SNX31 (sorting nexin 31) - Rat Genome Database

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Gene: SNX31 (sorting nexin 31) Homo sapiens
Analyze
Symbol: SNX31
Name: sorting nexin 31
RGD ID: 1603261
HGNC Page HGNC
Description: Predicted to have phosphatidylinositol binding activity. Predicted to be involved in intracellular protein transport and retrograde transport, endosome to plasma membrane. Predicted to localize to early endosome; INTERACTS WITH aflatoxin B1; aflatoxin B2; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC39715; sorting nexin-31
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8100,572,889 - 100,663,415 (-)EnsemblGRCh38hg38GRCh38
GRCh388100,572,874 - 100,663,410 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378101,585,102 - 101,661,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,654,299 - 101,731,069 (-)NCBINCBI36hg18NCBI36
Celera897,770,483 - 97,847,271 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef896,784,677 - 96,860,804 (-)NCBIHuRef
CHM1_18101,625,996 - 101,702,710 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:12516573   PMID:14702039   PMID:16344560   PMID:16782399   PMID:20379614   PMID:21873635   PMID:24914955   PMID:25416956   PMID:25496667   PMID:27107012   PMID:28892079  
PMID:29676528   PMID:30021884   PMID:32296183  


Genomics

Comparative Map Data
SNX31
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8100,572,889 - 100,663,415 (-)EnsemblGRCh38hg38GRCh38
GRCh388100,572,874 - 100,663,410 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378101,585,102 - 101,661,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,654,299 - 101,731,069 (-)NCBINCBI36hg18NCBI36
Celera897,770,483 - 97,847,271 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef896,784,677 - 96,860,804 (-)NCBIHuRef
CHM1_18101,625,996 - 101,702,710 (-)NCBICHM1_1
Snx31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391536,504,208 - 36,560,274 (-)NCBIGRCm39mm39
GRCm39 Ensembl1536,504,208 - 36,555,718 (-)Ensembl
GRCm381536,504,062 - 36,560,129 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,504,062 - 36,555,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371536,433,817 - 36,485,327 (-)NCBIGRCm37mm9NCBIm37
MGSCv361536,448,651 - 36,500,161 (-)NCBImm8
Celera1537,131,901 - 37,175,770 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Snx31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2767,676,514 - 67,776,925 (-)NCBI
Rnor_6.0 Ensembl775,309,255 - 75,364,166 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0775,308,847 - 75,364,264 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0775,456,983 - 75,512,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4772,015,735 - 72,070,732 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1772,036,464 - 72,097,245 (-)NCBI
Celera764,756,762 - 64,803,973 (-)NCBICelera
Cytogenetic Map7q22NCBI
Snx31
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541715,778,838 - 15,835,733 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541715,779,500 - 15,835,668 (-)NCBIChiLan1.0ChiLan1.0
SNX31
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1899,389,353 - 99,465,796 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl899,389,362 - 99,465,796 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0897,216,289 - 97,293,064 (-)NCBIMhudiblu_PPA_v0panPan3
SNX31
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,425,143 - 2,497,798 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl132,385,611 - 2,498,364 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,422,258 - 2,494,793 (-)NCBI
ROS_Cfam_1.0132,578,243 - 2,650,892 (-)NCBI
UMICH_Zoey_3.1132,422,818 - 2,495,566 (-)NCBI
UNSW_CanFamBas_1.0132,534,477 - 2,607,054 (-)NCBI
UU_Cfam_GSD_1.0132,551,812 - 2,624,429 (-)NCBI
Snx31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530335,258,158 - 35,316,885 (+)NCBI
SpeTri2.0NW_00493647042,684,346 - 42,743,001 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNX31
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl436,303,501 - 36,388,952 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1436,303,313 - 36,390,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2439,227,961 - 39,312,750 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNX31
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1895,427,818 - 95,515,132 (-)NCBI
ChlSab1.1 Ensembl895,428,800 - 95,502,606 (-)Ensembl
Snx31
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247637,455,924 - 7,515,120 (-)NCBI

