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Gene: NKX2-6 (NK2 homeobox 6) Homo sapiens
Symbol: NKX2-6
Name: NK2 homeobox 6
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in embryonic heart tube development and positive regulation of transcription by RNA polymerase II. Predicted to localize to the nuclear chromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSX2; CTHM; homeobox protein NK-2 homolog F; homeobox protein NK2 homolog F; homeobox protein Nkx-2.6; homeobox protein NKX2.6; NK2 transcription factor related, locus 6; NKX2F; NKX4-2; tinman paralog
Mus musculus (house mouse) : Nkx2-6 (NK2 homeobox 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkx2-6 (NK2 homeobox 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-6 (NK2 homeobox 6)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-6 (NK2 homeobox 6)
Canis lupus familiaris (dog) : NKX2-6 (NK2 homeobox 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-6 (NK2 homeobox 6)
Sus scrofa (pig) : NKX2-6 (NK2 homeobox 6)
Chlorocebus sabaeus (green monkey) : NKX2-6 (NK2 homeobox 6)
Heterocephalus glaber (naked mole-rat) : Nkx2-6 (NK2 homeobox 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl823,702,451 - 23,706,598 (-)Ensembl
GRCh38823,702,451 - 23,706,598 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37823,559,964 - 23,564,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,615,909 - 23,621,070 (-)NCBINCBI36hg18NCBI36
Celera822,523,400 - 22,527,359 (-)NCBI
Cytogenetic Map8p21.2NCBI
HuRef822,105,267 - 22,109,415 (-)NCBIHuRef
CHM1_1823,762,157 - 23,766,304 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NKX2-6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603362
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.