DCTPP1 (dCTP pyrophosphatase 1) - Rat Genome Database

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Gene: DCTPP1 (dCTP pyrophosphatase 1) Homo sapiens
Analyze
Symbol: DCTPP1
Name: dCTP pyrophosphatase 1
RGD ID: 1601967
HGNC Page HGNC:28777
Description: Enables dCTP diphosphatase activity and identical protein binding activity. Involved in DNA protection and dCTP catabolic process. Located in cytosol; mitochondrion; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CDA03; dCTPase 1; deoxycytidine-triphosphatase 1; MGC5627; RS21C6; XTP3-transactivated gene A protein; XTP3-transactivated protein A; XTP3TPA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,423,615 - 30,430,030 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,423,615 - 30,430,030 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,434,936 - 30,441,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,342,520 - 30,348,874 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,857,548 - 29,863,885 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,997,232 - 28,003,588 (-)NCBIHuRef
CHM1_11631,751,466 - 31,757,820 (-)NCBICHM1_1
T2T-CHM13v2.01630,809,819 - 30,816,234 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
CGP 52608  (EXP)
chloropicrin  (EXP)
chromium(6+)  (EXP,ISO)
Cinobufagin  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
DDE  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (EXP)
leflunomide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
SB 431542  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sunitinib  (EXP)
temozolomide  (EXP)
testosterone  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA,ISS)
mitochondrion  (IDA,IEA,ISO)
nucleoplasm  (IDA)
nucleus  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15740738   PMID:16169070   PMID:16189514   PMID:18029348   PMID:19596235   PMID:21145461   PMID:21653829   PMID:21671327   PMID:21832049   PMID:21873635   PMID:22658674  
PMID:22863883   PMID:22939629   PMID:24085278   PMID:24467396   PMID:24550385   PMID:25416956   PMID:25756610   PMID:26075750   PMID:26496610   PMID:27107014   PMID:27173435   PMID:27432908  
PMID:27612427   PMID:27880917   PMID:28380382   PMID:28514442   PMID:28515276   PMID:28675297   PMID:28986522   PMID:29128334   PMID:29874556   PMID:31091453   PMID:31173446   PMID:31377845  
PMID:31515488   PMID:32296183   PMID:32552912   PMID:32716908   PMID:32989298   PMID:33187986   PMID:33545068   PMID:33961781   PMID:35013218   PMID:35446349   PMID:35944360   PMID:36215168  
PMID:37167062   PMID:37827155   PMID:38113892   PMID:38686496  


