MIR524 (microRNA 524) - Rat Genome Database
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Gene: MIR524 (microRNA 524) Homo sapiens
Analyze
Symbol: MIR524
Name: microRNA 524
RGD ID: 1603745
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-524; mir-524; MIRN524
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1953,711,002 - 53,711,088 (+)EnsemblGRCh38hg38GRCh38
GRCh381953,711,002 - 53,711,088 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371954,214,256 - 54,214,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,906,067 - 58,906,153 (+)NCBINCBI36hg18NCBI36
Celera1951,255,350 - 51,255,436 (+)NCBI
Cytogenetic Map19q13.42NCBI
HuRef1950,533,801 - 50,533,887 (+)NCBIHuRef
CHM1_11954,216,055 - 54,216,141 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15965474   PMID:16381832   PMID:17604727   PMID:21037258   PMID:22871495   PMID:25275294   PMID:27880941   PMID:28472828   PMID:28778566   PMID:28962647   PMID:29949157   PMID:30941771  
PMID:30980391   PMID:31599422   PMID:31990904   PMID:32174132  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
JAG1hsa-miR-524-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22871495
JAG1hsa-miR-524-5pOncomiRDBexternal_infoNANA22871495

Predicted Targets
Summary Value
Count of predictions:34062
Count of gene targets:13202
Count of transcripts:27404
Interacting mature miRNAs:hsa-miR-524-3p, hsa-miR-524-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system exocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system sensory system appendage
High
Medium
Low 3 2 2 2 2 3 1 2
Below cutoff 5 3 1 3 2 3 7 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385242
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1953,711,002 - 53,711,088 (+)Ensembl
RefSeq Acc Id: NR_030200
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,711,002 - 53,711,088 (+)NCBI
GRCh371954,214,256 - 54,214,342 (+)RGD
Celera1951,255,350 - 51,255,436 (+)RGD
HuRef1950,533,801 - 50,533,887 (+)ENTREZGENE
CHM1_11954,216,055 - 54,216,141 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.42(chr19:53692245-53808292)x3 copy number gain See cases [RCV000141357] Chr19:53692245..53808292 [GRCh38]
Chr19:54195499..54311546 [GRCh37]
Chr19:58887311..59003358 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3 copy number gain See cases [RCV000142008] Chr19:52143873..58445521 [GRCh38]
Chr19:52647126..58956888 [GRCh37]
Chr19:57338938..63648700 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.42(chr19:53553042-53899466)x3 copy number gain See cases [RCV000052593] Chr19:53553042..53899466 [GRCh38]
Chr19:54056296..54402720 [GRCh37]
Chr19:58748108..59094532 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.42(chr19:53601298-53773028)x3 copy number gain See cases [RCV000052594] Chr19:53601298..53773028 [GRCh38]
Chr19:54104552..54276282 [GRCh37]
Chr19:58796364..58968094 [NCBI36]
Chr19:19q13.42		 uncertain significance
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
NC_000019.9:g.54039784_54484439dup duplication Silver Russell Syndrome-related disorder [RCV000785667] Chr19:53536530..53981185 [GRCh38]
Chr19:54039784..54484439 [GRCh37]
Chr19:19q13.42		 uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR524 COSMIC
Ensembl Genes ENSG00000283289 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385242 ENTREZGENE
GTEx ENSG00000283289 GTEx
HGNC ID HGNC:32110 ENTREZGENE
Human Proteome Map MIR524 Human Proteome Map
miRBase MI0003160 ENTREZGENE
NCBI Gene 574478 ENTREZGENE
PharmGKB PA164722804 PharmGKB
RNAcentral URS00003BD367 RNACentral
  URS00003E236A RNACentral
  URS000063B6CA RNACentral