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Gene: MAP3K20 (mitogen-activated protein kinase kinase kinase 20) Homo sapiens
Symbol: MAP3K20
Name: mitogen-activated protein kinase kinase kinase 20
Description: Exhibits ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Involved in several processes, including activation of JUN kinase activity; cellular response to gamma radiation; and negative regulation of cell cycle. Localizes to the cytosol. Implicated in centronuclear myopathy 6 with fiber-type disproportion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AZK; cervical cancer suppressor gene 4 protein; CNM6; HCCS-4; human cervical cancer suppressor gene 4 protein; leucine zipper- and sterile alpha motif-containing kinase; mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; mixed lineage kinase-related kinase MRK-beta; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MLK7; mlklak; MLT; MLTK; MLTKalpha; MLTKbeta; MRK; pk; protein kinase; SFMMP; sterile alpha motif and leucine zipper containing kinase AZK; sterile alpha motif- and leucine zipper-containing kinase AZK; ZAK; ZAK1 homolog, leucine zipper and sterile-alpha motif kinase
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2173,075,435 - 173,268,015 (+)Ensembl
GRCh382173,075,435 - 173,268,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372173,940,440 - 174,132,737 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,648,811 - 173,840,983 (+)NCBINCBI36hg18NCBI36
Celera2167,553,959 - 167,746,148 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2165,819,879 - 166,012,160 (+)NCBIHuRef
CHM1_12173,947,661 - 174,139,938 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MAP3K20
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1601997
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.