PRSS37 (serine protease 37) - Rat Genome Database

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Gene: PRSS37 (serine protease 37) Homo sapiens
Analyze
Symbol: PRSS37
Name: serine protease 37
RGD ID: 1604236
HGNC Page HGNC
Description: Predicted to have serine-type endopeptidase activity. Involved in positive regulation of acrosome reaction and regulation of protein processing. Localizes to acrosomal vesicle; INTERACTS WITH benzo[a]pyrene; bis(2-ethylhexyl) phthalate; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Peptidase S1 domain-containing protein LOC136242; probable inactive serine protease 37; probable inactive trypsin-X2; protease, serine 37; protease, serine, 37; TRYX2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7141,836,300 - 141,841,487 (-)EnsemblGRCh38hg38GRCh38
GRCh387141,836,278 - 141,849,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377141,536,078 - 141,541,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,182,555 - 141,187,690 (-)NCBINCBI36hg18NCBI36
Celera7136,257,527 - 136,262,670 (-)NCBI
Cytogenetic Map7q34NCBI
HuRef7135,832,747 - 135,837,890 (-)NCBIHuRef
CHM1_17141,470,427 - 141,475,570 (-)NCBICHM1_1
CRA_TCAGchr7v27140,873,792 - 140,878,935 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:12690205   PMID:14702039   PMID:21630459   PMID:21873635   PMID:27649891   PMID:28514442   PMID:30824926  


Genomics

Comparative Map Data
PRSS37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7141,836,300 - 141,841,487 (-)EnsemblGRCh38hg38GRCh38
GRCh387141,836,278 - 141,849,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377141,536,078 - 141,541,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,182,555 - 141,187,690 (-)NCBINCBI36hg18NCBI36
Celera7136,257,527 - 136,262,670 (-)NCBI
Cytogenetic Map7q34NCBI
HuRef7135,832,747 - 135,837,890 (-)NCBIHuRef
CHM1_17141,470,427 - 141,475,570 (-)NCBICHM1_1
CRA_TCAGchr7v27140,873,792 - 140,878,935 (-)NCBI
Prss37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,491,754 - 40,496,469 (-)NCBIGRCm39mm39
GRCm39 Ensembl640,491,758 - 40,496,442 (-)Ensembl
GRCm38640,514,820 - 40,519,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,464,823 - 40,469,507 (-)NCBIGRCm37mm9NCBIm37
MGSCv36640,444,431 - 40,449,113 (-)NCBImm8
Celera640,502,240 - 40,506,924 (-)NCBICelera
Cytogenetic Map6B1NCBI
Prss37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2469,322,977 - 69,334,555 (-)NCBI
Rnor_6.0 Ensembl468,337,480 - 68,349,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0468,337,498 - 68,349,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04133,126,537 - 133,140,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4468,086,470 - 68,101,076 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1468,362,599 - 68,377,199 (-)NCBI
Celera464,325,342 - 64,336,751 (-)NCBICelera
Cytogenetic Map4q22NCBI
Prss37
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,744,044 - 1,747,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,742,104 - 1,747,310 (+)NCBIChiLan1.0ChiLan1.0
PRSS37
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17146,236,906 - 146,242,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,236,906 - 146,242,157 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07133,767,802 - 133,773,321 (-)NCBIMhudiblu_PPA_v0panPan3
PRSS37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,379,344 - 7,385,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,379,830 - 7,385,159 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,224,008 - 8,229,814 (+)NCBI
ROS_Cfam_1.0167,300,896 - 7,306,702 (+)NCBI
UMICH_Zoey_3.1167,254,225 - 7,260,030 (+)NCBI
UNSW_CanFamBas_1.0167,096,603 - 7,102,409 (+)NCBI
UU_Cfam_GSD_1.0167,164,356 - 7,170,162 (+)NCBI
Prss37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,537,705 - 13,542,968 (+)NCBI
SpeTri2.0NW_0049365925,676,944 - 5,681,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS37
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,111,850 - 8,118,681 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,112,288 - 8,119,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,207,603 - 8,214,569 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS37
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,583,991 - 110,588,985 (-)NCBI
ChlSab1.1 Ensembl21110,584,109 - 110,588,046 (-)Ensembl
Vero_WHO_p1.0NW_0236660727,262,134 - 7,266,660 (-)NCBI
Prss37
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476521,838,292 - 21,844,887 (-)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1377
Count of miRNA genes:692
Interacting mature miRNAs:776
Transcripts:ENST00000350549, ENST00000419085, ENST00000438520, ENST00000452758
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 344
Low 7 7 39 3 37 3 111 4 351 26 167 40 1 105
