MIR496 (microRNA 496) - Rat Genome Database

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Gene: MIR496 (microRNA 496) Homo sapiens
Analyze
Symbol: MIR496
Name: microRNA 496
RGD ID: 1603768
HGNC Page HGNC:32086
Description: Predicted to be involved in energy homeostasis. Predicted to act upstream of or within cellular response to ethanol and cellular response to phenylalanine. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-496; mir-496; MIRN496
RGD Orthologs
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,060,573 - 101,060,674 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,060,573 - 101,060,674 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,526,910 - 101,527,011 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,596,662 - 100,596,763 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,582,971 - 81,583,072 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,710,283 - 81,710,384 (+)NCBIHuRef
CHM1_114101,465,932 - 101,466,033 (+)NCBICHM1_1
T2T-CHM13v2.01495,295,959 - 95,296,060 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
RISC complex  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15965474   PMID:16381832   PMID:17604727   PMID:21037258   PMID:24204564   PMID:27097372   PMID:29266795   PMID:29935424   PMID:30597231   PMID:30811087   PMID:30998968   PMID:31273789  
PMID:31421833   PMID:31436348   PMID:31848324   PMID:32271424   PMID:33548006   PMID:33832090   PMID:34038061   PMID:34895039   PMID:35032277   PMID:38523522   PMID:38546290  


Genomics

Comparative Map Data
MIR496
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,060,573 - 101,060,674 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,060,573 - 101,060,674 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,526,910 - 101,527,011 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,596,662 - 100,596,763 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,582,971 - 81,583,072 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,710,283 - 81,710,384 (+)NCBIHuRef
CHM1_114101,465,932 - 101,466,033 (+)NCBICHM1_1
T2T-CHM13v2.01495,295,959 - 95,296,060 (+)NCBIT2T-CHM13v2.0
Mir496a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,705,553 - 109,705,631 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,705,553 - 109,705,631 (+)EnsemblGRCm39 Ensembl
GRCm3812109,739,119 - 109,739,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,739,119 - 109,739,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,977,329 - 110,977,407 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,936,349 - 110,936,427 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
Mir496
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,575,049 - 134,575,127 (+)NCBIGRCr8
mRatBN7.26128,753,644 - 128,753,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,753,644 - 128,753,722 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,932,883 - 128,932,961 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,228,715 - 129,228,793 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,590,340 - 128,590,418 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,889,283 - 133,889,361 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,889,283 - 133,889,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,051,640 - 143,051,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,338,023 - 126,338,101 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR496
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,289,410 - 69,289,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl869,289,410 - 69,289,507 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,807,556 - 68,807,653 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,571,053 - 69,571,150 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,234,599 - 69,234,696 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,300,693 - 69,300,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,698,697 - 69,698,794 (+)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
NC_000014.9:g.100806482_101281031del474550 deletion Paternal uniparental disomy of chromosome 14 [RCV000149429] Chr14:100806482..101281031 [GRCh38]
Chr14:101272819..101747368 [GRCh37]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8609
Count of gene targets:3993
Count of transcripts:6960
Interacting mature miRNAs:hsa-miR-496
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
14 18 12 5 96 45 39 2 8 17 6 14 69 62 9 76 6 50 31 3

Sequence


Ensembl Acc Id: ENST00000385226
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl14101,060,573 - 101,060,674 (+)Ensembl
RefSeq Acc Id: NR_030176
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,060,573 - 101,060,674 (+)NCBI
GRCh3714101,526,910 - 101,527,011 (+)RGD
Celera1481,582,971 - 81,583,072 (+)RGD
HuRef1481,710,283 - 81,710,384 (+)ENTREZGENE
CHM1_114101,465,932 - 101,466,033 (+)NCBI
T2T-CHM13v2.01495,295,959 - 95,296,060 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32086 AgrOrtholog
COSMIC MIR496 COSMIC
Ensembl Genes ENSG00000207961 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385226 ENTREZGENE
GTEx ENSG00000207961 GTEx
HGNC ID HGNC:32086 ENTREZGENE
Human Proteome Map MIR496 Human Proteome Map
miRBase MI0003136 ENTREZGENE
NCBI Gene 574454 ENTREZGENE
PharmGKB PA164722742 PharmGKB
RNAcentral URS000003BF62 RNACentral
  URS000075BE7B RNACentral