Genomics

Comparative Map Data
DCTPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,423,615 - 30,430,030 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,423,615 - 30,430,030 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,434,936 - 30,441,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,342,520 - 30,348,874 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,857,548 - 29,863,885 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,997,232 - 28,003,588 (-)NCBIHuRef
CHM1_11631,751,466 - 31,757,820 (-)NCBICHM1_1
T2T-CHM13v2.01630,809,819 - 30,816,234 (-)NCBIT2T-CHM13v2.0
Dctpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,856,131 - 126,859,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,856,131 - 126,859,881 (-)EnsemblGRCm39 Ensembl
GRCm387127,256,959 - 127,260,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,256,959 - 127,260,709 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,400,473 - 134,404,181 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,048,107 - 127,051,815 (-)NCBIMGSCv36mm8
Celera7127,105,674 - 127,109,383 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.42NCBI
Dctpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,307,933 - 191,311,326 (-)NCBIGRCr8
mRatBN7.21181,877,440 - 181,880,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,877,437 - 181,880,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,228,131 - 190,231,512 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,414,218 - 197,417,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,082,593 - 190,085,974 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,703,459 - 198,706,852 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,703,461 - 198,706,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,696,305 - 205,699,698 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,519,955 - 186,523,348 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,669,837 - 186,673,229 (-)NCBI
Celera1179,528,917 - 179,532,300 (-)NCBICelera
Cytogenetic Map1q37NCBI
Dctpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,357,204 - 7,360,034 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,357,204 - 7,360,034 (-)NCBIChiLan1.0ChiLan1.0
DCTPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21833,629,486 - 33,636,121 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11638,430,932 - 38,438,331 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01624,538,023 - 24,545,426 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11630,794,268 - 30,802,207 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,794,268 - 30,802,179 (-)Ensemblpanpan1.1panPan2
DCTPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,679,681 - 17,683,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,679,722 - 17,683,570 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,253,648 - 19,257,592 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,810,663 - 17,814,594 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,810,709 - 17,814,520 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,610,846 - 17,614,777 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,526,330 - 17,530,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,841,310 - 17,845,272 (+)NCBIUU_Cfam_GSD_1.0
Dctpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,782,876 - 124,786,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,879,241 - 12,884,287 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,880,745 - 12,884,240 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCTPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,886,890 - 17,900,557 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,896,426 - 17,900,562 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,312,086 - 18,316,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCTPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,096,489 - 27,102,778 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,096,212 - 27,102,835 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,416,903 - 2,423,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DCTPP1
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p12.2-11.2(chr16:23047969-30632245)x3 copy number gain See cases [RCV000052401] Chr16:23047969..30632245 [GRCh38]
Chr16:23059290..30643566 [GRCh37]
Chr16:22966791..30551067 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p11.2(chr16:30359229-30570499)x3 copy number gain See cases [RCV000053863] Chr16:30359229..30570499 [GRCh38]
Chr16:30370550..30581820 [GRCh37]
Chr16:30278051..30489321 [NCBI36]
Chr16:16p11.2		 uncertain significance
GRCh38/hg38 16p11.2(chr16:29909613-31438697)x3 copy number gain See cases [RCV000135339] Chr16:29909613..31438697 [GRCh38]
Chr16:29920934..31450018 [GRCh37]
Chr16:29828435..31357519 [NCBI36]
Chr16:16p11.2		 pathogenic
GRCh38/hg38 16p11.2(chr16:29581462-30691912)x1 copy number loss See cases [RCV000135589] Chr16:29581462..30691912 [GRCh38]
Chr16:29592783..30703233 [GRCh37]
Chr16:29500284..30610734 [NCBI36]
