,814 - 77,500,199 (+)NCBICelera
Cytogenetic Map15D3NCBI
Mapk15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27107,694,907 - 107,714,640 (+)NCBI
Rnor_6.0 Ensembl7117,055,395 - 117,061,047 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07117,041,287 - 117,061,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07117,027,214 - 117,046,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,026,694 - 114,032,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17114,060,919 - 114,066,236 (+)NCBI
Celera7104,066,261 - 104,071,573 (+)NCBICelera
Cytogenetic Map7q34NCBI
Mapk15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,413,822 - 2,419,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,413,393 - 2,420,703 (+)NCBIChiLan1.0ChiLan1.0
MAPK15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18143,482,245 - 143,488,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,481,567 - 143,492,859 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08140,468,365 - 140,474,604 (+)NCBIMhudiblu_PPA_v0panPan3
MAPK15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,317,061 - 37,322,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,316,424 - 37,322,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,273,594 - 37,279,329 (+)NCBI
ROS_Cfam_1.01337,789,031 - 37,794,766 (+)NCBI
UMICH_Zoey_3.11337,463,171 - 37,468,902 (+)NCBI
UNSW_CanFamBas_1.01337,580,097 - 37,585,790 (+)NCBI
UU_Cfam_GSD_1.01338,061,417 - 38,067,119 (+)NCBI
Mapk15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303994,469 - 1,000,806 (-)NCBI
SpeTri2.0NW_0049364708,420,850 - 8,425,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4902,439 - 915,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14909,266 - 915,537 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK15
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,932,291 - 137,938,392 (+)NCBI
ChlSab1.1 Ensembl8137,932,364 - 137,938,626 (+)Ensembl
Mapk15
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,049,509 - 13,077,509 (-)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2862
Count of miRNA genes:862
Interacting mature miRNAs:1046
Transcripts:ENST00000338033, ENST00000395107, ENST00000395108, ENST00000461928, ENST00000475376, ENST00000484654, ENST00000528175, ENST00000533830
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3
Medium 59 2 884 19 14 14 250 32 540 120 656 1091 9 57 114
Low 2240 986 274 294 542 139 2390 894 2104 240 756 475 161 530 1557 2 2
Below cutoff 135 1739 529 281 838 282 1626 1181 989 46 39 40 3 602 1066 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000338033   ⟹   ENSP00000337691
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,716,349 - 143,722,458 (+)Ensembl
RefSeq Acc Id: ENST00000395107   ⟹   ENSP00000378539
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,716,378 - 143,720,291 (+)Ensembl
RefSeq Acc Id: ENST00000395108   ⟹   ENSP00000378540
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,716,378 - 143,720,591 (+)Ensembl
RefSeq Acc Id: ENST00000461928
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,720,698 - 143,721,859 (+)Ensembl
RefSeq Acc Id: ENST00000475376
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,716,349 - 143,718,302 (+)Ensembl
RefSeq Acc Id: ENST00000484654
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,716,340 - 143,722,458 (+)Ensembl
RefSeq Acc Id: ENST00000528175
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,721,548 - 143,722,132 (+)Ensembl
RefSeq Acc Id: ENST00000533830
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,720,192 - 143,721,356 (+)Ensembl
RefSeq Acc Id: NM_139021   ⟹   NP_620590
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,349 - 143,722,458 (+)NCBI
GRCh378144,798,507 - 144,804,633 (+)RGD
Build 368144,870,495 - 144,876,621 (+)NCBI Archive
Celera8141,109,455 - 141,115,595 (+)RGD
HuRef8140,051,333 - 140,057,442 (+)ENTREZGENE
CHM1_18144,838,551 - 144,844,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516925   ⟹   XP_011515227
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,456 - 143,722,458 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516926   ⟹   XP_011515228
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,305 - 143,722,458 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516927   ⟹   XP_011515229
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,456 - 143,722,458 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516928   ⟹   XP_011515230
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,456 - 143,721,323 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017013218   ⟹   XP_016868707
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,456 - 143,722,458 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001745493
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,456 - 143,721,092 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001745494
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,456 - 143,721,323 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_620590   ⟸   NM_139021
- UniProtKB: Q8TD08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011515228   ⟸   XM_011516926
