LPCAT3 (lysophosphatidylcholine acyltransferase 3) - Rat Genome Database

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Gene: LPCAT3 (lysophosphatidylcholine acyltransferase 3) Homo sapiens
Analyze
Symbol: LPCAT3
Name: lysophosphatidylcholine acyltransferase 3
RGD ID: 1604396
HGNC Page HGNC:30244
Description: Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT; lyso-PC acyltransferase 3; lyso-PS acyltransferase; lysophosphatidylserine acyltransferase; lysophospholipid acyltransferase 12; lysophospholipid acyltransferase 5; MBOAT5; membrane bound O-acyltransferase domain containing 5; membrane-bound O-acyltransferase domain-containing protein 5; nessy; O-acyltransferase (membrane bound) domain containing 5; O-acyltransferase domain-containing protein 5; OACT5; putative protein similar to nessy
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AL136228.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,976,185 - 7,018,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl126,976,185 - 7,018,477 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,085,347 - 7,125,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,955,608 - 6,996,103 (-)NCBINCBI36Build 36hg18NCBI36
Celera128,706,367 - 8,748,731 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,943,813 - 6,986,151 (-)NCBIHuRef
CHM1_1127,084,301 - 7,124,856 (-)NCBICHM1_1
T2T-CHM13v2.0126,989,663 - 7,031,946 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8723724   PMID:9074930   PMID:10446276   PMID:11076863   PMID:11230166   PMID:12477932   PMID:14702039   PMID:15489334   PMID:15489336   PMID:16344560   PMID:16381901   PMID:16541075  
PMID:18195019   PMID:18772128   PMID:18781350   PMID:18782225   PMID:19351971   PMID:19946888   PMID:20018618   PMID:20837115   PMID:21873635   PMID:22511767   PMID:22810586   PMID:23580142  
PMID:25994902   PMID:26186194   PMID:26638075   PMID:27173435   PMID:27913621   PMID:28514442   PMID:28611215   PMID:28683445   PMID:29507755   PMID:30160786   PMID:30652415   PMID:31056421  
PMID:31091453   PMID:32628020   PMID:32780898   PMID:33087821   PMID:33845483   PMID:33961781   PMID:34432599   PMID:35013556   PMID:35286868  


Genomics

Comparative Map Data
LPCAT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,976,185 - 7,018,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl126,976,185 - 7,018,477 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,085,347 - 7,125,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,955,608 - 6,996,103 (-)NCBINCBI36Build 36hg18NCBI36
Celera128,706,367 - 8,748,731 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,943,813 - 6,986,151 (-)NCBIHuRef
CHM1_1127,084,301 - 7,124,856 (-)NCBICHM1_1
T2T-CHM13v2.0126,989,663 - 7,031,946 (-)NCBIT2T-CHM13v2.0
Lpcat3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,639,762 - 124,681,679 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,639,990 - 124,681,381 (+)EnsemblGRCm39 Ensembl
GRCm386124,663,094 - 124,704,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,663,027 - 124,704,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,613,122 - 124,654,734 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,628,747 - 124,669,798 (+)NCBIMGSCv36mm8
Celera6126,344,780 - 126,386,441 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Lpcat3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,468,397 - 157,509,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,468,290 - 157,509,880 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,691,494 - 163,738,379 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,474,396 - 159,521,285 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04158,121,481 - 158,162,851 (+)NCBIRnor_WKY
Rnor_6.04157,181,722 - 157,222,997 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,181,795 - 157,222,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,199,925 - 224,240,593 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,786,349 - 160,827,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,031,284 - 161,072,491 (+)NCBI
Celera4146,207,013 - 146,248,552 (+)NCBICelera
Cytogenetic Map4q42NCBI
Lpcat3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,571,028 - 4,605,097 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,571,028 - 4,605,097 (-)NCBIChiLan1.0ChiLan1.0
LPCAT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,024,015 - 7,065,945 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,024,015 - 7,065,945 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,107,925 - 7,149,982 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LPCAT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,028,438 - 38,068,854 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,028,120 - 38,068,502 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,547,836 - 8,588,333 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,380,888 - 38,421,451 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,380,568 - 38,424,143 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,255,853 - 38,296,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,296,886 - 38,337,321 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,026,597 - 8,067,116 (-)NCBIUU_Cfam_GSD_1.0
