ENDOU (endonuclease, poly(U) specific) - Rat Genome Database

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Gene: ENDOU (endonuclease, poly(U) specific) Homo sapiens
Analyze
Symbol: ENDOU
Name: endonuclease, poly(U) specific
RGD ID: 1604059
HGNC Page HGNC:14369
Description: Enables RNA binding activity; RNA endonuclease activity; and serine-type peptidase activity. Involved in several processes, including female pregnancy; negative regulation of lipid catabolic process; and post-transcriptional gene silencing. Located in cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 22 serine protease; 26 serine protease; endonuclease, polyU-specific; MGC133268; P11; placental protein 11; poly(U)-specific endoribonuclease; PP11; PRSS26; uridylate-specific endoribonuclease
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,709,734 - 47,725,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1247,709,734 - 47,725,567 (-)EnsemblGRCh38hg38GRCh38
GRCh371248,103,517 - 48,119,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,389,795 - 46,405,617 (-)NCBINCBI36Build 36hg18NCBI36
Celera1246,900,985 - 46,916,824 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,134,616 - 45,150,455 (-)NCBIHuRef
CHM1_11248,069,425 - 48,085,261 (-)NCBICHM1_1
T2T-CHM13v2.01247,671,053 - 47,686,808 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1710108   PMID:2350438   PMID:6755403   PMID:12477932   PMID:15489334   PMID:15755742   PMID:16303743   PMID:16344560   PMID:18936097   PMID:20379614   PMID:21873635   PMID:28514442  
PMID:33197855   PMID:33511665   PMID:33961781   PMID:37803019  


Genomics

Comparative Map Data
ENDOU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,709,734 - 47,725,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1247,709,734 - 47,725,567 (-)EnsemblGRCh38hg38GRCh38
GRCh371248,103,517 - 48,119,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,389,795 - 46,405,617 (-)NCBINCBI36Build 36hg18NCBI36
Celera1246,900,985 - 46,916,824 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,134,616 - 45,150,455 (-)NCBIHuRef
CHM1_11248,069,425 - 48,085,261 (-)NCBICHM1_1
T2T-CHM13v2.01247,671,053 - 47,686,808 (-)NCBIT2T-CHM13v2.0
Endou
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,608,896 - 97,629,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1597,608,896 - 97,629,220 (-)EnsemblGRCm39 Ensembl
GRCm381597,711,015 - 97,731,405 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1597,711,015 - 97,731,339 (-)EnsemblGRCm38mm10GRCm38
MGSCv371597,541,450 - 97,561,836 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361597,539,053 - 97,549,184 (-)NCBIMGSCv36mm8
Celera1599,839,086 - 99,859,430 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1553.7NCBI
Endou
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,723,972 - 130,745,672 (-)NCBIGRCr8
mRatBN7.27128,844,872 - 128,866,572 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,844,862 - 128,866,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7130,642,925 - 130,663,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07132,868,461 - 132,889,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07132,780,920 - 132,801,626 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,202,342 - 139,223,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,201,054 - 139,223,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,393,949 - 139,414,672 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,423,018 - 136,443,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7125,337,357 - 125,358,109 (-)NCBICelera
Cytogenetic Map7q36NCBI
Endou
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,632,743 - 6,646,657 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555006,631,749 - 6,653,457 (-)NCBIChiLan1.0ChiLan1.0
ENDOU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21046,442,149 - 46,461,995 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11246,438,904 - 46,455,441 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01241,003,037 - 41,024,127 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11241,882,397 - 41,898,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,882,483 - 41,897,119 (+)Ensemblpanpan1.1panPan2
