Gbp3 (guanylate binding protein 3) - Rat Genome Database

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Gene: Gbp3 (guanylate binding protein 3) Rattus norvegicus
Analyze
Symbol: Gbp3
Name: guanylate binding protein 3
RGD ID: 1597766
Description: Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in cellular response to interleukin-1; cellular response to tumor necrosis factor; and cellular response to type II interferon. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP3 (guanylate binding protein 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanylate-binding protein 1-like; guanylate-binding protein 4-like; guanylate-binding protein 6-like; LOC102553780; LOC304267; LOC685116; RGD1561239; similar to guanylate binding protein 1, interferon-inducible, 67kDa; similar to guanylate binding protein family, member 6; uncharacterized protein Gbp3
RGD Orthologs
Human
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82234,144,042 - 234,173,527 (-)NCBIGRCr8
mRatBN7.22231,460,032 - 231,500,266 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,486,062 - 231,493,098 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02248,450,908 - 248,491,258 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,451,547 - 248,484,100 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02266,976,190 - 267,016,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,672,946 - 240,686,468 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2223,503,902 - 223,514,499 (-)NCBICelera
Celera2223,514,599 - 223,543,713 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17266443   PMID:21151871  


Genomics

Comparative Map Data
Gbp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82234,144,042 - 234,173,527 (-)NCBIGRCr8
mRatBN7.22231,460,032 - 231,500,266 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,486,062 - 231,493,098 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02248,450,908 - 248,491,258 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,451,547 - 248,484,100 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02266,976,190 - 267,016,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,672,946 - 240,686,468 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2223,503,902 - 223,514,499 (-)NCBICelera
Celera2223,514,599 - 223,543,713 (-)NCBICelera
Cytogenetic Map2q44NCBI
GBP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,006,680 - 89,022,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,006,679 - 89,022,894 (-)EnsemblGRCh38hg38GRCh38
GRCh37189,472,363 - 89,488,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,244,948 - 89,261,137 (-)NCBINCBI36Build 36hg18NCBI36
Build 34189,184,388 - 89,200,565NCBI
Celera187,718,156 - 87,734,345 (-)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef187,589,740 - 87,605,932 (-)NCBIHuRef
CHM1_1189,587,403 - 89,603,592 (-)NCBICHM1_1
T2T-CHM13v2.0188,850,078 - 88,866,271 (-)NCBIT2T-CHM13v2.0
LOC100994880
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,948,504 - 137,967,792 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11137,107,420 - 137,123,960 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,718,213 - 91,734,356 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1190,469,939 - 90,486,079 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl190,467,260 - 90,528,491 (-)Ensemblpanpan1.1panPan2
LOC100523668
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14127,290,026 - 127,345,677 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24139,559,283 - 139,570,952 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103224480
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12044,373,122 - 44,388,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2044,380,314 - 44,386,713 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603373,518,742 - 73,534,616 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gbp3
505 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000040856
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
D2Got158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,473,370 - 231,473,592 (+)MAPPERmRatBN7.2
Rnor_6.02248,464,319 - 248,464,540NCBIRnor6.0
Rnor_5.02266,989,445 - 266,989,666UniSTSRnor5.0
RGSC_v3.42240,673,914 - 240,674,136RGDRGSC3.4
RGSC_v3.42240,673,915 - 240,674,136UniSTSRGSC3.4
RGSC_v3.12240,660,655 - 240,660,876RGD
Celera2223,668,284 - 223,668,512UniSTS
Celera2223,517,025 - 223,517,246UniSTS
RH 3.4 Map21580.9RGD
RH 3.4 Map21580.9UniSTS
Cytogenetic Map2q44UniSTS
BI292069  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,468,124 - 231,468,298 (+)MAPPERmRatBN7.2
Rnor_6.02248,458,529 - 248,458,702NCBIRnor6.0
Rnor_5.02266,983,655 - 266,983,828UniSTSRnor5.0
RGSC_v3.42240,679,209 - 240,679,382UniSTSRGSC3.4
Celera2223,511,779 - 223,511,952UniSTS
RH 3.4 Map21590.4UniSTS
Cytogenetic Map2q44UniSTS
AU049512  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,483,912 - 231,484,165 (+)MAPPERmRatBN7.2
Rnor_6.02248,474,916 - 248,475,168NCBIRnor6.0
Rnor_5.02266,999,755 - 267,000,007UniSTSRnor5.0
RGSC_v3.42240,663,470 - 240,663,722UniSTSRGSC3.4
Celera2223,527,372 - 223,527,624UniSTS
Cytogenetic Map2q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 3 8 20 18 7 18 4 6 6 9 4
Below cutoff 5 15 5 12 5 4 4 12 13 5 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040856   ⟹   ENSRNOP00000044805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,486,062 - 231,493,098 (-)Ensembl
Rnor_6.0 Ensembl2248,451,547 - 248,484,100 (-)Ensembl
RefSeq Acc Id: XM_063282922   ⟹   XP_063138992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82234,144,042 - 234,173,527 (-)NCBI
Protein Sequences
Protein RefSeqs XP_063138992 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044805.5
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000044805   ⟸   ENSRNOT00000040856
RefSeq Acc Id: XP_063138992   ⟸   XM_063282922
Protein Domains
GB1/RHD3-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJ56-F1-model_v2 AlphaFold D3ZJ56 1-633 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597766 AgrOrtholog
BioCyc Gene G2FUF-50994 BioCyc
Ensembl Genes ENSRNOG00000036885 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040856.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Guanylate-binding protein, C-terminal domain UniProtKB/TrEMBL
InterPro G_GB1_RHD3_dom UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
  Guanylate-bd_C UniProtKB/TrEMBL
  Guanylate-bd_C_sf UniProtKB/TrEMBL
  Guanylate-bd_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 685116 ENTREZGENE
PANTHER GUANYLATE BINDING PROTEIN UniProtKB/TrEMBL
  GUANYLATE-BINDING PROTEIN 2 UniProtKB/TrEMBL
Pfam GBP UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
PhenoGen Gbp3 PhenoGen
PROSITE G_GB1_RHD3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036885 RatGTEx
Superfamily-SCOP GBP UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt D3ZJ56_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gbp3  guanylate binding protein 3  LOC102553780  guanylate-binding protein 6-like  Data merged from RGD:7601453 737654 PROVISIONAL
2015-07-29 Gbp3  guanylate binding protein 3  RGD1561239  similar to guanylate binding protein 1, interferon-inducible, 67kDa  Data merged from RGD:1561239 737654 PROVISIONAL
2014-11-04 Gbp3  guanylate binding protein 3  LOC685116  similar to guanylate binding protein family, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102553780  guanylate-binding protein 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1561239  similar to guanylate binding protein 1, interferon-inducible, 67kDa   RGD1561239_predicted  similar to guanylate binding protein 1, interferon-inducible, 67kDa (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC685116  similar to guanylate binding protein family, member 6  LOC687523  similar to guanylate nucleotide binding protein 4  Data merged from RGD:1584242 1643240 APPROVED
2006-11-20 LOC685116  similar to guanylate binding protein family, member 6      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687523  similar to guanylate nucleotide binding protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1561239_predicted  similar to guanylate binding protein 1, interferon-inducible, 67kDa (predicted)  LOC304267  similar to guanylate binding protein 1, interferon-inducible, 67kDa  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304267  similar to guanylate binding protein 1, interferon-inducible, 67kDa      Symbol and Name status set to provisional 70820 PROVISIONAL