Below cutoff 1918 1861 1228 334 786 191 3208 1488 2980 197 700 1166 144 862 2110 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001171951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005249946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005249947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011515792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011515793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA628371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX247864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX318279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000350549   ⟹   ENSP00000297767
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7141,836,300 - 141,841,485 (-)Ensembl
RefSeq Acc Id: ENST00000419085   ⟹   ENSP00000398810
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7141,836,300 - 141,841,485 (-)Ensembl
RefSeq Acc Id: ENST00000438520   ⟹   ENSP00000414461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7141,836,329 - 141,841,487 (-)Ensembl
RefSeq Acc Id: ENST00000452758   ⟹   ENSP00000395287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7141,836,359 - 141,841,211 (-)Ensembl
RefSeq Acc Id: NM_001008270   ⟹   NP_001008271
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,836,300 - 141,841,485 (-)NCBI
GRCh377141,536,078 - 141,541,332 (-)NCBI
Build 367141,182,555 - 141,187,690 (-)NCBI Archive
Celera7136,257,527 - 136,262,670 (-)RGD
HuRef7135,832,747 - 135,837,890 (-)RGD
CHM1_17141,470,427 - 141,475,570 (-)NCBI
CRA_TCAGchr7v27140,873,792 - 140,878,935 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001171951   ⟹   NP_001165422
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,836,300 - 141,841,485 (-)NCBI
GRCh377141,536,078 - 141,541,332 (-)NCBI
Celera7136,257,527 - 136,262,670 (-)RGD
HuRef7135,832,747 - 135,837,890 (-)RGD
CHM1_17141,470,427 - 141,475,570 (-)NCBI
CRA_TCAGchr7v27140,873,792 - 140,878,935 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001370403   ⟹   NP_001357332
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,836,278 - 141,841,485 (-)NCBI
RefSeq Acc Id: XM_005249946   ⟹   XP_005250003
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,836,283 - 141,849,725 (-)NCBI
GRCh377141,536,078 - 141,541,332 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005249947   ⟹   XP_005250004
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,836,283 - 141,842,929 (-)NCBI
GRCh377141,536,078 - 141,541,332 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011515792   ⟹   XP_011514094
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,836,283 - 141,841,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011515793   ⟹   XP_011514095
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,836,283 - 141,839,331 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001008271   ⟸   NM_001008270
- Peptide Label: isoform 1 precursor
- UniProtKB: A4D1T9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001165422   ⟸   NM_001171951
- Peptide Label: isoform 2 precursor
- UniProtKB: B7ZMK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005250004   ⟸   XM_005249947
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005250003   ⟸   XM_005249946
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011514094   ⟸   XM_011515792
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011514095   ⟸   XM_011515793
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001357332   ⟸   NM_001370403
- Peptide Label: isoform 1 precursor
RefSeq Acc Id: ENSP00000414461   ⟸   ENST00000438520
RefSeq Acc Id: ENSP00000395287   ⟸   ENST00000452758
RefSeq Acc Id: ENSP00000297767   ⟸   ENST00000350549
RefSeq Acc Id: ENSP00000398810   ⟸   ENST00000419085
Protein Domains
Peptidase S1

Promoters
RGD ID:7212123
Promoter ID:EPDNEW_H11808
Type:multiple initiation site
Name:PRSS37_1
Description:protease, serine 37
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,841,485 - 141,841,545EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 copy number gain See cases [RCV000051101] Chr7:132850196..159325876 [GRCh38]
Chr7:132534956..159118566 [GRCh37]
Chr7:132185496..158811327 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 copy number gain See cases [RCV000053576] Chr7:136309982..159307523 [GRCh38]
Chr7:135994730..159100212 [GRCh37]
Chr7:135645270..158792973 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] Chr7:132023155..149309794 [GRCh38]
Chr7:131707914..149006885 [GRCh37]
Chr7:131358454..148637818 [NCBI36]
Chr7:7q32.3-36.1
pathogenic
GRCh38/hg38 7q33-35(chr7:135414108-144140219)x1 copy number loss See cases [RCV000054173] Chr7:135414108..144140219 [GRCh38]
Chr7:135098857..143837312 [GRCh37]
Chr7:134749397..143468245 [NCBI36]
Chr7:7q33-35
pathogenic
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] Chr7:139365967..159282531 [GRCh38]
Chr7:139050713..159075220 [GRCh37]
Chr7:138701253..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:140754198-159307523)x1 copy number loss See cases [RCV000054176] Chr7:140754198..159307523 [GRCh38]
Chr7:140453998..159100212 [GRCh37]
Chr7:140100467..158792973 [NCBI36]
Chr7:7q34-36.3
pathogenic
NM_001008270.2(PRSS37):c.255C>T (p.Ile85=) single nucleotide variant Malignant melanoma [RCV000061571] Chr7:141838035 [GRCh38]
Chr7:141537835 [GRCh37]
Chr7:141184304 [NCBI36]
Chr7:7q34
not provided
