TMEM68 (transmembrane protein 68) - Rat Genome Database

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Gene: TMEM68 (transmembrane protein 68) Homo sapiens
Analyze
Symbol: TMEM68
Name: transmembrane protein 68
RGD ID: 1603902
HGNC Page HGNC
Description: Predicted to enable acyltransferase activity. Predicted to be integral component of membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ32370; MGC87778
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl855,696,424 - 55,773,407 (-)EnsemblGRCh38hg38GRCh38
GRCh38855,738,758 - 55,773,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37856,651,317 - 56,685,937 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36856,813,874 - 56,848,439 (-)NCBINCBI36hg18NCBI36
Celera852,641,534 - 52,677,152 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef852,119,027 - 52,154,339 (-)NCBIHuRef
CHM1_1856,703,016 - 56,737,479 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15146197   PMID:15489334   PMID:16344560   PMID:19322201   PMID:20379614   PMID:21873635   PMID:24852370   PMID:26186194   PMID:28472192   PMID:28514442  
PMID:32694731   PMID:33845483  


Genomics

Comparative Map Data
TMEM68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl855,696,424 - 55,773,407 (-)EnsemblGRCh38hg38GRCh38
GRCh38855,738,758 - 55,773,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37856,651,317 - 56,685,937 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36856,813,874 - 56,848,439 (-)NCBINCBI36hg18NCBI36
Celera852,641,534 - 52,677,152 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef852,119,027 - 52,154,339 (-)NCBIHuRef
CHM1_1856,703,016 - 56,737,479 (-)NCBICHM1_1
Tmem68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,549,041 - 3,574,853 (-)NCBIGRCm39mm39
GRCm39 Ensembl43,549,041 - 3,574,853 (-)Ensembl
GRCm3843,549,041 - 3,574,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,549,041 - 3,574,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv3743,476,188 - 3,501,915 (-)NCBIGRCm37mm9NCBIm37
MGSCv3643,476,188 - 3,501,915 (-)NCBImm8
Celera43,493,982 - 3,520,608 (-)NCBICelera
Cytogenetic Map4A1NCBI
Tmem68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2516,494,054 - 16,524,842 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl516,494,276 - 16,524,569 (-)Ensembl
Rnor_6.0516,363,908 - 16,413,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,382,538 - 16,413,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,163,802 - 21,194,571 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4516,787,573 - 16,818,342 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1516,789,003 - 16,818,154 (-)NCBI
Celera515,860,301 - 15,891,085 (-)NCBICelera
Cytogenetic Map5q12NCBI
Tmem68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545414,857,396 - 14,895,250 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545414,857,918 - 14,895,250 (-)NCBIChiLan1.0ChiLan1.0
TMEM68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1849,549,585 - 49,586,260 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl849,549,593 - 49,586,260 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0852,135,766 - 52,214,537 (-)NCBIMhudiblu_PPA_v0panPan3
TMEM68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,192,130 - 7,241,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,160,489 - 7,232,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,505,747 - 7,553,987 (-)NCBI
ROS_Cfam_1.0297,266,356 - 7,314,648 (-)NCBI
UMICH_Zoey_3.1297,280,929 - 7,329,078 (-)NCBI
UNSW_CanFamBas_1.0297,413,655 - 7,461,856 (-)NCBI
UU_Cfam_GSD_1.0297,690,072 - 7,738,304 (-)NCBI
Tmem68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530372,300,823 - 72,332,471 (+)NCBI
SpeTri2.0NW_0049364962,453,014 - 2,484,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,969,203 - 76,001,178 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,969,201 - 76,003,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,911,899 - 82,943,871 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1851,781,021 - 51,819,454 (-)NCBI
ChlSab1.1 Ensembl851,782,434 - 51,807,062 (-)Ensembl
Vero_WHO_p1.0NW_02366603989,984,064 - 90,022,744 (+)NCBI
Tmem68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624965120,862 - 148,769 (+)NCBI

Position Markers
