CIAO2A (cytosolic iron-sulfur assembly component 2A) - Rat Genome Database

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Gene: CIAO2A (cytosolic iron-sulfur assembly component 2A) Homo sapiens
Analyze
Symbol: CIAO2A
Name: cytosolic iron-sulfur assembly component 2A
RGD ID: 1602086
HGNC Page HGNC:26235
Description: Predicted to enable metal ion binding activity. Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytosol and nucleoplasm. Part of cytosolic [4Fe-4S] assembly targeting complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CIA2A; FAM96A; family with sequence similarity 96 member A; family with sequence similarity 96, member A; FLJ22875; MIP18 family protein FAM96A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CIAO2AP1   CIAO2AP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381564,072,565 - 64,093,838 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1564,072,565 - 64,094,262 (-)EnsemblGRCh38hg38GRCh38
GRCh371564,364,764 - 64,386,037 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,151,814 - 62,173,260 (-)NCBINCBI36Build 36hg18NCBI36
Celera1541,244,173 - 41,265,622 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1541,189,395 - 41,210,854 (-)NCBIHuRef
CHM1_11564,484,272 - 64,505,725 (-)NCBICHM1_1
T2T-CHM13v2.01561,879,723 - 61,900,991 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
2. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD and Lill R, Biochim Biophys Acta. 2015 Jun;1853(6):1528-39. doi: 10.1016/j.bbamcr.2014.12.018. Epub 2015 Jan 10.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:14702039   PMID:15146197   PMID:15489334   PMID:15851553   PMID:16189514   PMID:21516116   PMID:22683786   PMID:23891004   PMID:24981860   PMID:25416956  
PMID:25716227   PMID:26344197   PMID:28443470   PMID:28615450   PMID:32222833   PMID:32296183   PMID:33393230   PMID:33961781   PMID:34315543   PMID:35337019   PMID:35513087   PMID:35545034  
PMID:36966392   PMID:37536630  


Genomics

Comparative Map Data
CIAO2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381564,072,565 - 64,093,838 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1564,072,565 - 64,094,262 (-)EnsemblGRCh38hg38GRCh38
GRCh371564,364,764 - 64,386,037 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,151,814 - 62,173,260 (-)NCBINCBI36Build 36hg18NCBI36
Celera1541,244,173 - 41,265,622 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1541,189,395 - 41,210,854 (-)NCBIHuRef
CHM1_11564,484,272 - 64,505,725 (-)NCBICHM1_1
T2T-CHM13v2.01561,879,723 - 61,900,991 (-)NCBIT2T-CHM13v2.0
Ciao2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,033,878 - 66,046,250 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,033,893 - 66,046,237 (+)EnsemblGRCm39 Ensembl
GRCm38966,126,596 - 66,138,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,126,611 - 66,138,955 (+)EnsemblGRCm38mm10GRCm38
MGSCv37965,974,418 - 65,986,775 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36965,924,617 - 65,936,974 (+)NCBIMGSCv36mm8
Celera963,362,237 - 63,374,668 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map935.73NCBI
Ciao2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,565,620 - 75,577,542 (+)NCBIGRCr8
mRatBN7.2866,670,533 - 66,682,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,670,483 - 66,682,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx872,183,136 - 72,195,001 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0870,456,195 - 70,468,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,326,000 - 68,337,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0871,786,336 - 71,798,258 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,786,310 - 71,798,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0871,455,249 - 71,467,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4870,410,776 - 70,422,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,429,829 - 70,441,755 (+)NCBI
Celera866,058,924 - 66,070,845 (+)NCBICelera
Cytogenetic Map8q24NCBI
Ciao2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,306,099 - 11,331,758 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545011,306,099 - 11,327,688 (+)NCBIChiLan1.0ChiLan1.0
CIAO2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21653,327,864 - 53,351,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11557,503,133 - 57,526,346 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01543,025,577 - 43,047,013 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11561,317,188 - 61,338,337 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1561,317,188 - 61,338,337 (-)Ensemblpanpan1.1panPan2
