MIR599 (microRNA 599) - Rat Genome Database

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Gene: MIR599 (microRNA 599) Homo sapiens
Analyze
Symbol: MIR599
Name: microRNA 599
RGD ID: 1603077
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-599; MIRN599
RGD Orthologs
Mouse
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl899,536,636 - 99,536,730 (-)EnsemblGRCh38hg38GRCh38
GRCh38899,536,636 - 99,536,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378100,548,864 - 100,548,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368100,618,039 - 100,618,133 (-)NCBINCBI36hg18NCBI36
Celera896,734,598 - 96,734,692 (-)NCBI
Cytogenetic Map8q22.2NCBI
HuRef895,751,798 - 95,751,892 (-)NCBIHuRef
CHM1_18100,589,807 - 100,589,901 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Cohen syndrome  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:26551255   PMID:28597372   PMID:29568870   PMID:30720180   PMID:31307174   PMID:31565805  


Genomics

Comparative Map Data
MIR599
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl899,536,636 - 99,536,730 (-)EnsemblGRCh38hg38GRCh38
GRCh38899,536,636 - 99,536,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378100,548,864 - 100,548,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368100,618,039 - 100,618,133 (-)NCBINCBI36hg18NCBI36
Celera896,734,598 - 96,734,692 (-)NCBI
Cytogenetic Map8q22.2NCBI
HuRef895,751,798 - 95,751,892 (-)NCBIHuRef
CHM1_18100,589,807 - 100,589,901 (-)NCBICHM1_1
Mir599
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391535,660,977 - 35,661,064 (-)NCBIGRCm39mm39
GRCm39 Ensembl1535,660,977 - 35,661,064 (-)Ensembl
GRCm381535,660,831 - 35,660,918 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1535,660,831 - 35,660,918 (-)EnsemblGRCm38mm10GRCm38
Celera1536,281,665 - 36,281,752 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.46NCBI
MIR599
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,538,928 - 1,539,022 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,538,928 - 1,539,022 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,534,530 - 1,534,624 (-)NCBI
ROS_Cfam_1.0131,691,779 - 1,691,873 (-)NCBI
UMICH_Zoey_3.1131,534,225 - 1,534,319 (-)NCBI
UNSW_CanFamBas_1.0131,647,416 - 1,647,510 (-)NCBI
UU_Cfam_GSD_1.0131,648,910 - 1,649,004 (-)NCBI

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:10153
Count of gene targets:4892
Count of transcripts:8560
Interacting mature miRNAs:hsa-miR-599
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 1 1
Low 15 20 19 7 45 7 23 10 14 12 31 22 4 12 1
Below cutoff 12 18 18 1 19 1 35 6 13 2 7 14 12 19

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385069
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,536,636 - 99,536,730 (-)Ensembl
RefSeq Acc Id: NR_030329
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,536,636 - 99,536,730 (-)NCBI
GRCh378100,548,864 - 100,548,958 (-)RGD
Celera896,734,598 - 96,734,692 (-)RGD
HuRef895,751,798 - 95,751,892 (-)RGD
CHM1_18100,589,807 - 100,589,901 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.2(chr8:99394612-99622937)x1 copy number loss See cases [RCV000141776] Chr8:99394612..99622937 [GRCh38]
Chr8:100406840..100635165 [GRCh37]
Chr8:100476016..100704341 [NCBI36]
Chr8:8q22.2
likely benign|uncertain significance
GRCh38/hg38 8q22.2(chr8:99055243-99917250)x1 copy number loss See cases [RCV000142353] Chr8:99055243..99917250 [GRCh38]
Chr8:100067471..100929478 [GRCh37]
Chr8:100136647..100998654 [NCBI36]
Chr8:8q22.2
uncertain significance
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NC_000008.11:g.(?_99274178)_(99721067_?)del deletion Cohen syndrome [RCV000634143] Chr8:99274178..99721067 [GRCh38]
Chr8:100286406..100733295 [GRCh37]
Chr8:8q22.2
pathogenic
NC_000008.11:g.(?_99096292)_(99577653_?)del deletion Cohen syndrome [RCV000708473] Chr8:99096292..99577653 [GRCh38]
Chr8:100108520..100589881 [GRCh37]
Chr8:8q22.2
pathogenic
NC_000008.11:g.(?_99431517)_(99721067_?)del deletion Cohen syndrome [RCV000708289] Chr8:99431517..99721067 [GRCh38]
Chr8:100443745..100733295 [GRCh37]
Chr8:8q22.2
pathogenic
NC_000008.11:g.(?_99274178)_(99577653_?)del deletion Cohen syndrome [RCV000813964] Chr8:99274178..99577653 [GRCh38]
Chr8:100286406..100589881 [GRCh37]
Chr8:8q22.2
pathogenic
NC_000008.11:g.(?_99384188)_(99721067_?)del deletion Cohen syndrome [RCV000822545] Chr8:99384188..99721067 [GRCh38]
Chr8:100396416..100733295 [GRCh37]
Chr8:8q22.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32855 AgrOrtholog
COSMIC MIR599 COSMIC
Ensembl Genes ENSG00000207804 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385069 ENTREZGENE
GTEx ENSG00000207804 GTEx
HGNC ID HGNC:32855 ENTREZGENE
Human Proteome Map MIR599 Human Proteome Map
miRBase MI0003611 ENTREZGENE
NCBI Gene 693184 ENTREZGENE
PharmGKB PA164722895 PharmGKB
RNAcentral URS0000728487 RNACentral
  URS000075A123 RNACentral