SHISA6 (shisa family member 6) - Rat Genome Database

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Gene: SHISA6 (shisa family member 6) Homo sapiens
Analyze
Symbol: SHISA6
Name: shisa family member 6
RGD ID: 1602039
HGNC Page HGNC
Description: Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; regulation of AMPA glutamate receptor clustering; and regulation of signal transduction. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Predicted to be integral component of postsynaptic density membrane; INTERACTS WITH all-trans-retinoic acid; benzo[a]pyrene; carbamazepine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ37030; FLJ37733; FLJ45455; protein shisa-6 homolog; shisa homolog 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1711,241,213 - 11,564,063 (+)EnsemblGRCh38hg38GRCh38
GRCh381711,241,213 - 11,564,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371711,144,530 - 11,467,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361711,085,465 - 11,402,921 (+)NCBINCBI36hg18NCBI36
Celera1711,175,533 - 11,498,055 (+)NCBI
Cytogenetic Map17p12NCBI
HuRef1711,046,153 - 11,369,076 (+)NCBIHuRef
CHM1_11711,154,593 - 11,476,588 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:16344560   PMID:20379614   PMID:21873635   PMID:23251661   PMID:23382691   PMID:23396134   PMID:24262325   PMID:32296183   PMID:33961781  


Genomics

Comparative Map Data
SHISA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1711,241,213 - 11,564,063 (+)EnsemblGRCh38hg38GRCh38
GRCh381711,241,213 - 11,564,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371711,144,530 - 11,467,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361711,085,465 - 11,402,921 (+)NCBINCBI36hg18NCBI36
Celera1711,175,533 - 11,498,055 (+)NCBI
Cytogenetic Map17p12NCBI
HuRef1711,046,153 - 11,369,076 (+)NCBIHuRef
CHM1_11711,154,593 - 11,476,588 (+)NCBICHM1_1
Shisa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391166,102,551 - 66,418,715 (-)NCBIGRCm39mm39
GRCm39 Ensembl1166,102,551 - 66,416,790 (-)Ensembl
GRCm381166,211,725 - 66,527,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1166,211,725 - 66,525,964 (-)EnsemblGRCm38mm10GRCm38
MGSCv371166,025,227 - 66,339,628 (-)NCBIGRCm37mm9NCBIm37
MGSCv361166,027,924 - 66,342,321 (-)NCBImm8
Celera1173,147,659 - 73,459,932 (-)NCBICelera
Cytogenetic Map11B3NCBI
Shisa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21050,897,740 - 51,192,413 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1050,903,333 - 51,192,063 (-)Ensembl
Rnor_6.01052,744,069 - 53,037,853 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1052,749,846 - 53,037,816 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01052,498,328 - 52,791,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41052,896,362 - 53,190,809 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1050,092,476 - 50,378,235 (-)NCBICelera
Cytogenetic Map10q24NCBI
Shisa6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554675,707,561 - 5,998,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554675,701,521 - 5,998,910 (-)NCBIChiLan1.0ChiLan1.0
SHISA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11744,831,076 - 45,154,237 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1744,836,825 - 45,154,241 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01740,081,234 - 40,405,916 (-)NCBIMhudiblu_PPA_v0panPan3
SHISA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1535,420,981 - 35,701,654 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl535,424,242 - 35,707,012 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha535,562,452 - 35,839,708 (+)NCBI
ROS_Cfam_1.0535,530,964 - 35,808,773 (+)NCBI
UMICH_Zoey_3.1535,496,683 - 35,775,486 (+)NCBI
UNSW_CanFamBas_1.0535,452,119 - 35,729,778 (+)NCBI
UU_Cfam_GSD_1.0535,635,323 - 35,913,764 (+)NCBI
Shisa6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560250,498,911 - 50,836,666 (+)NCBI
SpeTri2.0NW_0049365953,973,099 - 4,152,706 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHISA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11255,757,837 - 56,024,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21258,849,892 - 58,898,751 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHISA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11610,584,375 - 10,913,012 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605910,348,109 - 10,676,091 (-)NCBIVero_WHO_p1.0
