FAM169BP (family with sequence similarity 169 member B, pseudogene) - Rat Genome Database

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Gene: FAM169BP (family with sequence similarity 169 member B, pseudogene) Homo sapiens
Analyze
Symbol: FAM169BP
Name: family with sequence similarity 169 member B, pseudogene
RGD ID: 1602962
HGNC Page HGNC:26835
Description: INTERACTS WITH aflatoxin B1; Aflatoxin B2 alpha; benzo[a]pyrene
Type: pseudo (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Previously known as: FAM169B; family with sequence similarity 169 member B; family with sequence similarity 169, member B; FLJ39743; hypothetical protein LOC283777
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381598,437,162 - 98,514,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1598,441,071 - 98,520,386 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1598,437,162 - 98,514,382 (-)EnsemblGRCh38hg38GRCh38
GRCh371598,980,391 - 99,057,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361596,797,914 - 96,875,134 (-)NCBINCBI36Build 36hg18NCBI36
Celera1575,398,171 - 75,475,245 (-)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1575,108,821 - 75,185,983 (-)NCBIHuRef
CHM1_11598,821,961 - 98,899,182 (-)NCBICHM1_1
T2T-CHM13v2.01596,201,545 - 96,278,778 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:21935397   PMID:22354554   PMID:33961781  


Genomics

Comparative Map Data
FAM169BP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381598,437,162 - 98,514,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1598,441,071 - 98,520,386 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1598,437,162 - 98,514,382 (-)EnsemblGRCh38hg38GRCh38
GRCh371598,980,391 - 99,057,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361596,797,914 - 96,875,134 (-)NCBINCBI36Build 36hg18NCBI36
Celera1575,398,171 - 75,475,245 (-)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1575,108,821 - 75,185,983 (-)NCBIHuRef
CHM1_11598,821,961 - 98,899,182 (-)NCBICHM1_1
T2T-CHM13v2.01596,201,545 - 96,278,778 (-)NCBIT2T-CHM13v2.0
Fam169b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39767,923,587 - 68,012,837 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl767,923,587 - 68,012,840 (+)EnsemblGRCm39 Ensembl
GRCm38768,273,839 - 68,363,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl768,273,839 - 68,363,092 (+)EnsemblGRCm38mm10GRCm38
MGSCv37775,418,725 - 75,507,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36768,174,346 - 68,236,602 (+)NCBIMGSCv36mm8
Celera765,730,746 - 65,819,701 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.49NCBI
Fam169b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81131,288,780 - 131,378,548 (+)NCBIGRCr8
mRatBN7.21121,878,670 - 121,968,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1121,878,713 - 121,958,470 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01129,254,242 - 129,336,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,255,396 - 129,334,292 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01130,313,012 - 130,392,159 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41123,056,102 - 123,114,691 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1114,076,719 - 114,158,704 (+)NCBICelera
Cytogenetic Map1q22NCBI
Fam169b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541625,886,592 - 26,061,346 (-)NCBIChiLan1.0ChiLan1.0
FAM169BP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21687,982,226 - 88,066,541 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11591,681,639 - 91,729,196 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01577,122,837 - 77,169,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11596,308,725 - 96,382,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1596,308,725 - 96,356,249 (-)Ensemblpanpan1.1panPan2
LOC608120
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1342,146,398 - 42,242,555 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha344,854,804 - 44,942,158 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0342,564,174 - 42,652,279 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl342,563,903 - 42,652,275 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1342,079,896 - 42,175,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0342,310,780 - 42,407,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0342,539,406 - 42,626,978 (+)NCBIUU_Cfam_GSD_1.0
FAM169B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11137,199,071 - 137,297,200 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,307,038 - 153,427,796 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231258
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12917,004,304 - 17,046,698 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605929,543,287 - 29,583,560 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam169b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247685,720,560 - 5,793,773 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FAM169BP
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q26.3(chr15:98364684-99338342)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052366]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052366]|See cases [RCV000052366] Chr15:98364684..99338342 [GRCh38]
Chr15:98907913..99878547 [GRCh37]
Chr15:96725436..97696070 [NCBI36]
Chr15:15q26.3
pathogenic
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3
pathogenic
NM_182562.2(FAM169B):c.367+2923G>A single nucleotide variant Lung cancer [RCV000099790] Chr15:98448905 [GRCh38]
Chr15:98992134 [GRCh37]
Chr15:15q26.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2166
Count of miRNA genes:671
Interacting mature miRNAs:752
Transcripts:ENST00000332908, ENST00000558256
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-145589  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371599,025,552 - 99,025,877UniSTSGRCh37
Build 361596,843,075 - 96,843,400RGDNCBI36
Celera1575,443,167 - 75,443,492RGD
Cytogenetic Map15q26.3UniSTS
HuRef1575,154,048 - 75,154,373UniSTS
TNG Radiation Hybrid Map1540925.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 2 12 12 12
Low 238 791 161 153 192 153 385 12 293 24 386 3 93 318
Below cutoff 1805 1657 972 206 1042 69 2947 1457 2547 95 700 891 137 947 1915

Sequence


RefSeq Acc Id: ENST00000558256
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1598,437,162 - 98,514,382 (-)Ensembl
RefSeq Acc Id: ENST00000636796
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1598,441,071 - 98,520,386 (-)Ensembl
RefSeq Acc Id: ENST00000637259
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1598,518,800 - 98,547,728 (-)Ensembl
RefSeq Acc Id: NR_171054
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381598,437,162 - 98,514,336 (-)NCBI
T2T-CHM13v2.01596,201,545 - 96,278,778 (-)NCBI
Sequence:
Protein Sequences
GenBank Protein BAC04940 (Get FASTA)   NCBI Sequence Viewer  
  Q8N8A8 (Get FASTA)   NCBI Sequence Viewer  

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N8A8-F1-model_v2 AlphaFold Q8N8A8 1-192 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26835 AgrOrtholog
COSMIC FAM169BP COSMIC
Ensembl Genes ENSG00000283597 Ensembl
  ENSG00000293555 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000558256 ENTREZGENE
GTEx ENSG00000283597 GTEx
  ENSG00000293555 GTEx
HGNC ID HGNC:26835 ENTREZGENE
Human Proteome Map FAM169BP Human Proteome Map
InterPro FAM169 UniProtKB/Swiss-Prot
NCBI Gene 283777 ENTREZGENE
PANTHER PTHR22442 UniProtKB/Swiss-Prot
  PTHR22442:SF4 UniProtKB/Swiss-Prot
PharmGKB PA162387148 PharmGKB
UniProt F169B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B5MDL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-13 FAM169BP  family with sequence similarity 169 member B, pseudogene  FAM169B  family with sequence similarity 169 member B  Symbol and/or name change 19259463 PROVISIONAL
2015-11-24 FAM169B  family with sequence similarity 169 member B    family with sequence similarity 169, member B  Symbol and/or name change 5135510 APPROVED