RH48170  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37856,651,414 - 56,651,538UniSTSGRCh37
Build 36856,813,968 - 56,814,092RGDNCBI36
Celera852,641,628 - 52,641,752RGD
Cytogenetic Map8q12.1UniSTS
HuRef852,119,121 - 52,119,245UniSTS
GeneMap99-GB4 RH Map8299.46UniSTS
RH47106  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37856,686,145 - 56,686,252UniSTSGRCh37
Build 36856,848,699 - 56,848,806RGDNCBI36
Celera852,677,412 - 52,677,519RGD
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map8q11UniSTS
HuRef852,154,599 - 52,154,706UniSTS
GeneMap99-GB4 RH Map8298.91UniSTS
RH94018  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37856,652,232 - 56,652,390UniSTSGRCh37
Build 36856,814,786 - 56,814,944RGDNCBI36
Celera852,642,446 - 52,642,604RGD
Cytogenetic Map8q12.1UniSTS
HuRef852,119,937 - 52,120,095UniSTS
GeneMap99-GB4 RH Map8314.57UniSTS
RH66108  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37856,672,378 - 56,672,459UniSTSGRCh37
Build 36856,834,932 - 56,835,013RGDNCBI36
Celera852,663,877 - 52,663,958RGD
Cytogenetic Map8q12.1UniSTS
HuRef852,141,064 - 52,141,145UniSTS
GeneMap99-GB4 RH Map8299.79UniSTS
D8S2041  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37856,674,976 - 56,675,073UniSTSGRCh37
Build 36856,837,530 - 56,837,627RGDNCBI36
Celera852,666,475 - 52,666,572RGD
Cytogenetic Map8q12.1UniSTS
HuRef852,143,662 - 52,143,759UniSTS
TNG Radiation Hybrid Map829441.0UniSTS
Stanford-G3 RH Map82234.0UniSTS
NCBI RH Map8789.3UniSTS
GeneMap99-G3 RH Map82324.0UniSTS
GDB:631802  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map14q13.2UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map9p13.3-p12UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map14q22UniSTS
Cytogenetic Map5q21-q22UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map2q33-q34UniSTS
Cytogenetic Map4q31.3UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map22q13.31-q13.33UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map10p11UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map1q44UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map1p36.22UniSTS
Cytogenetic Map1p35.3-p33UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map1p31UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map17qterUniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map10p15.1UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map15q23UniSTS
Cytogenetic MapXp11.22UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map5q31.2-q34UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map3q21-q22UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map1p36-p35UniSTS
Cytogenetic Map17q11-q21UniSTS
Cytogenetic Map21q22.1UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map18p11.22-p11.21UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map2q21UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map2q36.3UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map20p11.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map2p24.1UniSTS
RH80031  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map8q21.3UniSTS
Cytogenetic MapXq23UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map10p12UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map8q21.11UniSTS
Cytogenetic Map1p36.22UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map1p36.12-p35.1UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map10p15.1UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map15q22UniSTS
Cytogenetic Map18q21.31UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map7q11.21UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map1p36UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map6q24.3UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map8p23UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic MapXq21.2UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map11q23UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3029
Count of miRNA genes:1086
Interacting mature miRNAs:1321
Transcripts:ENST00000334667, ENST00000434581, ENST00000517576, ENST00000519460, ENST00000519780, ENST00000519784, ENST00000520061, ENST00000520414, ENST00000521229, ENST00000522030, ENST00000522090, ENST00000522470, ENST00000522576, ENST00000523073, ENST00000523180, ENST00000523423, ENST00000524121