Shisa6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478613,697,178 - 14,007,891 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D17S748  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,396,837 - 11,396,957UniSTSGRCh37
Build 361711,337,562 - 11,337,682RGDNCBI36
Celera1711,427,555 - 11,427,675RGD
Cytogenetic Map17p12UniSTS
HuRef1711,298,531 - 11,298,651UniSTS
Marshfield Genetic Map1725.14UniSTS
Marshfield Genetic Map1725.14RGD
deCODE Assembly Map1732.15UniSTS
D17S731  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,140,701 - 11,140,989UniSTSGRCh37
Celera1711,171,488 - 11,171,782UniSTS
Cytogenetic Map17p12UniSTS
HuRef1711,042,295 - 11,042,601UniSTS
Marshfield Genetic Map1714.69UniSTS
Marshfield Genetic Map1714.69RGD
deCODE Assembly Map1732.15UniSTS
D17S1875  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,384,615 - 11,384,748UniSTSGRCh37
Build 361711,325,340 - 11,325,473RGDNCBI36
Celera1711,415,338 - 11,415,467RGD
Cytogenetic Map17p12UniSTS
HuRef1711,286,307 - 11,286,442UniSTS
Marshfield Genetic Map1725.14RGD
Marshfield Genetic Map1725.14UniSTS
Genethon Genetic Map1725.0UniSTS
RH92936  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,283,518 - 11,283,638UniSTSGRCh37
Build 361711,224,243 - 11,224,363RGDNCBI36
Celera1711,314,289 - 11,314,409RGD
Cytogenetic Map17p12UniSTS
HuRef1711,184,696 - 11,184,816UniSTS
GeneMap99-GB4 RH Map1767.2UniSTS
RH102954  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,467,053 - 11,467,212UniSTSGRCh37
Build 361711,407,778 - 11,407,937RGDNCBI36
Celera1711,497,728 - 11,497,887RGD
Cytogenetic Map17p12UniSTS
HuRef1711,368,749 - 11,368,908UniSTS
SHGC-85041  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,389,227 - 11,389,505UniSTSGRCh37
Build 361711,329,952 - 11,330,230RGDNCBI36
Celera1711,419,944 - 11,420,222RGD
Cytogenetic Map17p12UniSTS
HuRef1711,290,917 - 11,291,195UniSTS
TNG Radiation Hybrid Map176832.0UniSTS
RH122223  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,373,710 - 11,374,035UniSTSGRCh37
Build 361711,314,435 - 11,314,760RGDNCBI36
Celera1711,404,439 - 11,404,764RGD
Cytogenetic Map17p12UniSTS
HuRef1711,275,408 - 11,275,733UniSTS
TNG Radiation Hybrid Map176839.0UniSTS
SHGC-133008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,214,781 - 11,214,989UniSTSGRCh37
Build 361711,155,506 - 11,155,714RGDNCBI36
Celera1711,245,555 - 11,245,763RGD
Cytogenetic Map17p12UniSTS
HuRef1711,115,947 - 11,116,155UniSTS
TNG Radiation Hybrid Map176884.0UniSTS
SHGC-152248  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,384,654 - 11,384,754UniSTSGRCh37
Build 361711,325,379 - 11,325,479RGDNCBI36
Celera1711,415,377 - 11,415,473RGD
Cytogenetic Map17p12UniSTS
HuRef1711,286,348 - 11,286,448UniSTS
HuRef1711,286,346 - 11,286,448UniSTS
TNG Radiation Hybrid Map136305.0UniSTS
SHGC-153164  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,384,528 - 11,384,754UniSTSGRCh37
Build 361711,325,253 - 11,325,479RGDNCBI36
Celera1711,415,251 - 11,415,473RGD
Cytogenetic Map17p12UniSTS
HuRef1711,286,220 - 11,286,448UniSTS
TNG Radiation Hybrid Map499384.0UniSTS
SHGC-5898  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,214,847 - 11,214,983UniSTSGRCh37
Build 361711,155,572 - 11,155,708RGDNCBI36
Celera1711,245,621 - 11,245,757RGD
Cytogenetic Map17p12UniSTS
HuRef1711,116,013 - 11,116,149UniSTS
Stanford-G3 RH Map17679.0UniSTS
NCBI RH Map17280.0UniSTS
D17S1546  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,250,412 - 11,250,512UniSTSGRCh37
Build 361711,191,137 - 11,191,237RGDNCBI36
Celera1711,281,185 - 11,281,285RGD
Cytogenetic Map17p12UniSTS
HuRef1711,151,582 - 11,151,682UniSTS
Whitehead-RH Map17110.8UniSTS
NCBI RH Map17279.0UniSTS
RH48639  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,394,343 - 11,394,495UniSTSGRCh37
Build 361711,335,068 - 11,335,220RGDNCBI36
Celera1711,425,060 - 11,425,212RGD
Cytogenetic Map17p12UniSTS
HuRef1711,296,037 - 11,296,189UniSTS
GeneMap99-GB4 RH Map1767.83UniSTS
NCBI RH Map17279.0UniSTS
UniSTS:487272  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371711,465,317 - 11,466,659UniSTSGRCh37