CIAO2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13028,582,048 - 28,597,856 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3028,582,902 - 28,597,748 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3028,501,777 - 28,517,587 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03028,758,001 - 28,773,814 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3028,758,012 - 28,773,776 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13028,692,569 - 28,708,362 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03028,755,102 - 28,770,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,993,565 - 29,009,399 (-)NCBIUU_Cfam_GSD_1.0
Ciao2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,699,806 - 106,719,929 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647124,548,235 - 24,567,792 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647124,547,862 - 24,568,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIAO2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1107,951,646 - 107,969,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11107,951,618 - 107,969,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CIAO2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12619,448,702 - 19,470,212 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2619,448,903 - 19,469,756 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048121,923,113 - 121,945,326 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ciao2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247818,467,683 - 8,485,677 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247818,467,682 - 8,485,677 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CIAO2A
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
Single allele deletion Nemaline myopathy 6 [RCV000677940] Chr15:63414894..66439797 [GRCh37]
Chr15:15q22.2-22.31		 likely pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
NM_032231.7(CIAO2A):c.143G>A (p.Arg48Gln) single nucleotide variant not specified [RCV004314469] Chr15:64088833 [GRCh38]
Chr15:64381032 [GRCh37]
Chr15:15q22.31		 uncertain significance
NC_000015.9:g.(?_62146656)_(64747263_?)del deletion not provided [RCV003107781] Chr15:62146656..64747263 [GRCh37]
Chr15:15q22.2-22.31		 pathogenic
NM_032231.7(CIAO2A):c.23T>C (p.Leu8Pro) single nucleotide variant not specified [RCV004321051] Chr15:64093746 [GRCh38]
Chr15:64385945 [GRCh37]
Chr15:15q22.31		 uncertain significance
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
NM_032231.7(CIAO2A):c.313C>G (p.Gln105Glu) single nucleotide variant not specified [RCV004287076] Chr15:64081128 [GRCh38]
Chr15:64373327 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.16G>C (p.Gly6Arg) single nucleotide variant not specified [RCV004268804] Chr15:64093753 [GRCh38]
Chr15:64385952 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.128T>C (p.Leu43Ser) single nucleotide variant not specified [RCV004348347] Chr15:64088848 [GRCh38]
Chr15:64381047 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.142C>T (p.Arg48Trp) single nucleotide variant not specified [RCV004339092] Chr15:64088834 [GRCh38]
Chr15:64381033 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.137C>G (p.Thr46Ser) single nucleotide variant not specified [RCV004441723] Chr15:64088839 [GRCh38]
Chr15:64381038 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.262C>T (p.Pro88Ser) single nucleotide variant not specified [RCV004441726] Chr15:64088714 [GRCh38]
Chr15:64380913 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.457G>A (p.Glu153Lys) single nucleotide variant not specified [RCV004441729] Chr15:64072957 [GRCh38]
Chr15:64365156 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.452T>C (p.Ile151Thr) single nucleotide variant not specified [RCV004441728] Chr15:64072962 [GRCh38]
Chr15:64365161 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.28T>G (p.Trp10Gly) single nucleotide variant not specified [RCV004441727] Chr15:64093741 [GRCh38]
Chr15:64385940 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.241A>G (p.Ile81Val) single nucleotide variant not specified [RCV004441725] Chr15:64088735 [GRCh38]
Chr15:64380934 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.47T>G (p.Leu16Arg) single nucleotide variant not specified [RCV004441731] Chr15:64093722 [GRCh38]
Chr15:64385921 [GRCh37]
Chr15:15q22.31		 uncertain significance
