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Gene: SIVA1 (SIVA1 apoptosis inducing factor) Homo sapiens
Symbol: SIVA1
Name: SIVA1 apoptosis inducing factor
Description: Exhibits CD27 receptor binding activity and zinc ion binding activity. Involved in several processes, including activation-induced cell death of T cells; apoptotic signaling pathway; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Localizes to mitochondrion and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis regulatory protein Siva; CD27-binding (Siva) protein; CD27-binding protein; CD27BP; SIVA; Siva-1; Siva-2; SIVA1, apoptosis-inducing factor
Mus musculus (house mouse) : Siva1 (SIVA1, apoptosis-inducing factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Siva1 (SIVA1, apoptosis-inducing factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Siva1 (SIVA1 apoptosis inducing factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SIVA1 (SIVA1 apoptosis inducing factor)
Canis lupus familiaris (dog) : SIVA1 (SIVA1 apoptosis inducing factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Siva1 (SIVA1 apoptosis inducing factor)
Sus scrofa (pig) : SIVA1 (SIVA1 apoptosis inducing factor)
Chlorocebus sabaeus (African green monkey) : SIVA1 (SIVA1 apoptosis inducing factor)
Heterocephalus glaber (naked mole-rat) : Siva1 (SIVA1 apoptosis inducing factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl14104,753,147 - 104,768,494 (+)EnsemblGRCh38hg38GRCh38
GRCh3814104,752,420 - 104,759,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714105,219,470 - 105,225,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,290,515 - 104,297,041 (+)NCBINCBI36hg18NCBI36
Celera1485,274,542 - 85,281,070 (+)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1485,416,458 - 85,422,986 (+)NCBIHuRef
CHM1_114105,157,086 - 105,163,614 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIVA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603317
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.