Ube2ql1 (ubiquitin conjugating enzyme E2 QL1) - Rat Genome Database

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Gene: Ube2ql1 (ubiquitin conjugating enzyme E2 QL1) Rattus norvegicus
Analyze
Symbol: Ube2ql1
Name: ubiquitin conjugating enzyme E2 QL1 (Ensembl:ubiquitin-conjugating enzyme E2Q family-like 1)
RGD ID: 1598121
Description: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Orthologous to human UBE2QL1 (ubiquitin conjugating enzyme E2 QL1); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC679949; probable ubiquitin-conjugating enzyme E2 FLJ25076 homolog; similar to CG4502-PA, isoform A; ubiquitin-conjugating enzyme E2Q family-like 1; ubiquitin-conjugating enzyme E2Q-like protein 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,377,264 - 35,417,624 (+)NCBIGRCr8
mRatBN7.2133,548,814 - 33,589,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,548,814 - 33,589,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,384,207 - 33,424,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,382,811 - 39,423,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,577,000 - 33,617,360 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,185,916 - 36,226,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,185,916 - 36,226,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,582,312 - 37,622,672 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,700,392 - 3,740,804 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera132,158,184 - 32,198,529 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
plasma membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22871113   PMID:24000165  


Genomics

Comparative Map Data
Ube2ql1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,377,264 - 35,417,624 (+)NCBIGRCr8
mRatBN7.2133,548,814 - 33,589,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,548,814 - 33,589,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,384,207 - 33,424,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,382,811 - 39,423,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,577,000 - 33,617,360 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,185,916 - 36,226,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,185,916 - 36,226,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,582,312 - 37,622,672 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,700,392 - 3,740,804 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera132,158,184 - 32,198,529 (+)NCBICelera
Cytogenetic Map1p11NCBI
UBE2QL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,448,859 - 6,496,723 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl56,448,859 - 6,496,723 (+)EnsemblGRCh38hg38GRCh38
GRCh3756,448,972 - 6,496,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,490,460 - 6,548,029 (+)NCBINCBI36Build 36hg18NCBI36
Celera56,476,425 - 6,520,375 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef56,466,054 - 6,471,560 (+)NCBIHuRef
CHM1_156,448,829 - 6,496,771 (+)NCBICHM1_1
T2T-CHM13v2.056,379,225 - 6,427,083 (+)NCBIT2T-CHM13v2.0
Ube2ql1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,850,951 - 69,888,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,850,951 - 69,888,008 (-)EnsemblGRCm39 Ensembl
GRCm381369,702,832 - 69,739,897 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,702,832 - 69,739,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv371369,841,710 - 69,878,775 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361370,170,200 - 70,206,712 (-)NCBIMGSCv36mm8
Celera1372,047,268 - 72,084,442 (-)NCBICelera
Cytogenetic Map13B3- C1NCBI
cM Map1335.55NCBI
UBE2QL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v246,699,965 - 6,744,078 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan154,853,572 - 4,897,685 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v056,772,764 - 6,817,062 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
UBE2QL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,237,350 - 7,277,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,238,561 - 7,277,853 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,747,421 - 11,788,422 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,147,582 - 7,188,609 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,147,810 - 7,189,186 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,194,330 - 7,235,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,174,627 - 7,215,642 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,387,934 - 7,428,940 (-)NCBIUU_Cfam_GSD_1.0
UBE2QL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,428,276 - 75,474,044 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11675,428,272 - 75,474,506 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,787,687 - 81,834,321 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2QL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,136,142 - 6,179,292 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,136,037 - 6,178,048 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606422,539,053 - 22,581,233 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2ql1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247514,193,962 - 4,232,309 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247514,193,968 - 4,228,468 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ube2ql1
120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:109
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000041762
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat

Markers in Region
RH130057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,588,815 - 33,589,004 (+)MAPPERmRatBN7.2
Rnor_6.0136,225,918 - 36,226,106NCBIRnor6.0
Rnor_5.0137,622,314 - 37,622,502UniSTSRnor5.0
RGSC_v3.4173,740,446 - 3,740,634UniSTSRGSC3.4
Celera132,198,171 - 32,198,359UniSTS
Cytogenetic Map17p14UniSTS
RH131139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,588,223 - 33,588,437 (+)MAPPERmRatBN7.2
Rnor_6.0136,225,326 - 36,225,539NCBIRnor6.0
Rnor_5.0137,621,722 - 37,621,935UniSTSRnor5.0
RGSC_v3.4173,739,854 - 3,740,067UniSTSRGSC3.4
Celera132,197,579 - 32,197,792UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 59 58 28 18 28 6 180 90 93 45 60 30

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041762   ⟹   ENSRNOP00000044214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl133,548,814 - 33,589,174 (+)Ensembl
Rnor_6.0 Ensembl136,185,916 - 36,226,276 (+)Ensembl
RefSeq Acc Id: NM_001145163   ⟹   NP_001138635
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8135,377,264 - 35,417,624 (+)NCBI
mRatBN7.2133,548,814 - 33,589,174 (+)NCBI
Rnor_6.0136,185,916 - 36,226,276 (+)NCBI
Rnor_5.0137,582,312 - 37,622,672 (+)NCBI
RGSC_v3.4173,700,392 - 3,740,804 (+)RGD
Celera132,158,184 - 32,198,529 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001138635 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044214.3
RefSeq Acc Id: NP_001138635   ⟸   NM_001145163
- UniProtKB: D3ZXV0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044214   ⟸   ENSRNOT00000041762
Protein Domains
UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXV0-F1-model_v2 AlphaFold D3ZXV0 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689574
Promoter ID:EPDNEW_R98
Type:initiation region
Name:Ube2ql1_1
Description:ubiquitin-conjugating enzyme E2Q family-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0136,185,944 - 36,186,004EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598121 AgrOrtholog
BioCyc Gene G2FUF-61872 BioCyc
Ensembl Genes ENSRNOG00000034075 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041762.4 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/TrEMBL
InterPro Ub_conjugating_enzyme UniProtKB/TrEMBL
  UBQ-conjugat/RWD-like UniProtKB/TrEMBL
  UBQ-conjugat_E2 UniProtKB/TrEMBL
KEGG Report rno:679949 UniProtKB/TrEMBL
NCBI Gene 679949 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/TrEMBL
Pfam UQ_con UniProtKB/TrEMBL
PhenoGen Ube2ql1 PhenoGen
PROSITE UBIQUITIN_CONJUGAT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034075 RatGTEx
SMART UBCc UniProtKB/TrEMBL
Superfamily-SCOP UBQ-conjugat/RWD-like UniProtKB/TrEMBL
UniProt D3ZXV0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-21 Ube2ql1  ubiquitin conjugating enzyme E2 QL1  Ube2ql1  ubiquitin-conjugating enzyme E2Q family-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Ube2ql1  ubiquitin-conjugating enzyme E2Q family-like 1  LOC682677  similar to CG4502-PA, isoform A  Data merged from RGD:1596616 1643240 APPROVED
2010-02-12 Ube2ql1  ubiquitin-conjugating enzyme E2Q family-like 1  LOC679949  similar to CG4502-PA, isoform A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679949  similar to CG4502-PA, isoform A      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682677  similar to CG4502-PA, isoform A      Symbol and Name status set to provisional 70820 PROVISIONAL