MIR650 (microRNA 650) - Rat Genome Database

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Gene: MIR650 (microRNA 650) Homo sapiens
Analyze
Symbol: MIR650
Name: microRNA 650
RGD ID: 1602013
HGNC Page HGNC:32906
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-650; MIRN650
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,822,776 - 22,822,871 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,822,776 - 22,822,871 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,165,270 - 23,165,365 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,495,269 - 21,495,364 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map22q11.22NCBI
HuRef226,133,087 - 6,133,182 (+)NCBIHuRef
CHM1_12223,177,246 - 23,177,341 (+)NCBICHM1_1
T2T-CHM13v2.02223,245,654 - 23,245,749 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Potential role of circulating microRNAs as early markers of preeclampsia. Ura B, etal., Taiwan J Obstet Gynecol. 2014 Jun;53(2):232-4. doi: 10.1016/j.tjog.2014.03.001.
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:20381459   PMID:21352815   PMID:22234685   PMID:22767438   PMID:23991130   PMID:24062138   PMID:25956032   PMID:26460926   PMID:28101578   PMID:28129626  
PMID:28548936   PMID:28574132   PMID:29039465   PMID:30348117   PMID:30481780   PMID:30556880   PMID:30927143   PMID:31399193   PMID:31556571   PMID:32986146   PMID:33086498   PMID:33147052  
PMID:33653372   PMID:34586953   PMID:35904110   PMID:36272152   PMID:37040719  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22669543-23300977)x3 copy number gain See cases [RCV000135338] Chr22:22669543..23300977 [GRCh38]
Chr22:23012013..23643164 [GRCh37]
Chr22:21342013..21973164 [NCBI36]
Chr22:22q11.22-11.23		 pathogenic
GRCh38/hg38 22q11.22(chr22:22374043-22886630)x1 copy number loss See cases [RCV000135086] Chr22:22374043..22886630 [GRCh38]
Chr22:22728411..23228810 [GRCh37]
Chr22:21058411..21558810 [NCBI36]
Chr22:22q11.22		 benign
GRCh38/hg38 22q11.21-11.23(chr22:21454661-23414686)x1 copy number loss See cases [RCV000135739] Chr22:21454661..23414686 [GRCh38]
Chr22:21808950..23756873 [GRCh37]
Chr22:20138950..22086873 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22669543-23301036)x3 copy number gain See cases [RCV000136533] Chr22:22669543..23301036 [GRCh38]
Chr22:23012013..23643223 [GRCh37]
Chr22:21342013..21973223 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22669599-24670517)x3 copy number gain See cases [RCV000136060] Chr22:22669599..24670517 [GRCh38]
Chr22:23012069..25066484 [GRCh37]
Chr22:21342069..23396484 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:20726972-24197852)x1 copy number loss See cases [RCV000136889] Chr22:20726972..24197852 [GRCh38]
Chr22:21081260..24593820 [GRCh37]
Chr22:19411260..22923820 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454661-24247140)x1 copy number loss See cases [RCV000137685] Chr22:21454661..24247140 [GRCh38]
Chr22:21808950..24643108 [GRCh37]
Chr22:20138950..22973108 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22660239-24644628)x3 copy number gain See cases [RCV000137410] Chr22:22660239..24644628 [GRCh38]
Chr22:23002709..25040595 [GRCh37]
Chr22:21332709..23370595 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454661-23312035)x1 copy number loss See cases [RCV000137767] Chr22:21454661..23312035 [GRCh38]
Chr22:21808950..23654222 [GRCh37]
Chr22:20138950..21984222 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22660239-24600238)x3 copy number gain See cases [RCV000137795] Chr22:22660239..24600238 [GRCh38]
Chr22:23002709..24996205 [GRCh37]
Chr22:21332709..23326205 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:21207181-24247140)x3 copy number gain See cases [RCV000138673] Chr22:21207181..24247140 [GRCh38]
Chr22:21561470..24643108 [GRCh37]
Chr22:19891470..22973108 [NCBI36]
Chr22:22q11.21-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22660239-24596054)x3 copy number gain See cases [RCV000138249] Chr22:22660239..24596054 [GRCh38]
Chr22:23002709..24992021 [GRCh37]
Chr22:21332709..23322021 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22669599-23312050)x1 copy number loss See cases [RCV000139467] Chr22:22669599..23312050 [GRCh38]
Chr22:23012069..23654237 [GRCh37]
Chr22:21342069..21984237 [NCBI36]
Chr22:22q11.22-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:18339130-23480799)x1 copy number loss See cases [RCV000141233] Chr22:18339130..23480799 [GRCh38]
Chr22:20279766..23822986 [GRCh37]
