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Gene: FAN1 (FANCD2 and FANCI associated nuclease 1) Homo sapiens
Symbol: FAN1
Name: FANCD2 and FANCI associated nuclease 1
Description: This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: coiled-coil domain-containing protein MTMR15; DKFZp451H236; DKFZp686K16147; FANCD2/FANCI-associated nuclease 1; fanconi anemia associated nuclease 1; fanconi-associated nuclease 1; hFAN1; KIAA1018; KMIN; MTMR15; myotubularin related protein 15; myotubularin-related protein 15; RP11-540B6.6
Mus musculus (house mouse) : Fan1 (FANCD2/FANCI-associated nuclease 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fan1 (FANCD2 and FANCI associated nuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fan1 (FANCD2 and FANCI associated nuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FAN1 (FANCD2 and FANCI associated nuclease 1)
Canis lupus familiaris (dog) : FAN1 (FANCD2 and FANCI associated nuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fan1 (FANCD2 and FANCI associated nuclease 1)
Sus scrofa (pig) : FAN1 (FANCD2 and FANCI associated nuclease 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381530,903,852 - 30,943,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371531,191,703 - 31,235,311 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361528,983,421 - 29,022,600 (+)NCBINCBI36hg18NCBI36
Celera158,921,590 - 8,960,771 (+)NCBI
Cytogenetic Map15q13.3NCBI
HuRef158,373,082 - 8,412,209 (+)NCBIHuRef
CHM1_11531,186,878 - 31,226,131 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FAN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1604829
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.