CCDC87 (coiled-coil domain containing 87) - Rat Genome Database

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Gene: CCDC87 (coiled-coil domain containing 87) Homo sapiens
Analyze
Symbol: CCDC87
Name: coiled-coil domain containing 87
RGD ID: 1602481
HGNC Page HGNC
Description: Predicted to be involved in positive regulation of acrosome reaction and positive regulation of fertilization; INTERACTS WITH benzo[a]pyrene; sunitinib; urethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: coiled-coil domain-containing protein 87; FLJ10786
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1166,590,176 - 66,593,063 (-)EnsemblGRCh38hg38GRCh38
GRCh381166,590,176 - 66,593,063 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,357,647 - 66,360,534 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,114,216 - 66,117,130 (-)NCBINCBI36hg18NCBI36
Cytogenetic Map11q13.2NCBI
HuRef1162,685,282 - 62,688,197 (-)NCBIHuRef
CHM1_11166,241,371 - 66,244,285 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:16189514   PMID:17643375   PMID:21926972   PMID:23443559   PMID:25416956   PMID:25814554   PMID:26949251   PMID:27591049   PMID:29507755   PMID:29676528  
PMID:29733332   PMID:32296183  


Genomics

Comparative Map Data
CCDC87
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1166,590,176 - 66,593,063 (-)EnsemblGRCh38hg38GRCh38
GRCh381166,590,176 - 66,593,063 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,357,647 - 66,360,534 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,114,216 - 66,117,130 (-)NCBINCBI36hg18NCBI36
Cytogenetic Map11q13.2NCBI
HuRef1162,685,282 - 62,688,197 (-)NCBIHuRef
CHM1_11166,241,371 - 66,244,285 (-)NCBICHM1_1
Ccdc87
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,889,394 - 4,892,556 (+)NCBIGRCm39mm39
GRCm39 Ensembl194,889,394 - 4,892,556 (+)Ensembl
GRCm38194,839,366 - 4,842,528 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,839,366 - 4,842,528 (+)EnsemblGRCm38mm10GRCm38
MGSCv37194,839,366 - 4,842,528 (+)NCBIGRCm37mm9NCBIm37
MGSCv36194,839,415 - 4,842,163 (+)NCBImm8
Celera194,710,421 - 4,713,583 (+)NCBICelera
Cytogenetic Map19ANCBI
Ccdc87
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,135,021 - 202,137,717 (+)NCBI
Rnor_6.0 Ensembl1220,096,422 - 220,099,611 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01220,096,478 - 220,099,174 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,027,475 - 227,030,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,451,155 - 207,453,851 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1199,675,524 - 199,678,217 (+)NCBICelera
Cytogenetic Map1q43NCBI
Ccdc87
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542218,772,869 - 18,775,548 (+)NCBIChiLan1.0ChiLan1.0
CCDC87
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11165,270,801 - 65,273,720 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01161,946,954 - 61,949,840 (-)NCBIMhudiblu_PPA_v0panPan3
CCDC87
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,759,378 - 50,762,205 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,759,436 - 50,762,057 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,368,112 - 49,370,929 (+)NCBI
ROS_Cfam_1.01851,790,913 - 51,793,730 (+)NCBI
UMICH_Zoey_3.11850,892,297 - 50,895,114 (+)NCBI
UNSW_CanFamBas_1.01850,472,130 - 50,474,948 (+)NCBI
UU_Cfam_GSD_1.01851,261,982 - 51,264,800 (+)NCBI
Ccdc87
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,562,699 - 6,565,919 (+)NCBI
SpeTri2.0NW_0049365993,005,067 - 3,008,053 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC87
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,833,464 - 5,836,686 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,833,431 - 5,838,922 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,863,943 - 4,867,188 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC87
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,686,514 - 7,689,390 (+)NCBI
ChlSab1.1 Ensembl17,686,575 - 7,689,061 (+)Ensembl
Vero_WHO_p1.0NW_023666038104,970,062 - 104,972,985 (+)NCBI
Ccdc87
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476719,815,664 - 19,818,796 (+)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:154
Interacting mature miRNAs:156
Transcripts:ENST00000333861
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 361 1
Low 587 95 890 87 128 64 471 382 1117 209 397 746 33 8 283 1
Below cutoff 1809 2434 801 508 1368 374 3745 1701 2583 201 677 781 139 1 1135 2405 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000333861   ⟹   ENSP00000328487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1166,590,176 - 66,593,063 (-)Ensembl
RefSeq Acc Id: NM_018219   ⟹   NP_060689
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381166,590,176 - 66,593,063 (-)NCBI
GRCh371166,357,640 - 66,360,554 (-)RGD
Build 361166,114,216 - 66,117,130 (-)NCBI Archive
HuRef1162,685,282 - 62,688,197 (-)ENTREZGENE
CHM1_11166,241,371 - 66,244,285 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_060689 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH34469 (Get FASTA)   NCBI Sequence Viewer  
  BAA91808 (Get FASTA)   NCBI Sequence Viewer  
  Q9NVE4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_060689   ⟸   NM_018219
- UniProtKB: Q9NVE4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000328487   ⟸   ENST00000333861


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.2(chr11:66193502-67890770)x3 copy number gain See cases [RCV000053623] Chr11:66193502..67890770 [GRCh38]
Chr11:65960973..67658241 [GRCh37]
Chr11:65717549..67414817 [NCBI36]
Chr11:11q13.2
pathogenic
NM_018219.2(CCDC87):c.544C>T (p.Leu182=) single nucleotide variant Malignant melanoma [RCV000069622] Chr11:66592472 [GRCh38]
Chr11:66359943 [GRCh37]
Chr11:66116519 [NCBI36]
Chr11:11q13.2
not provided
NM_018219.2(CCDC87):c.1620C>T (p.Ile540=) single nucleotide variant Malignant melanoma [RCV000062329] Chr11:66591396 [GRCh38]
Chr11:66358867 [GRCh37]
Chr11:66115443 [NCBI36]
Chr11:11q13.2
not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh38/hg38 11q13.1-13.2(chr11:65741431-67705669)x1 copy number loss See cases [RCV000142881] Chr11:65741431..67705669 [GRCh38]
Chr11:65508902..67473140 [GRCh37]
Chr11:65265478..67229716 [NCBI36]
Chr11:11q13.1-13.2
pathogenic
GRCh37/hg19 11q13.2(chr11:66024774-67430781)x3 copy number gain See cases [RCV000240374] Chr11:66024774..67430781 [GRCh37]
Chr11:11q13.2
uncertain significance
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:65138976-67574402) copy number gain not provided [RCV000767601] Chr11:65138976..67574402 [GRCh37]
Chr11:11q13.1-13.2
pathogenic
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Epilepsy, familial temporal lobe, 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25579 AgrOrtholog
COSMIC CCDC87 COSMIC
Ensembl Genes ENSG00000182791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000328487 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000333861 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000182791 GTEx
HGNC ID HGNC:25579 ENTREZGENE
Human Proteome Map CCDC87 Human Proteome Map
InterPro CCDC87 UniProtKB/Swiss-Prot
KEGG Report hsa:55231 UniProtKB/Swiss-Prot
NCBI Gene 55231 ENTREZGENE
PANTHER PTHR16078 UniProtKB/Swiss-Prot
PharmGKB PA144596455 PharmGKB
UniProt CCD87_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8NE76 UniProtKB/Swiss-Prot