ENDOU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,025,752 - 7,044,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,028,263 - 7,043,475 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2739,264,472 - 39,285,264 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,089,458 - 7,111,515 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,095,266 - 7,112,880 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1277,026,214 - 7,048,208 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,061,761 - 7,083,534 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02739,551,602 - 39,573,616 (-)NCBIUU_Cfam_GSD_1.0
ENDOU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,072,063 - 78,089,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,072,062 - 78,090,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ENDOU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11143,930,671 - 43,946,795 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1143,930,687 - 43,941,205 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037202,436,176 - 202,451,262 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Endou
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248164,526,487 - 4,541,794 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248164,526,136 - 4,542,530 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ENDOU
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001172439.1(ENDOU):c.217G>A (p.Glu73Lys) single nucleotide variant Malignant melanoma [RCV000070006] Chr12:47718156 [GRCh38]
Chr12:48111939 [GRCh37]
Chr12:46398206 [NCBI36]
Chr12:12q13.11		 not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p11.21-q13.12(chr12:31886971-50360461)x3 copy number gain See cases [RCV000207454] Chr12:31886971..50360461 [GRCh37]
Chr12:12p11.21-q13.12		 pathogenic
GRCh37/hg19 12q11-13.12(chr12:37857750-49791459)x3 copy number gain See cases [RCV000448835] Chr12:37857750..49791459 [GRCh37]
Chr12:12q11-13.12		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13		 uncertain significance
NM_001172439.2(ENDOU):c.277C>T (p.Arg93Cys) single nucleotide variant Inborn genetic diseases [RCV003253527] Chr12:47717623 [GRCh38]
Chr12:48111406 [GRCh37]
Chr12:12q13.11		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_001172439.2(ENDOU):c.684C>T (p.Asp228=) single nucleotide variant not provided [RCV000965888] Chr12:47716367 [GRCh38]
Chr12:48110150 [GRCh37]
Chr12:12q13.11		 benign
NM_001172439.2(ENDOU):c.951C>T (p.Tyr317=) single nucleotide variant not provided [RCV000893767] Chr12:47712537 [GRCh38]
Chr12:48106320 [GRCh37]
Chr12:12q13.11		 benign
NM_001172439.2(ENDOU):c.632G>A (p.Arg211Gln) single nucleotide variant not provided [RCV000970246] Chr12:47716419 [GRCh38]
Chr12:48110202 [GRCh37]
Chr12:12q13.11		 benign
NM_001172439.2(ENDOU):c.208C>G (p.Gln70Glu) single nucleotide variant Inborn genetic diseases [RCV003273608] Chr12:47718165 [GRCh38]
Chr12:48111948 [GRCh37]
Chr12:12q13.11		 likely benign
GRCh37/hg19 12q11-13.12(chr12:37873948-49578619)x3 copy number gain See cases [RCV001353185] Chr12:37873948..49578619 [GRCh37]
Chr12:12q11-13.12		 likely pathogenic
GRCh37/hg19 12q11-13.12(chr12:37857750-49791459) copy number gain not specified [RCV002052988] Chr12:37857750..49791459 [GRCh37]
Chr12:12q11-13.12		 pathogenic
GRCh37/hg19 12q12-13.11(chr12:44661149-48921204)x1 copy number loss not provided [RCV002291537] Chr12:44661149..48921204 [GRCh37]
Chr12:12q12-13.11		 pathogenic
NM_001172439.2(ENDOU):c.523A>G (p.Arg175Gly) single nucleotide variant Inborn genetic diseases [RCV002728356] Chr12:47716918 [GRCh38]
Chr12:48110701 [GRCh37]
Chr12:12q13.11		 likely benign
NM_001172439.2(ENDOU):c.1060C>A (p.Pro354Thr) single nucleotide variant Inborn genetic diseases [RCV002883702] Chr12:47711688 [GRCh38]
Chr12:48105471 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.1210G>C (p.Ala404Pro) single nucleotide variant Inborn genetic diseases [RCV002757629] Chr12:47710825 [GRCh38]
Chr12:48104608 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.118T>C (p.Cys40Arg) single nucleotide variant Inborn genetic diseases [RCV002781819] Chr12:47720813 [GRCh38]
Chr12:48114596 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.851A>C (p.Glu284Ala) single nucleotide variant Inborn genetic diseases [RCV002924020] Chr12:47713289 [GRCh38]