Chr16:16p11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:27311746-31193406)x3 copy number gain See cases [RCV000140341] Chr16:27311746..31193406 [GRCh38]
Chr16:27323067..31204727 [GRCh37]
Chr16:27230568..31112228 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23752047-31943755)x3 copy number gain See cases [RCV000141141] Chr16:23752047..31943755 [GRCh38]
Chr16:23763368..31955076 [GRCh37]
Chr16:23670869..31862577 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p11.2(chr16:29892937-30433124)x3 copy number gain See cases [RCV000143385] Chr16:29892937..30433124 [GRCh38]
Chr16:29904258..30444445 [GRCh37]
Chr16:29811759..30351946 [NCBI36]
Chr16:16p11.2		 pathogenic|likely benign
GRCh37/hg19 16p11.2(chr16:30391304-31122666)x3 copy number gain Breast ductal adenocarcinoma [RCV000207028] Chr16:30391304..31122666 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p11.2(chr16:28826162-29043901)x1 copy number loss See cases [RCV000448084] Chr16:28826162..29043901 [GRCh37]
Chr16:16p11.2		 likely pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:30350747-31905898)x3 copy number gain not provided [RCV001258619] Chr16:30350747..31905898 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:29974415-30596982)x1 copy number loss Distal 16p11.2 microdeletion syndrome [RCV001801174] Chr16:29974415..30596982 [GRCh37]
Chr16:16p11.2		 likely pathogenic
GRCh37/hg19 16p11.2(chr16:29808153-30750270)x3 copy number gain Chromosome 16p11.2 duplication syndrome [RCV001801218] Chr16:29808153..30750270 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_024096.2(DCTPP1):c.22A>T (p.Ile8Phe) single nucleotide variant not specified [RCV004223045] Chr16:30429959 [GRCh38]
Chr16:30441280 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.266G>A (p.Arg89Gln) single nucleotide variant not specified [RCV004104370] Chr16:30424480 [GRCh38]
Chr16:30435801 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.286C>T (p.Leu96Phe) single nucleotide variant not specified [RCV004179797] Chr16:30424460 [GRCh38]
Chr16:30435781 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.37G>T (p.Gly13Trp) single nucleotide variant not specified [RCV004123265] Chr16:30429944 [GRCh38]
Chr16:30441265 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.311T>C (p.Val104Ala) single nucleotide variant not specified [RCV004113068] Chr16:30424435 [GRCh38]
Chr16:30435756 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.44A>C (p.Glu15Ala) single nucleotide variant not specified [RCV004168124] Chr16:30429937 [GRCh38]
Chr16:30441258 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.422A>T (p.Tyr141Phe) single nucleotide variant not specified [RCV004187847] Chr16:30424324 [GRCh38]
Chr16:30435645 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.332G>A (p.Arg111His) single nucleotide variant not specified [RCV004168322] Chr16:30424414 [GRCh38]
Chr16:30435735 [GRCh37]
Chr16:16p11.2		 likely benign
NM_024096.2(DCTPP1):c.404G>A (p.Arg135His) single nucleotide variant not specified [RCV004077564] Chr16:30424342 [GRCh38]
Chr16:30435663 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.238G>A (p.Gly80Ser) single nucleotide variant not specified [RCV004280787] Chr16:30424508 [GRCh38]
Chr16:30435829 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.403C>T (p.Arg135Cys) single nucleotide variant not specified [RCV004275624] Chr16:30424343 [GRCh38]
Chr16:30435664 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.5C>T (p.Ser2Phe) single nucleotide variant not specified [RCV004356777] Chr16:30429976 [GRCh38]
Chr16:30441297 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.256C>A (p.Pro86Thr) single nucleotide variant not specified [RCV004346869] Chr16:30424490 [GRCh38]
Chr16:30435811 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.226G>A (p.Asp76Asn) single nucleotide variant not specified [RCV004375467] Chr16:30424520 [GRCh38]
Chr16:30435841 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.64C>T (p.Arg22Trp) single nucleotide variant not specified [RCV004375468] Chr16:30429917 [GRCh38]
Chr16:30441238 [GRCh37]
Chr16:16p11.2		 uncertain significance
NC_000016.9:g.(?_28889993)_(31202759_?)del deletion Dilated Cardiomyopathy, Dominant [RCV004582801] Chr16:28889993..31202759 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024096.2(DCTPP1):c.463G>A (p.Val155Met) single nucleotide variant not specified [RCV004611509] Chr16:30424283 [GRCh38]
Chr16:30435604 [GRCh37]
Chr16:16p11.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1395
Count of miRNA genes:419
Interacting mature miRNAs:459
Transcripts:ENST00000319285, ENST00000565758, ENST00000567983, ENST00000568434, ENST00000568973
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597172245GWAS1268319_HDCTP pyrophosphatase 1 measurement QTL GWAS1268319 (human)1e-12DCTP pyrophosphatase 1 measurement163042428030424281Human
407074766GWAS723742_Hsodium measurement QTL GWAS723742 (human)5e-12sodium measurementblood sodium level (CMO:0000499)163042798830427989Human
597264999GWAS1361073_HDCTP pyrophosphatase 1 measurement QTL GWAS1361073 (human)6e-50DCTP pyrophosphatase 1 measurement163042448130424482Human

