CCNP (cyclin P) - Rat Genome Database

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Gene: CCNP (cyclin P) Homo sapiens
Analyze
Symbol: CCNP
Name: cyclin P
RGD ID: 1602462
HGNC Page HGNC:25805
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition. Located in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CNTD2; cyclin N-terminal domain containing 2; cyclin N-terminal domain-containing protein 2; cyclin-P; FLJ13265
RGD Orthologs
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,222,208 - 40,226,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,222,208 - 40,226,697 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,728,115 - 40,732,596 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,419,962 - 45,424,404 (-)NCBINCBI36Build 36hg18NCBI36
Celera1937,527,663 - 37,532,144 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,163,049 - 37,167,531 (-)NCBIHuRef
CHM1_11940,727,792 - 40,732,274 (-)NCBICHM1_1
T2T-CHM13v2.01943,042,709 - 43,047,189 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References
Additional References at PubMed
PMID:8889548   PMID:11237006   PMID:14702039   PMID:21873635   PMID:28860486   PMID:30087414   PMID:34604945  


Genomics

Comparative Map Data
CCNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,222,208 - 40,226,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,222,208 - 40,226,697 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,728,115 - 40,732,596 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,419,962 - 45,424,404 (-)NCBINCBI36Build 36hg18NCBI36
Celera1937,527,663 - 37,532,144 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,163,049 - 37,167,531 (-)NCBIHuRef
CHM1_11940,727,792 - 40,732,274 (-)NCBICHM1_1
T2T-CHM13v2.01943,042,709 - 43,047,189 (-)NCBIT2T-CHM13v2.0
Gm9881
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,963,733 - 90,968,496 (-)NCBIGRCm39GRCm39mm39
GRCm381691,166,845 - 91,171,608 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371691,168,442 - 91,171,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1692,251,763 - 92,254,980 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1652.52NCBI
Ccnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555781,009,159 - 1,013,368 (+)NCBIChiLan1.0ChiLan1.0
CCNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,481,470 - 46,486,450 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,351,363 - 48,357,050 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,266,426 - 37,271,829 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,782,036 - 45,786,916 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,782,042 - 45,786,916 (-)Ensemblpanpan1.1panPan2
CCNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,412,012 - 113,417,046 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,415,225 - 113,416,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,813,171 - 112,819,026 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,010,063 - 114,015,921 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,012,394 - 114,015,150 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,569,630 - 113,574,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,201,554 - 113,207,403 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,195,410 - 114,201,284 (+)NCBIUU_Cfam_GSD_1.0
Ccnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,215,832 - 14,222,396 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366612,643,546 - 2,648,600 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,680,996 - 34,685,550 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607312,774,130 - 12,778,292 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624925254,903 - 268,695 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCNP
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.12-13.2(chr19:37319377-42738688)x3 copy number gain See cases [RCV000050636] Chr19:37319377..42738688 [GRCh38]
Chr19:37810279..43242840 [GRCh37]
Chr19:42502119..47934680 [NCBI36]
Chr19:19q13.12-13.2		 pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh37/hg19 19q13.12-13.2(chr19:37582250-41630908)x3 copy number gain See cases [RCV000239839] Chr19:37582250..41630908 [GRCh37]
Chr19:19q13.12-13.2		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19q13.2(chr19:40636400-41060616)x3 copy number gain not provided [RCV000752683] Chr19:40636400..41060616 [GRCh37]
Chr19:19q13.2		 benign
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
NC_000019.9:g.(?_39904727)_(42931301_?)dup duplication Diamond-Blackfan anemia [RCV003122291]|MEGF8-related Carpenter syndrome [RCV003105286]|Maple syrup urine disease [RCV003105287]|TWIST1-related craniosynostosis [RCV003105285] Chr19:39904727..42931301 [GRCh37]
Chr19:19q13.2		 uncertain significance
NC_000019.9:g.(?_39205089)_(40913839_?)dup duplication Type 2 diabetes mellitus [RCV003107444]|not provided [RCV003122562] Chr19:39205089..40913839 [GRCh37]
Chr19:19q13.2		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3 copy number gain Specific learning disability [RCV001801194] Chr19:19546923..41313229 [GRCh37]
Chr19:19p13.11-q13.2		 pathogenic
NM_024877.4(CCNP):c.403C>A (p.Leu135Met) single nucleotide variant Inborn genetic diseases [RCV003201096] Chr19:40224598 [GRCh38]
Chr19:40730505 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_024877.4(CCNP):c.632G>A (p.Cys211Tyr) single nucleotide variant Inborn genetic diseases [RCV003175176] Chr19:40223428 [GRCh38]
Chr19:40729335 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_024877.4(CCNP):c.203C>A (p.Ala68Glu) single nucleotide variant Inborn genetic diseases [RCV003345218] Chr19:40226439 [GRCh38]
Chr19:40732346 [GRCh37]
Chr19:19q13.2		 uncertain significance
GRCh37/hg19 19q11-13.2(chr19:28271146-41508851)x3 copy number gain not specified [RCV003986115] Chr19:28271146..41508851 [GRCh37]
Chr19:19q11-13.2		 pathogenic
NM_024877.4(CCNP):c.774G>T (p.Ala258=) single nucleotide variant CCNP-related condition [RCV003904075] Chr19:40223202 [GRCh38]
Chr19:40729109 [GRCh37]
Chr19:19q13.2		 likely benign
NM_024877.4(CCNP):c.89G>A (p.Ser30Asn) single nucleotide variant CCNP-related condition [RCV003964401] Chr19:40226553 [GRCh38]
Chr19:40732460 [GRCh37]