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 105 1 55 24 372 27 204 32 78 89 181 180 5 1 3 2
Low 2334 2415 1671 600 1121 438 4101 2015 3636 329 1279 1433 170 1203 2733 4 2
Below cutoff 575 458 52 150 20 1 1 52

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_156454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC100817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF147306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX461617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN272366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA121422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA549603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB370750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000334667   ⟹   ENSP00000335416
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,738,758 - 55,773,407 (-)Ensembl
RefSeq Acc Id: ENST00000434581   ⟹   ENSP00000395204
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,738,758 - 55,773,378 (-)Ensembl
RefSeq Acc Id: ENST00000517576   ⟹   ENSP00000431018
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,739,944 - 55,756,385 (-)Ensembl
RefSeq Acc Id: ENST00000519460
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,738,758 - 55,746,047 (-)Ensembl
RefSeq Acc Id: ENST00000519780   ⟹   ENSP00000429667
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,743,481 - 55,773,367 (-)Ensembl
RefSeq Acc Id: ENST00000519784   ⟹   ENSP00000428688
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,739,701 - 55,773,352 (-)Ensembl
RefSeq Acc Id: ENST00000520061   ⟹   ENSP00000428236
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,745,092 - 55,762,775 (-)Ensembl
RefSeq Acc Id: ENST00000520414   ⟹   ENSP00000429758
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,756,358 - 55,773,121 (-)Ensembl
RefSeq Acc Id: ENST00000521229   ⟹   ENSP00000429210
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,760,773 - 55,773,367 (-)Ensembl
RefSeq Acc Id: ENST00000522030   ⟹   ENSP00000430838
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,751,051 - 55,763,008 (-)Ensembl
RefSeq Acc Id: ENST00000522090   ⟹   ENSP00000430542
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,745,078 - 55,773,381 (-)Ensembl
RefSeq Acc Id: ENST00000522470   ⟹   ENSP00000428318
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,696,424 - 55,751,134 (-)Ensembl
RefSeq Acc Id: ENST00000522576   ⟹   ENSP00000431047
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,762,400 - 55,773,378 (-)Ensembl
RefSeq Acc Id: ENST00000523073   ⟹   ENSP00000429026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,740,172 - 55,773,334 (-)Ensembl
RefSeq Acc Id: ENST00000523180   ⟹   ENSP00000427939
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,762,954 - 55,773,378 (-)Ensembl
RefSeq Acc Id: ENST00000523423   ⟹   ENSP00000429175
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,756,245 - 55,773,307 (-)Ensembl
RefSeq Acc Id: ENST00000524121
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,750,887 - 55,756,402 (-)Ensembl
RefSeq Acc Id: ENST00000617782   ⟹   ENSP00000478242
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,738,744 - 55,763,980 (-)Ensembl
RefSeq Acc Id: ENST00000617977   ⟹   ENSP00000481143
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl855,738,766 - 55,748,115 (-)Ensembl
RefSeq Acc Id: NM_001286657   ⟹   NP_001273586
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,738,758 - 55,773,378 (-)NCBI
HuRef852,119,010 - 52,154,420 (-)NCBI
CHM1_1856,702,999 - 56,728,235 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286660   ⟹   NP_001273589
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,760,775 - 55,773,378 (-)NCBI
HuRef852,119,010 - 52,154,420 (-)NCBI
CHM1_1856,725,028 - 56,737,560 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286661   ⟹   NP_001273590
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,738,758 - 55,773,378 (-)NCBI
HuRef852,119,010 - 52,154,420 (-)NCBI
CHM1_1856,702,999 - 56,737,560 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363176   ⟹   NP_001350105
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,738,758 - 55,773,378 (-)NCBI
RefSeq Acc Id: NM_001363177   ⟹   NP_001350106
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,738,758 - 55,773,378 (-)NCBI
RefSeq Acc Id: NM_152417   ⟹   NP_689630
