MIR608 (microRNA 608) - Rat Genome Database

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Gene: MIR608 (microRNA 608) Homo sapiens
Analyze
Symbol: MIR608
Name: microRNA 608
RGD ID: 1603068
HGNC Page HGNC:32864
Description: Enables mRNA base-pairing translational repressor activity. Involved in miRNA-mediated gene silencing by mRNA destabilization.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-608; MIRN608
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,974,985 - 100,975,084 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,974,985 - 100,975,084 (+)EnsemblGRCh38hg38GRCh38
GRCh3710102,734,742 - 102,734,841 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,724,731 - 102,724,830 (+)NCBINCBI36Build 36hg18NCBI36
Celera1096,472,463 - 96,472,562 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1096,363,755 - 96,363,854 (+)NCBIHuRef
CHM1_110103,018,951 - 103,019,050 (+)NCBICHM1_1
T2T-CHM13v2.010101,858,360 - 101,858,459 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:19138993   PMID:19851984   PMID:20732906   PMID:22586447   PMID:22606253   PMID:23347277   PMID:23796562   PMID:24339958   PMID:24621885   PMID:24722204  
PMID:25190221   PMID:25368035   PMID:25385442   PMID:25700346   PMID:25861865   PMID:26474589   PMID:26646451   PMID:26815502   PMID:26886638   PMID:26935642   PMID:27031722   PMID:27223084  
PMID:27381831   PMID:27515039   PMID:27713147   PMID:28358823   PMID:28653886   PMID:28829821   PMID:28887583   PMID:29075783   PMID:29412127   PMID:29777702   PMID:29909406   PMID:29948421  
PMID:30070326   PMID:30453063   PMID:30552364   PMID:31043452   PMID:31389670   PMID:31485614   PMID:31749032   PMID:31913701   PMID:33147064   PMID:33402146   PMID:33523578   PMID:34918962  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_176792.2(MRPL43):c.611C>T (p.Pro204Leu) single nucleotide variant Malignant melanoma [RCV000061981] Chr10:100979290 [GRCh38]
Chr10:102739047 [GRCh37]
Chr10:102729037 [NCBI36]
Chr10:10q24.31
not provided
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1 copy number loss See cases [RCV000052565] Chr10:93181201..101356779 [GRCh38]
Chr10:94940958..103116536 [GRCh37]
Chr10:94930948..103106526 [NCBI36]
Chr10:10q23.33-24.32
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
CDC42hsa-miR-608Mirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//WFunctional MTI21149267
TP53hsa-miR-608Mirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)20542001
TP53hsa-miR-608Tarbaseexternal_infoqPCRNEGATIVE

Predicted Targets
Summary Value
Count of predictions:92905
Count of gene targets:22084
Count of transcripts:58766
Interacting mature miRNAs:hsa-miR-608
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Rnahybrid,Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 164 26 136 109 54 109 149 14 131 29 69 66 1 8 101 1
Below cutoff 162 50 74 43 58 40 206 47 164 22 70 47 4 27 126 2

Sequence


RefSeq Acc Id: ENST00000384820
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10100,974,985 - 100,975,084 (+)Ensembl
RefSeq Acc Id: NR_030339
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810100,974,985 - 100,975,084 (+)NCBI
GRCh3710102,734,742 - 102,734,841 (+)RGD
Celera1096,472,463 - 96,472,562 (+)RGD
HuRef1096,363,755 - 96,363,854 (+)ENTREZGENE
CHM1_110103,018,951 - 103,019,050 (+)NCBI
T2T-CHM13v2.010101,858,360 - 101,858,459 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR608 COSMIC
Ensembl Genes ENSG00000207551 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384820 ENTREZGENE
GTEx ENSG00000207551 GTEx
HGNC ID HGNC:32864 ENTREZGENE
Human Proteome Map MIR608 Human Proteome Map
miRBase MI0003621 ENTREZGENE
NCBI Gene 693193 ENTREZGENE
PharmGKB PA164722904 PharmGKB
RNAcentral URS000075A578 RNACentral
  URS000075EBEF RNACentral