OR8U8 (olfactory receptor family 8 subfamily U member 8)

Gene: OR8U8 (olfactory receptor family 8 subfamily U member 8) Homo sapiens

Analyze

No known orthologs.

Symbol:

OR8U8

Name:

olfactory receptor family 8 subfamily U member 8

RGD ID:

1601900

HGNC Page

HGNC:27538

Description:

Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in plasma membrane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

olfactory receptor 8U8; olfactory receptor, family 8, subfamily U, member 8

RGD Orthologs

Alliance Genes

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Alliance orthologs ³				less info ...
Rattus norvegicus (Norway rat):	Or8u8 (olfactory receptor family 8 subfamily U member 8)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Or8u8 (olfactory receptor family 8 subfamily U member 8)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdca4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	or5f1l1.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	or5f1l1.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|SonicParanoid)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Annotation category: only annotated on alternate loci in reference assembly

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Build 36	11	55,899,676 - 55,900,635 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	53,483,178 - 53,484,137 (+)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI
HuRef	11	52,472,409 - 52,473,368 (+)	NCBI		HuRef

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

aflatoxin B1 (EXP)

bisphenol A (EXP)

cyclosporin A (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of smell (IEA)

G protein-coupled receptor signaling pathway (IBA,IEA)

sensory perception of smell (IBA,IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA,TAS)

Molecular Function

G protein-coupled receptor activity (IEA)

odorant binding (IBA,IEA)

olfactory receptor activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations

Additional References at PubMed

PMID:11237011	PMID:15496913	PMID:21873635	PMID:30021884

Genomics

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_001004743.1(OR5M9):c.624C>T (p.Ser208=)	single nucleotide variant	Malignant melanoma [RCV000062282]	Chr11:56462778 [GRCh38] Chr11:56230254 [GRCh37] Chr11:55986830 [NCBI36] Chr11:11q12.1	not provided
NM_001004743.1(OR5M9):c.623C>T (p.Ser208Phe)	single nucleotide variant	Malignant melanoma [RCV000062283]	Chr11:56462779 [GRCh38] Chr11:56230255 [GRCh37] Chr11:55986831 [NCBI36] Chr11:11q12.1	not provided
NM_001002925.1(OR5AP2):c.845T>A (p.Val282Asp)	single nucleotide variant	Malignant melanoma [RCV000062284]	Chr11:56641595 [GRCh38] Chr11:56409071 [GRCh37] Chr11:56165647 [NCBI36] Chr11:11q12.1	not provided
NM_001005284.1(OR9G4):c.688C>T (p.Leu230=)	single nucleotide variant	Malignant melanoma [RCV000062285]	Chr11:56743124 [GRCh38] Chr11:56510600 [GRCh37] Chr11:56267176 [NCBI36] Chr11:11q12.1	not provided
NM_001005204.1(OR8U1):c.442C>T (p.Pro148Ser)	single nucleotide variant	Malignant melanoma [RCV000069491]	Chr11:56376065 [GRCh38] Chr11:56143541 [GRCh37] Chr11:55900117 [NCBI36] Chr11:11q12.1	not provided
NM_001004743.1(OR5M9):c.431C>T (p.Ser144Phe)	single nucleotide variant	Malignant melanoma [RCV000069492]	Chr11:56462971 [GRCh38] Chr11:56230447 [GRCh37] Chr11:55987023 [NCBI36] Chr11:11q12.1	not provided
NM_001005245.1(OR5M11):c.675C>T (p.Leu225=)	single nucleotide variant	Malignant melanoma [RCV000069493]	Chr11:56542583 [GRCh38] Chr11:56310059 [GRCh37] Chr11:56066635 [NCBI36] Chr11:11q12.1	not provided
NM_001005245.1(OR5M11):c.309C>T (p.Phe103=)	single nucleotide variant	Malignant melanoma [RCV000069494]	Chr11:56542949 [GRCh38] Chr11:56310425 [GRCh37] Chr11:56067001 [NCBI36] Chr11:11q12.1	not provided
NM_001002925.1(OR5AP2):c.339C>T (p.Phe113=)	single nucleotide variant	Malignant melanoma [RCV000069496]	Chr11:56642101 [GRCh38] Chr11:56409577 [GRCh37] Chr11:56166153 [NCBI36] Chr11:11q12.1	not provided
NM_001005213.1(OR9G1):c.585A>G (p.Lys195=)	single nucleotide variant	Malignant melanoma [RCV000069498]	Chr11:56700972 [GRCh38] Chr11:56468448 [GRCh37] Chr11:56225024 [NCBI36] Chr11:11q12.1	not provided
NM_001004741.1(OR5M10):c.828C>T (p.Val276=)	single nucleotide variant	Malignant melanoma [RCV000069495]	Chr11:56576894 [GRCh38] Chr11:56344370 [GRCh37] Chr11:56100946 [NCBI36] Chr11:11q12.1	not provided
NM_001002925.1(OR5AP2):c.336C>T (p.Ser112=)	single nucleotide variant	Malignant melanoma [RCV000069497]	Chr11:56642104 [GRCh38] Chr11:56409580 [GRCh37] Chr11:56166156 [NCBI36] Chr11:11q12.1	not provided

