Cfap299 (cilia and flagella associated protein 299) - Rat Genome Database

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Gene: Cfap299 (cilia and flagella associated protein 299) Rattus norvegicus
Analyze
Symbol: Cfap299
Name: cilia and flagella associated protein 299
RGD ID: 1597725
Description: Predicted to be located in cytoplasm. Orthologous to human CFAP299 (cilia and flagella associated protein 299); INTERACTS WITH aflatoxin B1 (ortholog); Aflatoxin B2 alpha (ortholog); antirheumatic drug (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cilia- and flagella-associated protein 299; LOC685158; similar to CG8138-PA; uncharacterized protein C4orf22 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81411,091,314 - 11,576,981 (-)NCBIGRCr8
mRatBN7.21410,787,191 - 11,272,894 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1410,787,203 - 11,272,943 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01412,437,350 - 12,921,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01412,380,655 - 12,864,816 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41412,140,734 - 12,661,514 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1410,876,139 - 11,348,861 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:30820741  


Genomics

Comparative Map Data
Cfap299
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81411,091,314 - 11,576,981 (-)NCBIGRCr8
mRatBN7.21410,787,191 - 11,272,894 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1410,787,203 - 11,272,943 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01412,437,350 - 12,921,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01412,380,655 - 12,864,816 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41412,140,734 - 12,661,514 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1410,876,139 - 11,348,861 (-)NCBICelera
Cytogenetic Map14p22NCBI
CFAP299
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38480,321,265 - 80,963,750 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl480,335,730 - 80,963,750 (+)EnsemblGRCh38hg38GRCh38
GRCh37481,256,884 - 81,884,904 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36481,475,898 - 82,103,928 (+)NCBINCBI36Build 36hg18NCBI36
Celera478,550,408 - 79,177,954 (+)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef477,000,824 - 77,628,786 (+)NCBIHuRef
CHM1_1481,233,379 - 81,861,422 (+)NCBICHM1_1
T2T-CHM13v2.0483,651,649 - 84,293,773 (+)NCBIT2T-CHM13v2.0
Cfap299
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39598,476,998 - 98,949,912 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl598,477,163 - 98,949,906 (+)EnsemblGRCm39 Ensembl
GRCm38598,329,138 - 98,802,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,329,304 - 98,802,047 (+)EnsemblGRCm38mm10GRCm38
MGSCv37598,758,323 - 99,231,038 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36598,569,606 - 99,042,321 (+)NCBIMGSCv36mm8
Celera595,652,932 - 96,125,979 (+)NCBICelera
Cytogenetic Map5E3NCBI
cM Map547.77NCBI
Cfap299
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554334,581,620 - 5,157,884 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554334,581,581 - 5,158,019 (+)NCBIChiLan1.0ChiLan1.0
CFAP299
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1324,569,871 - 5,147,670 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl324,569,816 - 5,147,979 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3236,733,881 - 37,311,506 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0324,594,239 - 5,178,209 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl324,593,473 - 5,178,170 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1324,632,243 - 5,207,993 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0324,537,229 - 5,114,899 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03234,852,499 - 35,433,884 (-)NCBIUU_Cfam_GSD_1.0
Cfap299
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052857,192,979 - 7,772,761 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367491,676,893 - 1,695,956 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP299
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8136,963,965 - 137,491,976 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18136,963,886 - 137,492,018 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CFAP299
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1728,761,112 - 29,389,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660377,217,325 - 7,459,157 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap299
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475710,051,210 - 10,675,247 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475710,048,665 - 10,675,311 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfap299
3907 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat