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,738,758 - 55,773,378 (-)NCBI
GRCh37856,651,317 - 56,685,955 (-)NCBI
Build 36856,813,874 - 56,848,439 (-)NCBI Archive
Celera852,641,534 - 52,677,152 (-)RGD
HuRef852,119,010 - 52,154,420 (-)NCBI
CHM1_1856,702,999 - 56,737,560 (-)NCBI
Sequence:
RefSeq Acc Id: NR_156454
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,738,758 - 55,773,378 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_689630   ⟸   NM_152417
- Peptide Label: isoform 2
- UniProtKB: Q96MH6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273590   ⟸   NM_001286661
- Peptide Label: isoform 4
- UniProtKB: E5RJN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273586   ⟸   NM_001286657
- Peptide Label: isoform 1
- UniProtKB: Q96MH6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273589   ⟸   NM_001286660
- Peptide Label: isoform 3
- UniProtKB: Q96MH6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001350106   ⟸   NM_001363177
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001350105   ⟸   NM_001363176
- Peptide Label: isoform 1
RefSeq Acc Id: ENSP00000431018   ⟸   ENST00000517576
RefSeq Acc Id: ENSP00000429667   ⟸   ENST00000519780
RefSeq Acc Id: ENSP00000428688   ⟸   ENST00000519784
RefSeq Acc Id: ENSP00000335416   ⟸   ENST00000334667
RefSeq Acc Id: ENSP00000428236   ⟸   ENST00000520061
RefSeq Acc Id: ENSP00000429758   ⟸   ENST00000520414
RefSeq Acc Id: ENSP00000429210   ⟸   ENST00000521229
RefSeq Acc Id: ENSP00000430838   ⟸   ENST00000522030
RefSeq Acc Id: ENSP00000430542   ⟸   ENST00000522090
RefSeq Acc Id: ENSP00000431047   ⟸   ENST00000522576
RefSeq Acc Id: ENSP00000428318   ⟸   ENST00000522470
RefSeq Acc Id: ENSP00000429175   ⟸   ENST00000523423
RefSeq Acc Id: ENSP00000427939   ⟸   ENST00000523180
RefSeq Acc Id: ENSP00000429026   ⟸   ENST00000523073
RefSeq Acc Id: ENSP00000481143   ⟸   ENST00000617977
RefSeq Acc Id: ENSP00000478242   ⟸   ENST00000617782
RefSeq Acc Id: ENSP00000395204   ⟸   ENST00000434581
Protein Domains
PlsC

Promoters
RGD ID:7213329
Promoter ID:EPDNEW_H12410
Type:initiation region
Name:TMEM68_1
Description:transmembrane protein 68
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38855,773,378 - 55,773,438EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q12.1(chr8:55423413-58836753)x1 copy number loss See cases [RCV000054240] Chr8:55423413..58836753 [GRCh38]
Chr8:56335973..59749312 [GRCh37]
Chr8:56498527..59911866 [NCBI36]
Chr8:8q12.1
pathogenic
NM_152417.2(TMEM68):c.170C>T (p.Pro57Leu) single nucleotide variant Malignant melanoma [RCV000061811] Chr8:55762790 [GRCh38]
Chr8:56675349 [GRCh37]
Chr8:56837903 [NCBI36]
Chr8:8q12.1
not provided
GRCh38/hg38 8q11.1-13.2(chr8:46031334-69303787)x3 copy number gain See cases [RCV000133720] Chr8:46031334..69303787 [GRCh38]
Chr8:46942956..70216022 [GRCh37]
Chr8:47062121..70378576 [NCBI36]
Chr8:8q11.1-13.2
pathogenic
GRCh38/hg38 8q11.23-12.1(chr8:53996579-56163431)x1 copy number loss See cases [RCV000135764] Chr8:53996579..56163431 [GRCh38]
Chr8:54909139..57075990 [GRCh37]
Chr8:55071692..57238544 [NCBI36]
Chr8:8q11.23-12.1
likely pathogenic
GRCh38/hg38 8q12.1-12.3(chr8:55315854-64952752)x3 copy number gain See cases [RCV000137672] Chr8:55315854..64952752 [GRCh38]
Chr8:56228414..65864987 [GRCh37]
Chr8:56390968..66027541 [NCBI36]
Chr8:8q12.1-12.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q12.1(chr8:55751116-55937248)x3 copy number gain See cases [RCV000138484] Chr8:55751116..55937248 [GRCh38]
Chr8:56663675..56849807 [GRCh37]
Chr8:56826229..57012361 [NCBI36]
Chr8:8q12.1
likely benign
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p12-q12.1(chr8:36580103-59618998)x3 copy number gain See cases [RCV000139582] Chr8:36580103..59618998 [GRCh38]
Chr8:36437621..60531557 [GRCh37]
Chr8:36556779..60694111 [NCBI36]
Chr8:8p12-q12.1
pathogenic
GRCh38/hg38 8q12.1-12.2(chr8:54821357-61146302)x1 copy number loss See cases [RCV000140643] Chr8:54821357..61146302 [GRCh38]
Chr8:55733917..62058861 [GRCh37]
Chr8:55896471..62221415 [NCBI36]
Chr8:8q12.1-12.2
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q12.1(chr8:54764950-56785299)x1 copy number loss See cases [RCV000142992] Chr8:54764950..56785299 [GRCh38]
Chr8:55677510..57697858 [GRCh37]
Chr8:55840064..57860412 [NCBI36]
