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Gene: TRMT1 (tRNA methyltransferase 1) Homo sapiens
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Symbol: TRMT1
Name: tRNA methyltransferase 1
Description: This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ20244; MRT68; N(2),N(2)-dimethylguanosine tRNA methyltransferase; TRM1; TRM1 tRNA methyltransferase 1 homolog; tRNA (guanine(26)-N(2))-dimethyltransferase; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA methyltransferase 1 homolog; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase
Orthologs:
Mus musculus (house mouse) : Trmt1 (tRNA methyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trmt1 (tRNA methyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trmt1 (tRNA methyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TRMT1 (tRNA methyltransferase 1)
Canis lupus familiaris (dog) : TRMT1 (tRNA methyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trmt1 (tRNA methyltransferase 1)
Sus scrofa (pig) : TRMT1 (tRNA methyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,104,900 - 13,117,567 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,215,714 - 13,227,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,076,715 - 13,088,332 (-)NCBINCBI36hg18NCBI36
Celera1913,106,119 - 13,117,969 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,788,354 - 12,799,966 (-)NCBIHuRef
CHM1_11913,216,745 - 13,228,558 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TRMT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1601995
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.