CMPK1 (cytidine/uridine monophosphate kinase 1) - Rat Genome Database

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Gene: CMPK1 (cytidine/uridine monophosphate kinase 1) Homo sapiens
Analyze
Symbol: CMPK1
Name: cytidine/uridine monophosphate kinase 1
RGD ID: 1604360
HGNC Page HGNC:18170
Description: Enables UMP kinase activity and nucleoside diphosphate kinase activity. Involved in UDP biosynthetic process. Located in nucleolus and nucleoplasm. Implicated in lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CK; CMK; CMPK; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; cytidylate kinase; dCMP kinase; deoxycytidylate kinase; nucleoside-diphosphate kinase; RP11-511I2.1; UMK; UMP-CMP kinase; UMP-CMPK; UMP/CMP kinase; UMP/CMPK; UMPK; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CMPK1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38147,333,790 - 47,378,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl147,333,790 - 47,394,866 (+)EnsemblGRCh38hg38GRCh38
GRCh37147,799,462 - 47,844,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,572,175 - 47,617,098 (+)NCBINCBI36Build 36hg18NCBI36
Celera146,085,741 - 46,130,781 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,915,968 - 45,960,944 (+)NCBIHuRef
CHM1_1147,916,317 - 47,961,359 (+)NCBICHM1_1
T2T-CHM13v2.0147,212,232 - 47,257,303 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,TAS)
cytosol  (TAS)
extracellular exosome  (HDA)
nucleolus  (IDA)
nucleoplasm  (IDA)
nucleus  (IBA,IEA,TAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Endocrine disrupting effect of di-(2-ethylhexyl)phthalate on female rats and proteome analyses of their pituitaries. Hirosawa N, etal., Proteomics. 2006 Feb;6(3):958-71.
2. De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Differential Effect of Polymorphisms of CMPK1 and RRM1 on Survival in Advanced Non-small Cell Lung Cancer Patients Treated with Gemcitabine or Taxane/Cisplatinum. Ryu JS, etal., J Thorac Oncol. 2011 Jun 2.
7. Up-regulated uridine kinase gene identified by RLCS in the ventral horn after crush injury to rat sciatic nerves. Yuh I, etal., Biochem Biophys Res Commun 1999 Dec 9;266(1):104-9.
Additional References at PubMed
PMID:40615   PMID:172293   PMID:220950   PMID:1286669   PMID:8125298   PMID:8313870   PMID:10462544   PMID:10931946   PMID:11453085   PMID:11681623   PMID:11912132   PMID:12477932  
PMID:12694191   PMID:15163660   PMID:15489334   PMID:15550676   PMID:15606899   PMID:16710414   PMID:17608725   PMID:19056867   PMID:19322201   PMID:19568409   PMID:21559290   PMID:21873635  
PMID:22658674   PMID:22838950   PMID:23376485   PMID:23416111   PMID:23533145   PMID:24963161   PMID:25659034   PMID:26186194   PMID:26344197   PMID:27558661   PMID:27576135   PMID:28380382  
PMID:28414100   PMID:28514442   PMID:29117863   PMID:30110629   PMID:30463901   PMID:30575818   PMID:31091453   PMID:31201869   PMID:31478661   PMID:31536960   PMID:31586073   PMID:31871319  
PMID:31980649   PMID:32296183   PMID:32344865   PMID:32416067   PMID:32814053   PMID:33545068   PMID:33726789   PMID:33961781   PMID:34079125   PMID:34349018   PMID:34373451   PMID:34709727  
PMID:34732716   PMID:34857952   PMID:35256949   PMID:35831314   PMID:35844135   PMID:35944360   PMID:36215168   PMID:36517590   PMID:36634849   PMID:37120454   PMID:37258394   PMID:37827155  
PMID:38113892  


Genomics

Comparative Map Data
CMPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38147,333,790 - 47,378,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl147,333,790 - 47,394,866 (+)EnsemblGRCh38hg38GRCh38
GRCh37147,799,462 - 47,844,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,572,175 - 47,617,098 (+)NCBINCBI36Build 36hg18NCBI36
Celera146,085,741 - 46,130,781 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,915,968 - 45,960,944 (+)NCBIHuRef
CHM1_1147,916,317 - 47,961,359 (+)NCBICHM1_1
T2T-CHM13v2.0147,212,232 - 47,257,303 (+)NCBIT2T-CHM13v2.0
Cmpk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394114,817,810 - 114,844,425 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4114,816,533 - 114,844,438 (-)EnsemblGRCm39 Ensembl
GRCm384114,960,613 - 114,987,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4114,959,336 - 114,987,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv374114,633,218 - 114,659,833 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364114,458,570 - 114,485,076 (-)NCBIMGSCv36mm8
Celera4113,708,548 - 113,734,653 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map452.73NCBI
