MIR181D (microRNA 181d) - Rat Genome Database
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Gene: MIR181D (microRNA 181d) Homo sapiens
Analyze
Symbol: MIR181D
Name: microRNA 181d
RGD ID: 1603765
HGNC Page HGNC
Description: Predicted to be involved in several processes, including SMAD protein signal transduction; long-term synaptic potentiation; and sensory perception of sound.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-181d; MIRN181D
RGD Orthologs
Mouse
Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,874,875 - 13,875,011 (+)EnsemblGRCh38hg38GRCh38
GRCh381913,874,875 - 13,875,011 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,985,689 - 13,985,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,846,688 - 13,846,824 (+)NCBINCBI36hg18NCBI36
Celera1913,879,434 - 13,879,570 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,557,000 - 13,557,136 (+)NCBIHuRef
CHM1_11913,986,385 - 13,986,521 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15965474   PMID:16381832   PMID:17604727   PMID:21037258   PMID:22207524   PMID:22570426   PMID:23034410   PMID:23993976   PMID:24103759   PMID:24573637   PMID:25336585   PMID:25535255  
PMID:26646931   PMID:26939869   PMID:27057640   PMID:27380024   PMID:27447109   PMID:27572270   PMID:28185956   PMID:28286260   PMID:28381166   PMID:28389653   PMID:28731516   PMID:28749470  
PMID:30024590   PMID:30031607   PMID:30628487   PMID:30915768   PMID:31352814   PMID:31413305   PMID:31524144   PMID:31696473  


Genomics

Comparative Map Data
MIR181D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,874,875 - 13,875,011 (+)EnsemblGRCh38hg38GRCh38
GRCh381913,874,875 - 13,875,011 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,985,689 - 13,985,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,846,688 - 13,846,824 (+)NCBINCBI36hg18NCBI36
Celera1913,879,434 - 13,879,570 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,557,000 - 13,557,136 (+)NCBIHuRef
CHM1_11913,986,385 - 13,986,521 (+)NCBICHM1_1
Mir181d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,905,345 - 84,905,416 (-)NCBIGRCm39mm39
GRCm39 Ensembl884,905,345 - 84,905,416 (-)Ensembl
GRCm38884,178,716 - 84,178,787 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,178,716 - 84,178,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,702,615 - 86,702,686 (-)NCBIGRCm37mm9NCBIm37
Celera888,479,159 - 88,479,230 (-)NCBICelera
Cytogenetic Map8C2NCBI
Mir181d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,983,706 - 23,983,788 (+)NCBI
Rnor_6.0 Ensembl1925,290,051 - 25,290,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01925,290,051 - 25,290,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01936,267,151 - 36,267,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,532,249 - 23,532,331 (+)NCBICelera
Cytogenetic Map19q11NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BCL2hsa-miR-181d-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20162574
BCL2hsa-miR-181d-5pMirtarbaseexternal_infoFACS//Immunohistochemistry//Luciferase reporter asFunctional MTI22207524
MGMThsa-miR-181d-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22570426
MGMThsa-miR-181d-5pOncomiRDBexternal_infoNANA22570426
KRAShsa-miR-181d-5pOncomiRDBexternal_infoNANA22207524
RASSF1hsa-miR-181d-5pOncomiRDBexternal_infoNANA21352471
CDX2hsa-miR-181d-5pOncomiRDBexternal_infoNANA19585654
TCL1Ahsa-miR-181d-5pOncomiRDBexternal_infoNANA17178851
BCL2hsa-miR-181d-3pTarbaseexternal_infoReporter GenePOSITIVE
BCL2hsa-miR-181d-3pTarbaseexternal_infoWesternblitPOSITIVE
NLKhsa-miR-181d-3pMirecordsexternal_infoNANA19585654
NRDChsa-miR-181d-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:35952
Count of gene targets:14210
Count of transcripts:29956
Interacting mature miRNAs:hsa-miR-181d-3p, hsa-miR-181d-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 3 1 2
Low 59 21 58 12 123 14 46 46 385 23 97 139 5 5 14 1
Below cutoff 162 145 146 23 93 11 136 111 662 43 153 130 12 35 78 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384853
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1913,874,875 - 13,875,011 (+)Ensembl
RefSeq Acc Id: NR_030179
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381913,874,875 - 13,875,011 (+)NCBI
GRCh371913,985,689 - 13,985,825 (+)RGD
Celera1913,879,434 - 13,879,570 (+)RGD
HuRef1913,557,000 - 13,557,136 (+)ENTREZGENE
CHM1_11913,986,385 - 13,986,521 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-15371089)x1 copy number loss See cases [RCV000136502] Chr19:13533925..15371089 [GRCh38]
Chr19:13644739..15481900 [GRCh37]
Chr19:13505739..15342900 [NCBI36]
Chr19:19p13.13-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12
pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-14258833)x1 copy number loss See cases [RCV000051051] Chr19:13533925..14258833 [GRCh38]
Chr19:13644739..14369645 [GRCh37]
Chr19:13505739..14230645 [NCBI36]
Chr19:19p13.13-13.12
uncertain significance
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32089 AgrOrtholog
COSMIC MIR181D COSMIC
Ensembl Genes ENSG00000207585 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384853 ENTREZGENE
GTEx ENSG00000207585 GTEx
HGNC ID HGNC:32089 ENTREZGENE
Human Proteome Map MIR181D Human Proteome Map
miRBase MI0003139 ENTREZGENE
NCBI Gene 574457 ENTREZGENE
PharmGKB PA164722526 PharmGKB
RNAcentral URS0000236310 RNACentral
  URS000075C355 RNACentral
  URS000075EF65 RNACentral