Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CHMP2A (charged multivesicular body protein 2A) Homo sapiens
Analyze
Symbol: CHMP2A
Name: charged multivesicular body protein 2A
Description: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC-2; BC2; CHMP2; chromatin modifying protein 2A; chromatin-modifying protein 2a; hVps2-1; putative breast adenocarcinoma marker (32kD); putative breast adenocarcinoma marker BC-2; vacuolar protein sorting-associated protein 2-1; VPS2; VPS2 homolog A; vps2-1; VPS2A
Orthologs:
Mus musculus (house mouse) : Chmp2a (charged multivesicular body protein 2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Chmp2a (charged multivesicular body protein 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chmp2a (charged multivesicular body protein 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : CHMP2A (charged multivesicular body protein 2A)
Canis lupus familiaris (dog) : CHMP2A (charged multivesicular body protein 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chmp2a (charged multivesicular body protein 2A)
Sus scrofa (pig) : CHMP2A (charged multivesicular body protein 2A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381958,551,566 - 58,555,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371959,062,933 - 59,066,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361963,754,745 - 63,758,298 (-)NCBINCBI36hg18NCBI36
Celera1956,106,112 - 56,109,665 (-)NCBI
Cytogenetic Map19q13.43NCBI
HuRef1955,373,170 - 55,376,723 (-)NCBIHuRef
CHM1_11959,056,762 - 59,060,320 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CHMP2A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603659
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.