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AADD01115766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC208786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC213240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH159136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KP290523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_001013356 ⟹ NP_001013374

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
Celera	11	53,483,178 - 53,484,137 (+)	RGD
HuRef	11	52,472,409 - 52,473,368 (+)	RGD

Sequence:

show sequence

ATGGCTCACATCAATTGCACCCAGGCGACAGAGTTTATTCTTGTGGGCCTCACAGATCGTCAGG
AGTTGAAGATGCCCCTCTTTGTGCTATTCTTATCCATCTACCTCTTCACAGTGGTAGGCAACTT
GGGTTTGATCCTACTCATTAGAGCGGATACAAGTCTCAACACACCAATGTACTTCTTTCTTAGC
AACCTAGCTTTTGTGGATTTCTGTTACTCTTCTGTCATTACACCCAAAATGCTTGGGAATTTCT
TGTACAAACAAAATGTTATATCCTTTGATGCATGTGCTACTCAACTGGGCTGCTTTCTCACCTT
CATGATATCAGAATCCTTGCTACTGGCTTCCATGGCCTATGACCGATATGTGGCCATTTGTAAC
CCTCTATTGTATATGGTTGTAATGACTCCAGGAATCTGCATTCAACTTGTAGCAGTTCCTTATA
GCTATAGCTTCCTAATGGCACTATTTCACACCATCCTCACCTTCTGCCTCTCCTATTGCCACTC
CAACATTGTCAACCATTTCTATTGTGATGACATGCCTCTCCTCAGGCTAACTTGCTCAGACACT
CGCTTCAAACAGCTATGGATTTTGGCCTGTGCTGGTATCACATTCATCTGCTCTGTTCTGATTG
TCTTTGTCTCCTACATGTTCATTATTTTTGCCATCCTGAGGATGAGCTCAGCTGAAGGAAGACG
CAAAGCCTTCTCCACCTGTAGCTCTCACATGCTGGCAGTCACCATATTCTATGGCACCCTGATC
TTTATGTACTTACAACCAAGCTCAAGCCATTCTCTTGATGCAGACAAGATGGCCTCTGTCTTCT
ACACGGTGATTATTCCCATGTTGAATCCCTTGATTTACAGTCTCAGGAACAAAGATGTAAAAGA
TGCCCTGAAGAAAGTCATCATCAATAGAAACCATGCTTTTATTTTTCTGAAACTGAGAAAATGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013374	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ALI87684	(Get FASTA)	NCBI Sequence Viewer
	EAW73711	(Get FASTA)	NCBI Sequence Viewer
	P0C7N1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013374 ⟸ NM_001013356

- UniProtKB:

P0C7N1 (UniProtKB/Swiss-Prot), A0A126GW66 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHINCTQATEFILVGLTDRQELKMPLFVLFLSIYLFTVVGNLGLILLIRADTSLNTPMYFFLS
NLAFVDFCYSSVITPKMLGNFLYKQNVISFDACATQLGCFLTFMISESLLLASMAYDRYVAICN
PLLYMVVMTPGICIQLVAVPYSYSFLMALFHTILTFCLSYCHSNIVNHFYCDDMPLLRLTCSDT
RFKQLWILACAGITFICSVLIVFVSYMFIIFAILRMSSAEGRRKAFSTCSSHMLAVTIFYGTLI
FMYLQPSSSHSLDADKMASVFYTVIIPMLNPLIYSLRNKDVKDALKKVIINRNHAFIFLKLRK

hide sequence

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P0C7N1-F1-model_v2	AlphaFold	P0C7N1	1-319	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:27538	AgrOrtholog
COSMIC	OR8U8	COSMIC
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	OR8U8	GTEx
HGNC ID	HGNC:27538	ENTREZGENE
Human Proteome Map	OR8U8	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Olfact_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	504189	ENTREZGENE
PANTHER	OLFACTORY RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OLFACTORY RECEPTOR 8U1-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA142671222	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OLFACTORYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A126GW66	ENTREZGENE, UniProtKB/TrEMBL
	OR8U8_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-15	OR8U8	olfactory receptor family 8 subfamily U member 8		olfactory receptor, family 8, subfamily U, member 8	Symbol and/or name change	5135510	APPROVED
2011-09-01	OR8U8	olfactory receptor, family 8, subfamily U, member 8	OR8U8	olfactory receptor, family 8, subfamily U, member 8	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message