GRCh38/hg38 7q34-35(chr7:141126407-145652221)x3 copy number gain See cases [RCV000133645] Chr7:141126407..145652221 [GRCh38]
Chr7:140826207..145349314 [GRCh37]
Chr7:140472676..144980247 [NCBI36]
Chr7:7q34-35
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.2(chr7:137751200-154815582)x3 copy number gain See cases [RCV000136592] Chr7:137751200..154815582 [GRCh38]
Chr7:137435946..154607292 [GRCh37]
Chr7:137086486..154238225 [NCBI36]
Chr7:7q33-36.2
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 copy number loss See cases [RCV000138120] Chr7:134666829..158591882 [GRCh38]
Chr7:134351581..158384574 [GRCh37]
Chr7:134002121..158077335 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q33-36.1(chr7:135017687-148807400)x1 copy number loss See cases [RCV000138903] Chr7:135017687..148807400 [GRCh38]
Chr7:134702438..148504492 [GRCh37]
Chr7:134352978..148135425 [NCBI36]
Chr7:7q33-36.1
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 copy number gain See cases [RCV000139654] Chr7:132444095..159335866 [GRCh38]
Chr7:132128854..159128556 [GRCh37]
Chr7:131779394..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 copy number gain See cases [RCV000142802] Chr7:131228764..159335866 [GRCh38]
Chr7:130913523..159128556 [GRCh37]
Chr7:130564063..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 copy number gain See cases [RCV000143754] Chr7:131171478..159327017 [GRCh38]
Chr7:130856237..159119707 [GRCh37]
Chr7:130506777..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q34-35(chr7:140061285-144622893)x3 copy number gain See cases [RCV000143724] Chr7:140061285..144622893 [GRCh38]
Chr7:139761085..144319986 [GRCh37]
Chr7:139407554..143950919 [NCBI36]
Chr7:7q34-35
uncertain significance
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 copy number gain See cases [RCV000143707] Chr7:132438072..159327017 [GRCh38]
Chr7:132122831..159119707 [GRCh37]
Chr7:131773371..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137589621-159119707)x3 copy number gain See cases [RCV000449264] Chr7:137589621..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:133799185-159119707)x1 copy number loss See cases [RCV000448836] Chr7:133799185..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:140636858-159119707)x1 copy number loss See cases [RCV000510250] Chr7:140636858..159119707 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_001171951.1(PRSS37):c.640G>A (p.Val214Ile) single nucleotide variant not specified [RCV000500273] Chr7:141836460 [GRCh38]
Chr7:141536260 [GRCh37]
Chr7:7q34
likely benign
GRCh37/hg19 7q33-36.3(chr7:136758593-159119707)x3 copy number gain See cases [RCV000510490] Chr7:136758593..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137917376-159119707)x1 copy number loss See cases [RCV000511889] Chr7:137917376..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:140133025-158982771)x1 copy number loss not provided [RCV000682910] Chr7:140133025..158982771 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q34-35(chr7:139623170-143710268)x3 copy number gain not provided [RCV000747069] Chr7:139623170..143710268 [GRCh37]
Chr7:7q34-35
benign
GRCh37/hg19 7q34-36.3(chr7:139623170-158329903)x3 copy number gain not provided [RCV000747070] Chr7:139623170..158329903 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q32.3-36.3(chr7:130592554-159119707)x3 copy number gain not provided [RCV000849569] Chr7:130592554..159119707 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q32.3-36.3(chr7:131414604-159126310)x1 copy number loss See cases [RCV001007432] Chr7:131414604..159126310 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29211 AgrOrtholog
COSMIC PRSS37 COSMIC
Ensembl Genes ENSG00000165076 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000297767 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000395287 UniProtKB/TrEMBL
  ENSP00000398810 UniProtKB/TrEMBL
  ENSP00000414461 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000350549 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000419085 UniProtKB/TrEMBL
  ENST00000438520 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000452758 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000165076 GTEx
HGNC ID HGNC:29211 ENTREZGENE
Human Proteome Map PRSS37 Human Proteome Map
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:136242 UniProtKB/Swiss-Prot
NCBI Gene 136242 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA165618277 PharmGKB
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4D1T9 ENTREZGENE
  B7ZMK3 ENTREZGENE, UniProtKB/TrEMBL
  F8WBF8_HUMAN UniProtKB/TrEMBL
  F8WDA6_HUMAN UniProtKB/TrEMBL
  PRS37_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2RPB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-23 PRSS37  serine protease 37    protease, serine 37  Symbol and/or name change 5135510 APPROVED
2015-11-24 PRSS37  protease, serine 37    protease, serine, 37  Symbol and/or name change 5135510 APPROVED
2011-07-27 PRSS37  protease, serine, 37  LOC136242  Peptidase S1 domain-containing protein LOC136242  Symbol and/or name change 5135510 APPROVED