Cmpk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85133,717,073 - 133,744,623 (-)NCBIGRCr8
mRatBN7.25128,480,301 - 128,507,830 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5128,480,301 - 128,507,830 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,169,403 - 131,196,989 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05132,899,052 - 132,926,636 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05132,920,733 - 132,948,328 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05133,759,722 - 133,786,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5133,759,735 - 133,786,452 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05137,551,825 - 137,578,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,320,845 - 135,348,973 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,326,070 - 135,354,120 (-)NCBI
Celera5127,132,281 - 127,159,748 (-)NCBICelera
Cytogenetic Map5q35NCBI
Cmpk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546411,179,432 - 11,213,147 (-)NCBIChiLan1.0ChiLan1.0
CMPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,437,907 - 179,468,944 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,579,344 - 178,610,662 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,642,602 - 46,673,568 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1148,156,641 - 48,186,778 (+)NCBIpanpan1.1PanPan1.1panPan2
CMPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,324,235 - 13,357,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1513,326,185 - 13,358,152 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1513,476,565 - 13,509,755 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01513,473,206 - 13,506,434 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,456,379 - 13,506,417 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,273,274 - 13,306,477 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,341,002 - 13,374,200 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,410,462 - 13,443,720 (-)NCBIUU_Cfam_GSD_1.0
Cmpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505862,322,681 - 62,355,997 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647428,147,085 - 28,182,043 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647428,147,459 - 28,180,779 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CMPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6164,162,518 - 164,197,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16164,161,439 - 164,197,429 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26151,714,202 - 151,748,280 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CMPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12085,541,796 - 85,584,167 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2085,541,205 - 85,584,068 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603331,498,081 - 31,540,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cmpk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248595,452,694 - 5,495,840 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CMPK1
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.3-33(chr1:39479787-47688131)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|See cases [RCV000051817] Chr1:39479787..47688131 [GRCh38]
Chr1:39945459..48153803 [GRCh37]
Chr1:39718046..47926390 [NCBI36]
Chr1:1p34.3-33		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p34.1-32.3(chr1:45303358-52157856)x1 copy number loss See cases [RCV000448358] Chr1:45303358..52157856 [GRCh37]
Chr1:1p34.1-32.3		 likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p33-32.3(chr1:47272184-52505405)x1 copy number loss not provided [RCV001005086] Chr1:47272184..52505405 [GRCh37]
Chr1:1p33-32.3		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p34.1-32.3(chr1:45303358-52157856) copy number loss not specified [RCV002053281] Chr1:45303358..52157856 [GRCh37]
Chr1:1p34.1-32.3		 likely pathogenic
GRCh37/hg19 1p35.1-33(chr1:33285582-47891811) copy number gain not specified [RCV002052781] Chr1:33285582..47891811 [GRCh37]
Chr1:1p35.1-33		 pathogenic
NC_000001.10:g.(?_47716808)_(47882947_?)dup duplication Congenital primary aphakia [RCV003116564] Chr1:47716808..47882947 [GRCh37]
Chr1:1p33		 uncertain significance
NM_016308.3(CMPK1):c.127G>T (p.Gly43Cys) single nucleotide variant not specified [RCV004121001] Chr1:47334072 [GRCh38]
Chr1:47799744 [GRCh37]
Chr1:1p33		 uncertain significance
NM_016308.3(CMPK1):c.439T>C (p.Ser147Pro) single nucleotide variant not specified [RCV004191263] Chr1:47373075 [GRCh38]