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011515227   ⟸   XM_011516925
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011515229   ⟸   XM_011516927
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011515230   ⟸   XM_011516928
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016868707   ⟸   XM_017013218
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000337691   ⟸   ENST00000338033
RefSeq Acc Id: ENSP00000378540   ⟸   ENST00000395108
RefSeq Acc Id: ENSP00000378539   ⟸   ENST00000395107
Protein Domains
Protein kinase

Promoters
RGD ID:7214381
Promoter ID:EPDNEW_H12937
Type:initiation region
Name:MAPK15_1
Description:mitogen-activated protein kinase 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,716,349 - 143,716,409EPDNEW
RGD ID:6806683
Promoter ID:HG_KWN:62279
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:ENST00000322233,   ENST00000338033,   ENST00000395108,   OTTHUMT00000300349,   OTTHUMT00000300351,   OTTHUMT00000300352
Position:
Human AssemblyChrPosition (strand)Source
Build 368144,870,414 - 144,870,914 (+)MPROMDB
RGD ID:6806862
Promoter ID:HG_KWN:62280
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:OTTHUMT00000300353
Position:
Human AssemblyChrPosition (strand)Source
Build 368144,874,216 - 144,875,062 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:143684819-144287978)x1 copy number loss See cases [RCV000054310] Chr8:143684819..144287978 [GRCh38]
Chr8:144940777..145511679 [GRCh37]
Chr8:144838977..145482487 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:142201468-144002730)x1 copy number loss See cases [RCV000135981] Chr8:142201468..144002730 [GRCh38]
Chr8:143282829..145076898 [GRCh37]
Chr8:143280736..145148886 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:141738068-144140607)x1 copy number loss See cases [RCV000140913] Chr8:141738068..144140607 [GRCh38]
Chr8:142764538..145195510 [GRCh37]
Chr8:142823655..145267498 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144725942-145508436)x3 copy number gain See cases [RCV000447256] Chr8:144725942..145508436 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144779442-146113113)x3 copy number gain See cases [RCV000510396] Chr8:144779442..146113113 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142840194-146280020) copy number gain Intellectual disability [RCV000626547] Chr8:142840194..146280020 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143815037-146295771)x3 copy number gain not provided [RCV000683020] Chr8:143815037..146295771 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144771630-144807456)x3 copy number gain not provided [RCV000747963] Chr8:144771630..144807456 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:144775871-144943223)x3 copy number gain not provided [RCV000747964] Chr8:144775871..144943223 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:144803809-144810322)x3 copy number gain not provided [RCV000747965] Chr8:144803809..144810322 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
NM_139021.3(MAPK15):c.575C>A (p.Ser192Ter) single nucleotide variant not provided [RCV000970192] Chr8:143719150 [GRCh38]
Chr8:144801320 [GRCh37]
Chr8:8q24.3
likely benign
GRCh37/hg19 8q24.3(chr8:142132678-145569441)x1 copy number loss not provided [RCV001006150] Chr8:142132678..145569441 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143616831-144930611)x1 copy number loss not provided [RCV001006152] Chr8:143616831..144930611 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144754114-144857373)x1 copy number loss not provided [RCV001006155] Chr8:144754114..144857373 [GRCh37]
Chr8:8q24.3
likely benign
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144190206-146295771)x3 copy number gain not provided [RCV000847854] Chr8:144190206..146295771 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144262042-146295771)x3 copy number gain not provided [RCV001259034] Chr8:144262042..146295771 [GRCh37]
Chr8:8q24.3
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24667 AgrOrtholog
COSMIC MAPK15 COSMIC
Ensembl Genes ENSG00000181085 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000274205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000337691 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000378539 UniProtKB/Swiss-Prot
  ENSP00000378540 UniProtKB/Swiss-Prot
  ENSP00000478678 UniProtKB/TrEMBL
  ENSP00000483093 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000338033 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000395107 UniProtKB/Swiss-Prot
  ENST00000395108 UniProtKB/Swiss-Prot
  ENST00000615253 UniProtKB/Swiss-Prot
  ENST00000620781 UniProtKB/TrEMBL
GTEx ENSG00000181085 GTEx
  ENSG00000274205 GTEx
HGNC ID HGNC:24667 ENTREZGENE
Human Proteome Map MAPK15 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:225689 UniProtKB/Swiss-Prot
NCBI Gene 225689 ENTREZGENE
OMIM 618616 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671478 PharmGKB
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1C7CYZ1_HUMAN UniProtKB/TrEMBL
  MK15_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q2TCF9 UniProtKB/Swiss-Prot
  Q8N362 UniProtKB/Swiss-Prot