Chr22:18659766..22152986 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22655333-24663664)x3 copy number gain See cases [RCV000141936] Chr22:22655333..24663664 [GRCh38]
Chr22:22997803..25059631 [GRCh37]
Chr22:21327803..23389631 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22655458-23308687)x1 copy number loss See cases [RCV000142309] Chr22:22655458..23308687 [GRCh38]
Chr22:22997928..23650874 [GRCh37]
Chr22:21327928..21980874 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22655333-24630890)x3 copy number gain See cases [RCV000142221] Chr22:22655333..24630890 [GRCh38]
Chr22:22997803..25026857 [GRCh37]
Chr22:21327803..23356857 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22660239-23306603)x1 copy number loss See cases [RCV000142985] Chr22:22660239..23306603 [GRCh38]
Chr22:23002709..23648790 [GRCh37]
Chr22:21332709..21978790 [NCBI36]
Chr22:22q11.22-11.23		 likely benign
GRCh38/hg38 22q11.22-11.23(chr22:22669543-23301036)x1 copy number loss See cases [RCV000142654] Chr22:22669543..23301036 [GRCh38]
Chr22:23012013..23643223 [GRCh37]
Chr22:21342013..21973223 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22660239-23312035)x3 copy number gain See cases [RCV000143347] Chr22:22660239..23312035 [GRCh38]
Chr22:23002709..23654222 [GRCh37]
Chr22:21332709..21984222 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22655333-24647020)x3 copy number gain See cases [RCV000143750] Chr22:22655333..24647020 [GRCh38]
Chr22:22997803..25042987 [GRCh37]
Chr22:21327803..23372987 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:21454661-23414686)x3 copy number gain See cases [RCV000148078] Chr22:21454661..23414686 [GRCh38]
Chr22:21808950..23756873 [GRCh37]
Chr22:20138950..22086873 [NCBI36]
Chr22:22q11.21-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22669543-24563859)x3 copy number gain See cases [RCV000148079] Chr22:22669543..24563859 [GRCh38]
Chr22:23012013..24959827 [GRCh37]
Chr22:21342013..23289827 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22655333-23310325)x1 copy number loss See cases [RCV000143461] Chr22:22655333..23310325 [GRCh38]
Chr22:22997803..23652512 [GRCh37]
Chr22:21327803..21982512 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22669543-24563859)x3 copy number gain See cases [RCV000050739] Chr22:22669543..24563859 [GRCh38]
Chr22:23012013..24959827 [GRCh37]
Chr22:21342013..23289827 [NCBI36]
Chr22:22q11.22-11.23		 conflicting interpretations of pathogenicity|uncertain significance|conflicting data from submitters
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3 copy number gain See cases [RCV000050768] Chr22:18178957..31821193 [GRCh38]
Chr22:18661724..32217179 [GRCh37]
Chr22:17041724..30547179 [NCBI36]
Chr22:22q11.21-12.3		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:20726772-23135971)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053061]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053061]|See cases [RCV000053061] Chr22:20726772..23135971 [GRCh38]
Chr22:21081060..23478158 [GRCh37]
Chr22:19411060..21808158 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21443815-24235645)x1 copy number loss See cases [RCV000053074] Chr22:21443815..24235645 [GRCh38]
Chr22:21798104..24631613 [GRCh37]
Chr22:20128104..22961613 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21443815-23397298)x1 copy number loss See cases [RCV000053075] Chr22:21443815..23397298 [GRCh38]
Chr22:21798104..23739485 [GRCh37]
Chr22:20128104..22069485 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454461-24247296)x1 copy number loss See cases [RCV000053077] Chr22:21454461..24247296 [GRCh38]
Chr22:21808750..24643264 [GRCh37]
Chr22:20138750..22973264 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454661-24289119)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053079]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053079]|See cases [RCV000053079] Chr22:21454661..24289119 [GRCh38]
Chr22:21808950..24685087 [GRCh37]
Chr22:20138950..23015087 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454661-24197852)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053084]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053084]|See cases [RCV000053084] Chr22:21454661..24197852 [GRCh38]
Chr22:21808950..24593820 [GRCh37]
Chr22:20138950..22923820 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454661-23301036)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053085]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053085]|See cases [RCV000053085] Chr22:21454661..23301036 [GRCh38]
Chr22:21808950..23643223 [GRCh37]
