DPRX (divergent-paired related homeobox) - Rat Genome Database

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Gene: DPRX (divergent-paired related homeobox) Homo sapiens
Analyze
Symbol: DPRX
Name: divergent-paired related homeobox
RGD ID: 1604883
HGNC Page HGNC:32166
Description: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: divergent paired-related homeobox
RGD Orthologs
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: DPRXP1   DPRXP2   DPRXP3   DPRXP4   DPRXP5   DPRXP6   DPRXP7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,601,114 - 53,637,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,600,777 - 53,637,014 (+)EnsemblGRCh38hg38GRCh38
GRCh371954,135,253 - 54,140,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,827,122 - 58,832,075 (+)NCBINCBI36Build 36hg18NCBI36
Celera1951,176,624 - 51,181,576 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,455,282 - 50,460,227 (+)NCBIHuRef
CHM1_11954,137,078 - 54,142,030 (+)NCBICHM1_1
T2T-CHM13v2.01956,680,646 - 56,716,531 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Dwarfism  (IAGP)
genetic disease  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISA)
nucleus  (IBA,IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Short stature  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17005330   PMID:19274049   PMID:21873635   PMID:28473536   PMID:38297188  


Genomics

Comparative Map Data
DPRX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,601,114 - 53,637,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,600,777 - 53,637,014 (+)EnsemblGRCh38hg38GRCh38
GRCh371954,135,253 - 54,140,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,827,122 - 58,832,075 (+)NCBINCBI36Build 36hg18NCBI36
Celera1951,176,624 - 51,181,576 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,455,282 - 50,460,227 (+)NCBIHuRef
CHM1_11954,137,078 - 54,142,030 (+)NCBICHM1_1
T2T-CHM13v2.01956,680,646 - 56,716,531 (+)NCBIT2T-CHM13v2.0
Dprx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955604370,544 - 376,004 (-)NCBIChiLan1.0ChiLan1.0
DPRX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22059,647,332 - 59,652,236 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,569,629 - 61,574,535 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01950,576,699 - 50,581,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,423,417 - 59,428,237 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1959,423,417 - 59,428,237 (+)Ensemblpanpan1.1panPan2
DPRX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,467,332 - 103,471,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1103,669,217 - 103,676,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,533,443 - 103,535,378 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01104,124,189 - 104,126,124 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1104,122,804 - 104,131,359 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11103,755,714 - 103,757,649 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,517,714 - 103,519,649 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01104,237,575 - 104,239,510 (-)NCBIUU_Cfam_GSD_1.0
DPRX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl656,561,189 - 56,568,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1656,561,183 - 56,568,357 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2652,438,801 - 52,445,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPRX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1646,352,445 - 46,357,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607326,391,126 - 26,396,433 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DPRX
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.42(chr19:53553042-53899466)x3 copy number gain See cases [RCV000052593] Chr19:53553042..53899466 [GRCh38]
Chr19:54056296..54402720 [GRCh37]
Chr19:58748108..59094532 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.42(chr19:53601298-53773028)x3 copy number gain See cases [RCV000052594] Chr19:53601298..53773028 [GRCh38]
Chr19:54104552..54276282 [GRCh37]
Chr19:58796364..58968094 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.42(chr19:54056297-54327621)x3 copy number gain See cases [RCV000239807] Chr19:54056297..54327621 [GRCh37]
Chr19:19q13.42		 uncertain significance
GRCh37/hg19 19q13.42(chr19:54082353-54486105)x3 copy number gain See cases [RCV000240228] Chr19:54082353..54486105 [GRCh37]
Chr19:19q13.42		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3 copy number gain See cases [RCV000445925] Chr19:50489390..59095359 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NM_001012728.2(DPRX):c.19C>T (p.Leu7Phe) single nucleotide variant Inborn genetic diseases [RCV003276359] Chr19:53632125 [GRCh38]
Chr19:54135379 [GRCh37]
Chr19:19q13.42		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19q13.42(chr19:54082504-54417191)x3 copy number gain not provided [RCV000684078] Chr19:54082504..54417191 [GRCh37]
Chr19:19q13.42		 uncertain significance
NM_001012728.2(DPRX):c.466C>T (p.Arg156Ter) single nucleotide variant Short stature [RCV000736172] Chr19:53636878 [GRCh38]
Chr19:54140132 [GRCh37]
Chr19:19q13.42		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3 copy number gain See cases [RCV000142008] Chr19:52143873..58445521 [GRCh38]
Chr19:52647126..58956888 [GRCh37]
Chr19:57338938..63648700 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh37/hg19 19q13.42(chr19:53867570-55833460)x3 copy number gain not provided [RCV000684091] Chr19:53867570..55833460 [GRCh37]
Chr19:19q13.42		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.41-13.42(chr19:53184204-54346718)x3 copy number gain not provided [RCV000740221] Chr19:53184204..54346718 [GRCh37]
Chr19:19q13.41-13.42		 uncertain significance
GRCh37/hg19 19q13.42(chr19:54074747-54314489)x3 copy number gain not provided [RCV000740239] Chr19:54074747..54314489 [GRCh37]
Chr19:19q13.42		 benign
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3 copy number gain not provided [RCV000740208] Chr19:50740074..59097160 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NC_000019.10:g.53536530_53981185dup duplication Silver Russell Syndrome-related disorder [RCV000785667] Chr19:53536530..53981185 [GRCh38]
Chr19:54039784..54484439 [GRCh37]
Chr19:19q13.42		 uncertain significance
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42		 not provided
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NM_001012728.2(DPRX):c.189G>T (p.Trp63Cys) single nucleotide variant Inborn genetic diseases [RCV002709987] Chr19:53636601 [GRCh38]
Chr19:54139855 [GRCh37]
Chr19:19q13.42		 uncertain significance
NM_001012728.2(DPRX):c.329T>G (p.Leu110Trp) single nucleotide variant Inborn genetic diseases [RCV002988010] Chr19:53636741 [GRCh38]
Chr19:54139995 [GRCh37]
Chr19:19q13.42		 uncertain significance
NM_001012728.2(DPRX):c.254C>T (p.Thr85Ile) single nucleotide variant Inborn genetic diseases [RCV002900912] Chr19:53636666 [GRCh38]
Chr19:54139920 [GRCh37]
Chr19:19q13.42		 uncertain significance
NM_001012728.2(DPRX):c.517G>A (p.Ala173Thr) single nucleotide variant Inborn genetic diseases [RCV002677110] Chr19:53636929 [GRCh38]
Chr19:54140183 [GRCh37]
Chr19:19q13.42		 uncertain significance
NM_001012728.2(DPRX):c.365C>T (p.Thr122Met) single nucleotide variant Inborn genetic diseases [RCV002680624] Chr19:53636777 [GRCh38]
Chr19:54140031 [GRCh37]
Chr19:19q13.42		 uncertain significance
NM_001012728.2(DPRX):c.298G>A (p.Gly100Ser) single nucleotide variant Inborn genetic diseases [RCV003196844] Chr19:53636710 [GRCh38]
Chr19:54139964 [GRCh37]
Chr19:19q13.42		 likely benign
NM_001012728.2(DPRX):c.403C>T (p.Pro135Ser) single nucleotide variant Inborn genetic diseases [RCV003349170] Chr19:53636815 [GRCh38]
Chr19:54140069 [GRCh37]
Chr19:19q13.42		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3 copy number gain not provided [RCV003485200] Chr19:49625130..57647352 [GRCh37]
Chr19:19q13.33-13.43		 likely pathogenic
GRCh37/hg19 19q13.42(chr19:53963333-54421591)x3 copy number gain not provided [RCV003485201] Chr19:53963333..54421591 [GRCh37]
Chr19:19q13.42		 uncertain significance
Single allele deletion ZNF331 deletion [RCV003493388] Chr19:53568105..53617993 [GRCh38]
Chr19:19q13.42		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:107
Interacting mature miRNAs:109
Transcripts:ENST00000376650
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2 1 2 3
Low 176 166 63 12 15 8 810 506 159 7 446 351 5 483 477 4
Below cutoff 1015 987 704 204 401 136 2173 1098 1921 128 487 647 72 503 1413

