SNHG15 (small nucleolar RNA host gene 15) - Rat Genome Database

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Gene: SNHG15 (small nucleolar RNA host gene 15) Homo sapiens
Analyze
Symbol: SNHG15
Name: small nucleolar RNA host gene 15
RGD ID: 1601702
HGNC Page HGNC:27797
Description: Predicted to act upstream of or within several processes, including mitotic sister chromatid segregation; satellite cell activation involved in skeletal muscle regeneration; and skeletal muscle satellite cell proliferation. Predicted to be located in cytoplasm.
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: REVIEWED
Previously known as: C7orf40; FLJ38860; Linc-Myo1g; MYO1GUN; MYO1GUT
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,983,023 - 44,986,696 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,983,019 - 44,986,961 (-)EnsemblGRCh38hg38GRCh38
GRCh37745,022,622 - 45,026,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,989,152 - 44,992,784 (-)NCBINCBI36Build 36hg18NCBI36
Celera745,121,376 - 45,125,025 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,907,793 - 44,911,442 (-)NCBIHuRef
CHM1_1745,026,541 - 45,030,190 (-)NCBICHM1_1
T2T-CHM13v2.0745,143,371 - 45,147,061 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,062,083 - 45,065,732 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12690205   PMID:14702039   PMID:16344560   PMID:24036268   PMID:26662309   PMID:27212162   PMID:28719640   PMID:28720111   PMID:29048682   PMID:29137412   PMID:29217194  
PMID:29604394   PMID:29630731   PMID:29750422   PMID:29771418   PMID:30280769   PMID:30317592   PMID:30402848   PMID:30840276   PMID:30945457   PMID:30981837   PMID:31014355   PMID:31310393  
PMID:31636472   PMID:31696491   PMID:31774607   PMID:32141559   PMID:32247266   PMID:32633324   PMID:32633365   PMID:32643707   PMID:32655137   PMID:33372376   PMID:33572758   PMID:33899079  
PMID:34016097   PMID:34551140   PMID:34734088   PMID:34868528   PMID:35650158   PMID:37148838  


Genomics

Comparative Map Data
SNHG15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,983,023 - 44,986,696 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,983,019 - 44,986,961 (-)EnsemblGRCh38hg38GRCh38
GRCh37745,022,622 - 45,026,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,989,152 - 44,992,784 (-)NCBINCBI36Build 36hg18NCBI36
Celera745,121,376 - 45,125,025 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,907,793 - 44,911,442 (-)NCBIHuRef
CHM1_1745,026,541 - 45,030,190 (-)NCBICHM1_1
T2T-CHM13v2.0745,143,371 - 45,147,061 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,062,083 - 45,065,732 (-)NCBI
Snhg15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,475,591 - 6,478,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,475,295 - 6,478,841 (-)EnsemblGRCm39 Ensembl
GRCm38116,525,591 - 6,528,760 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,525,591 - 6,528,779 (-)EnsemblGRCm38mm10GRCm38
MGSCv37116,425,594 - 6,428,763 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,425,594 - 6,428,965 (-)NCBIMGSCv36mm8
Celera117,012,670 - 7,015,839 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.37NCBI