Lpcat3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,132,454 - 102,185,140 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936709800,197 - 852,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPCAT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,708,020 - 63,746,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,707,674 - 63,746,369 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,143,944 - 66,182,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LPCAT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,009,911 - 7,051,391 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,005,701 - 7,051,605 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,165,941 - 1,207,838 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpcat3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,611,300 - 3,642,686 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,611,300 - 3,642,682 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH47084  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,099,854 - 7,099,975UniSTSGRCh37
Build 36126,970,115 - 6,970,236RGDNCBI36
Celera128,721,944 - 8,722,065RGD
Cytogenetic Map12p13UniSTS
HuRef126,959,393 - 6,959,514UniSTS
GeneMap99-GB4 RH Map1245.71UniSTS
NCBI RH Map12118.3UniSTS
SHGC-33346  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,084,993 - 7,085,119UniSTSGRCh37
Build 36126,955,254 - 6,955,380RGDNCBI36
Celera128,706,013 - 8,706,139RGD
Cytogenetic Map12p13UniSTS
Cytogenetic Map12p13.3UniSTS
HuRef126,943,459 - 6,943,585UniSTS
Stanford-G3 RH Map12374.0UniSTS
NCBI RH Map12110.6UniSTS
GeneMap99-G3 RH Map12374.0UniSTS
RH11325  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,085,374 - 7,085,542UniSTSGRCh37
Build 36126,955,635 - 6,955,803RGDNCBI36
Celera128,706,394 - 8,706,562RGD
Cytogenetic Map12p13UniSTS
Cytogenetic Map12p13.3UniSTS
HuRef126,943,840 - 6,944,008UniSTS
GeneMap99-GB4 RH Map1244.37UniSTS
NCBI RH Map12118.3UniSTS
RH26657  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,084,860 - 7,084,991UniSTSGRCh37
Build 36126,955,121 - 6,955,252RGDNCBI36
Celera128,705,880 - 8,706,011RGD
Cytogenetic Map12p13UniSTS
Cytogenetic Map12p13.3UniSTS
HuRef126,943,326 - 6,943,457UniSTS
RH44811  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,087,783 - 7,087,897UniSTSGRCh37
Build 36126,958,044 - 6,958,158RGDNCBI36
Celera128,708,803 - 8,708,917RGD
Cytogenetic Map12p13UniSTS
HuRef126,946,249 - 6,946,363UniSTS
GeneMap99-GB4 RH Map1245.21UniSTS
D12S1206E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,088,911 - 7,089,001UniSTSGRCh37
Build 36126,959,172 - 6,959,262RGDNCBI36
Celera128,709,931 - 8,710,021RGD
Cytogenetic Map12p13UniSTS
HuRef126,947,377 - 6,947,467UniSTS
GeneMap99-GB4 RH Map1245.71UniSTS
NCBI RH Map12117.7UniSTS
C3F__4486  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,085,163 - 7,086,029UniSTSGRCh37
Build 36126,955,424 - 6,956,290RGDNCBI36
Celera128,706,183 - 8,707,049RGD
HuRef126,943,629 - 6,944,495UniSTS
RH80030  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic MapXq26.1UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map9p13UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map12q15-q21UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map2p22.2UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map11q22.2-q22.3UniSTS
Cytogenetic Map1p36-p35UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map10q26.13-q26.3UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map2q32.2UniSTS
G33059  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,099,862 - 7,100,129UniSTSGRCh37
Celera128,721,952 - 8,722,219UniSTS
Cytogenetic Map12p13UniSTS
HuRef126,959,401 - 6,959,668UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4229
Count of miRNA genes:1091
Interacting mature miRNAs:1346
Transcripts:ENST00000261407, ENST00000535021, ENST00000535479, ENST00000536797, ENST00000536971, ENST00000537179, ENST00000538910, ENST00000538987, ENST00000539868, ENST00000540060, ENST00000540090, ENST00000543794, ENST00000545459
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2118 1889 1511 546 1285 390 3995 1631 1303 350 1146 1570 171 1 1184 2493 5 2
Low 321 1093 215 78 666 75 362 557 2410 69 314 43 4 20 295 1
Below cutoff 9 9 21

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC006512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK058063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU125262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261407   ⟹   ENSP00000261407
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,976,185 - 7,018,476 (-)Ensembl
RefSeq Acc Id: ENST00000535021
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,976,806 - 6,981,148 (-)Ensembl