Chr1:47838747 [GRCh37]
Chr1:1p33		 uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
GRCh37/hg19 1p33-32.2(chr1:47493178-57042671)x3 copy number gain not specified [RCV003986484] Chr1:47493178..57042671 [GRCh37]
Chr1:1p33-32.2		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1488
Count of miRNA genes:753
Interacting mature miRNAs:870
Transcripts:ENST00000371870, ENST00000371871, ENST00000371873, ENST00000450808, ENST00000471289
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2314561GLUCO47_HGlucose level QTL 47 (human)1.1Glucose level14477336070773360Human

Markers in Region
RH69525  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37635,735,695 - 35,735,805UniSTSGRCh37
GRCh37147,843,406 - 47,843,515UniSTSGRCh37
Build 36147,615,993 - 47,616,102RGDNCBI36
Celera146,129,676 - 46,129,785RGD
Celera637,290,278 - 37,290,388UniSTS
Cytogenetic Map1p32UniSTS
HuRef145,959,839 - 45,959,948UniSTS
HuRef635,453,428 - 35,453,538UniSTS
AL033960  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,804,528 - 47,804,608UniSTSGRCh37
Build 36147,577,115 - 47,577,195RGDNCBI36
Celera146,090,800 - 46,090,880RGD
Cytogenetic Map1p32UniSTS
HuRef145,920,982 - 45,921,062UniSTS
D1S2073E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,841,525 - 47,841,615UniSTSGRCh37
Build 36147,614,112 - 47,614,202RGDNCBI36
Celera146,127,795 - 46,127,885RGD
Cytogenetic Map1p32UniSTS
HuRef145,957,958 - 45,958,048UniSTS
SHGC-132626  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,843,775 - 47,844,088UniSTSGRCh37
Build 36147,616,362 - 47,616,675RGDNCBI36
Celera146,130,045 - 46,130,358RGD
Cytogenetic Map1p32UniSTS
HuRef145,960,208 - 45,960,521UniSTS
TNG Radiation Hybrid Map126349.0UniSTS
SHGC-36697  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37147,843,774 - 47,843,902UniSTSGRCh37
Build 36147,616,361 - 47,616,489RGDNCBI36
Celera146,130,044 - 46,130,172RGD
Cytogenetic Map1p32UniSTS
HuRef145,960,207 - 45,960,335UniSTS
GeneMap99-G3 RH Map12377.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001136140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001366135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_046394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_046395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF070416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF110643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF259961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL513322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL607122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB494965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000371870
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl147,333,941 - 47,373,443 (+)Ensembl
Ensembl Acc Id: ENST00000371871   ⟹   ENSP00000360937
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl147,333,809 - 47,377,210 (+)Ensembl
Ensembl Acc Id: ENST00000371873   ⟹   ENSP00000360939
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl147,333,790 - 47,378,839 (+)Ensembl
Ensembl Acc Id: ENST00000450808   ⟹   ENSP00000398192
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl147,333,914 - 47,377,123 (+)Ensembl
Ensembl Acc Id: ENST00000471289   ⟹   ENSP00000433782
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl147,333,879 - 47,358,875 (+)Ensembl
Ensembl Acc Id: ENST00000699074   ⟹   ENSP00000514113
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl147,333,870 - 47,394,866 (+)Ensembl
Ensembl Acc Id: ENST00000699075   ⟹   ENSP00000514114
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl147,333,914 - 47,378,839 (+)Ensembl
RefSeq Acc Id: NM_001136140   ⟹   NP_001129612
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38147,333,790 - 47,378,839 (+)NCBI
GRCh37147,799,469 - 47,844,511 (+)ENTREZGENE
HuRef145,915,968 - 45,960,944 (+)ENTREZGENE
CHM1_1147,916,317 - 47,961,359 (+)NCBI
T2T-CHM13v2.0147,212,232 - 47,257,303 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001366135   ⟹   NP_001353064
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38147,333,790 - 47,378,839 (+)NCBI
T2T-CHM13v2.0147,212,232 - 47,257,303 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016308   ⟹   NP_057392
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38147,333,790 - 47,378,839 (+)NCBI
GRCh37147,799,469 - 47,844,511 (+)ENTREZGENE
Build 36147,572,175 - 47,617,098 (+)NCBI Archive
HuRef145,915,968 - 45,960,944 (+)ENTREZGENE
CHM1_1147,916,317 - 47,961,359 (+)NCBI