Position Markers
SHGC-83048  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,662,498 - 101,662,810UniSTSGRCh37
Build 368101,731,674 - 101,731,986RGDNCBI36
Celera897,847,876 - 97,848,188RGD
Cytogenetic Map8q22.3UniSTS
HuRef896,861,409 - 96,861,722UniSTS
TNG Radiation Hybrid Map848663.0UniSTS
G59689  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,585,217 - 101,585,318UniSTSGRCh37
Build 368101,654,393 - 101,654,494RGDNCBI36
Celera897,770,590 - 97,770,691RGD
Cytogenetic Map8q22.3UniSTS
HuRef896,784,784 - 96,784,885UniSTS
TNG Radiation Hybrid Map848702.0UniSTS
D8S1517  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,644,481 - 101,644,593UniSTSGRCh37
Build 368101,713,657 - 101,713,769RGDNCBI36
Celera897,829,856 - 97,829,968RGD
Cytogenetic Map8q22.3UniSTS
HuRef896,843,461 - 96,843,573UniSTS
Whitehead-RH Map8584.3UniSTS
Whitehead-YAC Contig Map8 UniSTS
NCBI RH Map81094.1UniSTS
RH45797  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,585,216 - 101,585,371UniSTSGRCh37
Build 368101,654,392 - 101,654,547RGDNCBI36
Celera897,770,589 - 97,770,744RGD
Cytogenetic Map8q22.3UniSTS
HuRef896,784,783 - 96,784,938UniSTS
GeneMap99-GB4 RH Map8438.21UniSTS
NCBI RH Map81014.8UniSTS
G31444  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378101,585,359 - 101,585,474UniSTSGRCh37
Build 368101,654,535 - 101,654,650RGDNCBI36
Celera897,770,732 - 97,770,847RGD
Cytogenetic Map8q22.3UniSTS
HuRef896,784,926 - 96,785,041UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:939
Count of miRNA genes:595
Interacting mature miRNAs:647
Transcripts:ENST00000311812, ENST00000428383, ENST00000518342, ENST00000519521, ENST00000520352, ENST00000520661, ENST00000520743
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2 4 29 23 11 2
Low 532 419 318 80 32 8 934 526 1085 51 851 321 74 431 601 1
Below cutoff 1608 1908 1059 361 716 274 3117 1566 2424 193 459 981 93 707 2056 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001363720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001745488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK093906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ012274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD106024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB312716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000311812   ⟹   ENSP00000312368
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,572,889 - 100,649,665 (-)Ensembl
RefSeq Acc Id: ENST00000428383   ⟹   ENSP00000405024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,573,665 - 100,618,393 (-)Ensembl
RefSeq Acc Id: ENST00000518342   ⟹   ENSP00000429110
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,573,585 - 100,584,160 (-)Ensembl
RefSeq Acc Id: ENST00000519521
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,582,345 - 100,596,706 (-)Ensembl
RefSeq Acc Id: ENST00000520352   ⟹   ENSP00000428210
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,612,039 - 100,663,415 (-)Ensembl
RefSeq Acc Id: ENST00000520661   ⟹   ENSP00000428855
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,617,644 - 100,663,219 (-)Ensembl
RefSeq Acc Id: ENST00000520743   ⟹   ENSP00000428262
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,635,930 - 100,663,403 (-)Ensembl
RefSeq Acc Id: NM_001363720   ⟹   NP_001350649
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,874 - 100,618,405 (-)NCBI
RefSeq Acc Id: NM_152628   ⟹   NP_689841
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,889 - 100,649,665 (-)NCBI
GRCh378101,585,110 - 101,661,893 (-)RGD
Build 368101,654,299 - 101,731,069 (-)NCBI Archive
Celera897,770,483 - 97,847,271 (-)RGD
HuRef896,784,677 - 96,860,804 (-)RGD
CHM1_18101,625,996 - 101,702,710 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011516899   ⟹   XP_011515201
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,663,410 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013153   ⟹   XP_016868642
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013154   ⟹   XP_016868643
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013155   ⟹   XP_016868644
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013156   ⟹   XP_016868645
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013157   ⟹   XP_016868646
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013158   ⟹   XP_016868647
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013159   ⟹   XP_016868648
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013160   ⟹   XP_016868649
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013161   ⟹   XP_016868650
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013162   ⟹   XP_016868651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013163   ⟹   XP_016868652
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,622,366 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013164   ⟹   XP_016868653
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,588,892 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013165   ⟹   XP_016868654
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,584,111 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447084   ⟹   XP_024302852
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,618,442 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447085   ⟹   XP_024302853
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,649,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447086   ⟹   XP_024302854
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,572,882 - 100,618,444 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001745488
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,588,904 - 100,649,665 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_689841   ⟸   NM_152628
- Peptide Label: isoform 1
- UniProtKB: Q8N9S9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011515201   ⟸   XM_011516899
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016868650   ⟸   XM_017013161
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_016868651   ⟸   XM_017013162
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_016868649   ⟸   XM_017013160
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_016868648   ⟸   XM_017013159
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016868647   ⟸   XM_017013158
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016868646   ⟸   XM_017013157
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016868645   ⟸   XM_017013156
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016868644   ⟸   XM_017013155
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016868643   ⟸   XM_017013154
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016868642   ⟸   XM_017013153
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868652   ⟸   XM_017013163
- Peptide Label: isoform X16
- Sequence:
RefSeq Acc Id: XP_016868654   ⟸   XM_017013165
- Peptide Label: isoform X17
- Sequence:
RefSeq Acc Id: XP_016868653   ⟸   XM_017013164
- Peptide Label: isoform X17
- Sequence:
RefSeq Acc Id: XP_024302853   ⟸   XM_024447085
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_024302854   ⟸   XM_024447086
- Peptide Label: isoform X15
- Sequence:
RefSeq Acc Id: XP_024302852   ⟸   XM_024447084
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: NP_001350649   ⟸   NM_001363720
- Peptide Label: isoform 2
RefSeq Acc Id: ENSP00000429110   ⟸   ENST00000518342
RefSeq Acc Id: ENSP00000405024   ⟸   ENST00000428383
RefSeq Acc Id: ENSP00000428210   ⟸   ENST00000520352
RefSeq Acc Id: ENSP00000428262   ⟸   ENST00000520743
RefSeq Acc Id: ENSP00000428855   ⟸   ENST00000520661
RefSeq Acc Id: ENSP00000312368   ⟸   ENST00000311812
Protein Domains
FERM   PX