RefSeq Acc Id: ENST00000535479   ⟹   ENSP00000438765
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,976,186 - 7,018,477 (-)Ensembl
RefSeq Acc Id: ENST00000536797   ⟹   ENSP00000440550
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,977,840 - 7,018,474 (-)Ensembl
RefSeq Acc Id: ENST00000536971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,981,542 - 7,018,474 (-)Ensembl
RefSeq Acc Id: ENST00000537179
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,978,041 - 6,979,270 (-)Ensembl
RefSeq Acc Id: ENST00000538910   ⟹   ENSP00000437827
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,981,809 - 7,018,474 (-)Ensembl
RefSeq Acc Id: ENST00000538987
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,979,595 - 6,981,157 (-)Ensembl
RefSeq Acc Id: ENST00000540060
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,980,707 - 6,981,858 (-)Ensembl
RefSeq Acc Id: ENST00000540090   ⟹   ENSP00000442454
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,977,647 - 7,018,474 (-)Ensembl
RefSeq Acc Id: ENST00000543794   ⟹   ENSP00000443166
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,977,699 - 7,018,474 (-)Ensembl
RefSeq Acc Id: ENST00000545459
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,981,560 - 6,983,465 (-)Ensembl
RefSeq Acc Id: ENST00000620843
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,981,294 - 6,982,783 (-)Ensembl
RefSeq Acc Id: NM_005768   ⟹   NP_005759
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,976,185 - 7,018,476 (-)NCBI
GRCh37127,085,347 - 7,125,842 (-)ENTREZGENE
Build 36126,955,608 - 6,996,103 (-)NCBI Archive
HuRef126,943,813 - 6,986,151 (-)ENTREZGENE
CHM1_1127,084,301 - 7,124,856 (-)NCBI
T2T-CHM13v2.0126,989,663 - 7,031,946 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005759   ⟸   NM_005768
- UniProtKB: Q9BW40 (UniProtKB/Swiss-Prot),   Q6P1A2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000443166   ⟸   ENST00000543794
RefSeq Acc Id: ENSP00000438765   ⟸   ENST00000535479
RefSeq Acc Id: ENSP00000440550   ⟸   ENST00000536797
RefSeq Acc Id: ENSP00000437827   ⟸   ENST00000538910
RefSeq Acc Id: ENSP00000261407   ⟸   ENST00000261407
RefSeq Acc Id: ENSP00000442454   ⟸   ENST00000540090

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P1A2-F1-model_v2 AlphaFold Q6P1A2 1-487 view protein structure

Promoters
RGD ID:6810340
Promoter ID:HG_ACW:15544
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:MBOAT5.DAPR07,   MBOAT5.PAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,958,521 - 6,959,021 (-)MPROMDB
RGD ID:6790248
Promoter ID:HG_KWN:14878
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005768,   UC009ZFP.1,   UC009ZFQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,995,736 - 6,996,557 (-)MPROMDB
RGD ID:6852180
Promoter ID:EP73896
Type:initiation region
Name:HS_C3F
Description:Putative protein similar to nessy (Drosophila).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,996,039 - 6,996,099EPD
RGD ID:7222999
Promoter ID:EPDNEW_H17245
Type:initiation region
Name:LPCAT3_1
Description:lysophosphatidylcholine acyltransferase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,018,474 - 7,018,534EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22
pathogenic
GRCh38/hg38 12p13.31(chr12:6728665-7705620)x1 copy number loss See cases [RCV000052779] Chr12:6728665..7705620 [GRCh38]
Chr12:6837831..7858216 [GRCh37]
Chr12:6708092..7749483 [NCBI36]
Chr12:12p13.31
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1
pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121055-7272606)x3 copy number gain See cases [RCV000053663] Chr12:121055..7272606 [GRCh38]
Chr12:282465..7425202 [GRCh37]
Chr12:100482..7316469 [NCBI36]
Chr12:12p13.33-13.31
pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121255-8361746)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|See cases [RCV000053664] Chr12:121255..8361746 [GRCh38]
Chr12:282465..8514342 [GRCh37]
Chr12:100682..8405609 [NCBI36]
Chr12:12p13.33-13.31
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.31(chr12:7069980-7094188)x3 copy number gain See cases [RCV000447567] Chr12:7069980..7094188 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-8257049)x3 copy number gain See cases [RCV000446749] Chr12:173786..8257049 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1
likely pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3 copy number gain See cases [RCV000510853] Chr12:173786..11677456 [GRCh37]
Chr12:12p13.33-13.2
pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:191242-8122785)x3 copy number gain not provided [RCV000683477] Chr12:191242..8122785 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21
pathogenic
GRCh37/hg19 12p13.31(chr12:6911437-9381254)x3 copy number gain not provided [RCV000750277] Chr12:6911437..9381254 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