Markers in Region
SHGC-61066  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371630,435,062 - 30,435,175UniSTSGRCh37
Build 361630,342,563 - 30,342,676RGDNCBI36
Celera1629,863,729 - 29,863,842RGD
Cytogenetic Map16p11.2UniSTS
HuRef1627,997,275 - 27,997,388UniSTS
D16S2672  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371630,435,067 - 30,435,175UniSTSGRCh37
Build 361630,342,568 - 30,342,676RGDNCBI36
Celera1629,863,729 - 29,863,837RGD
Cytogenetic Map16p11.2UniSTS
HuRef1627,997,280 - 27,997,388UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4942 1723 2345 4 622 1948 464 2268 7281 6454 52 3708 847 1731 1612 171

Sequence


Ensembl Acc Id: ENST00000319285   ⟹   ENSP00000322524
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1630,423,615 - 30,430,030 (-)Ensembl
Ensembl Acc Id: ENST00000565758   ⟹   ENSP00000460933
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1630,424,034 - 30,429,992 (-)Ensembl
Ensembl Acc Id: ENST00000567983   ⟹   ENSP00000456612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1630,423,698 - 30,430,030 (-)Ensembl
Ensembl Acc Id: ENST00000568434   ⟹   ENSP00000455391
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1630,423,914 - 30,429,289 (-)Ensembl
Ensembl Acc Id: ENST00000568973   ⟹   ENSP00000460764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1630,423,979 - 30,429,800 (-)Ensembl
Ensembl Acc Id: ENST00000678016   ⟹   ENSP00000503857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1630,423,698 - 30,429,824 (-)Ensembl
RefSeq Acc Id: NM_024096   ⟹   NP_077001
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381630,423,615 - 30,430,030 (-)NCBI
GRCh371630,435,019 - 30,441,373 (-)RGD
Build 361630,342,520 - 30,348,874 (-)NCBI Archive
Celera1629,857,548 - 29,863,885 (+)RGD
HuRef1627,997,232 - 28,003,588 (-)RGD
CHM1_11631,751,466 - 31,757,820 (-)NCBI
T2T-CHM13v2.01630,809,819 - 30,816,234 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134470
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381630,423,615 - 30,430,030 (-)NCBI
CHM1_11631,751,466 - 31,757,820 (-)NCBI
T2T-CHM13v2.01630,809,819 - 30,816,234 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134471
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381630,423,615 - 30,429,800 (-)NCBI
CHM1_11631,751,466 - 31,757,568 (-)NCBI
T2T-CHM13v2.01630,809,819 - 30,816,004 (-)NCBI
Sequence:
RefSeq Acc Id: NP_077001   ⟸   NM_024096
- UniProtKB: Q9H773 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000460933   ⟸   ENST00000565758
Ensembl Acc Id: ENSP00000456612   ⟸   ENST00000567983
Ensembl Acc Id: ENSP00000460764   ⟸   ENST00000568973
Ensembl Acc Id: ENSP00000455391   ⟸   ENST00000568434
Ensembl Acc Id: ENSP00000322524   ⟸   ENST00000319285
Ensembl Acc Id: ENSP00000503857   ⟸   ENST00000678016

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H773-F1-model_v2 AlphaFold Q9H773 1-170 view protein structure

Promoters
RGD ID:6792949
Promoter ID:HG_KWN:23540
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000255553
Position:
Human AssemblyChrPosition (strand)Source
Build 361630,348,734 - 30,349,234 (-)MPROMDB
RGD ID:7231975
Promoter ID:EPDNEW_H21731
Type:initiation region
Name:DCTPP1_1
Description:dCTP pyrophosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381630,430,015 - 30,430,075EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28777 AgrOrtholog
COSMIC DCTPP1 COSMIC
Ensembl Genes ENSG00000179958 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000319285 ENTREZGENE
  ENST00000319285.5 UniProtKB/Swiss-Prot
  ENST00000565758.1 UniProtKB/TrEMBL
  ENST00000567983.1 UniProtKB/TrEMBL
  ENST00000568434.1 UniProtKB/TrEMBL
  ENST00000568973.5 UniProtKB/TrEMBL
  ENST00000678016.1 UniProtKB/TrEMBL
Gene3D-CATH MazG-like UniProtKB/Swiss-Prot
GTEx ENSG00000179958 GTEx
HGNC ID HGNC:28777 ENTREZGENE
Human Proteome Map DCTPP1 Human Proteome Map
InterPro dCTP_Pyrophosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DCTPP UniProtKB/Swiss-Prot
KEGG Report hsa:79077 UniProtKB/Swiss-Prot
NCBI Gene 79077 ENTREZGENE
OMIM 615840 OMIM
PANTHER DCTP PYROPHOSPHATASE 1 UniProtKB/Swiss-Prot
  DCTP PYROPHOSPHATASE 1 UniProtKB/Swiss-Prot
  DCTP PYROPHOSPHATASE 1 UniProtKB/TrEMBL
  DCTP PYROPHOSPHATASE 1 UniProtKB/TrEMBL
Pfam MazG-like UniProtKB/Swiss-Prot
PharmGKB PA164718733 PharmGKB
Superfamily-SCOP all-alpha NTP pyrophosphatases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DCTP1_HUMAN UniProtKB/Swiss-Prot
  H3BPN2_HUMAN UniProtKB/TrEMBL
  H3BSA6_HUMAN UniProtKB/TrEMBL
  Q9H773 ENTREZGENE