Markers in Region
D14Mit1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21411,030,622 - 11,030,812 (+)MAPPERmRatBN7.2
Rnor_6.01412,680,424 - 12,680,613NCBIRnor6.0
Rnor_5.01412,623,297 - 12,623,486UniSTSRnor5.0
RGSC_v3.41412,386,493 - 12,386,683RGDRGSC3.4
RGSC_v3.41412,386,494 - 12,386,683UniSTSRGSC3.4
RGSC_v3.11412,386,414 - 12,386,732RGD
Celera1411,118,295 - 11,118,482UniSTS
RH 2.0 Map14176.7RGD
FHH x ACI Map146.9299RGD
Cytogenetic Map14p22UniSTS
D14Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,988,594 - 10,988,749 (+)MAPPERmRatBN7.2
Rnor_6.01412,638,408 - 12,638,562NCBIRnor6.0
Rnor_5.01412,581,281 - 12,581,435UniSTSRnor5.0
RGSC_v3.41412,344,477 - 12,344,632RGDRGSC3.4
RGSC_v3.41412,344,478 - 12,344,632UniSTSRGSC3.4
RGSC_v3.11412,344,477 - 12,344,632RGD
Celera1411,076,185 - 11,076,339UniSTS
RH 2.0 Map14175.6RGD
SHRSP x BN Map146.9RGD
Cytogenetic Map14p22UniSTS
D14Got100  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,885,680 - 10,885,902 (+)MAPPERmRatBN7.2
Rnor_6.01412,535,772 - 12,535,991NCBIRnor6.0
Rnor_5.01412,478,645 - 12,478,864UniSTSRnor5.0
RGSC_v3.41412,241,575 - 12,241,794UniSTSRGSC3.4
Celera1410,974,011 - 10,974,228UniSTS
Cytogenetic Map14p22UniSTS
RH133527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,787,227 - 10,787,377 (+)MAPPERmRatBN7.2
Rnor_6.01412,437,387 - 12,437,536NCBIRnor6.0
Rnor_5.01412,380,687 - 12,380,836UniSTSRnor5.0
RGSC_v3.41412,140,766 - 12,140,915UniSTSRGSC3.4
Celera1410,876,176 - 10,876,325UniSTS
Cytogenetic Map14p22UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000116175   ⟹   ENSRNOP00000080537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1410,787,203 - 11,272,943 (-)Ensembl
RefSeq Acc Id: XM_039092653   ⟹   XP_038948581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81411,091,314 - 11,576,981 (-)NCBI
mRatBN7.21410,787,191 - 11,272,892 (-)NCBI
RefSeq Acc Id: XM_039092654   ⟹   XP_038948582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81411,134,147 - 11,576,978 (-)NCBI
mRatBN7.21410,830,060 - 11,272,894 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038948581 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948582 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99617 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080537
  ENSRNOP00000080537.1
Reference Protein Sequences
RefSeq Acc Id: XP_038948581   ⟸   XM_039092653
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZT97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948582   ⟸   XM_039092654
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000080537   ⟸   ENSRNOT00000116175

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597725 AgrOrtholog
BioCyc Gene G2FUF-16365 BioCyc
Ensembl Genes ENSRNOG00000067409 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000116175.1 UniProtKB/TrEMBL
InterPro DUF4464 UniProtKB/TrEMBL
NCBI Gene 685158 ENTREZGENE
PANTHER CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299 UniProtKB/TrEMBL
  PTHR33588 UniProtKB/TrEMBL
Pfam DUF4464 UniProtKB/TrEMBL
PhenoGen Cfap299 PhenoGen
RatGTEx ENSRNOG00000067409 RatGTEx
UniProt A0A8I5ZT97 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Cfap299  cilia and flagella associated protein 299  Cfap299  cilia and flagella associated protein 299  Data merged from RGD:149736124 737654 PROVISIONAL
2021-08-09 Cfap299  cilia and flagella associated protein 299      Symbol and Name status set to provisional 45752 PROVISIONAL
2018-02-12 Cfap299  cilia and flagella associated protein 299  LOC685158  similar to CG8138-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 LOC685158  similar to CG8138-PA  LOC100363796  hypothetical LOC100363796  Data merged from RGD:2322356 1643240 APPROVED
2010-05-06 LOC100363796  hypothetical LOC100363796      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC685158  similar to CG8138-PA  LOC684094  similar to CG8138-PA  Data merged from RGD:1595154 1643240 APPROVED
2006-11-20 LOC685158  similar to CG8138-PA      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684094  similar to CG8138-PA      Symbol and Name status set to provisional 70820 PROVISIONAL