MIR518A2 (microRNA 518a-2) - Rat Genome Database
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Gene: MIR518A2 (microRNA 518a-2) Homo sapiens
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Symbol: MIR518A2
Name: microRNA 518a-2
RGD ID: 1603732
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-518a-2; MIRN518A-2; MIRN518A2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1953,739,333 - 53,739,419 (+)EnsemblGRCh38hg38GRCh38
GRCh381953,739,333 - 53,739,419 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371954,242,587 - 54,242,673 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,934,398 - 58,934,484 (+)NCBINCBI36hg18NCBI36
Celera1951,283,684 - 51,283,770 (+)NCBI
Cytogenetic Map19q13.42NCBI
HuRef1950,562,161 - 50,562,247 (+)NCBIHuRef
CHM1_11954,244,386 - 54,244,472 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:15965474   PMID:16381832   PMID:17604727   PMID:20829195   PMID:21037258   PMID:24559209   PMID:26950487  


Genomics

Position Markers
G64901  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371954,241,227 - 54,241,582UniSTSGRCh37
GRCh371954,186,322 - 54,186,676UniSTSGRCh37
Build 361958,878,134 - 58,878,488RGDNCBI36
Celera1951,282,324 - 51,282,679UniSTS
Celera1951,227,412 - 51,227,766RGD
Cytogenetic Map19q13.42UniSTS
HuRef1950,505,976 - 50,506,330UniSTS
HuRef1950,560,801 - 50,561,156UniSTS

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MCL1hsa-miR-518a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195

Predicted Targets
Summary Value
Count of predictions:18457
Count of gene targets:7653
Count of transcripts:14566
Interacting mature miRNAs:hsa-miR-518a-3p, hsa-miR-518a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1
Low 5 1 3 2 18 2 5 3 1 14 6 1
Below cutoff 2 1 5 3 1 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384966
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1953,739,333 - 53,739,419 (+)Ensembl
RefSeq Acc Id: NR_030213
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,739,333 - 53,739,419 (+)NCBI
GRCh371954,242,587 - 54,242,673 (+)RGD
Celera1951,283,684 - 51,283,770 (+)RGD
HuRef1950,562,161 - 50,562,247 (+)ENTREZGENE
CHM1_11954,244,386 - 54,244,472 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.42(chr19:53692245-53808292)x3 copy number gain See cases [RCV000141357] Chr19:53692245..53808292 [GRCh38]
Chr19:54195499..54311546 [GRCh37]
Chr19:58887311..59003358 [NCBI36]
Chr19:19q13.42
uncertain significance
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3 copy number gain See cases [RCV000142008] Chr19:52143873..58445521 [GRCh38]
Chr19:52647126..58956888 [GRCh37]
Chr19:57338938..63648700 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh38/hg38 19q13.42(chr19:53553042-53899466)x3 copy number gain See cases [RCV000052593] Chr19:53553042..53899466 [GRCh38]
Chr19:54056296..54402720 [GRCh37]
Chr19:58748108..59094532 [NCBI36]
Chr19:19q13.42
uncertain significance
GRCh38/hg38 19q13.42(chr19:53601298-53773028)x3 copy number gain See cases [RCV000052594] Chr19:53601298..53773028 [GRCh38]
Chr19:54104552..54276282 [GRCh37]
Chr19:58796364..58968094 [NCBI36]
Chr19:19q13.42
uncertain significance
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
NC_000019.9:g.54039784_54484439dup duplication Silver Russell Syndrome-related disorder [RCV000785667] Chr19:53536530..53981185 [GRCh38]
Chr19:54039784..54484439 [GRCh37]
Chr19:19q13.42
uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR518A2 COSMIC
Ensembl Genes ENSG00000207699 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384966 ENTREZGENE
GTEx ENSG00000207699 GTEx
HGNC ID HGNC:32123 ENTREZGENE
Human Proteome Map MIR518A2 Human Proteome Map
miRBase MI0003173 ENTREZGENE
NCBI Gene 574491 ENTREZGENE
PharmGKB PA164722780 PharmGKB
RNAcentral URS0000024ACC RNACentral
  URS0000068BEA RNACentral
  URS0000647988 RNACentral