Variants

.
Variants in SNHG15
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p13-12.3(chr7:44193369-46558381)x1 copy number loss See cases [RCV000052316] Chr7:44193369..46558381 [GRCh38]
Chr7:44232968..46597979 [GRCh37]
Chr7:44199493..46564504 [NCBI36]
Chr7:7p13-12.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:39814159-45749735)x1 copy number loss See cases [RCV000053132] Chr7:39814159..45749735 [GRCh38]
Chr7:39853758..45789334 [GRCh37]
Chr7:39820283..45755859 [NCBI36]
Chr7:7p14.1-12.3
pathogenic
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 copy number gain See cases [RCV000053532] Chr7:33328312..62377476 [GRCh38]
Chr7:33367924..61831899 [GRCh37]
Chr7:33334449..61469334 [NCBI36]
Chr7:7p14.3-q11.21
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p13-12.1(chr7:44571949-53699760)x1 copy number loss See cases [RCV000134973] Chr7:44571949..53699760 [GRCh38]
Chr7:44611548..53767453 [GRCh37]
Chr7:44578073..53734947 [NCBI36]
Chr7:7p13-12.1
pathogenic
GRCh38/hg38 7p14.1-11.2(chr7:40534157-56107122)x1 copy number loss See cases [RCV000136092] Chr7:40534157..56107122 [GRCh38]
Chr7:40573756..56174815 [GRCh37]
Chr7:40540281..56142309 [NCBI36]
Chr7:7p14.1-11.2
pathogenic
GRCh38/hg38 7p14.1-12.1(chr7:40020598-50543500)x1 copy number loss See cases [RCV000136904] Chr7:40020598..50543500 [GRCh38]
Chr7:40060197..50611198 [GRCh37]
Chr7:40026722..50578692 [NCBI36]
Chr7:7p14.1-12.1
pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:37303478-48660738)x1 copy number loss See cases [RCV000137139] Chr7:37303478..48660738 [GRCh38]
Chr7:37343082..48700334 [GRCh37]
Chr7:37309607..48670880 [NCBI36]
Chr7:7p14.1-12.3
pathogenic
GRCh38/hg38 7p14.1-13(chr7:39063400-45363096)x1 copy number loss See cases [RCV000137305] Chr7:39063400..45363096 [GRCh38]
Chr7:39103000..45402695 [GRCh37]
Chr7:39069525..45369220 [NCBI36]
Chr7:7p14.1-13
pathogenic
GRCh38/hg38 7p13(chr7:44345798-45076469)x3 copy number gain See cases [RCV000140230] Chr7:44345798..45076469 [GRCh38]
Chr7:44385397..45116068 [GRCh37]
Chr7:44351922..45082593 [NCBI36]
Chr7:7p13
uncertain significance
GRCh38/hg38 7p14.1-13(chr7:38177999-45304100)x1 copy number loss See cases [RCV000142297] Chr7:38177999..45304100 [GRCh38]
Chr7:38217601..45343699 [GRCh37]
Chr7:38184126..45310224 [NCBI36]
Chr7:7p14.1-13
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p14.1-12.3(chr7:40350383-47034422)x1 copy number loss See cases [RCV000446941] Chr7:40350383..47034422 [GRCh37]
Chr7:7p14.1-12.3
pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p13(chr7:44688036-45364793)x3 copy number gain See cases [RCV000511814] Chr7:44688036..45364793 [GRCh37]
Chr7:7p13
likely benign
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p13(chr7:44990619-45233464)x3 copy number gain not provided [RCV001005946] Chr7:44990619..45233464 [GRCh37]
Chr7:7p13
uncertain significance
GRCh37/hg19 7p14.1-12.3(chr7:41124364-47945566) copy number loss Syndactyly [RCV001352654] Chr7:41124364..47945566 [GRCh37]
Chr7:7p14.1-12.3
pathogenic
GRCh37/hg19 7p13-12.2(chr7:43341583-50171623) copy number loss Intracranial hemorrhage [RCV001352658] Chr7:43341583..50171623 [GRCh37]
Chr7:7p13-12.2
pathogenic
GRCh37/hg19 7p14.1-12.2(chr7:40778439-50228656) copy number loss not specified [RCV002053688] Chr7:40778439..50228656 [GRCh37]
Chr7:7p14.1-12.2
pathogenic
GRCh37/hg19 7p13(chr7:44765589-45364793) copy number gain not specified [RCV002053690] Chr7:44765589..45364793 [GRCh37]
Chr7:7p13
uncertain significance
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3
uncertain significance
GRCh37/hg19 7p14.1-12.3(chr7:42516660-46202495)x1 copy number loss not provided [RCV003482956] Chr7:42516660..46202495 [GRCh37]
Chr7:7p14.1-12.3
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1484
Count of miRNA genes:589
Interacting mature miRNAs:649
Transcripts:ENST00000438705, ENST00000577700, ENST00000578968, ENST00000579383, ENST00000580458, ENST00000580528, ENST00000582727, ENST00000584327, ENST00000584686, ENST00000585030
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-R52131  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,022,749 - 45,022,899UniSTSGRCh37
Build 36744,989,274 - 44,989,424RGDNCBI36
Celera745,121,498 - 45,121,648RGD
Cytogenetic Map7p13UniSTS
HuRef744,907,915 - 44,908,065UniSTS
CRA_TCAGchr7v2745,062,205 - 45,062,355UniSTS
GeneMap99-GB4 RH Map7214.21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1156 1019 1089 101 1324 72 2798 501 1658 217 1353 1507 41 1024 1436 3
Low 1274 1964 624 516 623 387 1554 1692 2044 201 95 96 130 180 1352 1