NM_032231.7(CIAO2A):c.445C>T (p.Arg149Trp) single nucleotide variant not specified [RCV004610620] Chr15:64072969 [GRCh38]
Chr15:64365168 [GRCh37]
Chr15:15q22.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:964
Count of miRNA genes:604
Interacting mature miRNAs:669
Transcripts:ENST00000300030, ENST00000380290, ENST00000557835, ENST00000558779, ENST00000559705, ENST00000559950
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407286630GWAS935606_Hvaginal microbiome measurement QTL GWAS935606 (human)0.000006vaginal microbiome measurement156407414464074145Human
407113221GWAS762197_Herythrocyte count QTL GWAS762197 (human)6e-12erythrocyte countred blood cell count (CMO:0000025)156407842364078424Human
407038177GWAS687153_Hthyroid stimulating hormone measurement QTL GWAS687153 (human)1e-08thyroid stimulating hormone measurementblood thyroid stimulating hormone level (CMO:0001247)156407314164073142Human
407184426GWAS833402_Hcystitis QTL GWAS833402 (human)4e-08cystitis156408033664080337Human

Markers in Region
RH70413  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371564,376,542 - 64,376,662UniSTSGRCh37
Build 361562,163,595 - 62,163,715RGDNCBI36
Celera1541,255,954 - 41,256,074RGD
Cytogenetic Map15q22.31UniSTS
HuRef1541,201,185 - 41,201,305UniSTS
GeneMap99-GB4 RH Map15221.72UniSTS
NCBI RH Map15369.4UniSTS
RH16689  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371564,364,959 - 64,365,063UniSTSGRCh37
Build 361562,152,012 - 62,152,116RGDNCBI36
Celera1541,244,371 - 41,244,475RGD
Cytogenetic Map15q22.31UniSTS
HuRef1541,189,593 - 41,189,697UniSTS
FLJ22875  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371228,302,377 - 228,302,520UniSTSGRCh37
GRCh371564,364,806 - 64,364,949UniSTSGRCh37
Build 361226,369,000 - 226,369,143RGDNCBI36
Celera1201,492,609 - 201,492,752RGD
Celera1541,244,218 - 41,244,361UniSTS
HuRef1541,189,440 - 41,189,583UniSTS
HuRef1198,817,498 - 198,817,641UniSTS
G19675  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371564,364,959 - 64,365,063UniSTSGRCh37
Build 361562,152,012 - 62,152,116RGDNCBI36
Celera1541,244,371 - 41,244,475RGD
Cytogenetic Map15q22.31UniSTS
HuRef1541,189,593 - 41,189,697UniSTS
RH45603  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371564,370,399 - 64,370,546UniSTSGRCh37
Build 361562,157,452 - 62,157,599RGDNCBI36
Celera1541,249,813 - 41,249,960RGD
Cytogenetic Map15q22.31UniSTS
HuRef1541,195,038 - 41,195,185UniSTS
GeneMap99-GB4 RH Map15219.96UniSTS
NCBI RH Map15372.8UniSTS
RH45716  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371564,364,861 - 64,365,016UniSTSGRCh37
Build 361562,151,914 - 62,152,069RGDNCBI36
Celera1541,244,273 - 41,244,428RGD
Cytogenetic Map15q22.31UniSTS
HuRef1541,189,495 - 41,189,650UniSTS
GeneMap99-GB4 RH Map15230.25UniSTS
RH66054  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.31UniSTS
GeneMap99-GB4 RH Map1723.47UniSTS
NCBI RH Map12059.9UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_110310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA809560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM706342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ269528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD722050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN421575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS072305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC415981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000300030   ⟹   ENSP00000300030
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1564,072,565 - 64,093,838 (-)Ensembl
Ensembl Acc Id: ENST00000380290   ⟹   ENSP00000369644
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1564,072,578 - 64,094,262 (-)Ensembl
Ensembl Acc Id: ENST00000557835   ⟹   ENSP00000454079
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1564,074,318 - 64,094,262 (-)Ensembl
Ensembl Acc Id: ENST00000558779
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1564,072,565 - 64,093,838 (-)Ensembl
Ensembl Acc Id: ENST00000559705   ⟹   ENSP00000453210
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1564,072,981 - 64,094,262 (-)Ensembl
Ensembl Acc Id: ENST00000559950   ⟹   ENSP00000452953
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1564,075,405 - 64,094,262 (-)Ensembl
RefSeq Acc Id: NM_001014812   ⟹   NP_001014812
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381564,072,565 - 64,093,838 (-)NCBI
GRCh371564,364,761 - 64,386,207 (-)RGD
Build 361562,151,814 - 62,173,260 (-)NCBI Archive
Celera1541,244,173 - 41,265,622 (-)RGD
HuRef1541,189,392 - 41,210,854 (-)NCBI
