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Gene: MIR450A2 (microRNA 450a-2) Homo sapiens
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Symbol: MIR450A2
Name: microRNA 450a-2
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-450a-2; MIRN450-2; MIRN450A-2; MIRN450A2
Orthologs:
Mus musculus (house mouse) : Mir450-2 (microRNA 450-2)  MGI
Sus scrofa (pig) : MIR450C (microRNA mir-450c)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,540,508 - 134,540,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X133,674,538 - 133,674,637 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,502,203 - 133,502,302 (-)NCBINCBI36hg18NCBI36
CeleraX134,061,366 - 134,061,465 (-)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX123,073,534 - 123,073,633 (-)NCBIHuRef
CHM1_1X133,586,288 - 133,586,387 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
  
More on MIR450A2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603436
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.