Celera1711,495,992 - 11,497,334UniSTS
HuRef1711,367,013 - 11,368,355UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10136
Count of miRNA genes:1253
Interacting mature miRNAs:1563
Transcripts:ENST00000343478, ENST00000409168, ENST00000432116, ENST00000441885
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 5 6 280 15 935 2 47 6 280
Low 1516 211 503 27 68 5 2086 1011 2421 147 995 420 24 1098 908
Below cutoff 783 2298 908 306 723 165 1848 1136 304 179 255 926 141 1 106 1574 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001173461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001173462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_207386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC055825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA362563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ070854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000343478   ⟹   ENSP00000477331
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1711,241,941 - 11,380,461 (+)Ensembl
RefSeq Acc Id: ENST00000409168   ⟹   ENSP00000387157
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1711,241,423 - 11,564,063 (+)Ensembl
RefSeq Acc Id: ENST00000432116   ⟹   ENSP00000388659
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1711,241,263 - 11,564,063 (+)Ensembl
RefSeq Acc Id: ENST00000441885   ⟹   ENSP00000390084
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1711,241,213 - 11,564,063 (+)Ensembl
RefSeq Acc Id: NM_001173461   ⟹   NP_001166932
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381711,241,423 - 11,564,063 (+)NCBI
GRCh371711,144,740 - 11,467,380 (+)RGD
Celera1711,175,533 - 11,498,055 (+)RGD
HuRef1711,046,153 - 11,369,076 (+)RGD
CHM1_11711,154,593 - 11,476,588 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001173462   ⟹   NP_001166933
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381711,241,213 - 11,564,063 (+)NCBI
GRCh371711,144,740 - 11,467,380 (+)RGD
Celera1711,175,533 - 11,498,055 (+)RGD
HuRef1711,046,153 - 11,369,076 (+)RGD
CHM1_11711,154,593 - 11,476,588 (+)NCBI
Sequence:
RefSeq Acc Id: NM_207386   ⟹   NP_997269
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381711,241,213 - 11,564,063 (+)NCBI
GRCh371711,144,740 - 11,467,380 (+)RGD
Celera1711,175,533 - 11,498,055 (+)RGD
HuRef1711,046,153 - 11,369,076 (+)RGD
CHM1_11711,154,593 - 11,476,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017024618   ⟹   XP_016880107
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381711,241,423 - 11,564,063 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_997269   ⟸   NM_207386
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6ZSJ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001166932   ⟸   NM_001173461
- Peptide Label: isoform 2 precursor
- UniProtKB: Q6ZSJ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001166933   ⟸   NM_001173462
- Peptide Label: isoform 3 precursor
- UniProtKB: Q6ZSJ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016880107   ⟸   XM_017024618
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000390084   ⟸   ENST00000441885
RefSeq Acc Id: ENSP00000388659   ⟸   ENST00000432116
RefSeq Acc Id: ENSP00000387157   ⟸   ENST00000409168
RefSeq Acc Id: ENSP00000477331   ⟸   ENST00000343478

Promoters
RGD ID:7234023
Promoter ID:EPDNEW_H22757
Type:initiation region
Name:SHISA6_1
Description:shisa family member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22758  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381711,241,212 - 11,241,272EPDNEW
RGD ID:7234025
Promoter ID:EPDNEW_H22758
Type:initiation region
Name:SHISA6_2
Description:shisa family member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22757  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381711,241,441 - 11,241,501EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17p12-11.2(chr17:10892259-17964282)x3 copy number gain See cases [RCV000052476] Chr17:10892259..17964282 [GRCh38]
Chr17:10795576..17867596 [GRCh37]
Chr17:10736301..17808321 [NCBI36]
Chr17:17p12-11.2
pathogenic
NM_001173461.1(SHISA6):c.749C>T (p.Ser250Leu) single nucleotide variant Malignant melanoma [RCV000071321] Chr17:11263476 [GRCh38]