Chr22:20138950..21973223 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21457690-24220231)x1 copy number loss See cases [RCV000053087] Chr22:21457690..24220231 [GRCh38]
Chr22:21811979..24616199 [GRCh37]
Chr22:20141979..22946199 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21562911-24307688)x1 copy number loss See cases [RCV000053090] Chr22:21562911..24307688 [GRCh38]
Chr22:21917200..24703656 [GRCh37]
Chr22:20247200..23033656 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.1-11.23(chr22:16916608-24358936)x3 copy number gain See cases [RCV000053104] Chr22:16916608..24358936 [GRCh38]
Chr22:17397498..24754904 [GRCh37]
Chr22:15777498..23084904 [NCBI36]
Chr22:22q11.1-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21623411-23315617)x1 copy number loss See cases [RCV000053108] Chr22:21623411..23315617 [GRCh38]
Chr22:21977700..23657804 [GRCh37]
Chr22:20307700..21987804 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22651209-23299955)x1 copy number loss See cases [RCV000053109] Chr22:22651209..23299955 [GRCh38]
Chr22:22993679..23642142 [GRCh37]
Chr22:21323679..21972142 [NCBI36]
Chr22:22q11.22-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22660238-23305976)x1 copy number loss See cases [RCV000053110] Chr22:22660238..23305976 [GRCh38]
Chr22:23002708..23648163 [GRCh37]
Chr22:21332708..21978163 [NCBI36]
Chr22:22q11.22-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22686122-23315617)x1 copy number loss See cases [RCV000053112] Chr22:22686122..23315617 [GRCh38]
Chr22:23028586..23657804 [GRCh37]
Chr22:21358586..21987804 [NCBI36]
Chr22:22q11.22-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22703701-23285204)x1 copy number loss See cases [RCV000053113] Chr22:22703701..23285204 [GRCh38]
Chr22:23046186..23627391 [GRCh37]
Chr22:21376186..21957391 [NCBI36]
Chr22:22q11.22-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21386914-23305976)x3 copy number gain See cases [RCV000053158] Chr22:21386914..23305976 [GRCh38]
Chr22:21741203..23648163 [GRCh37]
Chr22:20071203..21978163 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic|uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:21454661-23414686)x3 copy number gain See cases [RCV000053159] Chr22:21454661..23414686 [GRCh38]
Chr22:21808950..23756873 [GRCh37]
Chr22:20138950..22086873 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic|uncertain significance|conflicting data from submitters
GRCh38/hg38 22q11.22-11.23(chr22:22686122-24577664)x3 copy number gain See cases [RCV000053161] Chr22:22686122..24577664 [GRCh38]
Chr22:23028586..24973632 [GRCh37]
Chr22:21358586..23303632 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22703701-24669609)x3 copy number gain See cases [RCV000053163] Chr22:22703701..24669609 [GRCh38]
Chr22:23046186..25065576 [GRCh37]
Chr22:21376186..23395576 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
Single allele duplication Schizophrenia [RCV000754256] Chr22:22624794..24654160 [GRCh38]
Chr22:22q11.22-11.23		 likely pathogenic
NC_000022.11:g.(?_22638171)_(23320336_?)del deletion Schizophrenia [RCV000754257] Chr22:22638171..23320336 [GRCh38]
Chr22:22q11.22-11.23		 likely pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ING4hsa-miR-650Mirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20381459
ING4hsa-miR-650Mirecordsexternal_infoNANA20381459
CDK1hsa-miR-650OncomiRDBexternal_infoNANA22234685
NDRG2hsa-miR-650OncomiRDBexternal_infoNANA21352815
ING4hsa-miR-650OncomiRDBexternal_infoNANA20381459

Predicted Targets
Summary Value
Count of predictions:49925
Count of gene targets:18537
Count of transcripts:41668
Interacting mature miRNAs:hsa-miR-650
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system exocrine system hemolymphoid system respiratory system sensory system adipose tissue
High
Medium 4 6 1
Low 10 1 4 23 1 4 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2222,822,776 - 22,822,871 (+)Ensembl
RefSeq Acc Id: NR_030755
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382222,822,776 - 22,822,871 (+)NCBI
GRCh372223,165,270 - 23,165,365 (+)NCBI
HuRef226,133,087 - 6,133,182 (+)NCBI
CHM1_12223,177,246 - 23,177,341 (+)NCBI
T2T-CHM13v2.02223,245,654 - 23,245,749 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR650 COSMIC
Ensembl Genes ENSG00000284049 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385101 ENTREZGENE
GTEx ENSG00000284049 GTEx
HGNC ID HGNC:32906 ENTREZGENE
Human Proteome Map MIR650 Human Proteome Map
miRBase MI0003665 ENTREZGENE
NCBI Gene 723778 ENTREZGENE
OMIM 615379 OMIM
PharmGKB PA164722946 PharmGKB
RNAcentral URS000075A00C RNACentral
  URS000075CEFF RNACentral