NC_000012.12:g.(1_3750000)_(5250000_9000000)del deletion Tumoral calcinosis, hyperphosphatemic, familial, 1 [RCV000758697] Chr12:3750000..5250000 [GRCh38]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:237588-8278292) copy number gain not provided [RCV000767818] Chr12:237588..8278292 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:189216-8185497) copy number gain not provided [RCV000767819] Chr12:189216..8185497 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
NC_000012.11:g.(?_6945914)_(9027627_?)dup duplication Temtamy syndrome [RCV000816630] Chr12:6945914..9027627 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-8393815)x3 copy number gain not provided [RCV000846343] Chr12:173786..8393815 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
NM_005768.6(LPCAT3):c.367-6T>C single nucleotide variant not provided [RCV000909566] Chr12:6981910 [GRCh38]
Chr12:7091071 [GRCh37]
Chr12:12p13.31
benign
NM_005768.6(LPCAT3):c.411C>T (p.Tyr137=) single nucleotide variant not provided [RCV000957667] Chr12:6981860 [GRCh38]
Chr12:7091021 [GRCh37]
Chr12:12p13.31
benign
NC_000012.11:g.(?_6945914)_(8248706_?)dup duplication Temtamy syndrome [RCV001031096] Chr12:6945914..8248706 [GRCh37]
Chr12:12p13.31
uncertain significance
NC_000012.11:g.(?_6438458)_(7362839_?)dup duplication Peroxisome biogenesis disorder 2B [RCV001031288] Chr12:6438458..7362839 [GRCh37]
Chr12:12p13.31
uncertain significance
NC_000012.11:g.(?_6945914)_(9027627_?)dup duplication Developmental and epileptic encephalopathy, 21 [RCV001325295]|Klippel-Feil syndrome 3, autosomal dominant [RCV001301079]|Temtamy syndrome [RCV000816630]|not provided [RCV001859243] Chr12:6945914..9027627 [GRCh37]
Chr12:12p13.31
uncertain significance
NC_000012.11:g.(?_6438478)_(7362819_?)dup duplication Temtamy syndrome [RCV001365174] Chr12:6438478..7362819 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:189145-7730395)x3 copy number gain not provided [RCV001537906] Chr12:189145..7730395 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:146240-8330229)x3 copy number gain Obesity [RCV001801197] Chr12:146240..8330229 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
NC_000012.11:g.(?_6438478)_(8248686_?)dup duplication TNF receptor-associated periodic fever syndrome (TRAPS) [RCV001913768]|not provided [RCV001913769] Chr12:6438478..8248686 [GRCh37]
Chr12:12p13.31
uncertain significance
NC_000012.11:g.(?_6438478)_(8756953_?)dup duplication not provided [RCV001970781] Chr12:6438478..8756953 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837) copy number gain not specified [RCV002052957] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.31(chr12:6530146-7376398) copy number gain not specified [RCV002052968] Chr12:6530146..7376398 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.31(chr12:6872634-7244086) copy number gain not specified [RCV002052969] Chr12:6872634..7244086 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301) copy number gain not specified [RCV002052958] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865) copy number gain not specified [RCV002052955] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1
pathogenic
NC_000012.11:g.(?_6978008)_(9010204_?)dup duplication Peroxisome biogenesis disorder 2B [RCV001877402] Chr12:6978008..9010204 [GRCh37]
Chr12:12p13.31
uncertain significance
NC_000012.11:g.(?_6438478)_(9027607_?)dup duplication not provided [RCV001943267] Chr12:6438478..9027607 [GRCh37]
Chr12:12p13.31
uncertain significance
NC_000012.11:g.(?_6945914)_(7362819_?)dup duplication not provided [RCV001943326] Chr12:6945914..7362819 [GRCh37]
Chr12:12p13.31
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30244 AgrOrtholog
COSMIC LPCAT3 COSMIC
Ensembl Genes ENSG00000111684 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000261407 ENTREZGENE
  ENSP00000261407.4 UniProtKB/Swiss-Prot
  ENSP00000437827.1 UniProtKB/TrEMBL
  ENSP00000438765.1 UniProtKB/TrEMBL
  ENSP00000440550.1 UniProtKB/TrEMBL
  ENSP00000442454.1 UniProtKB/TrEMBL
  ENSP00000443166.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000261407 ENTREZGENE
  ENST00000261407.9 UniProtKB/Swiss-Prot
  ENST00000535479.5 UniProtKB/TrEMBL
  ENST00000536797.5 UniProtKB/TrEMBL
  ENST00000538910.1 UniProtKB/TrEMBL
  ENST00000540090.5 UniProtKB/TrEMBL
  ENST00000543794.5 UniProtKB/TrEMBL
GTEx ENSG00000111684 GTEx
HGNC ID HGNC:30244 ENTREZGENE
Human Proteome Map LPCAT3 Human Proteome Map
InterPro MBOAT_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10162 UniProtKB/Swiss-Prot
NCBI Gene 10162 ENTREZGENE
OMIM 611950 OMIM
Pfam MBOAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162394266 PharmGKB
UniProt B7Z3N5_HUMAN UniProtKB/TrEMBL
  F5GYT3_HUMAN UniProtKB/TrEMBL
  F5H0M4_HUMAN UniProtKB/TrEMBL
  F5H680_HUMAN UniProtKB/TrEMBL
  F5H7K7_HUMAN UniProtKB/TrEMBL
  MBOA5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9BW40 ENTREZGENE
UniProt Secondary B2RDH0 UniProtKB/Swiss-Prot
  B7Z3N3 UniProtKB/Swiss-Prot
  Q7KZS1 UniProtKB/Swiss-Prot
  Q92980 UniProtKB/Swiss-Prot
  Q9BW40 UniProtKB/Swiss-Prot