Chr12:48107072 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.802T>C (p.Phe268Leu) single nucleotide variant Inborn genetic diseases [RCV002737671] Chr12:47713338 [GRCh38]
Chr12:48107121 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.988G>A (p.Asp330Asn) single nucleotide variant Inborn genetic diseases [RCV002931787] Chr12:47711760 [GRCh38]
Chr12:48105543 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.941T>A (p.Val314Asp) single nucleotide variant Inborn genetic diseases [RCV002645189] Chr12:47712547 [GRCh38]
Chr12:48106330 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.127C>T (p.Arg43Trp) single nucleotide variant Inborn genetic diseases [RCV002853522] Chr12:47720804 [GRCh38]
Chr12:48114587 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.131G>A (p.Cys44Tyr) single nucleotide variant Inborn genetic diseases [RCV002787644] Chr12:47720800 [GRCh38]
Chr12:48114583 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.715G>C (p.Val239Leu) single nucleotide variant Inborn genetic diseases [RCV002964811] Chr12:47716336 [GRCh38]
Chr12:48110119 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.268T>C (p.Cys90Arg) single nucleotide variant Inborn genetic diseases [RCV002672883] Chr12:47717632 [GRCh38]
Chr12:48111415 [GRCh37]
Chr12:12q13.11		 uncertain significance
NM_001172439.2(ENDOU):c.941T>C (p.Val314Ala) single nucleotide variant Inborn genetic diseases [RCV003197130] Chr12:47712547 [GRCh38]
Chr12:48106330 [GRCh37]
Chr12:12q13.11		 uncertain significance
GRCh37/hg19 12q12-13.11(chr12:38258635-48235837)x3 copy number gain not specified [RCV003987001] Chr12:38258635..48235837 [GRCh37]
Chr12:12q12-13.11		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1525
Count of miRNA genes:573
Interacting mature miRNAs:626
Transcripts:ENST00000229003, ENST00000422538, ENST00000542202, ENST00000545824, ENST00000551186
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH122603  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,118,984 - 48,119,292UniSTSGRCh37
Build 361246,405,251 - 46,405,559RGDNCBI36
Celera1246,916,453 - 46,916,761RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,150,084 - 45,150,392UniSTS
TNG Radiation Hybrid Map1221564.0UniSTS
STS-M32402  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,103,647 - 48,103,876UniSTSGRCh37
Build 361246,389,914 - 46,390,143RGDNCBI36
Celera1246,901,115 - 46,901,344RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,134,746 - 45,134,975UniSTS
GeneMap99-GB4 RH Map12210.95UniSTS
NCBI RH Map12394.0UniSTS
D12S1892  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,104,363 - 48,104,507UniSTSGRCh37
Build 361246,390,630 - 46,390,774RGDNCBI36
Celera1246,901,831 - 46,901,975RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,135,462 - 45,135,606UniSTS
Stanford-G3 RH Map121891.0UniSTS
NCBI RH Map12382.3UniSTS
GeneMap99-G3 RH Map121837.0UniSTS
STS-H03346  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,103,580 - 48,103,741UniSTSGRCh37
Build 361246,389,847 - 46,390,008RGDNCBI36
Celera1246,901,048 - 46,901,209RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,134,679 - 45,134,840UniSTS
GeneMap99-GB4 RH Map12210.95UniSTS
NCBI RH Map12394.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 13 23 13 41 51 1301 7 36 1 135 15 41 52 678 2
Low 1629 1446 906 100 473 11 2019 1100 3229 127 1020 1181 95 1127 1365 3
Below cutoff 728 1376 701 391 1195 363 894 1070 418 246 265 331 35 25 740

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001172439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI039727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX772808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA838842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA841959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC381238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000229003   ⟹   ENSP00000229003
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1247,709,734 - 47,725,567 (-)Ensembl
RefSeq Acc Id: ENST00000422538   ⟹   ENSP00000397679
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1247,709,734 - 47,725,490 (-)Ensembl
RefSeq Acc Id: ENST00000545824   ⟹   ENSP00000445004
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1247,710,454 - 47,725,534 (-)Ensembl
RefSeq Acc Id: ENST00000551186
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1247,716,379 - 47,717,879 (-)Ensembl
