MIR630 (microRNA 630) - Rat Genome Database

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Gene: MIR630 (microRNA 630) Homo sapiens
Analyze
Symbol: MIR630
Name: microRNA 630
RGD ID: 1602923
HGNC Page HGNC:32886
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-630; MIRN630
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381572,587,217 - 72,587,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1572,587,217 - 72,587,313 (+)EnsemblGRCh38hg38GRCh38
GRCh371572,879,558 - 72,879,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361570,666,611 - 70,666,707 (+)NCBINCBI36Build 36hg18NCBI36
Celera1549,764,276 - 49,764,372 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1549,710,216 - 49,710,312 (+)NCBIHuRef
CHM1_11572,997,502 - 72,997,598 (+)NCBICHM1_1
T2T-CHM13v2.01570,404,494 - 70,404,590 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:23675407   PMID:24621930   PMID:24655723   PMID:24909689   PMID:24981248   PMID:25031755   PMID:25255219   PMID:25731670   PMID:26263387   PMID:26345808  
PMID:26595523   PMID:26725326   PMID:26940839   PMID:26993767   PMID:27040767   PMID:27163713   PMID:27563011   PMID:27752905   PMID:28601080   PMID:28657541   PMID:29131262   PMID:29208462  
PMID:29452092   PMID:29507618   PMID:30475754   PMID:30964171   PMID:31749230   PMID:31869263   PMID:32888124   PMID:33324395   PMID:33506896   PMID:34011217   PMID:34018619   PMID:34545623  
PMID:35008480   PMID:35676548   PMID:36277475   PMID:38132173  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q23-24.1(chr15:72366869-72671688)x1 copy number loss See cases [RCV000136699] Chr15:72366869..72671688 [GRCh38]
Chr15:72659210..72964029 [GRCh37]
Chr15:70446264..70751082 [NCBI36]
Chr15:15q23-24.1		 pathogenic|uncertain significance
GRCh38/hg38 15q23-25.1(chr15:70025300-78705993)x1 copy number loss See cases [RCV000141666] Chr15:70025300..78705993 [GRCh38]
Chr15:70317639..78998335 [GRCh37]
Chr15:68104693..76785390 [NCBI36]
Chr15:15q23-25.1		 pathogenic
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3		 pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh38/hg38 15q23-24.1(chr15:68830574-73823337)x1 copy number loss See cases [RCV000050780] Chr15:68830574..73823337 [GRCh38]
Chr15:69122913..74115678 [GRCh37]
Chr15:66909967..71902731 [NCBI36]
Chr15:15q23-24.1		 pathogenic
GRCh38/hg38 15q23-24.2(chr15:70788624-76057736)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053219]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053219]|See cases [RCV000053219] Chr15:70788624..76057736 [GRCh38]
Chr15:71080963..76350077 [GRCh37]
Chr15:68868017..74137132 [NCBI36]
Chr15:15q23-24.2		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BCL2hsa-miR-630Mirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI21274007
SNAI2hsa-miR-630Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23434592
SNAI2hsa-miR-630Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23435373

Predicted Targets
Summary Value
Count of predictions:11459
Count of gene targets:5101
Count of transcripts:9162
Interacting mature miRNAs:hsa-miR-630
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
A004P07  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371572,877,575 - 72,877,840UniSTSGRCh37
Build 361570,664,629 - 70,664,894RGDNCBI36
Celera1549,762,293 - 49,762,558RGD
Cytogenetic Map15q24UniSTS
Cytogenetic Map15q24.1UniSTS
HuRef1549,708,233 - 49,708,498UniSTS
GeneMap99-GB4 RH Map15256.87UniSTS
NCBI RH Map15486.2UniSTS
RH47216  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371572,878,548 - 72,878,695UniSTSGRCh37
Build 361570,665,602 - 70,665,749RGDNCBI36
Celera1549,763,266 - 49,763,413RGD
Cytogenetic Map15q24UniSTS
Cytogenetic Map15q24.1UniSTS
HuRef1549,709,206 - 49,709,353UniSTS
GeneMap99-GB4 RH Map15253.26UniSTS
NCBI RH Map15436.8UniSTS
SHGC-36787  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371572,877,748 - 72,877,851UniSTSGRCh37
Build 361570,664,802 - 70,664,905RGDNCBI36
Celera1549,762,466 - 49,762,569RGD
Cytogenetic Map15q24UniSTS
Cytogenetic Map15q24.1UniSTS
HuRef1549,708,406 - 49,708,509UniSTS
Stanford-G3 RH Map152515.0UniSTS
GeneMap99-G3 RH Map152510.0UniSTS
SHGC-34211  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371572,878,547 - 72,878,696UniSTSGRCh37
Build 361570,665,601 - 70,665,750RGDNCBI36
Celera1549,763,265 - 49,763,414RGD
Cytogenetic Map15q24UniSTS
Cytogenetic Map15q24.1UniSTS
HuRef1549,709,205 - 49,709,354UniSTS
TNG Radiation Hybrid Map1527913.0UniSTS
GeneMap99-GB4 RH Map15255.26UniSTS
Whitehead-RH Map15247.2UniSTS
NCBI RH Map15440.4UniSTS
GeneMap99-G3 RH Map152510.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384957
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1572,587,217 - 72,587,313 (+)Ensembl
RefSeq Acc Id: NR_030359
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381572,587,217 - 72,587,313 (+)NCBI
GRCh371572,879,558 - 72,879,654 (+)RGD
Celera1549,764,276 - 49,764,372 (+)RGD
HuRef1549,710,216 - 49,710,312 (+)ENTREZGENE
CHM1_11572,997,502 - 72,997,598 (+)NCBI
T2T-CHM13v2.01570,404,494 - 70,404,590 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR630 COSMIC
Ensembl Genes ENSG00000283798 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384957 ENTREZGENE
GTEx ENSG00000283798 GTEx
HGNC ID HGNC:32886 ENTREZGENE
Human Proteome Map MIR630 Human Proteome Map
miRBase MI0003644 ENTREZGENE
NCBI Gene 693215 ENTREZGENE
PharmGKB PA164722926 PharmGKB
RNAcentral URS000075A45A RNACentral
  URS000075AFB4 RNACentral