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Gene: TRMT1 (tRNA methyltransferase 1) Homo sapiens
Symbol: TRMT1
Name: tRNA methyltransferase 1
Description: This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ20244; MRT68; N(2),N(2)-dimethylguanosine tRNA methyltransferase; TRM1; TRM1 tRNA methyltransferase 1 homolog; tRNA (guanine(26)-N(2))-dimethyltransferase; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA methyltransferase 1 homolog; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase
Mus musculus (house mouse) : Trmt1 (tRNA methyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trmt1 (tRNA methyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trmt1 (tRNA methyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TRMT1 (tRNA methyltransferase 1)
Canis lupus familiaris (dog) : TRMT1 (tRNA methyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trmt1 (tRNA methyltransferase 1)
Sus scrofa (pig) : TRMT1 (tRNA methyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381913,104,900 - 13,117,567 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,215,714 - 13,227,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,076,715 - 13,088,332 (-)NCBINCBI36hg18NCBI36
Celera1913,106,119 - 13,117,969 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,788,354 - 12,799,966 (-)NCBIHuRef
CHM1_11913,216,745 - 13,228,558 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRMT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1601995
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.