RefSeq Acc Id: NM_001172439   ⟹   NP_001165910
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,709,734 - 47,725,490 (-)NCBI
GRCh371248,103,517 - 48,119,355 (-)RGD
Celera1246,900,985 - 46,916,824 (-)RGD
HuRef1245,134,616 - 45,150,455 (-)RGD
CHM1_11248,069,425 - 48,085,261 (-)NCBI
T2T-CHM13v2.01247,671,053 - 47,686,808 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001172440   ⟹   NP_001165911
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,709,734 - 47,725,490 (-)NCBI
GRCh371248,103,517 - 48,119,355 (-)RGD
Celera1246,900,985 - 46,916,824 (-)RGD
HuRef1245,134,616 - 45,150,455 (-)RGD
CHM1_11248,069,425 - 48,085,261 (-)NCBI
T2T-CHM13v2.01247,671,053 - 47,686,808 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006025   ⟹   NP_006016
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,709,734 - 47,725,490 (-)NCBI
GRCh371248,103,517 - 48,119,355 (-)RGD
Build 361246,389,795 - 46,405,617 (-)NCBI Archive
Celera1246,900,985 - 46,916,824 (-)RGD
HuRef1245,134,616 - 45,150,455 (-)RGD
CHM1_11248,069,425 - 48,085,261 (-)NCBI
T2T-CHM13v2.01247,671,053 - 47,686,808 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_006016   ⟸   NM_006025
- Peptide Label: isoform 2 precursor
- UniProtKB: P21128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001165910   ⟸   NM_001172439
- Peptide Label: isoform 1 precursor
- UniProtKB: B7Z6E1 (UniProtKB/Swiss-Prot),   B3KQS7 (UniProtKB/Swiss-Prot),   B2RBJ3 (UniProtKB/Swiss-Prot),   Q2NKJ4 (UniProtKB/Swiss-Prot),   P21128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001165911   ⟸   NM_001172440
- Peptide Label: isoform 3 precursor
- UniProtKB: P21128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000229003   ⟸   ENST00000229003
RefSeq Acc Id: ENSP00000445004   ⟸   ENST00000545824
RefSeq Acc Id: ENSP00000397679   ⟸   ENST00000422538
Protein Domains
EndoU   SMB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21128-F1-model_v2 AlphaFold P21128 1-410 view protein structure

Promoters
RGD ID:6789889
Promoter ID:HG_KWN:15458
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid,   NB4
Transcripts:NM_001172439,   NM_001172440,   NM_006025
Position:
Human AssemblyChrPosition (strand)Source
Build 361246,405,541 - 46,406,062 (-)MPROMDB
RGD ID:7223715
Promoter ID:EPDNEW_H17603
Type:initiation region
Name:ENDOU_1
Description:endonuclease, poly specific
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,725,490 - 47,725,550EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14369 AgrOrtholog
COSMIC ENDOU COSMIC
Ensembl Genes ENSG00000111405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000229003 ENTREZGENE
  ENST00000229003.7 UniProtKB/Swiss-Prot
  ENST00000422538 ENTREZGENE
  ENST00000422538.8 UniProtKB/Swiss-Prot
  ENST00000545824 ENTREZGENE
  ENST00000545824.2 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.410.20 UniProtKB/Swiss-Prot
GTEx ENSG00000111405 GTEx
HGNC ID HGNC:14369 ENTREZGENE
Human Proteome Map ENDOU Human Proteome Map
InterPro ENDOU UniProtKB/Swiss-Prot
  EndoU-like UniProtKB/Swiss-Prot
  EndoU_C UniProtKB/Swiss-Prot
  Somatomedin_B-like_dom_sf UniProtKB/Swiss-Prot
  Somatomedin_B_chordata UniProtKB/Swiss-Prot
  Somatomedin_B_dom UniProtKB/Swiss-Prot
KEGG Report hsa:8909 UniProtKB/Swiss-Prot
NCBI Gene 8909 ENTREZGENE
OMIM 606720 OMIM
PANTHER POLY(U)-SPECIFIC ENDORIBONUCLEASE UniProtKB/Swiss-Prot
  PTHR12439 UniProtKB/Swiss-Prot
Pfam Somatomedin_B UniProtKB/Swiss-Prot
  XendoU UniProtKB/Swiss-Prot
PharmGKB PA165512645 PharmGKB
PRINTS SOMATOMEDINB UniProtKB/Swiss-Prot
PROSITE ENDOU UniProtKB/Swiss-Prot
  SMB_1 UniProtKB/Swiss-Prot
  SMB_2 UniProtKB/Swiss-Prot
SMART SM00201 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF142877 UniProtKB/Swiss-Prot
  SSF90188 UniProtKB/Swiss-Prot
UniProt B2RBJ3 ENTREZGENE
  B3KQS7 ENTREZGENE
  B7Z6E1 ENTREZGENE
  ENDOU_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q2NKJ4 ENTREZGENE
UniProt Secondary B2RBJ3 UniProtKB/Swiss-Prot
  B3KQS7 UniProtKB/Swiss-Prot
  B7Z6E1 UniProtKB/Swiss-Prot
  Q2NKJ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 ENDOU  endonuclease, poly(U) specific  ENDOU  endonuclease, polyU-specific  Symbol and/or name change 5135510 APPROVED
2011-07-27 ENDOU  endonuclease, polyU-specific  P11  26 serine protease  Symbol and/or name change 5135510 APPROVED