Chr19:19q13.2		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2262
Count of miRNA genes:803
Interacting mature miRNAs:933
Transcripts:ENST00000221818, ENST00000430325, ENST00000433940, ENST00000513948, ENST00000593335, ENST00000599263
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D2S2333  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37285,488,173 - 85,488,426UniSTSGRCh37
Build 36285,341,684 - 85,341,937RGDNCBI36
Celera285,316,486 - 85,316,739RGD
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map2p12-q22UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map2p12-p11.1UniSTS
HuRef285,384,880 - 85,385,137UniSTS
Marshfield Genetic Map2103.16UniSTS
Marshfield Genetic Map2103.16RGD
Genethon Genetic Map2107.7UniSTS
TNG Radiation Hybrid Map253524.0UniSTS
deCODE Assembly Map2108.81UniSTS
Stanford-G3 RH Map23607.0UniSTS
GeneMap99-G3 RH Map23518.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 36 100 28 15 28 1 493 23 40 72
Low 1139 628 1496 383 445 371 2069 659 2630 195 1179 1130 21 1044 1035 1
Below cutoff 1246 2283 121 203 1133 60 2256 1506 599 171 225 394 150 1 160 1737 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001411133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047439455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047439456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047439457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054322204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054322205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054322206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001753763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_935861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI924992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM709160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU732215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000221818   ⟹   ENSP00000221818
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1940,222,215 - 40,226,657 (-)Ensembl
RefSeq Acc Id: ENST00000430325   ⟹   ENSP00000396755
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1940,222,208 - 40,226,689 (-)Ensembl
RefSeq Acc Id: ENST00000513948   ⟹   ENSP00000425529
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1940,223,048 - 40,224,937 (-)Ensembl
RefSeq Acc Id: ENST00000593335
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1940,222,214 - 40,223,564 (-)Ensembl
RefSeq Acc Id: ENST00000599263   ⟹   ENSP00000470643
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1940,222,208 - 40,226,697 (-)Ensembl
RefSeq Acc Id: NM_001411133   ⟹   NP_001398062
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381940,222,208 - 40,226,689 (-)NCBI
T2T-CHM13v2.01943,042,709 - 43,047,189 (-)NCBI
RefSeq Acc Id: NM_024877   ⟹   NP_079153
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381940,222,208 - 40,226,689 (-)NCBI
GRCh371940,728,115 - 40,732,674 (-)NCBI
Build 361945,419,962 - 45,424,404 (-)NCBI Archive
Celera1937,527,663 - 37,532,144 (-)RGD
HuRef1937,163,049 - 37,167,531 (-)RGD
CHM1_11940,727,792 - 40,732,274 (-)NCBI
T2T-CHM13v2.01943,042,709 - 43,047,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047439455   ⟹   XP_047295411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381940,223,457 - 40,226,689 (-)NCBI
RefSeq Acc Id: XM_047439456   ⟹   XP_047295412
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381940,223,457 - 40,226,689 (-)NCBI
RefSeq Acc Id: XM_047439457   ⟹   XP_047295413
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381940,223,457 - 40,226,689 (-)NCBI
RefSeq Acc Id: XM_054322204   ⟹   XP_054178179
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01943,043,958 - 43,047,189 (-)NCBI
RefSeq Acc Id: XM_054322205   ⟹   XP_054178180
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01943,043,958 - 43,047,189 (-)NCBI
RefSeq Acc Id: XM_054322206   ⟹   XP_054178181
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01943,043,958 - 43,047,189 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_079153   ⟸   NM_024877
- Peptide Label: isoform 2
- UniProtKB: B4DX65 (UniProtKB/Swiss-Prot),   Q9H8S5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000470643   ⟸   ENST00000599263
RefSeq Acc Id: ENSP00000396755   ⟸   ENST00000430325
RefSeq Acc Id: ENSP00000221818   ⟸   ENST00000221818
RefSeq Acc Id: ENSP00000425529   ⟸   ENST00000513948
RefSeq Acc Id: XP_047295413   ⟸   XM_047439457
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047295412   ⟸   XM_047439456
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047295411   ⟸   XM_047439455
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001398062   ⟸   NM_001411133
- Peptide Label: isoform 3
- UniProtKB: M0QZM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054178181   ⟸   XM_054322206
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054178180   ⟸   XM_054322205
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054178179   ⟸   XM_054322204
- Peptide Label: isoform X1
Protein Domains
Cyclin C-terminal   Cyclin N-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H8S5-F1-model_v2 AlphaFold Q9H8S5 1-307 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25805 AgrOrtholog
COSMIC CCNP COSMIC
Ensembl Genes ENSG00000105219 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000221818 ENTREZGENE
  ENST00000221818.5 UniProtKB/Swiss-Prot
  ENST00000430325 ENTREZGENE
  ENST00000430325.7 UniProtKB/Swiss-Prot
  ENST00000513948.1 UniProtKB/TrEMBL
  ENST00000599263 ENTREZGENE
  ENST00000599263.6 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000105219 GTEx
HGNC ID HGNC:25805 ENTREZGENE
Human Proteome Map CCNP Human Proteome Map
InterPro Cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:79935 UniProtKB/Swiss-Prot
NCBI Gene 79935 ENTREZGENE
OMIM 620396 OMIM
PANTHER CYCLIN-P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DX65 ENTREZGENE
  CNTD2_HUMAN UniProtKB/Swiss-Prot
  D6RCS3_HUMAN UniProtKB/TrEMBL
  M0QZM5 ENTREZGENE, UniProtKB/TrEMBL
  Q9H8S5 ENTREZGENE
UniProt Secondary B4DX65 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-04 CCNP  cyclin P  CNTD2  cyclin N-terminal domain containing 2  Symbol and/or name change 5135510 APPROVED