Below cutoff 2 1 10 5 1 5 2 5 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_003697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_152594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_152595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_152596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_152597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA488149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA767840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD639046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB280360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB450983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA988822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA988823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA988824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000438705
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,085 - 44,986,570 (-)Ensembl
RefSeq Acc Id: ENST00000577700
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,023 - 44,986,637 (-)Ensembl
RefSeq Acc Id: ENST00000578968
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,019 - 44,986,834 (-)Ensembl
RefSeq Acc Id: ENST00000579383
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,023 - 44,986,696 (-)Ensembl
RefSeq Acc Id: ENST00000580458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,034 - 44,986,650 (-)Ensembl
RefSeq Acc Id: ENST00000580528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,038 - 44,986,961 (-)Ensembl
RefSeq Acc Id: ENST00000582727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,023 - 44,986,680 (-)Ensembl
RefSeq Acc Id: ENST00000584327
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,137 - 44,986,560 (-)Ensembl
RefSeq Acc Id: ENST00000584686
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,847 - 44,986,668 (-)Ensembl
RefSeq Acc Id: ENST00000585030
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,023 - 44,986,669 (-)Ensembl
RefSeq Acc Id: ENST00000653305
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,086 - 44,986,665 (-)Ensembl
RefSeq Acc Id: ENST00000667119
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,026 - 44,986,693 (-)Ensembl
RefSeq Acc Id: ENST00000667823
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,025 - 44,986,668 (-)Ensembl
RefSeq Acc Id: ENST00000668580
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,983,023 - 44,986,699 (-)Ensembl
RefSeq Acc Id: NR_003697
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,983,023 - 44,986,696 (-)NCBI
GRCh37745,022,627 - 45,026,259 (-)RGD
Build 36744,989,152 - 44,992,784 (-)NCBI Archive
Celera745,121,376 - 45,125,025 (-)RGD
HuRef744,907,793 - 44,911,442 (-)RGD
CHM1_1745,026,541 - 45,030,190 (-)NCBI
T2T-CHM13v2.0745,143,371 - 45,147,061 (-)NCBI
CRA_TCAGchr7v2745,062,083 - 45,065,732 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NR_152594
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,983,023 - 44,986,696 (-)NCBI
T2T-CHM13v2.0745,143,371 - 45,147,061 (-)NCBI
Sequence:
RefSeq Acc Id: NR_152595
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,983,023 - 44,986,696 (-)NCBI
T2T-CHM13v2.0745,143,371 - 45,147,061 (-)NCBI
Sequence:
RefSeq Acc Id: NR_152596
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,983,023 - 44,986,696 (-)NCBI
T2T-CHM13v2.0745,143,371 - 45,147,061 (-)NCBI
Sequence:
RefSeq Acc Id: NR_152597
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,983,023 - 44,986,696 (-)NCBI
T2T-CHM13v2.0745,143,371 - 45,147,061 (-)NCBI
Sequence:
Promoters
RGD ID:15096142
Promoter ID:EPDNEWNC_H968
Type:initiation region
Name:SNHG15_1
Description:small nucleolar RNA host gene 15 [Source:HGNCSymbol;Acc:HGNC:27797]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,986,656 - 44,986,716EPDNEWNC
RGD ID:15096135
Promoter ID:EPDNEWNC_H969
Type:initiation region
Name:SNHG15_2
Description:small nucleolar RNA host gene 15 [Source:HGNCSymbol;Acc:HGNC:27797]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,986,949 - 44,987,009EPDNEWNC
RGD ID:6805320
Promoter ID:HG_KWN:57281
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NR_003697,   UC003TMK.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36744,991,551 - 44,992,802 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:27797 AgrOrtholog
COSMIC SNHG15 COSMIC
Ensembl Genes ENSG00000232956 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578968 ENTREZGENE
  ENST00000579383 ENTREZGENE
  ENST00000580458 ENTREZGENE
  ENST00000585030 ENTREZGENE
GTEx ENSG00000232956 GTEx
HGNC ID HGNC:27797 ENTREZGENE
Human Proteome Map SNHG15 Human Proteome Map
NCBI Gene 285958 ENTREZGENE
PharmGKB PA147358570 PharmGKB
RNAcentral URS0000CCDF70 RNACentral
  URS0000CCDFDE RNACentral
  URS0000CCE065 RNACentral
  URS0000CCE070 RNACentral
  URS0000CCE0DA RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-02-24 SNHG15  small nucleolar RNA host gene 15    small nucleolar RNA host gene 15 (non-protein coding)  Symbol and/or name change 5135510 APPROVED
2011-11-29 SNHG15  small nucleolar RNA host gene 15 (non-protein coding)  C7orf40  chromosome 7 open reading frame 40  Symbol and/or name change 5135510 APPROVED