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Gene: WWC1 (WW and C2 domain containing 1) Homo sapiens
Symbol: WWC1
Name: WW and C2 domain containing 1
RGD ID: 1601880
Description: Exhibits kinase binding activity; molecular adaptor activity; and transcription coactivator activity. Involved in several processes, including negative regulation of organ growth; negative regulation of transcription by RNA polymerase II; and regulation of intracellular signal transduction. Localizes to several cellular components, including cytosol; perinuclear region of cytoplasm; and ruffle membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ10865; FLJ23369; HBeAg-binding protein 3; HBEBP3; HBEBP36; KIAA0869; KIBRA; kidney and brain protein; MEMRYQTL; PPP1R168; WW, C2 and coiled-coil domain containing 1
Mus musculus (house mouse) : Wwc1 (WW, C2 and coiled-coil domain containing 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wwc1 (WW and C2 domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wwc1 (WW and C2 domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : WWC1 (WW and C2 domain containing 1)
Canis lupus familiaris (dog) : WWC1 (WW and C2 domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wwc1 (WW and C2 domain containing 1)
Sus scrofa (pig) : WWC1 (WW and C2 domain containing 1)
Chlorocebus sabaeus (African green monkey) : WWC1 (WW and C2 domain containing 1)
Heterocephalus glaber (naked mole-rat) : Wwc1 (WW and C2 domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5168,291,645 - 168,472,303 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5168,291,651 - 168,472,303 (+)EnsemblGRCh38hg38GRCh38
GRCh385168,291,645 - 168,472,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375167,719,065 - 167,899,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365167,651,670 - 167,829,342 (+)NCBINCBI36hg18NCBI36
Celera5163,754,431 - 163,934,646 (+)NCBI
Cytogenetic Map5q34NCBI
HuRef5162,818,257 - 162,998,068 (+)NCBIHuRef
CHM1_15167,152,124 - 167,332,374 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on WWC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1601880
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.