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Gene: ALKBH5 (alkB homolog 5, RNA demethylase) Homo sapiens
Symbol: ALKBH5
Name: alkB homolog 5, RNA demethylase
RGD ID: 1603209
Description: Exhibits 2-oxoglutarate-dependent dioxygenase activity and RNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Localizes to Golgi apparatus; cytosol; and nuclear speck; INTERACTS WITH aflatoxin B2; cobalt dichloride; formaldehyde.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ABH5; AlkB family member 5, RNA demethylase; alkB, alkylation repair homolog 5; alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; FLJ20308; OFOXD; OFOXD1; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; RNA demethylase ALKBH5
Mus musculus (house mouse) : Alkbh5 (alkB homolog 5, RNA demethylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alkbh5 (alkB homolog 5, RNA demethylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alkbh5 (alkB homolog 5, RNA demethylase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALKBH5 (alkB homolog 5, RNA demethylase)
Canis lupus familiaris (dog) : ALKBH5 (alkB homolog 5, RNA demethylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alkbh5 (alkB homolog 5, RNA demethylase)
Sus scrofa (pig) : ALKBH5 (alkB homolog 5, RNA demethylase)
Chlorocebus sabaeus (African green monkey) : ALKBH5 (alkB homolog 5, RNA demethylase)
Heterocephalus glaber (naked mole-rat) : Alkbh5 (alkB homolog 5, RNA demethylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1718,183,078 - 18,209,954 (+)EnsemblGRCh38hg38GRCh38
GRCh381718,183,828 - 18,209,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371718,086,867 - 18,113,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,027,592 - 18,053,993 (+)NCBINCBI36hg18NCBI36
Celera1719,028,003 - 19,054,331 (+)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1717,840,215 - 17,866,584 (+)NCBIHuRef
CHM1_11718,095,612 - 18,122,007 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ALKBH5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603209
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.