MIR550A2 (microRNA 550a-2) - Rat Genome Database

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Gene: MIR550A2 (microRNA 550a-2) Homo sapiens
Analyze
Symbol: MIR550A2
Name: microRNA 550a-2
RGD ID: 1603122
HGNC Page HGNC:32805
Description: Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Located in extracellular space.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-550a-2; mir-550a-2; MIR550-2; MIRN550-2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38732,732,981 - 32,733,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl732,732,981 - 32,733,077 (+)EnsemblGRCh38hg38GRCh38
GRCh37732,772,593 - 32,772,689 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36732,739,117 - 32,739,213 (+)NCBINCBI36Build 36hg18NCBI36
Celera732,757,961 - 32,758,057 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef732,651,236 - 32,651,332 (+)NCBIHuRef
CHM1_1732,772,369 - 32,772,465 (+)NCBICHM1_1
T2T-CHM13v2.0732,872,574 - 32,872,670 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2732,817,112 - 32,817,208 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:17604727   PMID:21037258   PMID:26646931   PMID:27462780   PMID:27935135  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p14.3-14.1(chr7:32678391-41044983)x1 copy number loss See cases [RCV000140283] Chr7:32678391..41044983 [GRCh38]
Chr7:32718003..41084581 [GRCh37]
Chr7:32684528..41051106 [NCBI36]
Chr7:7p14.3-14.1		 pathogenic
GRCh38/hg38 7p14.3(chr7:30938370-33400996)x1 copy number loss See cases [RCV000141441] Chr7:30938370..33400996 [GRCh38]
Chr7:30977985..33440608 [GRCh37]
Chr7:30944510..33407133 [NCBI36]
Chr7:7p14.3		 likely pathogenic
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1		 pathogenic
GRCh38/hg38 7p14.3(chr7:30420933-34560665)x3 copy number gain See cases [RCV000051178] Chr7:30420933..34560665 [GRCh38]
Chr7:30460549..34600277 [GRCh37]
Chr7:30427074..34566802 [NCBI36]
Chr7:7p14.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
DNAJA3hsa-miR-550a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CPEB4hsa-miR-550a-3pOncomiRDBexternal_infoNANA23145039
WNK1hsa-miR-550a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:31792
Count of gene targets:14543
Count of transcripts:28168
Interacting mature miRNAs:hsa-miR-550a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system appendage entire extraembryonic component
High
Medium 21 1 1 1
Low 61 7 31 23 122 26 67 22 70 53 78 119 1 1 3
Below cutoff 19 3 10 5 17 6 6 14 6 18 11 22

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384841
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl732,732,981 - 32,733,077 (+)Ensembl
RefSeq Acc Id: NR_030320
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38732,732,981 - 32,733,077 (+)NCBI
GRCh37732,772,593 - 32,772,689 (+)RGD
Celera732,757,961 - 32,758,057 (+)RGD
HuRef732,651,236 - 32,651,332 (+)RGD
CHM1_1732,772,369 - 32,772,465 (+)NCBI
T2T-CHM13v2.0732,872,574 - 32,872,670 (+)NCBI
CRA_TCAGchr7v2732,817,112 - 32,817,208 (+)ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR550A2 COSMIC
Ensembl Genes ENSG00000207573 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384841 ENTREZGENE
GTEx ENSG00000207573 GTEx
HGNC ID HGNC:32805 ENTREZGENE
Human Proteome Map MIR550A2 Human Proteome Map
miRBase MI0003601 ENTREZGENE
NCBI Gene 693134 ENTREZGENE
PharmGKB PA164722848 PharmGKB
RNAcentral URS00001F14FE RNACentral
  URS00003FFA6C RNACentral
  URS000070ACB1 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 MIR550A2  microRNA 550a-2  MIR550-2  microRNA 550-2  Symbol and/or name change 5135510 APPROVED