MIR591 (microRNA 591) - Rat Genome Database

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Gene: MIR591 (microRNA 591) Homo sapiens
Analyze
Symbol: MIR591
Name: microRNA 591
RGD ID: 1603084
HGNC Page HGNC:32847
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-591; MIRN591
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38796,219,662 - 96,219,756 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl796,219,662 - 96,219,756 (-)EnsemblGRCh38hg38GRCh38
GRCh37795,848,974 - 95,849,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36795,686,909 - 95,687,003 (-)NCBINCBI36Build 36hg18NCBI36
Celera790,548,852 - 90,548,946 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef790,456,765 - 90,456,859 (-)NCBIHuRef
CHM1_1795,779,013 - 95,779,107 (-)NCBICHM1_1
T2T-CHM13v2.0797,455,570 - 97,455,664 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2795,178,029 - 95,178,123 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:23807165   PMID:31280269   PMID:33309838   PMID:33658057   PMID:35000195   PMID:37052456  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3(chr7:95127070-97873487)x1 copy number loss See cases [RCV000135435] Chr7:95127070..97873487 [GRCh38]
Chr7:94756382..97502799 [GRCh37]
Chr7:94594318..97340735 [NCBI36]
Chr7:7q21.3		 pathogenic
GRCh38/hg38 7q21.2-21.3(chr7:92759144-97568646)x1 copy number loss See cases [RCV000141756] Chr7:92759144..97568646 [GRCh38]
Chr7:92388458..97197958 [GRCh37]
Chr7:92226394..97035894 [NCBI36]
Chr7:7q21.2-21.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8615
Count of gene targets:4679
Count of transcripts:7889
Interacting mature miRNAs:hsa-miR-591
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 2 1
Low 23 12 30 24 64 23 37 9 22 14 20 22 1 3 9 1
Below cutoff 25 3 17 8 29 9 34 17 27 17 22 18 1 6 14 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385290
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl796,219,662 - 96,219,756 (-)Ensembl
RefSeq Acc Id: NR_030322
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38796,219,662 - 96,219,756 (-)NCBI
GRCh37795,848,974 - 95,849,068 (-)RGD
Celera790,548,852 - 90,548,946 (-)RGD
HuRef790,456,765 - 90,456,859 (-)ENTREZGENE
CHM1_1795,779,013 - 95,779,107 (-)NCBI
T2T-CHM13v2.0797,455,570 - 97,455,664 (-)NCBI
CRA_TCAGchr7v2795,178,029 - 95,178,123 (-)ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR591 COSMIC
Ensembl Genes ENSG00000208025 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385290 ENTREZGENE
GTEx ENSG00000208025 GTEx
HGNC ID HGNC:32847 ENTREZGENE
Human Proteome Map MIR591 Human Proteome Map
miRBase MI0003603 ENTREZGENE
NCBI Gene 693176 ENTREZGENE
PharmGKB PA164722888 PharmGKB
RNAcentral URS000075D670 RNACentral
  URS000075DDAA RNACentral