CHM1_11564,484,269 - 64,505,725 (-)NCBI
T2T-CHM13v2.01561,879,723 - 61,900,991 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289108   ⟹   NP_001276037
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381564,072,565 - 64,093,838 (-)NCBI
HuRef1541,189,392 - 41,210,854 (-)NCBI
CHM1_11564,484,269 - 64,505,725 (-)NCBI
T2T-CHM13v2.01561,879,723 - 61,900,991 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032231   ⟹   NP_115607
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381564,072,565 - 64,093,838 (-)NCBI
GRCh371564,364,761 - 64,386,207 (-)RGD
Build 361562,151,814 - 62,173,260 (-)NCBI Archive
Celera1541,244,173 - 41,265,622 (-)RGD
HuRef1541,189,392 - 41,210,854 (-)NCBI
CHM1_11564,484,269 - 64,505,725 (-)NCBI
T2T-CHM13v2.01561,879,723 - 61,900,991 (-)NCBI
Sequence:
RefSeq Acc Id: NR_110310
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381564,072,565 - 64,093,838 (-)NCBI
HuRef1541,189,392 - 41,210,854 (-)NCBI
CHM1_11564,484,269 - 64,505,725 (-)NCBI
T2T-CHM13v2.01561,879,723 - 61,900,991 (-)NCBI
Sequence:
RefSeq Acc Id: NP_115607   ⟸   NM_032231
- Peptide Label: isoform a
- UniProtKB: B2R5F8 (UniProtKB/Swiss-Prot),   A6NKS1 (UniProtKB/Swiss-Prot),   B7Z8Z5 (UniProtKB/Swiss-Prot),   Q9H5X1 (UniProtKB/Swiss-Prot),   H0YKV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001014812   ⟸   NM_001014812
- Peptide Label: isoform b
- UniProtKB: Q9H5X1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276037   ⟸   NM_001289108
- Peptide Label: isoform b
- UniProtKB: Q9H5X1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000454079   ⟸   ENST00000557835
Ensembl Acc Id: ENSP00000452953   ⟸   ENST00000559950
Ensembl Acc Id: ENSP00000453210   ⟸   ENST00000559705
Ensembl Acc Id: ENSP00000300030   ⟸   ENST00000300030
Ensembl Acc Id: ENSP00000369644   ⟸   ENST00000380290
Protein Domains
MIP18 family-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H5X1-F1-model_v2 AlphaFold Q9H5X1 1-160 view protein structure

Promoters
RGD ID:6792333
Promoter ID:HG_KWN:21636
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000380290,   NM_001014812,   OTTHUMT00000256520
Position:
Human AssemblyChrPosition (strand)Source
Build 361562,172,986 - 62,173,542 (-)MPROMDB
RGD ID:7229753
Promoter ID:EPDNEW_H20622
Type:initiation region
Name:FAM96A_1
Description:family with sequence similarity 96 member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20623  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381564,093,795 - 64,093,855EPDNEW
RGD ID:7229757
Promoter ID:EPDNEW_H20623
Type:initiation region
Name:FAM96A_2
Description:family with sequence similarity 96 member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20622  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381564,093,929 - 64,093,989EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26235 AgrOrtholog
COSMIC CIAO2A COSMIC
Ensembl Genes ENSG00000166797 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000300030 ENTREZGENE
  ENST00000300030.8 UniProtKB/Swiss-Prot
  ENST00000380290 ENTREZGENE
  ENST00000380290.8 UniProtKB/Swiss-Prot
  ENST00000557835 ENTREZGENE
  ENST00000557835.6 UniProtKB/Swiss-Prot
  ENST00000558779.2 UniProtKB/TrEMBL
  ENST00000559705.2 UniProtKB/TrEMBL
  ENST00000559950.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1280 UniProtKB/Swiss-Prot
GTEx ENSG00000166797 GTEx
HGNC ID HGNC:26235 ENTREZGENE
Human Proteome Map CIAO2A Human Proteome Map
InterPro FSCA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP18-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:84191 UniProtKB/Swiss-Prot
NCBI Gene 84191 ENTREZGENE
OMIM 618382 OMIM
PANTHER CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FeS_assembly_P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671829 PharmGKB
Superfamily-SCOP SSF117916 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AAQ5BII0_HUMAN UniProtKB/TrEMBL
  A6NKS1 ENTREZGENE
  B2R5F8 ENTREZGENE
  B7Z8Z5 ENTREZGENE
  CIA2A_HUMAN UniProtKB/Swiss-Prot
  H0YKV4 ENTREZGENE, UniProtKB/TrEMBL
  H0YLH6_HUMAN UniProtKB/TrEMBL
  Q9H5X1 ENTREZGENE
UniProt Secondary A6NKS1 UniProtKB/Swiss-Prot
  B2R5F8 UniProtKB/Swiss-Prot
  B7Z8Z5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-22 CIAO2A  cytosolic iron-sulfur assembly component 2A  FAM96A  family with sequence similarity 96 member A  Symbol and/or name change 5135510 APPROVED
2015-11-24 FAM96A  family with sequence similarity 96 member A    family with sequence similarity 96, member A  Symbol and/or name change 5135510 APPROVED