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Gene: FBXW4 (F-box and WD repeat domain containing 4) Homo sapiens
Symbol: FBXW4
Name: F-box and WD repeat domain containing 4
Description: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to localize to the SCF ubiquitin ligase complex. Implicated in split hand-foot malformation 3.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DAC; dactylin; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; F-box/WD repeat protein 4; F-box/WD repeat-containing protein 4; FBW4; FBWD4; SHFM3; SHSF3
Mus musculus (house mouse) : Fbxw4 (F-box and WD-40 domain protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fbxw4 (F-box and WD repeat domain containing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbxw4 (F-box and WD repeat domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FBXW4 (F-box and WD repeat domain containing 4)
Canis lupus familiaris (dog) : FBXW4 (F-box and WD repeat domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbxw4 (F-box and WD repeat domain containing 4)
Sus scrofa (pig) : FBXW4 (F-box and WD repeat domain containing 4)
Chlorocebus sabaeus (African green monkey) : FBXW4 (F-box and WD repeat domain containing 4)
Heterocephalus glaber (naked mole-rat) : Fbxw4 (F-box and WD repeat domain containing 4)
more info ...
Related Pseudogenes: FBXW4P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10101,610,664 - 101,695,295 (-)EnsemblGRCh38hg38GRCh38
GRCh3810101,610,664 - 101,695,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710103,370,421 - 103,455,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,360,411 - 103,444,733 (-)NCBINCBI36hg18NCBI36
Celera1097,109,207 - 97,193,536 (-)NCBI
Cytogenetic Map10q24.32NCBI
HuRef1097,000,717 - 97,084,921 (-)NCBIHuRef
CHM1_110103,654,100 - 103,738,750 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FBXW4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603710
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.