Chr17:11166793 [GRCh37]
Chr17:11107518 [NCBI36]
Chr17:17p12
not provided
NM_001173461.1(SHISA6):c.800-111590C>T single nucleotide variant Lung cancer [RCV000100340] Chr17:11444150 [GRCh38]
Chr17:11347467 [GRCh37]
Chr17:17p12
uncertain significance
NM_001173461.1(SHISA6):c.800-25598T>C single nucleotide variant Lung cancer [RCV000100341] Chr17:11530142 [GRCh38]
Chr17:11433459 [GRCh37]
Chr17:17p12
uncertain significance
GRCh38/hg38 17p13.2-12(chr17:5732953-12095349)x3 copy number gain See cases [RCV000134851] Chr17:5732953..12095349 [GRCh38]
Chr17:5636273..11998666 [GRCh37]
Chr17:5576997..11939391 [NCBI36]
Chr17:17p13.2-12
pathogenic
GRCh38/hg38 17p13.1-12(chr17:10713492-11312542)x3 copy number gain See cases [RCV000136370] Chr17:10713492..11312542 [GRCh38]
Chr17:10616809..11215859 [GRCh37]
Chr17:10557534..11156584 [NCBI36]
Chr17:17p13.1-12
uncertain significance
GRCh38/hg38 17p13.3-12(chr17:162016-12343901)x3 copy number gain See cases [RCV000138531] Chr17:162016..12343901 [GRCh38]
Chr17:45835..12247218 [GRCh37]
Chr17:11807..12187943 [NCBI36]
Chr17:17p13.3-12
pathogenic
GRCh38/hg38 17p13.3-12(chr17:150732-14764202)x3 copy number gain See cases [RCV000142236] Chr17:150732..14764202 [GRCh38]
Chr17:525..14667519 [GRCh37]
Chr17:525..14608244 [NCBI36]
Chr17:17p13.3-12
pathogenic
GRCh38/hg38 17p13.1-12(chr17:9701182-11983353)x1 copy number loss Ductal breast carcinoma [RCV000207166] Chr17:9701182..11983353 [GRCh38]
Chr17:9604499..11886670 [GRCh37]
Chr17:17p13.1-12
uncertain significance
Single allele complex Ductal breast carcinoma [RCV000207129] Chr17:9586165..16325968 [GRCh37]
Chr17:17p13.1-11.2
uncertain significance
GRCh37/hg19 17p12(chr17:11225886-12623364)x3 copy number gain See cases [RCV000449472] Chr17:11225886..12623364 [GRCh37]
Chr17:17p12
uncertain significance
GRCh37/hg19 17p12-11.2(chr17:10771948-21510992)x1 copy number loss See cases [RCV000447345] Chr17:10771948..21510992 [GRCh37]
Chr17:17p12-11.2
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-12(chr17:525-15027737)x3 copy number gain See cases [RCV000511786] Chr17:525..15027737 [GRCh37]
Chr17:17p13.3-12
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-12(chr17:525-11186432)x3 copy number gain not provided [RCV000683866] Chr17:525..11186432 [GRCh37]
Chr17:17p13.3-12
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p12(chr17:11411698-11415679)x0 copy number loss not provided [RCV000739401] Chr17:11411698..11415679 [GRCh37]
Chr17:17p12
benign
GRCh37/hg19 17p12(chr17:11211344-11222734)x3 copy number gain not provided [RCV000751932] Chr17:11211344..11222734 [GRCh37]
Chr17:17p12
benign
GRCh37/hg19 17p12(chr17:11411698-11412326)x0 copy number loss not provided [RCV000751933] Chr17:11411698..11412326 [GRCh37]
Chr17:17p12
benign
GRCh37/hg19 17p13.1-12(chr17:10493837-15099023)x1 copy number loss See cases [RCV001195076] Chr17:10493837..15099023 [GRCh37]
Chr17:17p13.1-12
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:34491 AgrOrtholog
COSMIC SHISA6 COSMIC
Ensembl Genes ENSG00000188803 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000387157 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000388659 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390084 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000477331 UniProtKB/TrEMBL
Ensembl Transcript ENST00000343478 UniProtKB/TrEMBL
  ENST00000409168 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000432116 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000441885 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000188803 GTEx
HGNC ID HGNC:34491 ENTREZGENE
Human Proteome Map SHISA6 Human Proteome Map
InterPro Shisa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:388336 UniProtKB/Swiss-Prot
NCBI Gene 388336 ENTREZGENE
OMIM 617327 OMIM
PANTHER PTHR31774 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Shisa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA165432740 PharmGKB
UniProt Q6ZSJ9 ENTREZGENE, UniProtKB/Swiss-Prot
  V9GZ25_HUMAN UniProtKB/TrEMBL
UniProt Secondary B3KXV5 UniProtKB/Swiss-Prot
  Q4PL63 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 SHISA6  shisa family member 6    shisa homolog 6 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED