TEX19 (testis expressed 19) - Rat Genome Database

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Gene: TEX19 (testis expressed 19) Homo sapiens
Analyze
Symbol: TEX19
Name: testis expressed 19
RGD ID: 1603143
HGNC Page HGNC:33802
Description: Predicted to enable piRNA binding activity. Involved in negative regulation of transposition. Predicted to be active in cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ35767; testis-expressed protein 19; testis-expressed sequence 19 protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,359,247 - 82,363,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1782,359,247 - 82,363,775 (+)EnsemblGRCh38hg38GRCh38
GRCh371780,317,123 - 80,321,651 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,910,409 - 77,914,909 (+)NCBINCBI36Build 36hg18NCBI36
Celera1776,910,011 - 76,913,791 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,715,637 - 75,720,216 (+)NCBIHuRef
CHM1_11780,403,327 - 80,407,115 (+)NCBICHM1_1
T2T-CHM13v2.01783,228,349 - 83,232,937 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:18096721   PMID:21555518   PMID:21873635   PMID:23674551   PMID:26695143   PMID:28446200   PMID:28806172   PMID:31343991   PMID:31391242   PMID:31843525  
PMID:32296183   PMID:32694731   PMID:32814053   PMID:33961781   PMID:34036740  


Genomics

Comparative Map Data
TEX19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,359,247 - 82,363,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1782,359,247 - 82,363,775 (+)EnsemblGRCh38hg38GRCh38
GRCh371780,317,123 - 80,321,651 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,910,409 - 77,914,909 (+)NCBINCBI36Build 36hg18NCBI36
Celera1776,910,011 - 76,913,791 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,715,637 - 75,720,216 (+)NCBIHuRef
CHM1_11780,403,327 - 80,407,115 (+)NCBICHM1_1
T2T-CHM13v2.01783,228,349 - 83,232,937 (+)NCBIT2T-CHM13v2.0
Tex19.2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911121,007,041 - 121,009,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11121,007,041 - 121,009,503 (-)EnsemblGRCm39 Ensembl
GRCm3811121,116,215 - 121,118,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11121,116,215 - 121,118,677 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,977,529 - 120,979,991 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,932,307 - 120,934,767 (-)NCBIMGSCv36mm8
Celera11132,853,989 - 132,856,451 (-)NCBICelera
Cytogenetic Map11E2NCBI
Tex19.2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210106,379,757 - 106,382,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,379,757 - 106,382,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,482,468 - 111,485,053 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010110,945,526 - 110,948,111 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010106,300,208 - 106,302,795 (-)NCBIRnor_WKY
Rnor_6.010110,305,926 - 110,308,514 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,305,928 - 110,308,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,892,724 - 109,895,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,325,885 - 110,353,003 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10104,918,466 - 104,921,052 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Tex19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955506773,128 - 775,155 (-)NCBIChiLan1.0ChiLan1.0
TEX19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11782,578,981 - 82,581,481 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,579,857 - 82,580,351 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01776,769,529 - 76,775,453 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Tex19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602567,996 - 569,990 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936923807 - 1,835 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TEX19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.112713,179 - 715,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2122,251 - 3,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TEX19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11674,269,731 - 74,272,047 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1674,270,403 - 74,270,897 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,919,144 - 45,921,305 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1030
Count of miRNA genes:441
Interacting mature miRNAs:471
Transcripts:ENST00000333437
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 4 3 3 40 3 2 3 7 1 375 6
Low 94 1 76 43 406 47 241 57 50 34 137 186 1 1 18 2
Below cutoff 796 668 931 226 514 163 1335 730 1254 107 368 803 70 386 938

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000333437   ⟹   ENSP00000331500
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1782,359,247 - 82,363,775 (+)Ensembl
RefSeq Acc Id: NM_207459   ⟹   NP_997342
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381782,359,247 - 82,363,775 (+)NCBI
GRCh371780,317,123 - 80,321,652 (+)RGD
Build 361777,910,409 - 77,914,909 (+)NCBI Archive
Celera1776,910,011 - 76,913,791 (+)RGD
HuRef1775,715,637 - 75,720,216 (+)RGD
CHM1_11780,403,327 - 80,407,115 (+)NCBI
T2T-CHM13v2.01783,228,349 - 83,232,937 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_997342   ⟸   NM_207459
- UniProtKB: Q8NA77 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000331500   ⟸   ENST00000333437

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8NA77-F1-model_v2 AlphaFold Q8NA77 1-164 view protein structure

Promoters
RGD ID:7236749
Promoter ID:EPDNEW_H24120
Type:single initiation site
Name:TEX19_1
Description:testis expressed 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381782,359,247 - 82,359,307EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q25.3(chr17:78901959-83086677)x3 copy number gain See cases [RCV000050934] Chr17:78901959..83086677 [GRCh38]
Chr17:76898041..81044553 [GRCh37]
Chr17:74409636..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78918650-83021095)x3 copy number gain See cases [RCV000052497] Chr17:78918650..83021095 [GRCh38]
Chr17:76914732..80978971 [GRCh37]
Chr17:74426327..78572260 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:80328106-83086677)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|See cases [RCV000053454] Chr17:80328106..83086677 [GRCh38]
Chr17:78301906..81044553 [GRCh37]
Chr17:75916501..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:82078456-82568008)x3 copy number gain See cases [RCV000054050] Chr17:82078456..82568008 [GRCh38]
Chr17:80036332..80525884 [GRCh37]
Chr17:77629621..78119173 [NCBI36]
Chr17:17q25.3
uncertain significance
GRCh38/hg38 17q25.3(chr17:82072338-83102552)x1 copy number loss See cases [RCV000137356] Chr17:82072338..83102552 [GRCh38]
Chr17:80030214..81048189 [GRCh37]
Chr17:77623503..78653717 [NCBI36]
Chr17:17q25.3
likely pathogenic
GRCh38/hg38 17q25.3(chr17:81008196-83102584)x3 copy number gain See cases [RCV000138688] Chr17:81008196..83102584 [GRCh38]
Chr17:78981996..81048189 [GRCh37]
Chr17:76596591..78653749 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:81401966-83084062)x1 copy number loss See cases [RCV000142007] Chr17:81401966..83084062 [GRCh38]
Chr17:79375766..81041938 [GRCh37]
Chr17:76990361..78635227 [NCBI36]
Chr17:17q25.3
likely pathogenic
GRCh38/hg38 17q25.3(chr17:82326074-82856150)x3 copy number gain See cases [RCV000141856] Chr17:82326074..82856150 [GRCh38]
Chr17:80283950..80814026 [GRCh37]
Chr17:77877239..78407315 [NCBI36]
Chr17:17q25.3
uncertain significance
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh37/hg19 17q25.3(chr17:78514452-81041938)x1 copy number loss See cases [RCV000449416] Chr17:78514452..81041938 [GRCh37]
Chr17:17q25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000447539] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:64241326-81041938)x3 copy number gain See cases [RCV000447577] Chr17:64241326..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000510919] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
GRCh37/hg19 17q25.3(chr17:80306702-80481025)x3 copy number gain not provided [RCV000584972] Chr17:80306702..80481025 [GRCh37]
Chr17:17q25.3
likely benign
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:67002415-81041938)x3 copy number gain See cases [RCV000512573] Chr17:67002415..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q25.3(chr17:80243845-80374899)x1 copy number loss not provided [RCV000683967] Chr17:80243845..80374899 [GRCh37]
Chr17:17q25.3
likely benign
GRCh37/hg19 17q24.1-25.3(chr17:63689671-81041938)x3 copy number gain not provided [RCV000683952] Chr17:63689671..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17q25.3(chr17:76552611-81041938)x3 copy number gain not provided [RCV000683965] Chr17:76552611..81041938 [GRCh37]
Chr17:17q25.3
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q25.3(chr17:79828248-81057996)x1 copy number loss not provided [RCV000752233] Chr17:79828248..81057996 [GRCh37]
Chr17:17q25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:62778720-81041938)x3 copy number gain not provided [RCV000849900] Chr17:62778720..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17q25.3(chr17:78608912-81041938)x3 copy number gain not provided [RCV000848418] Chr17:78608912..81041938 [GRCh37]
Chr17:17q25.3
pathogenic
NM_207459.4(TEX19):c.438del (p.Trp147fs) deletion not provided [RCV000957697] Chr17:82362586 [GRCh38]
Chr17:80320462 [GRCh37]
Chr17:17q25.3
benign
GRCh37/hg19 17q25.3(chr17:79976464-81041938) copy number loss not specified [RCV002052608] Chr17:79976464..81041938 [GRCh37]
Chr17:17q25.3
uncertain significance
GRCh37/hg19 17q25.1-25.3(chr17:73481509-81043199)x3 copy number gain not provided [RCV002276051] Chr17:73481509..81043199 [GRCh37]
Chr17:17q25.1-25.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33802 AgrOrtholog
COSMIC TEX19 COSMIC
Ensembl Genes ENSG00000182459 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000331500 ENTREZGENE
  ENSP00000331500.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000333437 ENTREZGENE
  ENST00000333437.5 UniProtKB/Swiss-Prot
GTEx ENSG00000182459 GTEx
HGNC ID HGNC:33802 ENTREZGENE
Human Proteome Map TEX19 Human Proteome Map
InterPro TEX19 UniProtKB/Swiss-Prot
KEGG Report hsa:400629 UniProtKB/Swiss-Prot
NCBI Gene 400629 ENTREZGENE
OMIM 615647 OMIM
PANTHER PTHR31387 UniProtKB/Swiss-Prot
Pfam TEX19 UniProtKB/Swiss-Prot
PharmGKB PA165433159 PharmGKB
UniProt Q8NA77 ENTREZGENE, UniProtKB/Swiss-Prot