DUOXA1 (dual oxidase maturation factor 1)

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Gene: DUOXA1 (dual oxidase maturation factor 1) Homo sapiens

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Symbol:

DUOXA1

Name:

dual oxidase maturation factor 1

RGD ID:

1602196

HGNC Page

HGNC:26507

Description:

Enables enzyme binding activity. Involved in positive regulation of hydrogen peroxide biosynthetic process and protein localization. Located in cell leading edge; endoplasmic reticulum; and plasma membrane.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

dual oxidase activator 1; dual oxidase maturation factor 1 alpha; dual oxidase maturation factor 1 beta; dual oxidase maturation factor 1 delta; dual oxidase maturation factor 1 gamma; FLJ32334; homolog of Drosophila Numb-interacting protein; mol; NIP; numb-interacting protein; NUMBIP

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Duoxa1 (dual oxidase maturation factor 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Duoxa1 (dual oxidase maturation factor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Duoxa1 (dual oxidase maturation factor 1)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	DUOXA1 (dual oxidase maturation factor 1)	NCBI	Ortholog
Canis lupus familiaris (dog):	DUOXA1 (dual oxidase maturation factor 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Duoxa1 (dual oxidase maturation factor 1)	NCBI	Ortholog
Sus scrofa (pig):	DUOXA1 (dual oxidase maturation factor 1)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	DUOXA1 (dual oxidase maturation factor 1)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Duoxa1 (dual oxidase maturation factor 1)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Duoxa1 (dual oxidase maturation factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Duoxa1 (dual oxidase maturation factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	duox2 (dual oxidase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	doxa-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mol	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus laevis (African clawed frog):	duoxa1.S	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	duoxa1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	duoxa1.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	45,117,366 - 45,129,879 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	45,117,366 - 45,129,938 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	45,409,564 - 45,422,077 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	43,196,977 - 43,209,349 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	22,301,120 - 22,313,493 (-)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	22,233,776 - 22,246,288 (-)	NCBI		HuRef
CHM1_1	15	45,527,897 - 45,540,408 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	42,925,387 - 42,937,902 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

AGAT deficiency (IAGP)

Bloom syndrome (IAGP)

colorectal cancer (IAGP)

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (EXP)

aflatoxin B1 (EXP)

Benzo[k]fluoranthene (ISO)

bisphenol A (ISO)

bromobenzene (ISO)

carbon nanotube (ISO)

CGP 52608 (EXP)

choline (ISO)

diazinon (EXP)

dimethylarsinic acid (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (EXP)

endosulfan (ISO)

epoxiconazole (ISO)

fipronil (ISO)

folic acid (ISO)

furan (ISO)

genistein (ISO)

glyphosate (ISO)

L-methionine (ISO)

methylarsonic acid (ISO)

nickel atom (EXP)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP,ISO)

rac-lactic acid (EXP)

resveratrol (EXP)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

sotorasib (EXP)

testosterone (ISO)

titanium dioxide (ISO)

trametinib (EXP)

trichloroethene (ISO)

troglitazone (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

hydrogen peroxide metabolic process (IEA,ISO)

positive regulation of hydrogen peroxide biosynthetic process (IMP)

positive regulation of neuron differentiation (IEA,ISO)

positive regulation of reactive oxygen species metabolic process (IEA,ISO)

protein localization (IGI)

protein transport (IEA)

regulation of inflammatory response (IEA,ISO)

regulation of thyroid hormone generation (IEA,ISO)

Cellular Component

cell leading edge (IGI)

endoplasmic reticulum (IDA)

endoplasmic reticulum membrane (IEA)

membrane (IBA,IEA)

plasma membrane (IDA,IEA)

Molecular Function

enzyme binding (IPI)

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:14670962	PMID:14702039	PMID:15489334	PMID:16651268	PMID:19074510	PMID:19322654	PMID:19339556	PMID:20060878	PMID:20122987	PMID:20407074
PMID:20826581	PMID:21362455	PMID:21367925	PMID:21873635	PMID:22814254	PMID:22874065	PMID:23010498	PMID:23033809	PMID:23503679	PMID:27262981	PMID:29704517	PMID:30745168
PMID:33420071

Genomics

Comparative Map Data

DUOXA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	45,117,366 - 45,129,879 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	45,117,366 - 45,129,938 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	45,409,564 - 45,422,077 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	43,196,977 - 43,209,349 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	22,301,120 - 22,313,493 (-)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	22,233,776 - 22,246,288 (-)	NCBI		HuRef
CHM1_1	15	45,527,897 - 45,540,408 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	42,925,387 - 42,937,902 (-)	NCBI		T2T-CHM13v2.0

Duoxa1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	122,134,012 - 122,144,255 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	122,132,672 - 122,144,211 (-)	Ensembl

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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