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000376650   ⟹   ENSP00000365838
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,631,999 - 53,637,014 (+)Ensembl
RefSeq Acc Id: ENST00000710707   ⟹   ENSP00000518423
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,600,777 - 53,637,014 (+)Ensembl
RefSeq Acc Id: NM_001012728   ⟹   NP_001012746
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,631,999 - 53,637,014 (+)NCBI
GRCh371954,135,310 - 54,140,263 (+)RGD
Build 361958,827,122 - 58,832,075 (+)NCBI Archive
Celera1951,176,624 - 51,181,576 (+)RGD
HuRef1950,455,282 - 50,460,227 (+)ENTREZGENE
CHM1_11954,137,078 - 54,142,030 (+)NCBI
T2T-CHM13v2.01956,711,517 - 56,716,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011527011   ⟹   XP_011525313
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,601,114 - 53,637,014 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011527012   ⟹   XP_011525314
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,607,009 - 53,637,014 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047438893   ⟹   XP_047294849
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,601,114 - 53,637,014 (+)NCBI
RefSeq Acc Id: XM_054321126   ⟹   XP_054177101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01956,680,646 - 56,716,531 (+)NCBI
RefSeq Acc Id: XM_054321127   ⟹   XP_054177102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01956,686,539 - 56,716,531 (+)NCBI
RefSeq Acc Id: XM_054321128   ⟹   XP_054177103
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01956,680,646 - 56,716,531 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001012746   ⟸   NM_001012728
- UniProtKB: A6NFQ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525313   ⟸   XM_011527011
- Peptide Label: isoform X1
- UniProtKB: A6NFQ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525314   ⟸   XM_011527012
- Peptide Label: isoform X1
- UniProtKB: A6NFQ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000365838   ⟸   ENST00000376650
RefSeq Acc Id: XP_047294849   ⟸   XM_047438893
- Peptide Label: isoform X1
- UniProtKB: A6NFQ7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054177101   ⟸   XM_054321126
- Peptide Label: isoform X1
- UniProtKB: A6NFQ7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054177103   ⟸   XM_054321128
- Peptide Label: isoform X1
- UniProtKB: A6NFQ7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054177102   ⟸   XM_054321127
- Peptide Label: isoform X1
- UniProtKB: A6NFQ7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSP00000518423   ⟸   ENST00000710707

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6NFQ7-F1-model_v2 AlphaFold A6NFQ7 1-191 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32166 AgrOrtholog
COSMIC DPRX COSMIC
Ensembl Genes ENSG00000204595 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000376650 ENTREZGENE
  ENST00000376650.2 UniProtKB/Swiss-Prot
  ENST00000710707 ENTREZGENE
  ENST00000710707.1 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
GTEx ENSG00000204595 GTEx
HGNC ID HGNC:32166 ENTREZGENE
Human Proteome Map DPRX Human Proteome Map
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
KEGG Report hsa:503834 UniProtKB/Swiss-Prot
NCBI Gene 503834 ENTREZGENE
OMIM 611165 OMIM
PANTHER DIVERGENT PAIRED-RELATED HOMEOBOX UniProtKB/Swiss-Prot
  HOMEOBOX PROTEIN UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
PharmGKB PA142671957 PharmGKB
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt A6NFQ7 ENTREZGENE, UniProtKB/Swiss-Prot