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Gene: FAN1 (FANCD2 and FANCI associated nuclease 1) Homo sapiens
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Symbol: FAN1
Name: FANCD2 and FANCI associated nuclease 1
Description: This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: coiled-coil domain-containing protein MTMR15; DKFZp451H236; DKFZp686K16147; FANCD2/FANCI-associated nuclease 1; fanconi anemia associated nuclease 1; fanconi-associated nuclease 1; hFAN1; KIAA1018; KMIN; MTMR15; myotubularin related protein 15; myotubularin-related protein 15; RP11-540B6.6
Orthologs:
Mus musculus (house mouse) : Fan1 (FANCD2/FANCI-associated nuclease 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fan1 (FANCD2 and FANCI associated nuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fan1 (FANCD2 and FANCI associated nuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FAN1 (FANCD2 and FANCI associated nuclease 1)
Canis lupus familiaris (dog) : FAN1 (FANCD2 and FANCI associated nuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fan1 (FANCD2 and FANCI associated nuclease 1)
Sus scrofa (pig) : FAN1 (FANCD2 and FANCI associated nuclease 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381530,903,852 - 30,943,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371531,191,703 - 31,235,311 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361528,983,421 - 29,022,600 (+)NCBINCBI36hg18NCBI36
Celera158,921,590 - 8,960,771 (+)NCBI
Cytogenetic Map15q13.3NCBI
HuRef158,373,082 - 8,412,209 (+)NCBIHuRef
CHM1_11531,186,878 - 31,226,131 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on FAN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1604829
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.