Chr8:8q12.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q11.21-12.1(chr8:49471778-57825470)x1 copy number loss See cases [RCV000142642] Chr8:49471778..57825470 [GRCh38]
Chr8:50384337..58738029 [GRCh37]
Chr8:50546890..58900583 [NCBI36]
Chr8:8q11.21-12.1
pathogenic|likely pathogenic
GRCh38/hg38 8q11.23-12.3(chr8:53325389-61863018)x1 copy number loss See cases [RCV000143182] Chr8:53325389..61863018 [GRCh38]
Chr8:54237949..62775577 [GRCh37]
Chr8:54400502..62938131 [NCBI36]
Chr8:8q11.23-12.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q11.23-12.3(chr8:53436131-65195953)x3 copy number gain See cases [RCV000239428] Chr8:53436131..65195953 [GRCh37]
Chr8:8q11.23-12.3
pathogenic
GRCh37/hg19 8q12.1(chr8:56405320-57358911)x1 copy number loss See cases [RCV000240504] Chr8:56405320..57358911 [GRCh37]
Chr8:8q12.1
likely pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q11.23-12.1(chr8:54661151-57790737)x3 copy number gain See cases [RCV000445710] Chr8:54661151..57790737 [GRCh37]
Chr8:8q11.23-12.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q12.1(chr8:56620114-56870065)x3 copy number gain not provided [RCV000682956] Chr8:56620114..56870065 [GRCh37]
Chr8:8q12.1
likely benign|uncertain significance
GRCh37/hg19 8q12.1(chr8:56288969-56854172)x3 copy number gain not provided [RCV000682985] Chr8:56288969..56854172 [GRCh37]
Chr8:8q12.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q11.21-12.1(chr8:49822483-58822602)x1 copy number loss not provided [RCV000747540] Chr8:49822483..58822602 [GRCh37]
Chr8:8q11.21-12.1
pathogenic
GRCh37/hg19 8p11.22-q12.3(chr8:39555657-64049089)x3 copy number gain not provided [RCV000846266] Chr8:39555657..64049089 [GRCh37]
Chr8:8p11.22-q12.3
pathogenic
GRCh37/hg19 8q12.1(chr8:56550884-56875491)x3 copy number gain not provided [RCV001258409] Chr8:56550884..56875491 [GRCh37]
Chr8:8q12.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26510 AgrOrtholog
COSMIC TMEM68 COSMIC
Ensembl Genes ENSG00000167904 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000335416 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000395204 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428236 UniProtKB/TrEMBL
  ENSP00000428318 UniProtKB/TrEMBL
  ENSP00000428688 UniProtKB/TrEMBL
  ENSP00000429026 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000429175 UniProtKB/TrEMBL
  ENSP00000429210 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429667 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000429758 UniProtKB/TrEMBL
  ENSP00000430542 UniProtKB/TrEMBL
  ENSP00000430838 UniProtKB/TrEMBL
  ENSP00000431018 UniProtKB/TrEMBL
  ENSP00000431047 UniProtKB/Swiss-Prot
  ENSP00000478242 UniProtKB/Swiss-Prot
  ENSP00000481143 UniProtKB/TrEMBL
Ensembl Transcript ENST00000334667 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000434581 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517576 UniProtKB/TrEMBL
  ENST00000519780 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000519784 UniProtKB/TrEMBL
  ENST00000520061 UniProtKB/TrEMBL
  ENST00000520414 UniProtKB/TrEMBL
  ENST00000521229 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000522030 UniProtKB/TrEMBL
  ENST00000522090 UniProtKB/TrEMBL
  ENST00000522470 UniProtKB/TrEMBL
  ENST00000522576 UniProtKB/Swiss-Prot
  ENST00000523073 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000523423 UniProtKB/TrEMBL
  ENST00000617782 UniProtKB/Swiss-Prot
  ENST00000617977 UniProtKB/TrEMBL
GTEx ENSG00000167904 GTEx
HGNC ID HGNC:26510 ENTREZGENE
Human Proteome Map TMEM68 Human Proteome Map
InterPro Plipid/glycerol_acylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:137695 UniProtKB/Swiss-Prot
NCBI Gene 137695 ENTREZGENE
Pfam Acyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142670781 PharmGKB
UniProt A0A024R7Y2_HUMAN UniProtKB/TrEMBL
  E5RGT2_HUMAN UniProtKB/TrEMBL
  E5RHI6_HUMAN UniProtKB/TrEMBL
  E5RHU1_HUMAN UniProtKB/TrEMBL
  E5RHZ2_HUMAN UniProtKB/TrEMBL
  E5RJ96_HUMAN UniProtKB/TrEMBL
  E5RJI9_HUMAN UniProtKB/TrEMBL
  E5RJN2 ENTREZGENE, UniProtKB/TrEMBL
  H0YAX4_HUMAN UniProtKB/TrEMBL
  H0YAY9_HUMAN UniProtKB/TrEMBL
  H0YC64_HUMAN UniProtKB/TrEMBL
  Q49A68_HUMAN UniProtKB/TrEMBL
  Q96MH6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q658X6 UniProtKB/Swiss-Prot
  Q8WUD2 UniProtKB/Swiss-Prot