T2T-CHM13v2.0147,212,232 - 47,257,303 (+)NCBI
Sequence:
RefSeq Acc Id: NR_046394
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38147,333,790 - 47,378,839 (+)NCBI
GRCh37147,799,469 - 47,844,511 (+)NCBI
HuRef145,915,968 - 45,960,944 (+)NCBI
CHM1_1147,916,317 - 47,961,359 (+)NCBI
T2T-CHM13v2.0147,212,232 - 47,257,303 (+)NCBI
Sequence:
RefSeq Acc Id: NR_046395
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38147,333,790 - 47,358,875 (+)NCBI
GRCh37147,799,469 - 47,844,511 (+)NCBI
HuRef145,915,968 - 45,960,944 (+)NCBI
CHM1_1147,916,317 - 47,941,390 (+)NCBI
T2T-CHM13v2.0147,212,232 - 47,237,332 (+)NCBI
Sequence:
RefSeq Acc Id: NP_057392   ⟸   NM_016308
- Peptide Label: isoform a
- UniProtKB: A0A8V8TMN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129612   ⟸   NM_001136140
- Peptide Label: isoform b
- UniProtKB: A0A494BXC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001353064   ⟸   NM_001366135
- Peptide Label: isoform c
- UniProtKB: Q9UBQ8 (UniProtKB/Swiss-Prot),   Q96C07 (UniProtKB/Swiss-Prot),   Q5SVZ0 (UniProtKB/Swiss-Prot),   Q53GB7 (UniProtKB/Swiss-Prot),   P30085 (UniProtKB/Swiss-Prot),   E9PGI8 (UniProtKB/Swiss-Prot),   B4DPU7 (UniProtKB/Swiss-Prot),   B2R6S5 (UniProtKB/Swiss-Prot),   Q9UIA2 (UniProtKB/Swiss-Prot),   A0A8V8TMN5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000360937   ⟸   ENST00000371871
Ensembl Acc Id: ENSP00000360939   ⟸   ENST00000371873
Ensembl Acc Id: ENSP00000398192   ⟸   ENST00000450808
Ensembl Acc Id: ENSP00000433782   ⟸   ENST00000471289
Ensembl Acc Id: ENSP00000514113   ⟸   ENST00000699074
Ensembl Acc Id: ENSP00000514114   ⟸   ENST00000699075

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30085-F1-model_v2 AlphaFold P30085 1-196 view protein structure

Promoters
RGD ID:6855472
Promoter ID:EPDNEW_H901
Type:initiation region
Name:CMPK1_1
Description:cytidine/uridine monophosphate kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H902  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38147,333,791 - 47,333,851EPDNEW
RGD ID:6855474
Promoter ID:EPDNEW_H902
Type:initiation region
Name:CMPK1_2
Description:cytidine/uridine monophosphate kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H901  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38147,333,914 - 47,333,974EPDNEW
RGD ID:6784937
Promoter ID:HG_KWN:2619
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000333103,   ENST00000371870,   ENST00000371871,   NM_001136140,   OTTHUMT00000021646,   OTTHUMT00000021647
Position:
Human AssemblyChrPosition (strand)Source
Build 36147,571,956 - 47,572,552 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18170 AgrOrtholog
COSMIC CMPK1 COSMIC
Ensembl Genes ENSG00000162368 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000371871.8 UniProtKB/TrEMBL
  ENST00000371873 ENTREZGENE
  ENST00000371873.10 UniProtKB/Swiss-Prot
  ENST00000450808 ENTREZGENE
  ENST00000450808.2 UniProtKB/TrEMBL
  ENST00000471289 ENTREZGENE
  ENST00000471289.2 UniProtKB/TrEMBL
  ENST00000699074.1 UniProtKB/TrEMBL
  ENST00000699075 ENTREZGENE
  ENST00000699075.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000162368 GTEx
HGNC ID HGNC:18170 ENTREZGENE
Human Proteome Map CMPK1 Human Proteome Map
InterPro Adenylat/UMP-CMP_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UMP_CMP_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51727 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 51727 ENTREZGENE
OMIM 191710 OMIM
PANTHER PTHR23359 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UMP-CMP KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CMPK1 RGD, PharmGKB
PRINTS ADENYLTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BXC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8V8TMN5 ENTREZGENE, UniProtKB/TrEMBL
  B2R6S5 ENTREZGENE
  B4DPU7 ENTREZGENE
  E9PGI8 ENTREZGENE
  E9PJD2_HUMAN UniProtKB/TrEMBL
  KCY_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53GB7 ENTREZGENE
  Q5SVZ0 ENTREZGENE
  Q5T0D2_HUMAN UniProtKB/TrEMBL
  Q96C07 ENTREZGENE
  Q9UBQ8 ENTREZGENE
  Q9UIA2 ENTREZGENE
UniProt Secondary B2R6S5 UniProtKB/Swiss-Prot
  B4DPU7 UniProtKB/Swiss-Prot
  E9PGI8 UniProtKB/Swiss-Prot
  Q53GB7 UniProtKB/Swiss-Prot
  Q5SVZ0 UniProtKB/Swiss-Prot
  Q96C07 UniProtKB/Swiss-Prot
  Q9UBQ8 UniProtKB/Swiss-Prot
  Q9UIA2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 CMPK1  cytidine/uridine monophosphate kinase 1    cytidine monophosphate (UMP-CMP) kinase 1, cytosolic  Symbol and/or name change 5135510 APPROVED