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q22.2-22.3(chr8:100023254-101190270)x3 copy number gain See cases [RCV000050759] Chr8:100023254..101190270 [GRCh38]
Chr8:101035482..102202498 [GRCh37]
Chr8:101104658..102271674 [NCBI36]
Chr8:8q22.2-22.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NM_152628.3(SNX31):c.1023G>A (p.Gln341=) single nucleotide variant Malignant melanoma [RCV000068051] Chr8:100588935 [GRCh38]
Chr8:101601163 [GRCh37]
Chr8:101670339 [NCBI36]
Chr8:8q22.3
not provided
NM_152628.3(SNX31):c.257-60A>G single nucleotide variant Lung cancer [RCV000106742] Chr8:100630451 [GRCh38]
Chr8:101642679 [GRCh37]
Chr8:8q22.3
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.2-22.3(chr8:99580206-101547228)x1 copy number loss See cases [RCV000137322] Chr8:99580206..101547228 [GRCh38]
Chr8:100592434..102559456 [GRCh37]
Chr8:100661610..102628632 [NCBI36]
Chr8:8q22.2-22.3
likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.2-23.1(chr8:100179408-106524667)x1 copy number loss See cases [RCV000141697] Chr8:100179408..106524667 [GRCh38]
Chr8:101191636..107536895 [GRCh37]
Chr8:101260812..107606071 [NCBI36]
Chr8:8q22.2-23.1
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8q22.2-22.3(chr8:100551211-103676738)x1 copy number loss not provided [RCV000683023] Chr8:100551211..103676738 [GRCh37]
Chr8:8q22.2-22.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28605 AgrOrtholog
COSMIC SNX31 COSMIC
Ensembl Genes ENSG00000174226 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000312368 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000405024 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428210 UniProtKB/TrEMBL
  ENSP00000428262 UniProtKB/TrEMBL
  ENSP00000428855 UniProtKB/TrEMBL
  ENSP00000429110 UniProtKB/TrEMBL
Ensembl Transcript ENST00000311812 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000428383 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000518342 UniProtKB/TrEMBL
  ENST00000520352 UniProtKB/TrEMBL
  ENST00000520661 UniProtKB/TrEMBL
  ENST00000520743 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000174226 GTEx
HGNC ID HGNC:28605 ENTREZGENE
Human Proteome Map SNX31 Human Proteome Map
InterPro FERM_domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Phox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNX17/27/31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNX17/31_FERM UniProtKB/Swiss-Prot
KEGG Report hsa:169166 UniProtKB/Swiss-Prot
NCBI Gene 169166 ENTREZGENE
PANTHER PTHR12431 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNX17_FERM_C UniProtKB/Swiss-Prot
PharmGKB PA162404313 PharmGKB
PROSITE FERM_3 UniProtKB/TrEMBL
  PS50195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00312 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF64268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E5RFI8_HUMAN UniProtKB/TrEMBL
  E5RJE9_HUMAN UniProtKB/TrEMBL
  E5RJK2_HUMAN UniProtKB/TrEMBL
  H0YBA9_HUMAN UniProtKB/TrEMBL
  Q8N9S9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary C9J6L9 UniProtKB/Swiss-Prot
  Q8N0U9 UniProtKB/Swiss-Prot